메뉴 건너뛰기




Volumn 5, Issue FEB, 2015, Pages

Estrogen receptors and their implications in colorectal carcinogenesis

Author keywords

Colorectal cancer; Estrogen; Estrogen receptor; Tumor immunology; Tumor microenvironment

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR 3; ESTROGEN RECEPTOR 4; ESTROGEN RECEPTOR 5; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STEROID HORMONE; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 84923224188     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2015.00019     Document Type: Review
Times cited : (152)

References (112)
  • 2
    • 84866536282 scopus 로고    scopus 로고
    • Estrogen receptors and human disease: an update
    • Burns KA, Korach KS. Estrogen receptors and human disease: an update. Arch Toxicol (2012) 86:1491-504. doi:10.1007/s00204-012-0868-5
    • (2012) Arch Toxicol , vol.86 , pp. 1491-1504
    • Burns, K.A.1    Korach, K.S.2
  • 3
    • 40949127406 scopus 로고    scopus 로고
    • Oestrogen and the colon: potential mechanisms for cancer prevention
    • Kennelly R, Kavanagh DO, Hogan AM, Winter DC. Oestrogen and the colon: potential mechanisms for cancer prevention. Lancet Oncol (2008) 9:385-91. doi:10.1016/S1470-2045(08)70100-1
    • (2008) Lancet Oncol , vol.9 , pp. 385-391
    • Kennelly, R.1    Kavanagh, D.O.2    Hogan, A.M.3    Winter, D.C.4
  • 4
    • 33747466839 scopus 로고    scopus 로고
    • Structure-function relationship of estrogen receptor alpha and beta: impact on human health
    • Ascenzi P, Bocedi A, Marino M. Structure-function relationship of estrogen receptor alpha and beta: impact on human health. Mol Aspects Med (2006) 27:299-402. doi:10.1016/j.mam.2006.07.001
    • (2006) Mol Aspects Med , vol.27 , pp. 299-402
    • Ascenzi, P.1    Bocedi, A.2    Marino, M.3
  • 5
    • 77954845425 scopus 로고    scopus 로고
    • Estrogen signal transduction pathways from plasma membrane to the nucleus
    • Grachevsky NO, editor. New York, NY: Nova Science Publisher
    • Marino M, Caiazza F. Estrogen signal transduction pathways from plasma membrane to the nucleus. In: Grachevsky NO, editor. Signal Transduction Research Trends. New York, NY: Nova Science Publisher (2007). p. 17-44.
    • (2007) Signal Transduction Research Trends , pp. 17-44
    • Marino, M.1    Caiazza, F.2
  • 6
    • 22444433545 scopus 로고    scopus 로고
    • A life-long search for the molecular pathways of steroid hormone action
    • O'Malley BW. A life-long search for the molecular pathways of steroid hormone action. Mol Endocrinol (2005) 19:1402-11. doi:10.1210/me.2004-0480
    • (2005) Mol Endocrinol , vol.19 , pp. 1402-1411
    • O'Malley, B.W.1
  • 7
    • 37349081370 scopus 로고    scopus 로고
    • Extranuclear steroid receptors: nature and actions
    • Hammes SR, Levin ER. Extranuclear steroid receptors: nature and actions. Endocr Rev (2007) 28:726-41. doi:10.1210/er.2007-0022
    • (2007) Endocr Rev , vol.28 , pp. 726-741
    • Hammes, S.R.1    Levin, E.R.2
  • 8
    • 15444368857 scopus 로고    scopus 로고
    • Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes
    • Björnström L, Sjöberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol (2005) 19:833-42. doi:10.1210/me.2004-0486
    • (2005) Mol Endocrinol , vol.19 , pp. 833-842
    • Björnström, L.1    Sjöberg, M.2
  • 9
    • 84904284909 scopus 로고    scopus 로고
    • Extranuclear estrogen receptor's roles in physiology: lessons from mouse models
    • Levin ER. Extranuclear estrogen receptor's roles in physiology: lessons from mouse models. Am J Physiol Endocrinol Metab (2014) 307:E133-40. doi:10.1152/ajpendo.00626.2013
    • (2014) Am J Physiol Endocrinol Metab , vol.307 , pp. E133-E140
    • Levin, E.R.1
  • 10
    • 17944375553 scopus 로고    scopus 로고
    • PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells
    • Castoria G, Migliaccio A, Bilancio A, Di Domenico M, de Falco A, Lombardi M, et al. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J (2001) 20:6050-9. doi:10.1093/emboj/20.21.6050
    • (2001) EMBO J , vol.20 , pp. 6050-6059
    • Castoria, G.1    Migliaccio, A.2    Bilancio, A.3    Di Domenico, M.4    de Falco, A.5    Lombardi, M.6
  • 11
    • 14744283561 scopus 로고    scopus 로고
    • Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling
    • Acconcia F, Totta P, Ogawa S, Cardillo I, Inoue S, Leone S, et al. Survival versus apoptotic 17beta-estradiol effect: role of ER alpha and ER beta activated non-genomic signaling. J Cell Physiol (2005) 203:193-201. doi:10.1002/jcp.20219
    • (2005) J Cell Physiol , vol.203 , pp. 193-201
    • Acconcia, F.1    Totta, P.2    Ogawa, S.3    Cardillo, I.4    Inoue, S.5    Leone, S.6
  • 12
    • 79960832381 scopus 로고    scopus 로고
    • The different roles of ER subtypes in cancer biology and therapy
    • Thomas C, Gustafsson JÅ. The different roles of ER subtypes in cancer biology and therapy. Nat Rev Cancer (2011) 11:597-608. doi:10.1038/nrc3093
    • (2011) Nat Rev Cancer , vol.11 , pp. 597-608
    • Thomas, C.1    Gustafsson, J.Å.2
  • 13
    • 34249682915 scopus 로고    scopus 로고
    • Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation
    • Galluzzo P, Caiazza F, Moreno S, Marino M. Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. Endocr Relat Cancer (2007) 14:153-67. doi:10.1677/ERC-06-0020
