Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats

Arthritis and Rheumatism

Volumn 65, Issue 8, 2013, Pages 2102-2112

  Siebelt, Michiel ^a   Jahr, Holger ^a   Groen, Harald C ^a   Sandker, Marjan ^a   Waarsing, Jan H ^a   Kops, Nicole ^a   Müller, Cristina ^b   Van Eden, Willem ^c   De Jong, Marion ^a   Weinans, Harrie ^a,d,e  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ETH Zurich   (Switzerland)

^c UTRECHT UNIVERSITY   (Netherlands)

^d DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIIB 021; GLYCOSAMINOGLYCAN POLYSULFATE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; CARTILAGE DEGENERATION; CONCENTRATION (PARAMETERS); CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE COURSE; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; MACROPHAGE ACTIVATION; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS; RAT; RUNNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SUBCHONDRAL BONE PLATE; THICKNESS; TISSUE LEVEL; WESTERN BLOTTING;

ADENINE; ANIMALS; APOPTOSIS; BIOMECHANICAL PHENOMENA; CARTILAGE, ARTICULAR; CHONDROCYTES; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; MALE; OSTEOARTHRITIS; PHYSICAL EXERTION; PYRIDINES; RATS; RATS, WISTAR; RUNNING; STIFLE; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 84881361859     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.38000     Document Type: Article

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