메뉴 건너뛰기




Volumn 153, Issue 5, 2008, Pages 1043-1053

Role of complement C5a in mechanical inflammatory hypernociception: Potential use of C5a receptor antagonists to control inflammatory pain

Author keywords

C5a; Complement system; Cytokines; Hyperalgesia; Inflammatory pain; Neutrophils

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; ANTIGEN; ANTIINFLAMMATORY AGENT; CARRAGEENAN; CYTOKINE; DOPAMINE; LIPOPOLYSACCHARIDE; PMX53; PROSTAGLANDIN E2; PROTEIN C5A; UNCLASSIFIED DRUG; ZYMOSAN;

EID: 40349096513     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707640     Document Type: Article
Times cited : (64)

References (61)
  • 1
    • 0025327758 scopus 로고
    • Mononuclear cells enhance prostaglandin E2 production of polymorphonuclear leukocytes via tumor necrosis factor alpha
    • Akama H, Ichikawa Y, Matsushita Y, Shinozawa T, Homma M (1990). Mononuclear cells enhance prostaglandin E2 production of polymorphonuclear leukocytes via tumor necrosis factor alpha. Biochem Biophys Res Commun 168: 857–862.
    • (1990) Biochem Biophys Res Commun , vol.168 , pp. 857-862
    • Akama, H1    Ichikawa, Y2    Matsushita, Y3    Shinozawa, T4    Homma, M5
  • 2
    • 4043106052 scopus 로고    scopus 로고
    • The role of the complement system in ischemia–reperfusion injury
    • Arumugam TV, Shiels IA, Woodruff TM, Granger DN, Taylor SM (2004). The role of the complement system in ischemia–reperfusion injury. Shock 21: 401–409.
    • (2004) Shock , vol.21 , pp. 401-409
    • Arumugam, TV1    Shiels, IA2    Woodruff, TM3    Granger, DN4    Taylor, SM5
  • 3
    • 17944382560 scopus 로고    scopus 로고
    • Acute inflammation in peritoneal dialysis: experimental studies in rats. Characterization of regulatory mechanisms
    • Bazargani F (2005). Acute inflammation in peritoneal dialysis: experimental studies in rats. Characterization of regulatory mechanisms. Swed Dent J Suppl 1–57: i.
    • (2005) Swed Dent J Suppl , vol.1–57 , pp. i
    • Bazargani, F1
  • 4
    • 0020051148 scopus 로고
    • Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker
    • Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982). Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78: 206–209.
    • (1982) J Invest Dermatol , vol.78 , pp. 206-209
    • Bradley, PP1    Priebat, DA2    Christensen, RD3    Rothstein, G4
  • 5
    • 12844273381 scopus 로고    scopus 로고
    • Complement C5a is a key mediator of meconium‐induced neutrophil activation
    • Castellheim A, Pharo A, Fung M, Saugstad OD, Mollnes TE (2005). Complement C5a is a key mediator of meconium‐induced neutrophil activation. Pediatr Res 57: 242–247.
    • (2005) Pediatr Res , vol.57 , pp. 242-247
    • Castellheim, A1    Pharo, A2    Fung, M3    Saugstad, OD4    Mollnes, TE5
  • 6
    • 0344154671 scopus 로고
    • Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes
    • Chenoweth DE, Hugli TE (1978). Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes. Proc Natl Acad Sci USA 75: 3943–3947.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 3943-3947
    • Chenoweth, DE1    Hugli, TE2
  • 7
    • 33744963014 scopus 로고    scopus 로고
    • Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expression
    • Clark JD, Qiao Y, Li X, Shi X, Angst MS, Yeomans DC (2006). Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expression. Anesthesiology 104: 1274–1282.
    • (2006) Anesthesiology , vol.104 , pp. 1274-1282
    • Clark, JD1    Qiao, Y2    Li, X3    Shi, X4    Angst, MS5    Yeomans, DC6
  • 8
    • 26244452238 scopus 로고    scopus 로고
    • Hyperalgesia and allodynia: peripheral mechanisms
    • Coutaux A, Adam F, Willer JC, Le Bars D (2005). Hyperalgesia and allodynia: peripheral mechanisms. Joint Bone Spine 72: 359–371.