    • (2007) Endocr Relat Cancer , vol.14 , pp. 153-167
    • Galluzzo, P.1    Caiazza, F.2    Moreno, S.3    Marino, M.4
  • 14
    • 84897589575 scopus 로고    scopus 로고
    • Estrogen hormone physiology: reproductive findings from estrogen receptor mutant mice
    • Hamilton KJ, Arao Y, Korach KS. Estrogen hormone physiology: reproductive findings from estrogen receptor mutant mice. Reprod Biol (2014) 14:3-8. doi:10.1016/j.repbio.2013.12.002
    • (2014) Reprod Biol , vol.14 , pp. 3-8
    • Hamilton, K.J.1    Arao, Y.2    Korach, K.S.3
  • 15
    • 84863980945 scopus 로고    scopus 로고
    • Estrogen regulation of epithelial ion transport: implications in health and disease
    • Saint-Criq V, Rapetti-Mauss R, Yusef YR, Harvey BJ. Estrogen regulation of epithelial ion transport: implications in health and disease. Steroids (2012) 77:918-23. doi:10.1016/j.steroids.2012.02.017
    • (2012) Steroids , vol.77 , pp. 918-923
    • Saint-Criq, V.1    Rapetti-Mauss, R.2    Yusef, Y.R.3    Harvey, B.J.4
  • 16
    • 84878467142 scopus 로고    scopus 로고
    • Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium
    • Rapetti-Mauss R, O'Mahony F, Sepulveda FV, Urbach V, Harvey BJ. Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium. J Physiol (2013) 591:2813-31. doi:10.1113/jphysiol.2013.251678
    • (2013) J Physiol , vol.591 , pp. 2813-2831
    • Rapetti-Mauss, R.1    O'Mahony, F.2    Sepulveda, F.V.3    Urbach, V.4    Harvey, B.J.5
  • 17
    • 70350469292 scopus 로고    scopus 로고
    • Genomic priming of the antisecretory response to estrogen in rat distal colon throughout the estrous cycle
    • O'Mahony F, Alzamora R, Chung H-L, Thomas W, Harvey BJ. Genomic priming of the antisecretory response to estrogen in rat distal colon throughout the estrous cycle. Mol Endocrinol (2009) 23:1885-99. doi:10.1210/me.2008-0248
    • (2009) Mol Endocrinol , vol.23 , pp. 1885-1899
    • O'Mahony, F.1    Alzamora, R.2    Chung, H-L.3    Thomas, W.4    Harvey, B.J.5
  • 18
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • Deroo BJ, Korach KS. Estrogen receptors and human disease. J Clin Invest (2006) 116:561-70. doi:10.1172/JCI27987
    • (2006) J Clin Invest , vol.116 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 19
    • 33845904405 scopus 로고    scopus 로고
    • Chemoprevention of breast cancer with selective oestrogen-receptor modulators
    • Jordan VC. Chemoprevention of breast cancer with selective oestrogen-receptor modulators. Nat Rev Cancer (2007) 7:46-53. doi:10.1038/nrc2048
    • (2007) Nat Rev Cancer , vol.7 , pp. 46-53
    • Jordan, V.C.1
  • 20
    • 0035884589 scopus 로고    scopus 로고
    • Expression of gonadotropin receptor and growth responses to key reproductive hormones in normal and malignant human ovarian surface epithelial cells
    • Syed V, Ulinski G, Mok SC, Yiu GK, Ho S-M. Expression of gonadotropin receptor and growth responses to key reproductive hormones in normal and malignant human ovarian surface epithelial cells. Cancer Res (2001) 61:6768-76.
    • (2001) Cancer Res , vol.61 , pp. 6768-6776
    • Syed, V.1    Ulinski, G.2    Mok, S.C.3    Yiu, G.K.4    Ho, S-M.5
  • 21
    • 84878108964 scopus 로고    scopus 로고
    • The expression ratios of estrogen receptor a (ERa) to estrogen receptor ß1 (ERß1) and ERa to ERß2 identify poor clinical outcome in endometrioid endometrial cancer
    • Zannoni GF, Monterossi G, De Stefano I, Gargini A, Salerno MG, Farulla I, et al. The expression ratios of estrogen receptor a (ERa) to estrogen receptor ß1 (ERß1) and ERa to ERß2 identify poor clinical outcome in endometrioid endometrial cancer. Hum Pathol (2013) 44:1047-54. doi:10.1016/j.humpath.2012.09.007
    • (2013) Hum Pathol , vol.44 , pp. 1047-1054
    • Zannoni, G.F.1    Monterossi, G.2    De Stefano, I.3    Gargini, A.4    Salerno, M.G.5    Farulla, I.6
  • 22
    • 12344298592 scopus 로고    scopus 로고
    • Role of estrogens in development of prostate cancer
    • Härkönen PL, Mäkelä SI. Role of estrogens in development of prostate cancer. J Steroid Biochem Mol Biol (2004) 92:297-305. doi:10.1016/j.jsbmb.2004.10.016
    • (2004) J Steroid Biochem Mol Biol , vol.92 , pp. 297-305
    • Härkönen, P.L.1    Mäkelä, S.I.2
  • 23
    • 84893059167 scopus 로고    scopus 로고
    • Smoking out reproductive hormone actions in lung cancer
    • Siegfried JM. Smoking out reproductive hormone actions in lung cancer. Mol Cancer Res (2014) 12:24-31. doi:10.1158/1541-7786.MCR-13-0580
    • (2014) Mol Cancer Res , vol.12 , pp. 24-31
    • Siegfried, J.M.1
  • 25
    • 33845929000 scopus 로고    scopus 로고
    • Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer
    • Jordan VC, Brodie AMH. Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer. Steroids (2007) 72:7-25. doi:10.1016/j.steroids.2006.10.009
    • (2007) Steroids , vol.72 , pp. 7-25
    • Jordan, V.C.1    Brodie, A.M.H.2
  • 26
    • 0036532167 scopus 로고    scopus 로고
    • Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen
    • Stabile LP, Davis ALG, Gubish CT, Hopkins TM, Luketich JD, Christie N, et al. Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res (2002) 62:2141-50.
