A Chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy

ChemMedChem

Volumn 9, Issue 3, 2014, Pages 602-613

  Patel, Hitisha K ^a   Siklos, Marton I ^a   Abdelkarim, Hazem ^a   Mendonca, Emma L ^a   Vaidya, Aditya ^a   Petukhov, Pavel A ^a   Thatcher, Gregory R J ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

breast cancer; estrogen receptors; HDAC inhibitors; histone deacetylases; SERMs

Indexed keywords

(4 ETHYNYLPHENYL)[6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHEN 3 YL]METHANONE; (4 IODOPHENYL)[6 METHOXY 2 (4 METHOXYPHENYL)BENZO[B]THIOPHEN 3 YL]METHANONE; 6 [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBOXAMIDO]HEPTANOIC ACID; 6 [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBOXAMIDO]HEXANOIC ACID; 6 HYDROXY N [4 HYDROXY (1,1' BIPHENYL) 3 YL] 2 (HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBOXAMIDE; 6 HYDROXY N [6 (HYDROXYAMINO) 6 OXOHEXYL) 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBOXAMIDE; 6 HYDROXY N [7 (HYDROXYAMINO) 7 OXOHEPTYL] 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBOXAMIDE; 6 METHOXY N [4 METHOXY (1,1' BIPHENYL) 3 YL) 2 (4 METHOXYPHENYL)BENZO[B]THIOPHENE 3 CARBOXAMIDE; [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHEN 3 YL][4 [(TRIMETHYLSILYL)ETHYNYL]PHENYL] METHANONE; [6 METHOXY 2 (4 METHOXYPHENYL)BENZO[B]THIOPHEN 3 YL][4 [(TRIMETHYLSILYL)ETHYNYL]PHENYL]METHANONE; ANTIESTROGEN; ARZOXIFENE; BENZAMIDE; BENZOTHIOPHENE; ENTINOSTAT; ETHYL 5 [4 [4 [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBONYL]PHENYL] 1 H 1,2,3 TRIAZOL 1 YL]PENTANOATE; FULVESTRANT; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; METHYL 6 [4 [4 [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBONYL]PHENYL] 1H 1,2,3 TRIAZOL 1 YL]HEXANOATE; METHYL 6 [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBOXAMIDO]HEXANOATE; METHYL 7 [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBOXAMIDO]HEPTANOATE; N HYDROXY 5 [4 [4 [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBONYL]PHENYL] 1H 1,2,3 TRIAZOL 1 YL]PENTANAMIDE; N HYDROXY 6 [4 [4 [6 HYDROXY 2 (4 HYDROXYPHENYL)BENZO[B]THIOPHENE 3 CARBONYL]PHENYL] 1H 1,2,3 TRIAZOL 1 YL]HEXANAMIDE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BREAST CANCER; BREAST TUMOR; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CELL DEATH; CELL NUCLEUS; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOADDITION; CYTOTOXICITY; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROMOTER REGION; SONOGASHIRA REACTION; UPREGULATION;

BREAST CANCER; ESTROGEN RECEPTORS; HDAC INHIBITORS; HISTONE DEACETYLASES; SERMS;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; ISOENZYMES; MCF-7 CELLS; MOLECULAR STRUCTURE; SELECTIVE ESTROGEN RECEPTOR MODULATORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896696956     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300270     Document Type: Article

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