    • (2005) Joint Bone Spine , vol.72 , pp. 359-371
    • Coutaux, A1    Adam, F2    Willer, JC3    Le Bars, D4
  • 9
    • 0026002752 scopus 로고
    • Interleukin‐8 as a mediator of sympathetic pain
    • Cunha FQ, Lorenzetti BB, Poole S, Ferreira SH (1991). Interleukin‐8 as a mediator of sympathetic pain. Br J Pharmacol 104: 765–767.
    • (1991) Br J Pharmacol , vol.104 , pp. 765-767
    • Cunha, FQ1    Lorenzetti, BB2    Poole, S3    Ferreira, SH4
  • 10
    • 0026787367 scopus 로고
    • The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia
    • Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH (1992). The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107: 660–664.
    • (1992) Br J Pharmacol , vol.107 , pp. 660-664
    • Cunha, FQ1    Poole, S2    Lorenzetti, BB3    Ferreira, SH4
  • 11
    • 0042168843 scopus 로고    scopus 로고
    • The critical role of leukotriene B4 in antigen‐induced mechanical hyperalgesia in immunised rats
    • Cunha JM, Sachs D, Canetti CA, Poole S, Ferreira SH, Cunha FQ (2003). The critical role of leukotriene B4 in antigen‐induced mechanical hyperalgesia in immunised rats. Br J Pharmacol 139: 1135–1145.
    • (2003) Br J Pharmacol , vol.139 , pp. 1135-1145
    • Cunha, JM1    Sachs, D2    Canetti, CA3    Poole, S4    Ferreira, SH5    Cunha, FQ6
  • 12
    • 40349101141 scopus 로고    scopus 로고
    • Pain facilitation by proinflammatory cytokine actions at peripheral nerve terminals, in: Immune and Glial Regulation of Pain
    • Cunha TM, Verri Jr WA, Poole S, Parada CA, Cunha FQ, Ferreira SH (2007). Pain facilitation by proinflammatory cytokine actions at peripheral nerve terminals. In: DeLeo J, Sorkin L, Watkins L (eds). Immune and Glial Regulation of Pain. IASP Press: Seattle.
    • (2007)
    • Cunha, TM1    Verri, WA2    Poole, S3    Parada, CA4    Cunha, FQ5    Ferreira, SH6
  • 13
    • 13444306159 scopus 로고    scopus 로고
    • A cascade of cytokines mediates mechanical inflammatory hypernociception in mice
    • Cunha TM, Verri Jr WA, Silva JS, Poole S, Cunha FQ, Ferreira SH (2005). A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci USA 102: 1755–1760.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1755-1760
    • Cunha, TM1    Verri, WA2    Silva, JS3    Poole, S4    Cunha, FQ5    Ferreira, SH6
  • 14
    • 4143090674 scopus 로고    scopus 로고
    • Blockade of leukotriene B4 prevents articular incapacitation in rat zymosan‐induced arthritis
    • da Rocha FA, Teixeira MM, Rocha JC, Girao VC, Bezerra MM, Ribeiro Rde A et al. (2004). Blockade of leukotriene B4 prevents articular incapacitation in rat zymosan‐induced arthritis. Eur J Pharmacol 497: 81–86.
    • (2004) Eur J Pharmacol , vol.497 , pp. 81-86
    • da Rocha, FA1    Teixeira, MM2    Rocha, JC3    Girao, VC4    Bezerra, MM5    Ribeiro Rde, A6
  • 15
    • 33847558828 scopus 로고
    • Cell migration and hyperalgesia: a paradoxical effect of endotoxin
    • de Abreu Castro MS, Ferreira SH (1979). Cell migration and hyperalgesia: a paradoxical effect of endotoxin. Adv Inflamm Res 1: 311–316.
    • (1979) Adv Inflamm Res , vol.1 , pp. 311-316
    • de Abreu Castro, MS1    Ferreira, SH2
  • 16
    • 0032941136 scopus 로고    scopus 로고
    • C5a receptor and interleukin‐6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells
    • Fayyazi A, Sandau R, Duong LQ, Gotze O, Radzun HJ, Schweyer S et al. (1999). C5a receptor and interleukin‐6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. Am J Pathol 154: 495–501.