    • (2002) Cancer Res , vol.62 , pp. 2141-2150
    • Stabile, L.P.1    Davis, A.L.G.2    Gubish, C.T.3    Hopkins, T.M.4    Luketich, J.D.5    Christie, N.6
  • 27
    • 77957786489 scopus 로고    scopus 로고
    • Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women
    • Olivo-Marston SE, Mechanic LE, Mollerup S, Bowman ED, Remaley AT, Forman MR, et al. Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women. Carcinogenesis (2010) 31:1778-86. doi:10.1093/carcin/bgq156
    • (2010) Carcinogenesis , vol.31 , pp. 1778-1786
    • Olivo-Marston, S.E.1    Mechanic, L.E.2    Mollerup, S.3    Bowman, E.D.4    Remaley, A.T.5    Forman, M.R.6
  • 29
    • 84888329808 scopus 로고    scopus 로고
    • Insight into the mechanisms of action of estrogen receptor ß in the breast, prostate, colon, and CNS
    • Dey P, Barros RPA, Warner M, Ström A, Gustafsson JÅ. Insight into the mechanisms of action of estrogen receptor ß in the breast, prostate, colon, and CNS. J Mol Endocrinol (2013) 51:T61-74. doi:10.1530/JME-13-0150
    • (2013) J Mol Endocrinol , vol.51 , pp. T61-74
    • Dey, P.1    Barros, R.P.A.2    Warner, M.3    Ström, A.4    Gustafsson, J.Å.5
  • 31
    • 84866132321 scopus 로고    scopus 로고
    • Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer
    • Bossard C, Busson M, Vindrieux D, Gaudin F, Machelon V, Brigitte M, et al. Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer. PLoS One (2012) 7:e44787. doi:10.1371/journal.pone.0044787
    • (2012) PLoS One , vol.7 , pp. e44787
    • Bossard, C.1    Busson, M.2    Vindrieux, D.3    Gaudin, F.4    Machelon, V.5    Brigitte, M.6
  • 32
    • 84857798710 scopus 로고    scopus 로고
    • Potential value of estrogen receptor beta expression in colorectal carcinoma: interaction with apoptotic index
    • Elbanna HG, Ebrahim MA, Abbas AM, Zalata K, Hashim MA. Potential value of estrogen receptor beta expression in colorectal carcinoma: interaction with apoptotic index. J Gastrointest Cancer (2012) 43:56-62. doi:10.1007/s12029-010-9214-4
    • (2012) J Gastrointest Cancer , vol.43 , pp. 56-62
    • Elbanna, H.G.1    Ebrahim, M.A.2    Abbas, A.M.3    Zalata, K.4    Hashim, M.A.5
  • 33
    • 0038579655 scopus 로고    scopus 로고
    • Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation
    • Konstantinopoulos PA, Kominea A, Vandoros G, Sykiotis GP, Andricopoulos P, Varakis I, et al. Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation. Eur J Cancer (2003) 39:1251-8. doi:10.1016/S0959-8049(03)00239-9
    • (2003) Eur J Cancer , vol.39 , pp. 1251-1258
    • Konstantinopoulos, P.A.1    Kominea, A.2    Vandoros, G.3    Sykiotis, G.P.4    Andricopoulos, P.5    Varakis, I.6
  • 35
    • 84865436063 scopus 로고    scopus 로고
    • Expression of oestrogen receptor ß and prognosis of colorectal cancer
    • Rudolph A, Toth C, Hoffmeister M, Roth W, Herpel E, Jansen L, et al. Expression of oestrogen receptor ß and prognosis of colorectal cancer. Br J Cancer (2012) 107:831-9. doi:10.1038/bjc.2012.323
    • (2012) Br J Cancer , vol.107 , pp. 831-839
    • Rudolph, A.1    Toth, C.2    Hoffmeister, M.3    Roth, W.4    Herpel, E.5    Jansen, L.6
  • 36
    • 24644454427 scopus 로고    scopus 로고
    • Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes' staging
    • Jassam N, Bell SM, Speirs V, Quirke P. Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes' staging. Oncol Rep (2005) 14:17-21. doi:10.3892/or.14.1.17
    • (2005) Oncol Rep , vol.14 , pp. 17-21
    • Jassam, N.1    Bell, S.M.2    Speirs, V.3    Quirke, P.4
  • 37
    • 68049129874 scopus 로고    scopus 로고
    • Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells
    • Hartman J, Edvardsson K, Lindberg K, Zhao C, Williams C, Ström A, et al. Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. Cancer Res (2009) 69:6100-6. doi:10.1158/0008-5472.CAN-09-0506
    • (2009) Cancer Res , vol.69 , pp. 6100-6106
    • Hartman, J.1    Edvardsson, K.2    Lindberg, K.3    Zhao, C.4    Williams, C.5    Ström, A.6
  • 39
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
    • Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer (2014) 136(5):E359-86. doi:10.1002/ijc.29210
    • (2014) Int J Cancer , vol.136 , Issue.5 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3    Eser, S.4    Mathers, C.5    Rebelo, M.6
  • 40
    • 84923245450 scopus 로고    scopus 로고
    • GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. globocaniarcfr
    • Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. globocaniarcfr. (2014). Available from: http://globocan.iarc.fr
    • (2014)
    • Ferlay, J.1    Soerjomataram, I.2    Ervik, M.3    Dikshit, R.4    Eser, S.5    Mathers, C.6
  • 43
    • 84887065892 scopus 로고    scopus 로고
    • Molecular pathways: estrogen pathway in colorectal cancer
    • Barzi A, Lenz AM, Labonte MJ, Lenz H-J. Molecular pathways: estrogen pathway in colorectal cancer. Clin Cancer Res (2013) 19:5842-8. doi:10.1158/1078-0432.CCR-13-0325
    • (2013) Clin Cancer Res , vol.19 , pp. 5842-5848
    • Barzi, A.1    Lenz, A.M.2    Labonte, M.J.3    Lenz, H-J.4
  • 44
    • 84878602238 scopus 로고    scopus 로고
    • Colorectal cancer risk associated with hormone use varies by expression of estrogen receptor-ß
    • Rudolph A, Toth C, Hoffmeister M, Roth W, Herpel E, Schirmacher P, et al. Colorectal cancer risk associated with hormone use varies by expression of estrogen receptor-ß. Cancer Res (2013) 73:3306-15. doi:10.1158/0008-5472.CAN-12-4051
    • (2013) Cancer Res , vol.73 , pp. 3306-3315
    • Rudolph, A.1    Toth, C.2    Hoffmeister, M.3    Roth, W.4    Herpel, E.5    Schirmacher, P.6
  • 45
    • 79851511414 scopus 로고    scopus 로고
    • Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field
    • Ogino S, Chan AT, Fuchs CS, Giovannucci E. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut (2011) 60:397-411. doi:10.1136/gut.2010.217182
    • (2011) Gut , vol.60 , pp. 397-411
    • Ogino, S.1    Chan, A.T.2    Fuchs, C.S.3    Giovannucci, E.4
