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Volumn 79, Issue 2, 2007, Pages 193-200

Preorganization in biological systems: Are conformational constraints worth the energy?

Author keywords

Enzyme inhibitors; Ligand preorganization; Molecular recognition; Protein ligand interactions; Structure; Thermodynamics

Indexed keywords


EID: 33846928472     PISSN: 00334545     EISSN: None     Source Type: Journal    
DOI: 10.1351/pac200779020193     Document Type: Conference Paper
Times cited : (34)

References (21)
  • 2
    • 0027241298 scopus 로고    scopus 로고
    • For example, see: (a) U. Gerhard, M. S. Searle, D. H. Williams. Bioorg. Med. Chem. Lett. 3, 803 (1993) and refs. therein;
    • For example, see: (a) U. Gerhard, M. S. Searle, D. H. Williams. Bioorg. Med. Chem. Lett. 3, 803 (1993) and refs. therein;
  • 20
    • 10944261243 scopus 로고    scopus 로고
    • For a discussion of effects of complexation upon changes in protein flexibility, see
    • For a discussion of effects of complexation upon changes in protein flexibility, see: D. H. Williams, E. Stephens, D. P. O'Brien, M. Zhou. Angew. Chem., Int. Ed. 43, 6596 (2004).
    • (2004) Angew. Chem., Int. Ed , vol.43 , pp. 6596
    • Williams, D.H.1    Stephens, E.2    O'Brien, D.P.3    Zhou, M.4
  • 21
    • 24744465619 scopus 로고    scopus 로고
    • For a recent discussion of using B-factors to compare protein flexibility in protein-ligand complexes, see: C.-Y. Yang, R. Wang, S. Wang. J. Med. Chem. 48, 5648 2005
    • For a recent discussion of using B-factors to compare protein flexibility in protein-ligand complexes, see: C.-Y. Yang, R. Wang, S. Wang. J. Med. Chem. 48, 5648 (2005).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.