    • (1999) Am J Pathol , vol.154 , pp. 495-501
    • Fayyazi, A1    Sandau, R2    Duong, LQ3    Gotze, O4    Radzun, HJ5    Schweyer, S6
  • 18
    • 0023679882 scopus 로고
    • Interleukin‐1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue
    • Ferreira SH, Lorenzetti BB, Bristow AF, Poole S (1988). Interleukin‐1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature 334: 698–700.
    • (1988) Nature , vol.334 , pp. 698-700
    • Ferreira, SH1    Lorenzetti, BB2    Bristow, AF3    Poole, S4
  • 19
    • 0018426637 scopus 로고
    • Central and peripheral antialgesic action of aspirin‐like drugs
    • Ferreira SH, Lorenzetti BB, Correa FM (1978a). Central and peripheral antialgesic action of aspirin‐like drugs. Eur J Pharmacol 53: 39–48.
    • (1978) Eur J Pharmacol , vol.53 , pp. 39-48
    • Ferreira, SH1    Lorenzetti, BB2    Correa, FM3
  • 20
    • 0027133614 scopus 로고
    • Bradykinin initiates cytokine‐mediated inflammatory hyperalgesia
    • Ferreira SH, Lorenzetti BB, Poole S (1993). Bradykinin initiates cytokine‐mediated inflammatory hyperalgesia. Br J Pharmacol 110: 1227–1231.
    • (1993) Br J Pharmacol , vol.110 , pp. 1227-1231
    • Ferreira, SH1    Lorenzetti, BB2    Poole, S3
  • 21
    • 0018653423 scopus 로고
    • II—Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists
    • Ferreira SH, Nakamura M (1979a). II—Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins 18: 191–200.
    • (1979) Prostaglandins , vol.18 , pp. 191-200
    • Ferreira, SH1    Nakamura, M2
  • 22
    • 0018653425 scopus 로고
    • III—Prostaglandin hyperalgesia: relevance of the peripheral effect for the analgesic action of opioid‐antagonists
    • Ferreira SH, Nakamura M (1979b). III—Prostaglandin hyperalgesia: relevance of the peripheral effect for the analgesic action of opioid‐antagonists. Prostaglandins 18: 201–208.
    • (1979) Prostaglandins , vol.18 , pp. 201-208
    • Ferreira, SH1    Nakamura, M2
  • 23
    • 0018187062 scopus 로고
    • The hyperalgesic effects of prostacyclin and prostaglandin E2
    • Ferreira SH, Nakamura M, de Abreu Castro MS (1978b). The hyperalgesic effects of prostacyclin and prostaglandin E2. Prostaglandins 16: 31–37.
    • (1978) Prostaglandins , vol.16 , pp. 31-37
    • Ferreira, SH1    Nakamura, M2    de Abreu Castro, MS3
  • 24
    • 77049248972 scopus 로고
    • The mode of action of immunologic adjuvants
    • Freund J (1956). The mode of action of immunologic adjuvants. Bibl Tuberc 10: 130–148.
    • (1956) Bibl Tuberc , vol.10 , pp. 130-148
    • Freund, J1
  • 25
    • 0024534975 scopus 로고
    • Characterization of a receptor for C5a anaphylatoxin on human eosinophils
    • Gerard NP, Hodges MK, Drazen JM, Weller PF, Gerard C (1989). Characterization of a receptor for C5a anaphylatoxin on human eosinophils. J Biol Chem 264: 1760–1766.
    • (1989) J Biol Chem , vol.264 , pp. 1760-1766
    • Gerard, NP1    Hodges, MK2    Drazen, JM3    Weller, PF4    Gerard, C5
  • 26
    • 34547865012 scopus 로고    scopus 로고
    • Complement induction in spinal cord microglia results in anaphylatoxin C5a‐mediated pain hypersensitivity
    • Griffin RS, Costigan M, Brenner GJ, Ma CH, Scholz J, Moss A et al. (2007). Complement induction in spinal cord microglia results in anaphylatoxin C5a‐mediated pain hypersensitivity. J Neurosci 27: 8699–8708.