  • 46
    • 84862514348 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression
    • Lin JH, Morikawa T, Chan AT, Kuchiba A, Shima K, Nosho K, et al. Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression. Cancer Res (2012) 72:3020-8. doi:10.1158/0008-5472.CAN-11-2619
    • (2012) Cancer Res , vol.72 , pp. 3020-3028
    • Lin, J.H.1    Morikawa, T.2    Chan, A.T.3    Kuchiba, A.4    Shima, K.5    Nosho, K.6
  • 48
    • 84859416851 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women
    • Limburg PJ, Limsui D, Vierkant RA, Tillmans LS, Wang AH, Lynch CF, et al. Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women. Cancer Epidemiol Biomarkers Prev (2012) 21:681-4. doi:10.1158/1055-9965.EPI-11-1168
    • (2012) Cancer Epidemiol Biomarkers Prev , vol.21 , pp. 681-684
    • Limburg, P.J.1    Limsui, D.2    Vierkant, R.A.3    Tillmans, L.S.4    Wang, A.H.5    Lynch, C.F.6
  • 49
    • 84865000709 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women
    • Limsui D, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, et al. Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women. Gut (2012) 61:1299-305. doi:10.1136/gutjnl-2011-300719
    • (2012) Gut , vol.61 , pp. 1299-1305
    • Limsui, D.1    Vierkant, R.A.2    Tillmans, L.S.3    Wang, A.H.4    Weisenberger, D.J.5    Laird, P.W.6
  • 50
    • 74549164761 scopus 로고    scopus 로고
    • Soy consumption and colorectal cancer risk in humans: a meta-analysis
    • Yan L, Spitznagel EL, Bosland MC. Soy consumption and colorectal cancer risk in humans: a meta-analysis. Cancer Epidemiol Biomarkers Prev (2010) 19:148-58. doi:10.1158/1055-9965.EPI-09-0856
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 148-158
    • Yan, L.1    Spitznagel, E.L.2    Bosland, M.C.3
  • 51
    • 0346095567 scopus 로고    scopus 로고
    • Dietary soy isoflavones and estrone protect ovariectomized ERalphaKO and wild-type mice from carcinogen-induced colon cancer
    • Guo J-Y, Li X, Browning JD, Rottinghaus GE, Lubahn DB, Constantinou A, et al. Dietary soy isoflavones and estrone protect ovariectomized ERalphaKO and wild-type mice from carcinogen-induced colon cancer. J Nutr (2004) 134:179-82.
    • (2004) J Nutr , vol.134 , pp. 179-182
    • Guo, J-Y.1    Li, X.2    Browning, J.D.3    Rottinghaus, G.E.4    Lubahn, D.B.5    Constantinou, A.6
  • 53
    • 34548019992 scopus 로고    scopus 로고
    • An association between obesity and the prevalence of colonic adenoma according to age and gender
    • Kim S-E, Shim K-N, Jung S-A, Yoo K, Moon IH. An association between obesity and the prevalence of colonic adenoma according to age and gender. J Gastroenterol (2007) 42:616-23. doi:10.1007/s00535-007-2074-4
    • (2007) J Gastroenterol , vol.42 , pp. 616-623
    • Kim, S-E.1    Shim, K-N.2    Jung, S-A.3    Yoo, K.4    Moon, I.H.5
  • 54
    • 84888012974 scopus 로고    scopus 로고
    • Adiposity, mediating biomarkers and risk of colon cancer in the European prospective investigation into cancer and nutrition study
    • Aleksandrova K, Drogan D, Boeing H, Jenab M, Bas Bueno-de-Mesquita H, Jansen E, et al. Adiposity, mediating biomarkers and risk of colon cancer in the European prospective investigation into cancer and nutrition study. Int J Cancer (2013) 134:612-21. doi:10.1002/ijc.28368
    • (2013) Int J Cancer , vol.134 , pp. 612-621
    • Aleksandrova, K.1    Drogan, D.2    Boeing, H.3    Jenab, M.4    Bas Bueno-de-Mesquita, H.5    Jansen, E.6
  • 55
    • 33751509395 scopus 로고    scopus 로고
    • Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones
    • Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, et al. Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones. Endocrinology (2006) 147:5826-34. doi:10.1210/en.2006-0311
    • (2006) Endocrinology , vol.147 , pp. 5826-5834
    • Yakar, S.1    Nunez, N.P.2    Pennisi, P.3    Brodt, P.4    Sun, H.5    Fallavollita, L.6
  • 56
    • 84855449461 scopus 로고    scopus 로고
    • Roles of hormones and signaling molecules in describing the relationship between obesity and colon cancer
    • Sikalidis AK, Varamini B. Roles of hormones and signaling molecules in describing the relationship between obesity and colon cancer. Pathol Oncol Res (2011) 17:785-90. doi:10.1007/s12253-010-9352-9
    • (2011) Pathol Oncol Res , vol.17 , pp. 785-790
    • Sikalidis, A.K.1    Varamini, B.2
  • 57
    • 84862551083 scopus 로고    scopus 로고
    • Adipokines linking obesity with colorectal cancer risk in postmenopausal women
    • Ho GYF, Wang T, Gunter MJ, Strickler HD, Cushman M, Kaplan RC, et al. Adipokines linking obesity with colorectal cancer risk in postmenopausal women. Cancer Res (2012) 72:3029-37. doi:10.1158/0008-5472.CAN-11-2771
    • (2012) Cancer Res , vol.72 , pp. 3029-3037
    • Ho, G.Y.F.1    Wang, T.2    Gunter, M.J.3    Strickler, H.D.4    Cushman, M.5    Kaplan, R.C.6
  • 58
    • 55249124734 scopus 로고    scopus 로고
    • Role of estrogen receptor-alpha and -beta in regulating leptin expression in 3T3-L1 adipocytes
    • Yi KW, Shin J-H, Seo HS, Lee JK, Oh M-J, Kim T, et al. Role of estrogen receptor-alpha and -beta in regulating leptin expression in 3T3-L1 adipocytes. Obesity (Silver Spring) (2008) 16:2393-9. doi:10.1038/oby.2008.389
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 2393-2399
    • Yi, K.W.1    Shin, J-H.2    Seo, H.S.3    Lee, J.K.4    Oh, M-J.5    Kim, T.6
  • 59
    • 39749104209 scopus 로고    scopus 로고
    • Mechanisms linking physical activity with cancer
    • McTiernan A. Mechanisms linking physical activity with cancer. Nat Rev Cancer (2008) 8:205-11. doi:10.1038/nrc2325
    • (2008) Nat Rev Cancer , vol.8 , pp. 205-211
    • McTiernan, A.1
  • 60
    • 1042281050 scopus 로고    scopus 로고
    • Expression of estrogen receptor beta in human colorectal cancer
    • Xie L-Q, Yu J-P, Luo H-S. Expression of estrogen receptor beta in human colorectal cancer. World J Gastroenterol (2004) 10:214-7.
