Dual-purpose linker for alpha helix stabilization and imaging agent conjugation to glucagon-like peptide-1 receptor ligands

Bioconjugate Chemistry

Volumn 26, Issue 2, 2015, Pages 329-337

  Zhang, Liang ^a   Navaratna, Tejas ^a   Liao, Jianshan ^a   Thurber, Greg M ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; IMAGE PROCESSING; LIGANDS;

ALPHA-HELIX; CELLULAR UPTAKE; GLUCAGON-LIKE PEPTIDE-1; IMAGING AGENT; IN-VIVO; LABELINGS; LOW-LOSS; MODELLING SYSTEMS; POOR STABILITY; RECEPTOR LIGANDS;

PEPTIDES;

ALANINE DERIVATIVE; ALKYNE DERIVATIVE; AZIDOHOMOALANINE; DIALKYNE; EXENDIN; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; PROTEINASE; UNCLASSIFIED DRUG; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; LIGAND; PEPTIDE; VENOM;

ALPHA HELIX; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; CONJUGATE; CONJUGATION; CONTROLLED STUDY; ENZYME STABILITY; IN VIVO STUDY; MOUSE; NONHUMAN; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; FLUORESCENCE IMAGING; HISTOLOGY; METABOLISM; MICROSCOPY; MOLECULAR GENETICS; PANCREAS ISLET BETA CELL; PANCREAS TUMOR; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANIMALS; GLUCAGON-LIKE PEPTIDE 1; HISTOLOGICAL TECHNIQUES; INSULIN-SECRETING CELLS; LIGANDS; MICE; MICE, INBRED C57BL; MICROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OPTICAL IMAGING; PANCREATIC NEOPLASMS; PEPTIDES; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GLUCAGON; VENOMS;

EID: 84923230371     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc500584t     Document Type: Article

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