    • (2007) J Neurosci , vol.27 , pp. 8699-8708
    • Griffin, RS1    Costigan, M2    Brenner, GJ3    Ma, CH4    Scholz, J5    Moss, A6
  • 27
    • 33746474101 scopus 로고    scopus 로고
    • Hypernociception elicited by tibio‐tarsal joint flexion in mice: a novel experimental arthritis model for pharmacological screening
    • Guerrero AT, Verri Jr WA, Cunha TM, Silva TA, Rocha FA, Ferreira SH et al. (2006). Hypernociception elicited by tibio‐tarsal joint flexion in mice: a novel experimental arthritis model for pharmacological screening. Pharmacol Biochem Behav 84: 244–251.
    • (2006) Pharmacol Biochem Behav , vol.84 , pp. 244-251
    • Guerrero, AT1    Verri, WA2    Cunha, TM3    Silva, TA4    Rocha, FA5    Ferreira, SH6
  • 28
    • 38149064496 scopus 로고    scopus 로고
    • Involvement of LTB4 in zymosan‐induced joint nociception in mice: participation of neutrophils and PGE2
    • Guerrero AT, Verri Jr WA, Cunha TM, Silva TA, Schivo IR, Dal‐Secco D et al. (2008). Involvement of LTB4 in zymosan‐induced joint nociception in mice: participation of neutrophils and PGE2. J Leukoc Biol 83: 9.
    • (2008) J Leukoc Biol , vol.83 , pp. 9
    • Guerrero, AT1    Verri, WA2    Cunha, TM3    Silva, TA4    Schivo, IR5    Dal‐Secco, D6
  • 29
    • 2442678025 scopus 로고    scopus 로고
    • The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
    • Hawlisch H, Wills‐Karp M, Karp CL, Kohl J (2004). The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma. Mol Immunol 41: 123–131.
    • (2004) Mol Immunol , vol.41 , pp. 123-131
    • Hawlisch, H1    Wills‐Karp, M2    Karp, CL3    Kohl, J4
  • 30
    • 0034285071 scopus 로고    scopus 로고
    • Inhibition of C5a‐induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist
    • Haynes DR, Harkin DG, Bignold LP, Hutchens MJ, Taylor SM, Fairlie DP (2000). Inhibition of C5a‐induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist. Biochem Pharmacol 60: 729–733.
    • (2000) Biochem Pharmacol , vol.60 , pp. 729-733
    • Haynes, DR1    Harkin, DG2    Bignold, LP3    Hutchens, MJ4    Taylor, SM5    Fairlie, DP6
  • 31
    • 0031956956 scopus 로고    scopus 로고
    • Processing of C5a by human polymorphonuclear leukocytes
    • Hetland G, Pfeifer PH, Hugli TE (1998). Processing of C5a by human polymorphonuclear leukocytes. J Leukoc Biol 63: 456–462.
    • (1998) J Leukoc Biol , vol.63 , pp. 456-462
    • Hetland, G1    Pfeifer, PH2    Hugli, TE3
  • 32
    • 0029996976 scopus 로고    scopus 로고
    • Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation
    • Issekutz TB, Miyasaka M, Issekutz AC (1996). Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation. J Exp Med 183: 2175–2184.
    • (1996) J Exp Med , vol.183 , pp. 2175-2184
    • Issekutz, TB1    Miyasaka, M2    Issekutz, AC3
  • 33
    • 0032977884 scopus 로고    scopus 로고
    • Epinephrine produces a beta‐adrenergic receptor‐mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors
    • Khasar SG, McCarter G, Levine JD (1999). Epinephrine produces a beta‐adrenergic receptor‐mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 81: 1104–1112.
    • (1999) J Neurophysiol , vol.81 , pp. 1104-1112
    • Khasar, SG1    McCarter, G2    Levine, JD3
  • 34
    • 0031951479 scopus 로고    scopus 로고
    • Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis
    • Kiener HP, Baghestanian M, Dominkus M, Walchshofer S, Ghannadan M, Willheim M et al. (1998). Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis. Arthritis Rheum 41: 233–245.