    • (2004) World J Gastroenterol , vol.10 , pp. 214-217
    • Xie, L-Q.1    Yu, J-P.2    Luo, H-S.3
  • 61
    • 84872539783 scopus 로고    scopus 로고
    • Common single-nucleotide polymorphisms in the estrogen receptor ß promoter are associated with colorectal cancer survival in postmenopausal women
    • Passarelli MN, Phipps AI, Potter JD, Makar KW, Coghill AE, Wernli KJ, et al. Common single-nucleotide polymorphisms in the estrogen receptor ß promoter are associated with colorectal cancer survival in postmenopausal women. Cancer Res (2013) 73:767-75. doi:10.1158/0008-5472.CAN-12-2484
    • (2013) Cancer Res , vol.73 , pp. 767-775
    • Passarelli, M.N.1    Phipps, A.I.2    Potter, J.D.3    Makar, K.W.4    Coghill, A.E.5    Wernli, K.J.6
  • 64
    • 84867076730 scopus 로고    scopus 로고
    • Estrogen receptor-ß protects against colitis-associated neoplasia in mice
    • Saleiro D, Murillo G, Benya RV, Bissonnette M, Hart J, Mehta RG. Estrogen receptor-ß protects against colitis-associated neoplasia in mice. Int J Cancer (2012) 131:2553-61. doi:10.1002/ijc.27578
    • (2012) Int J Cancer , vol.131 , pp. 2553-2561
    • Saleiro, D.1    Murillo, G.2    Benya, R.V.3    Bissonnette, M.4    Hart, J.5    Mehta, R.G.6
  • 65
    • 44949170611 scopus 로고    scopus 로고
    • Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice
    • Giroux V, Lemay F, Bernatchez G, Robitaille Y, Carrier JC. Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int J Cancer (2008) 123:303-11. doi:10.1002/ijc.23532
    • (2008) Int J Cancer , vol.123 , pp. 303-311
    • Giroux, V.1    Lemay, F.2    Bernatchez, G.3    Robitaille, Y.4    Carrier, J.C.5
  • 66
    • 84864375438 scopus 로고    scopus 로고
    • Estrogen receptor ß potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells
    • Tu Z, Ma Y, Tian J, Li H, Akers W, Achilefu S, et al. Estrogen receptor ß potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells. J Cancer Res Clin Oncol (2012) 138:1091-103. doi:10.1007/s00432-011-1145-3
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 1091-1103
    • Tu, Z.1    Ma, Y.2    Tian, J.3    Li, H.4    Akers, W.5    Achilefu, S.6
  • 67
    • 84897136044 scopus 로고    scopus 로고
    • Raloxifene and antiestrogenic gonadorelin inhibits intestinal tumorigenesis by modulating immune cells and decreasing stem-like cells
    • Janakiram NB, Mohammed A, Brewer M, Bryant T, Biddick L, Lightfoot S, et al. Raloxifene and antiestrogenic gonadorelin inhibits intestinal tumorigenesis by modulating immune cells and decreasing stem-like cells. Cancer Prev Res (Phila) (2014) 7:300-9. doi:10.1158/1940-6207.CAPR-13-0345
    • (2014) Cancer Prev Res (Phila) , vol.7 , pp. 300-309
    • Janakiram, N.B.1    Mohammed, A.2    Brewer, M.3    Bryant, T.4    Biddick, L.5    Lightfoot, S.6
  • 68
    • 84882772276 scopus 로고    scopus 로고
    • A novel shift in estrogen receptor expression occurs as estradiol suppresses inflammation-associated colon tumor formation
    • Armstrong CM, Billimek AR, Allred KF, Sturino JM, Weeks BR, Allred CD. A novel shift in estrogen receptor expression occurs as estradiol suppresses inflammation-associated colon tumor formation. Endocr Relat Cancer (2013) 20:515-25. doi:10.1530/ERC-12-0308
    • (2013) Endocr Relat Cancer , vol.20 , pp. 515-525
    • Armstrong, C.M.1    Billimek, A.R.2    Allred, K.F.3    Sturino, J.M.4    Weeks, B.R.5    Allred, C.D.6
  • 69
    • 69249221595 scopus 로고    scopus 로고
    • A comparison of the effects of soya isoflavonoids and fish oil on cell proliferation, apoptosis and the expression of oestrogen receptors alpha and beta in the mammary gland and colon of the rat
    • Kramer F, Johnson IT, Doleman JF, Lund EK. A comparison of the effects of soya isoflavonoids and fish oil on cell proliferation, apoptosis and the expression of oestrogen receptors alpha and beta in the mammary gland and colon of the rat. Br J Nutr (2009) 102:29-36. doi:10.1017/S0007114508137862
    • (2009) Br J Nutr , vol.102 , pp. 29-36
    • Kramer, F.1    Johnson, I.T.2    Doleman, J.F.3    Lund, E.K.4
  • 70
    • 0035866476 scopus 로고    scopus 로고
    • Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis
    • Weyant MJ, Carothers AM, Mahmoud NN, Bradlow HL, Remotti H, Bilinski RT, et al. Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis. Cancer Res (2001) 61:2547-51.
