Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury

Biochemical and Biophysical Research Communications

Volumn 390, Issue 3, 2009, Pages 925-930

  Zhang, Bin ^a   Au, Qingyan ^a   Yoon, Il Sang ^a   Tremblay, Marie Helene ^a   Yip, Gary ^a   Zhou, Yuefen ^a   Barber, Jack R ^a   Ng, Shi Chung ^a  

^a CytRx Corporation   (United States)

Author keywords

Chaperone proteins; Gedunin; High content screening; HSF1; Protein folding

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHAPERONE; DEACETOXY 7 OXOGEDUNIN; DEACETYLGEDUNIN; DEOXYGEDUNIN; DOXYCYCLINE; GEDUNIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; SAPPANONE A DERIVATIVE; SAPPANONE A TRIMETHYL ETHER; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; GENE AMPLIFICATION; GENE SILENCING; HEAT SHOCK RESPONSE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MOLECULAR LIBRARY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING; RNA INTERFERENCE; STABLE TRANSFECTION; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

CYTOPROTECTION; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; GENE SILENCING; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; SMALL MOLECULE LIBRARIES; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 70449705818     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.10.079     Document Type: Article

References (30)

1. Forman M.S.M., Trojanowski J.Q., and Lee V.M. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat. Med. 10 (2004) 1055-1063
2. Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat. Rev. Neurosci. 4 (2003) 49-60
3. Soto C., and Estrada L.D. Protein misfolding and neurodegeneration. Arch. Neurol. 65 (2008) 184-189
4. Cummings C.J., Sun Y., Opal P., Antalffy B., Mestril R., Orr H.T., Dillmann W.H., and Zoghbi H.Y. Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum. Mol. Genet. 10 (2001) 1511-1518
5. Adachi H., Katsuno M., Minamiyama M., Sang C., Pagoulatos G., Angelidis C., Kusakabe M., Yoshiki A., Kobayashi Y., Doyu M., and Sobue G. Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J. Neurosci. 23 (2003) 2203-2211
6. Magrane J., Smith R.C., Walsh K., and Querfurth H.W. Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons. J. Neurosci. 24 (2004) 1700-1706
7. Nollen E.A., Garcia S.M., van Haaften G., Kim S., Chavez A., Morimoto R.I., and Plasterk R.H. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc. Natl. Acad. Sci. USA 101 (2004) 6403-6408
8. Fernandez-Funez P., Nino-Rosales M.L., de Gouyon B., She W.C., Luchak J.M., Martinez P., Turiegano E., Benito J., Capovilla M., Skinner P.J., McCall A., Canal I., Orr H.T., Zoghbi H.Y., and Botas J. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 408 (2000) 101-106
9. Kazemi-Esfarjani P., and Benzer S. Genetic suppression of polyglutamine toxicity in Drosophila. Science 287 (2000) 1837-1840
10. Willingham S., Outeiro T.F., DeVit M.J., Lindquist S.L., and Muchowski P.J. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 302 (2003) 1769-1772
11. Muchowski P.J., and Wacker J.L. Modulation of neurodegeneration by molecular chaperones. Nat. Rev. Neurosci. 6 (2005) 11-22
12. Pirkkala L., Nykanen P., and Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 15 (2001) 1118-1131
13. Brodsky J.L., and Chiosis G. Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators. Curr. Top. Med. Chem. 6 (2006) 1215-1225
14. Westerheide S.D., and Morimoto R.I. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J. Biol. Chem. 280 (2005) 33097-33100
15. Sõti C., Nagy E., Giricz Z., Vígh L., Csermely P., and Ferdinandy P. Heat shock proteins as emerging therapeutic targets. Br. J. Pharmacol. 146 (2005) 769-780
16. Kieran D., Kalmar B., Dick J.R., Riddoch-Contreras J., Burnstock G., and Greensmith L. Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice. Nat. Med. 10 (2004) 402-405
17. Au Q., Kanchanastit P., Barber J.R., Ng S.C., and Zhang B. High-content image-based screening for small-molecule chaperone amplifiers in heat shock. J. Biomol. Screen. 13 (2008) 953-959
18. Zhou Y., Vu K., Chen Y., Pham J., Brady T., Liu G., Chen J., Nam J., Reddy P.S.M., Au Q., Yoon I.Y., Tremblay M.H., Yip G., Cher C., Zhang B., Barber J.R., and Ng S.C. Chloro-oxime derivatives as novel small molecule chaperone amplifiers. Bioorg. Med. Chem. Lett. 19 (2009) 3128-3135
19. Cotto J., Fox S., and Morimoto R.I. HSF1 granules: a novel stress-induced nuclear compartment of human cells. J. Cell Sci. 110 (1997) 2925-2934
20. Nonaka T., Akimoto T., Mitsuhashi N., Tamaki Y., and Nakano T. Changes in the number of HSF1 positive granules in the nucleus reflects heat shock semiquantitatively. Cancer Lett. 202 (2003) 89-100
21. Zeng X.C., Bhasin S., Wu X., Lee J.G., Maffi S., Nichols C.J., Lee K.J., Taylor J.P., Greene L.E., and Eisenberg E. Hsp70 dynamics in vivo: effect of heat shock and protein aggregation:. J. Cell Sci. 117 (2004) 4991-5000
22. Westerheide S.D., Bosman J.D., Mbadugha B.N., Kawahara T.L., Matsumoto G., Kim S., Gu W., Devlin J.P., Silverman R.B., and Morimoto R.I. Celastrols as inducers of the heat shock response and cytoprotection. J. Biol. Chem. 279 (2004) 56053-56060
23. Rossi A., Elia G., and Santoro M.G. Activation of the heat shock factor 1 by serine protease inhibitors, an effect associated with nuclear factor-kappaB inhibition. J. Biol. Chem. 273 (1998) 16446-16452
24. Lee D.H., and Goldberg A.L. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol. 8 (1998) 397-403
25. Khalid S.A., Duddeck H., and Gonzalez-Sierra M. Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica. J. Nat. Prod. 52 (1989) 922-926
26. Nathan S.S., Kalaivani K., and Murugan K. Behavioural responses and changes in biology of rice leaffolder following treatment with a combination of bacterial toxins and botanical insecticides. Chemosphere 64 (2006) 1650-1658
27. Hieronymus H., Lamb J., Ross K.N., Peng X.P., Clement C., Rodina A., Nieto M., Du J., Stegmaier K., Raj S.M., Maloney K.N., Clardy J., Hahn W.C., Chiosis G., and Golub T.R. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell 10 (2006) 321-330
28. Brandt G.E., Schmidt M.D., Prisinzano T.E., and Blagg B.S. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J. Med. Chem. 51 (2008) 6495-6502
29. Zhang B., Senator D., Wilson C.J., and Ng S.C. Development of a high-throughput robotic fluorescence-based assay for HsEg5 inhibitor screening. Anal. Biochem. 345 (2005) 326-335
30. Siddaiah V., Rao C.V., Venkateswarlu S., Krishnaraju A.V., and Subbaraju G.V. Synthesis, stereochemical assignments, and biological activities of homoisoflavonoids. Bioorg. Med. Chem. 14 (2006) 2545-2551