    • (1998) Arthritis Rheum , vol.41 , pp. 233-245
    • Kiener, HP1    Baghestanian, M2    Dominkus, M3    Walchshofer, S4    Ghannadan, M5    Willheim, M6
  • 35
    • 0033833435 scopus 로고    scopus 로고
    • Intratracheal administration of anaphylatoxin C5a potentiates antigen‐induced pulmonary reactions through the prolonged production of cysteinyl‐leukotrienes
    • Kodani M, Sakata N, Takano Y, Kamiya H, Katsuragi T, Hugli TE et al. (2000). Intratracheal administration of anaphylatoxin C5a potentiates antigen‐induced pulmonary reactions through the prolonged production of cysteinyl‐leukotrienes. Immunopharmacology 49: 263–274.
    • (2000) Immunopharmacology , vol.49 , pp. 263-274
    • Kodani, M1    Sakata, N2    Takano, Y3    Kamiya, H4    Katsuragi, T5    Hugli, TE6
  • 36
    • 0037111535 scopus 로고    scopus 로고
    • Expression and function of C5a receptor in mouse microvascular endothelial cells
    • Laudes IJ, Chu JC, Huber‐Lang M, Guo RF, Riedemann NC, Sarma JV et al. (2002). Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol 169: 5962–5970.
    • (2002) J Immunol , vol.169 , pp. 5962-5970
    • Laudes, IJ1    Chu, JC2    Huber‐Lang, M3    Guo, RF4    Riedemann, NC5    Sarma, JV6
  • 37
    • 33749366134 scopus 로고    scopus 로고
    • Neutrophil infiltration is implicated in the sustained thermal hyperalgesic response evoked by allergen provocation in actively sensitized rats
    • Lavich TR, Siqueira Rde A, Farias‐Filho FA, Cordeiro RS, Rodrigues e Silva PM, Martins MA (2006). Neutrophil infiltration is implicated in the sustained thermal hyperalgesic response evoked by allergen provocation in actively sensitized rats. Pain 125: 180–187.
    • (2006) Pain , vol.125 , pp. 180-187
    • Lavich, TR1    Siqueira Rde, A2    Farias‐Filho, FA3    Cordeiro, RS4    Rodrigues e Silva, PM5    Martins, MA6
  • 38
    • 0022409548 scopus 로고
    • The role of the polymorphonuclear leukocyte in hyperalgesia
    • Levine JD, Gooding J, Donatoni P, Borden L, Goetzl EJ (1985). The role of the polymorphonuclear leukocyte in hyperalgesia. J Neurosci 5: 3025–3029.
    • (1985) J Neurosci , vol.5 , pp. 3025-3029
    • Levine, JD1    Gooding, J2    Donatoni, P3    Borden, L4    Goetzl, EJ5
  • 39
    • 0033390443 scopus 로고    scopus 로고
    • Complement activation and inhibition in experimental models of arthritis
    • Linton SM, Morgan BP (1999). Complement activation and inhibition in experimental models of arthritis. Mol Immunol 36: 905–914.
    • (1999) Mol Immunol , vol.36 , pp. 905-914
    • Linton, SM1    Morgan, BP2
  • 40
    • 0036824633 scopus 로고    scopus 로고
    • Cytokine‐induced neutrophil chemoattractant 1 (CINC‐1) mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats
    • Lorenzetti BB, Veiga FH, Canetti CA, Poole S, Cunha FQ, Ferreira SH (2002). Cytokine‐induced neutrophil chemoattractant 1 (CINC‐1) mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats. Eur Cytokine Netw 13: 456–461.
    • (2002) Eur Cytokine Netw , vol.13 , pp. 456-461
    • Lorenzetti, BB1    Veiga, FH2    Canetti, CA3    Poole, S4    Cunha, FQ5    Ferreira, SH6
  • 41
    • 12144290258 scopus 로고    scopus 로고
    • Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity
    • March DR, Proctor LM, Stoermer MJ, Sbaglia R, Abbenante G, Reid RC et al. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol Pharmacol 65: 868–879.