    • (2001) Cancer Res , vol.61 , pp. 2547-2551
    • Weyant, M.J.1    Carothers, A.M.2    Mahmoud, N.N.3    Bradlow, H.L.4    Remotti, H.5    Bilinski, R.T.6
  • 72
    • 33748346434 scopus 로고    scopus 로고
    • Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling
    • Leung Y-K, Mak P, Hassan S, Ho S-M. Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Proc Natl Acad Sci USA (2006) 103:13162-7. doi:10.1073/pnas.0605676103
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13162-13167
    • Leung, Y-K.1    Mak, P.2    Hassan, S.3    Ho, S-M.4
  • 74
    • 23944475103 scopus 로고    scopus 로고
    • ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates
    • Wong NACS, Malcomson RDG, Jodrell DI, Groome NP, Harrison DJ, Saunders PTK. ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates. J Pathol (2005) 207:53-60. doi:10.1002/path.1807
    • (2005) J Pathol , vol.207 , pp. 53-60
    • Wong, N.A.C.S.1    Malcomson, R.D.G.2    Jodrell, D.I.3    Groome, N.P.4    Harrison, D.J.5    Saunders, P.T.K.6
  • 75
    • 73449128751 scopus 로고    scopus 로고
    • Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival
    • Benedix F, Kube R, Meyer F, Schmidt U, Gastinger I, Lippert H, et al. Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival. Dis Colon Rectum (2010) 53:57-64. doi:10.1007/DCR.0b013e3181c703a4
    • (2010) Dis Colon Rectum , vol.53 , pp. 57-64
    • Benedix, F.1    Kube, R.2    Meyer, F.3    Schmidt, U.4    Gastinger, I.5    Lippert, H.6
  • 76
    • 33744506902 scopus 로고    scopus 로고
    • Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas
    • Sugai T, Habano W, Jiao Y-F, Tsukahara M, Takeda Y, Otsuka K, et al. Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. J Mol Diagn (2006) 8:193-201. doi:10.2353/jmoldx.2006.050052
    • (2006) J Mol Diagn , vol.8 , pp. 193-201
    • Sugai, T.1    Habano, W.2    Jiao, Y-F.3    Tsukahara, M.4    Takeda, Y.5    Otsuka, K.6
  • 77
    • 40349100700 scopus 로고    scopus 로고
    • Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology
    • Nawa T, Kato J, Kawamoto H, Okada H, Yamamoto H, Kohno H, et al. Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology. J Gastroenterol Hepatol (2008) 23:418-23. doi:10.1111/j.1440-1746.2007.04923.x
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 418-423
    • Nawa, T.1    Kato, J.2    Kawamoto, H.3    Okada, H.4    Yamamoto, H.5    Kohno, H.6
  • 78
    • 0037057510 scopus 로고    scopus 로고
    • Are there two sides to colorectal cancer?
    • Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer (2002) 101:403-8. doi:10.1002/ijc.10635
    • (2002) Int J Cancer , vol.101 , pp. 403-408
    • Iacopetta, B.1
  • 79
    • 84922536963 scopus 로고    scopus 로고
    • Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features
    • Missiaglia E, Jacobs B, D'Ario G, Di Narzo AF, Soneson C, Budinska E, et al. Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. Ann Oncol (2014) 25:1995-2001. doi:10.1093/annonc/mdu275
    • (2014) Ann Oncol , vol.25 , pp. 1995-2001
    • Missiaglia, E.1    Jacobs, B.2    D'Ario, G.3    Di Narzo, A.F.4    Soneson, C.5    Budinska, E.6
  • 80
    • 73449086997 scopus 로고    scopus 로고
    • Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer
    • Koo JH, Leong RWL. Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer. J Gastroenterol Hepatol (2010) 25:33-42. doi:10.1111/j.1440-1746.2009.05992.x
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 33-42
    • Koo, J.H.1    Leong, R.W.L.2
  • 81
    • 0034997971 scopus 로고    scopus 로고
    • Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
    • Ward R, Meagher A, Tomlinson I, O'Connor T, Norrie M, Wu R, et al. Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut (2001) 48:821-9. doi:10.1136/gut.48.6.821
    • (2001) Gut , vol.48 , pp. 821-829
    • Ward, R.1    Meagher, A.2    Tomlinson, I.3    O'Connor, T.4    Norrie, M.5    Wu, R.6
  • 82
    • 0035138814 scopus 로고    scopus 로고
    • Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer
    • Slattery ML, Potter JD, Curtin K, Edwards S, Ma KN, Anderson K, et al. Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer. Cancer Res (2001) 61:126-30.