    • (2004) Mol Pharmacol , vol.65 , pp. 868-879
    • March, DR1    Proctor, LM2    Stoermer, MJ3    Sbaglia, R4    Abbenante, G5    Reid, RC6
  • 42
    • 21744433587 scopus 로고    scopus 로고
    • Role of the immune system in chronic pain
    • Marchand F, Perretti M, McMahon SB (2005). Role of the immune system in chronic pain. Nat Rev Neurosci 6: 521–532.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 521-532
    • Marchand, F1    Perretti, M2    McMahon, SB3
  • 43
    • 0034703179 scopus 로고    scopus 로고
    • The C5a complement activation peptide increases IL‐1beta and IL‐6 release from amyloid‐beta primed human monocytes: implications for Alzheimer's disease
    • O'Barr S, Cooper NR (2000). The C5a complement activation peptide increases IL‐1beta and IL‐6 release from amyloid‐beta primed human monocytes: implications for Alzheimer's disease. J Neuroimmunol 109: 87–94.
    • (2000) J Neuroimmunol , vol.109 , pp. 87-94
    • O'Barr, S1    Cooper, NR2
  • 44
    • 0028982492 scopus 로고
    • Contribution of interleukin‐1 beta to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia
    • Safieh‐Garabedian B, Poole S, Allchorne A, Winter J, Woolf CJ (1995). Contribution of interleukin‐1 beta to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br J Pharmacol 115: 1265–1275.
    • (1995) Br J Pharmacol , vol.115 , pp. 1265-1275
    • Safieh‐Garabedian, B1    Poole, S2    Allchorne, A3    Winter, J4    Woolf, CJ5
  • 46
    • 26944454482 scopus 로고    scopus 로고
    • Glucocorticoids suppress inflammation but spare innate immune responses in airway epithelium
    • Schleimer RP (2004). Glucocorticoids suppress inflammation but spare innate immune responses in airway epithelium. Proc Am Thorac Soc 1: 222–230.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 222-230
    • Schleimer, RP1
  • 47
    • 0034283793 scopus 로고    scopus 로고
    • Effects of a BLT receptor antagonist on local and remote reperfusion injuries after transient ischemia of the superior mesenteric artery in rats
    • Souza DG, Coutinho SF, Silveira MR, Cara DC, Teixeira MM (2000). Effects of a BLT receptor antagonist on local and remote reperfusion injuries after transient ischemia of the superior mesenteric artery in rats. Eur J Pharmacol 403: 121–128.
    • (2000) Eur J Pharmacol , vol.403 , pp. 121-128
    • Souza, DG1    Coutinho, SF2    Silveira, MR3    Cara, DC4    Teixeira, MM5
  • 48
    • 0033563866 scopus 로고    scopus 로고
    • Activation of several MAP kinases upon stimulation of rat alveolar macrophages: role of the NADPH oxidase
    • Torres M, Forman HJ (1999). Activation of several MAP kinases upon stimulation of rat alveolar macrophages: role of the NADPH oxidase. Arch Biochem Biophys 366: 231–239.
    • (1999) Arch Biochem Biophys , vol.366 , pp. 231-239
    • Torres, M1    Forman, HJ2
  • 49
    • 14944376107 scopus 로고    scopus 로고
    • Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization
    • Twining CM, Sloane EM, Schoeniger DK, Milligan ED, Martin D, Marsh H et al. (2005). Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization. J Pain 6: 174–183.
    • (2005) J Pain , vol.6 , pp. 174-183
    • Twining, CM1    Sloane, EM2    Schoeniger, DK3    Milligan, ED4    Martin, D5    Marsh, H6
  • 50
    • 0032499629 scopus 로고    scopus 로고
    • Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti‐C5 therapy
    • Vakeva AP, Agah A, Rollins SA, Matis LA, Li L, Stahl GL (1998). Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti‐C5 therapy. Circulation 97: 2259–2267.
    • (1998) Circulation , vol.97 , pp. 2259-2267
    • Vakeva, AP1    Agah, A2    Rollins, SA3    Matis, LA4    Li, L5    Stahl, GL6
  • 51
    • 10844263351 scopus 로고    scopus 로고
    • Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain
    • Vale ML, Benevides VM, Sachs D, Brito GA, da Rocha FA, Poole S et al. (2004). Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br J Pharmacol 143: 833–844.
    • (2004) Br J Pharmacol , vol.143 , pp. 833-844
    • Vale, ML1    Benevides, VM2    Sachs, D3    Brito, GA4    da Rocha, FA5    Poole, S6
  • 52
    • 0037791771 scopus 로고    scopus 로고
    • Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection
    • van Beek J, Elward K, Gasque P (2003). Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection. Ann N Y Acad Sci 992: 56–71.