    • (2001) Cancer Res , vol.61 , pp. 126-130
    • Slattery, M.L.1    Potter, J.D.2    Curtin, K.3    Edwards, S.4    Ma, K.N.5    Anderson, K.6
  • 83
    • 84871396144 scopus 로고    scopus 로고
    • Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-ß in colorectal cells
    • He Y-Q, Sheng J-Q, Ling X-L, Fu L, Jin P, Yen L, et al. Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-ß in colorectal cells. Exp Mol Med (2012) 44:723. doi:10.3858/emm.2012.44.12.079
    • (2012) Exp Mol Med , vol.44 , pp. 723
    • He, Y-Q.1    Sheng, J-Q.2    Ling, X-L.3    Fu, L.4    Jin, P.5    Yen, L.6
  • 84
    • 80054995764 scopus 로고    scopus 로고
    • Progression of low-grade dysplasia in ulcerative colitis: effect of colonic location
    • Goldstone R, Itzkowitz S, Harpaz N, Ullman T. Progression of low-grade dysplasia in ulcerative colitis: effect of colonic location. Gastrointest Endosc (2011) 74:1087-93. doi:10.1016/j.gie.2011.06.028
    • (2011) Gastrointest Endosc , vol.74 , pp. 1087-1093
    • Goldstone, R.1    Itzkowitz, S.2    Harpaz, N.3    Ullman, T.4
  • 86
    • 84860589077 scopus 로고    scopus 로고
    • Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
    • Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R, et al. Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut (2012) 61:847-54. doi:10.1136/gutjnl-2011-300865
    • (2012) Gut , vol.61 , pp. 847-854
    • Yamauchi, M.1    Morikawa, T.2    Kuchiba, A.3    Imamura, Y.4    Qian, Z.R.5    Nishihara, R.6
  • 87
    • 84879001702 scopus 로고    scopus 로고
    • PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival
    • Rosty C, Young JP, Walsh MD, Clendenning M, Sanderson K, Walters RJ, et al. PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival. PLoS One (2013) 8:e65479. doi:10.1371/journal.pone.0065479
    • (2013) PLoS One , vol.8 , pp. e65479
    • Rosty, C.1    Young, J.P.2    Walsh, M.D.3    Clendenning, M.4    Sanderson, K.5    Walters, R.J.6
  • 88
    • 84882661889 scopus 로고    scopus 로고
    • Anatomic subsite of primary colorectal cancer and subsequent risk and distribution of second cancers
    • Phipps AI, Chan AT, Ogino S. Anatomic subsite of primary colorectal cancer and subsequent risk and distribution of second cancers. Cancer (2013) 119:3140-7. doi:10.1002/cncr.28076
    • (2013) Cancer , vol.119 , pp. 3140-3147
    • Phipps, A.I.1    Chan, A.T.2    Ogino, S.3
  • 90
    • 84858751926 scopus 로고    scopus 로고
    • Gender differences in autoimmunity associated with exposure to environmental factors
    • Pollard KM. Gender differences in autoimmunity associated with exposure to environmental factors. J Autoimmun (2012) 38:J177-86. doi:10.1016/j.jaut.2011.11.007
    • (2012) J Autoimmun , vol.38 , pp. J177-J186
    • Pollard, K.M.1
  • 91
    • 78650624793 scopus 로고    scopus 로고
    • Innate immune mechanisms of colitis and colitis-associated colorectal cancer
    • Saleh M, Trinchieri G. Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol (2010) 11:9-20. doi:10.1038/nri2891
    • (2010) Nat Rev Immunol , vol.11 , pp. 9-20
    • Saleh, M.1    Trinchieri, G.2
  • 93
    • 79957667295 scopus 로고    scopus 로고
    • Estrogen receptor ß induces antiinflammatory and antitumorigenic networks in colon cancer cells
    • Edvardsson K, Ström A, Jonsson P, Gustafsson JÅ, Williams C. Estrogen receptor ß induces antiinflammatory and antitumorigenic networks in colon cancer cells. Mol Endocrinol (2011) 25:969-79. doi:10.1210/me.2010-0452
    • (2011) Mol Endocrinol , vol.25 , pp. 969-979
    • Edvardsson, K.1    Ström, A.2    Jonsson, P.3    Gustafsson, J.Å.4    Williams, C.5
  • 94
    • 84890859206 scopus 로고    scopus 로고
    • Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway
    • Zhu L, Cheng X, Ding Y, Shi J, Jin H, Wang H, et al. Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. Cancer Lett (2014) 343:80-9. doi:10.1016/j.canlet.2013.09.017
    • (2014) Cancer Lett , vol.343 , pp. 80-89
    • Zhu, L.1    Cheng, X.2    Ding, Y.3    Shi, J.4    Jin, H.5    Wang, H.6
  • 95
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu G-Y, Vallabhapurapu S, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell (2009) 15:103-13. doi:10.1016/j.ccr.2009.01.001
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G-Y.5    Vallabhapurapu, S.6
  • 96
    • 48349109595 scopus 로고    scopus 로고
    • Regulation of dendritic cell differentiation and function by estrogen receptor ligands
    • Kovats S, Carreras E. Regulation of dendritic cell differentiation and function by estrogen receptor ligands. Cell Immunol (2008) 252:81-90. doi:10.1016/j.cellimm.2007.10.008
    • (2008) Cell Immunol , vol.252 , pp. 81-90
    • Kovats, S.1    Carreras, E.2
  • 97
    • 75649112342 scopus 로고    scopus 로고
    • Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4
    • Carreras E, Turner S, Frank MB, Knowlton N, Osban J, Centola M, et al. Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4. Blood (2010) 115:238-46. doi:10.1182/blood-2009-08-236935
    • (2010) Blood , vol.115 , pp. 238-246
    • Carreras, E.1    Turner, S.2    Frank, M.B.3    Knowlton, N.4    Osban, J.5    Centola, M.6
  • 98
    • 4444304413 scopus 로고    scopus 로고
    • 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells
    • Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood (2004) 104:1404-10. doi:10.1182/blood-2003-10-3380
    • (2004) Blood , vol.104 , pp. 1404-1410
    • Bengtsson, A.K.1    Ryan, E.J.2    Giordano, D.3    Magaletti, D.M.4    Clark, E.A.5
  • 99
    • 40449107415 scopus 로고    scopus 로고
    • Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes
    • Cvoro A, Tatomer D, Tee M-K, Zogovic T, Harris HA, Leitman DC. Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes. J Immunol (2008) 180:630-6. doi:10.4049/jimmunol.180.1.630
    • (2008) J Immunol , vol.180 , pp. 630-636
    • Cvoro, A.1    Tatomer, D.2    Tee, M-K.3    Zogovic, T.4    Harris, H.A.5    Leitman, D.C.6
  • 100
    • 0035931345 scopus 로고    scopus 로고
    • Crucial role of cytokines in sex steroid formation in normal and tumoral tissues
    • Simard J, Gingras S. Crucial role of cytokines in sex steroid formation in normal and tumoral tissues. Mol Cell Endocrinol (2001) 171:25-40. doi:10.1016/S0303-7207(00)00387-7
    • (2001) Mol Cell Endocrinol , vol.171 , pp. 25-40
    • Simard, J.1    Gingras, S.2
  • 101
    • 84884239702 scopus 로고    scopus 로고
    • Diet complexity and estrogen receptor ß status affect the composition of the murine intestinal microbiota
    • Menon R, Watson SE, Thomas LN, Allred CD, Dabney A, Azcarate-Peril MA, et al. Diet complexity and estrogen receptor ß status affect the composition of the murine intestinal microbiota. Appl Environ Microbiol (2013) 79:5763. doi:10.1128/AEM.01182-13
    • (2013) Appl Environ Microbiol , vol.79 , pp. 5763
    • Menon, R.1    Watson, S.E.2    Thomas, L.N.3    Allred, C.D.4    Dabney, A.5    Azcarate-Peril, M.A.6
  • 102
    • 9744284211 scopus 로고    scopus 로고
    • Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor alpha and beta signalling
    • Totta P, Acconcia F, Leone S, Cardillo I, Marino M. Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor alpha and beta signalling. IUBMB Life (2004) 56:491-9. doi:10.1080/15216540400010792
    • (2004) IUBMB Life , vol.56 , pp. 491-499
    • Totta, P.1    Acconcia, F.2    Leone, S.3    Cardillo, I.4    Marino, M.5
  • 103
    • 84856185031 scopus 로고    scopus 로고
    • The pro-apoptotic effect of quercetin in cancer cell lines requires ERß-dependent signals
    • Bulzomi P, Galluzzo P, Bolli A, Leone S, Acconcia F, Marino M. The pro-apoptotic effect of quercetin in cancer cell lines requires ERß-dependent signals. J Cell Physiol (2012) 227:1891-8. doi:10.1002/jcp.22917
    • (2012) J Cell Physiol , vol.227 , pp. 1891-1898
    • Bulzomi, P.1    Galluzzo, P.2    Bolli, A.3    Leone, S.4    Acconcia, F.5    Marino, M.6
  • 104
    • 78649745992 scopus 로고    scopus 로고
    • Bisphenol A impairs estradiol-induced protective effects against DLD-1 colon cancer cell growth
    • Bolli A, Bulzomi P, Galluzzo P, Acconcia F, Marino M. Bisphenol A impairs estradiol-induced protective effects against DLD-1 colon cancer cell growth. IUBMB Life (2010) 62:684-7. doi:10.1002/iub.370
    • (2010) IUBMB Life , vol.62 , pp. 684-687
    • Bolli, A.1    Bulzomi, P.2    Galluzzo, P.3    Acconcia, F.4    Marino, M.5
  • 106
    • 80052835714 scopus 로고    scopus 로고
    • Current and future development of estrogen receptor ligands: applications in estrogen-related cancers
    • Bolli A, Marino M. Current and future development of estrogen receptor ligands: applications in estrogen-related cancers. Recent Pat Endocr Metab Immune Drug Discov (2011) 5:210-29. doi:10.2174/187221411797265881
    • (2011) Recent Pat Endocr Metab Immune Drug Discov , vol.5 , pp. 210-229
    • Bolli, A.1    Marino, M.2
  • 107
    • 84898058371 scopus 로고    scopus 로고
    • Oestrogen receptor-beta as a potential target for treatment in advanced colorectal cancer: a pilot study
    • van Halteren H, Mulder D, Ruijter E. Oestrogen receptor-beta as a potential target for treatment in advanced colorectal cancer: a pilot study. Histopathology (2014) 64:787-90. doi:10.1111/his.12340
    • (2014) Histopathology , vol.64 , pp. 787-790
    • van Halteren, H.1    Mulder, D.2    Ruijter, E.3
  • 108
    • 34249712435 scopus 로고    scopus 로고
    • 17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells
    • Caiazza F, Galluzzo P, Lorenzetti S, Marino M. 17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells. Biochem Biophys Res Commun (2007) 359:102-7. doi:10.1016/j.bbrc.2007.05.059
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 102-107
    • Caiazza, F.1    Galluzzo, P.2    Lorenzetti, S.3    Marino, M.4
  • 109
    • 84891947795 scopus 로고    scopus 로고
    • Regulation of estrogen receptor ß1 expression in breast cancer by epigenetic modification of the 5' regulatory region
    • Al-Nakhle H, Smith L, Bell SM, Burns PA, Cummings M, Hanby AM, et al. Regulation of estrogen receptor ß1 expression in breast cancer by epigenetic modification of the 5' regulatory region. Int J Oncol (2013) 43:2039-45. doi:10.3892/ijo.2013.2112
    • (2013) Int J Oncol , vol.43 , pp. 2039-2045
    • Al-Nakhle, H.1    Smith, L.2    Bell, S.M.3    Burns, P.A.4    Cummings, M.5    Hanby, A.M.6
  • 110
  • 111
    • 84899471598 scopus 로고    scopus 로고
    • Therapeutic effect of the treatment for colorectal cancer with adenoviral vectors mediated estrogen receptor ß gene therapy combined with thermotherapy
    • Tu Z, Ma Y, Akers W, Achilefu S, Gu Y. Therapeutic effect of the treatment for colorectal cancer with adenoviral vectors mediated estrogen receptor ß gene therapy combined with thermotherapy. J Cancer Res Clin Oncol (2014) 140:623-32. doi:10.1007/s00432-014-1611-9
    • (2014) J Cancer Res Clin Oncol , vol.140 , pp. 623-632
    • Tu, Z.1    Ma, Y.2    Akers, W.3    Achilefu, S.4    Gu, Y.5
  • 112
    • 84908668490 scopus 로고    scopus 로고
    • From empirical to mechanism-based discovery of clinically useful selective estrogen receptor modulators (SERMs)
    • Wardell SE, Nelson ER, McDonnell DP. From empirical to mechanism-based discovery of clinically useful selective estrogen receptor modulators (SERMs). Steroids (2014) 90:30-8. doi:10.1016/j.steroids.2014.07.013
    • (2014) Steroids , vol.90 , pp. 30-38
    • Wardell, S.E.1    Nelson, E.R.2    McDonnell, D.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.