    • (2003) Ann N Y Acad Sci , vol.992 , pp. 56-71
    • van Beek, J1    Elward, K2    Gasque, P3
  • 53
    • 33748053352 scopus 로고    scopus 로고
    • Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development
    • Verri Jr WA, Cunha TM, Parada CA, Poole S, Cunha FQ, Ferreira SH (2006). Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development Pharmacol Ther 112: 116–138.
    • (2006) Pharmacol Ther , vol.112 , pp. 116-138
    • Verri, WA1    Cunha, TM2    Parada, CA3    Poole, S4    Cunha, FQ5    Ferreira, SH6
  • 54
    • 1142310879 scopus 로고    scopus 로고
    • The dark side of C5a in sepsis
    • Ward PA (2004). The dark side of C5a in sepsis. Nat Rev Immunol 4: 133–142.
    • (2004) Nat Rev Immunol , vol.4 , pp. 133-142
    • Ward, PA1
  • 55
    • 33750324311 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • Weissmann G (2006). The pathogenesis of rheumatoid arthritis. Bull Hosp Jt Dis 64: 12–15.
    • (2006) Bull Hosp Jt Dis , vol.64 , pp. 12-15
    • Weissmann, G1
  • 56
    • 0026604784 scopus 로고
    • Binding of fluorescein‐labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes
    • Werfel T, Oppermann M, Schulze M, Krieger G, Weber M, Gotze O (1992). Binding of fluorescein‐labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes. Blood 79: 152–160.
    • (1992) Blood , vol.79 , pp. 152-160
    • Werfel, T1    Oppermann, M2    Schulze, M3    Krieger, G4    Weber, M5    Gotze, O6
  • 57
    • 0242494255 scopus 로고    scopus 로고
    • A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease
    • Woodruff TM, Arumugam TV, Shiels IA, Reid RC, Fairlie DP, Taylor SM (2003). A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. J Immunol 171: 5514–5520.
    • (2003) J Immunol , vol.171 , pp. 5514-5520
    • Woodruff, TM1    Arumugam, TV2    Shiels, IA3    Reid, RC4    Fairlie, DP5    Taylor, SM6
  • 58
    • 0345829310 scopus 로고    scopus 로고
    • Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia–reperfusion in rats
    • Woodruff TM, Arumugam TV, Shiels IA, Reid RC, Fairlie DP, Taylor SM (2004). Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia–reperfusion in rats. J Surg Res 116: 81–90.
    • (2004) J Surg Res , vol.116 , pp. 81-90
    • Woodruff, TM1    Arumugam, TV2    Shiels, IA3    Reid, RC4    Fairlie, DP5    Taylor, SM6
  • 59
    • 33746505701 scopus 로고    scopus 로고
    • Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration
    • Woodruff TM, Crane JW, Proctor LM, Buller KM, Shek AB, de Vos K et al. (2006). Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration. FASEB J 20: 1407–1417.
    • (2006) FASEB J , vol.20 , pp. 1407-1417
    • Woodruff, TM1    Crane, JW2    Proctor, LM3    Buller, KM4    Shek, AB5    de Vos, K6
  • 60
    • 0036745078 scopus 로고    scopus 로고
    • Antiarthritic activity of an orally active C5a receptor antagonist against antigen‐induced monarticular arthritis in the rat
    • Woodruff TM, Strachan AJ, Dryburgh N, Shiels IA, Reid RC, Fairlie DP et al. (2002). Antiarthritic activity of an orally active C5a receptor antagonist against antigen‐induced monarticular arthritis in the rat. Arthritis Rheum 46: 2476–2485.
    • (2002) Arthritis Rheum , vol.46 , pp. 2476-2485
    • Woodruff, TM1    Strachan, AJ2    Dryburgh, N3    Shiels, IA4    Reid, RC5    Fairlie, DP6
  • 61
    • 0028023450 scopus 로고
    • Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity
    • Woolf CJ, Safieh‐Garabedian B, Ma QP, Crilly P, Winter J (1994). Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 62: 327–331.
    • (1994) Neuroscience , vol.62 , pp. 327-331
    • Woolf, CJ1    Safieh‐Garabedian, B2    Ma, QP3    Crilly, P4    Winter, J5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.