Survival versus apoptotic 17β-estradiol effect: Role of ERα and ERβ activated non-genomic signaling

Journal of Cellular Physiology

Volumn 203, Issue 1, 2005, Pages 193-201

  Acconcia, Filippo ^a   Totta, Pierangela ^a   Ogawa, Sumito ^b   Cardillo, Irene ^a   Inoue, Satoshi ^b   Leone, Stefano ^a   Trentalance, Anna ^a   Muramatsu, Masami ^b   Marino, Maria ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UTERINE CERVIX;

APOPTOSIS; CELL DIVISION; CELL LINE; CELL SURVIVAL; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE TRANSFER TECHNIQUES; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR CROSS-TALK; SIGNAL TRANSDUCTION;

EID: 14744283561     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20219     Document Type: Article

References (50)

1. Acconcia F, Ascenzi P, Fabozzi G, Visca P, Marino M. 2004. S-palmitoylation modulates human estrogen receptor-alpha functions. Biochem Biophys Res Commun 6:878-883.
2. Ambrosino C, Nebreda AR. 2001. Cell cycle regulation by p38 MAP kinases. Biol Cell 93:47-51.
3. Badger AM, Bradbeer JN, Votta B, Lee JC, Adams JL, Griswold DE. 1996. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther 279:1453-1461.
4. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 772:248-254.
5. Castoria G, Barone MV, Di Domenico M, Bilancio A, Ametrano D, Migliaccio A, Auricchio F. 1999. Non-trascriptional action of oestradiol and progestin triggers DNA synthesis. EMBO J 18:2500-2510.
6. Castoria G, Migliaccio A, Bilancio A, Di Domenico M, de Falco A, Lombardi M, Fiorentino R, Varricchio L, Barone MV, Auricchio F. 2001. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J 20:6050-6059.
7. Cheng J, Lee EJ, Madison LD, Lazennec G. 2004. Expression of estrogen receptor β in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis. FEBS Lett 566:169-172.
8. Couse JF, Korach KS. 1999. Reproductive phenotypes in the estrogen receptor-α knockout mouse. Ann Endocrinol 60:143-148.
9. Di Leo A, Messa C, Cavallini A, Linsalata M. 2001. Estrogens and colorectal cancer. Curr Drug Targets Immune Endocr Metabol Disord 1:1-12.
10. Dubal DB, Wilson ME, Wise PM. 1999. Estradiol: A protective and trophic factor in the brain. J Alzheimers Dis 1:265-274.
11. Fernando RI, Wimalasena J. 2004. Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras dependent non-genomic pathways requiring signaling through ERK and Akt. Mol Biol Cell 15:3266-3284.
12. Fiorelli G, Picariello L, Martineti V, Tonelli F, Brandi ML. 1999. Functional estrogen receptor β in colon cancer cells. Biochem Biophys Res Commun 261:521-527.
13. Geraldes P, Sirois MG, Tanguay J-F. 2003. Specific contribution of estrogen receptors on mitogen-activated protein kinase pathways and vascular cell activation. Circulation Res 93:399-405.
14. Han J, Lee JD, Bibbs L, Ulevitch HJ. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811.
15. Harper SJ, LoGrasso P. 2001. Signalling for survival and death in neurones: The role of stress-activated kinases, JNK and p38. Cell Signal 13:299-310.
16. Horvath LG, Henshall SM, Lee CS, Head DR, Quinn DI, Makela S, Delprado W, Golovsky D, Crenner PC, O'Neill G, Kooner R, Stricker PD, Grygiel JJ, Gustafsson J-Å, Sutherland RL. 2001. Frequent loss of estrogen receptor-β expression in prostate cancer. Cancer Res 61:5331-5335.
17. Kang HJ, Soh Y, Kim MS, Lee EJ, Surh YJ, Kim HR, Kim SH, Moon A. 2003. Roles of JNK-I and p38 in selective induction of apoptosis by capsaicin in Ras-transformed human breast epithelial cells. Int J Cancer 103:475-482.
18. Konstantinopoulos PA, Kominea A, Vandoros G, Sykiotis GP, Andricopoulos P, Varakis I, Sotiropoulou-Bonikou G, Papavassiliou AG. 2003. Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation. Eur J Cancer 39:1251-1258.
19. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Robertson PK, Weinstein RS, Jilka RL, Manolagas SC. 2001. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity. Cell 104:719-790.
20. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson J-Å. 1998. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139:4252-4263.
21. Lee H, Bai W. 2002. Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation. Mol Cell Biol 22:5835-5845.
22. Lobenhofer EK, Huper G, Iglehart JD, Marks JR. 2000. Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. Cell Growth Differ 11:99-110.
23. 3-PKC-α signal transduction pathway in HepG2 cells. Biochem Biophys Res Commun 245:254-258.
24. 3 mediate the estrogen receptor activity expressed in human cells. Mol Cell Endocrinol 182:19-26.
25. 1 gene transcription in HepG2 cells. Mol Biol Cell 13:3720-3729.
26. Marino M, Acconcia F, Trentalance A. 2003. Biphasic estradiol-induced AKT-phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells. Mol Biol Cell 14:2583-2591.
27. Matthews J, Gustafsson J-Å. 2003. Estrogen signalling: A subtle balance between ERα and ERβ. Mol Interventions 3:281-292.
28. Moon WS, Chang K, Tarnawski AS. 2004. Overexpression of metastatic tumor antigen 1 in hepatocellular carcinoma: Relationship to vascular invasion and estrogen receptor-α. Hum Pathol 35:424-429.
29. Mori-Abe A, Tsutsumi S, Takahashi K, Toya M, Yoshida M, Du B, Kawagoe J, Nakahara K, Takahashi T, Ohmichi M, Kurachi H. 2003. Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells. J Endocrinol 178:417-426.
30. Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M. 1998. Molecular cloning and characterization of human estrogen receptor βcx: A potential inhibitor of estrogen action in human. Nucleic Acids Res 26:3505-3512.
31. Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL, Leitman DC. 2004. Estrogen receptor β inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res 64:423-428.
32. Porras A, Zuluaga S, Black E, Valladares A, Alvarez AM, Ambrosino C, Benito M, Nebreda AR. 2004. p38α mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol Biol Cell 15:922-933.
33. Rapp UR, Rennefahrt U, Troppmair J. 2004. Bcl-2 proteins: Master switches at the intersection of death signaling and the survival control by Raf kinases. Biochim Biophys Acta 1644:149-158.
34. Razandi M, Pedram A, Greene GL, Levin ER. 1999. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: Studies of ERα and ERβ expressed in Chinese hamster ovary cells. Mol Endocrinol 13:307-319.
35. Razandi M, Pedram A, Levin ER. 2000a. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Mol Endocrinol 14:1434-1447.
36. Razandi M, Pedram A, Levin ER. 2000b. Estrogen signals to the preservation of endothelial cell form and function. J Biol Chem 275:38540-38546.
37. Razandi M, Oh P, Pedram A, Schnitzer J, Levin ER. 2002. ERs associate with and regulate the production of caveolin: Implications for signaling and cellular actions. Mol Endocrinol 16:100-115.
38. Roger P, Sahla ME, Makela S, Gustafsson J-Å, Baldet P, Rochefort H. 2001. Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res 61:2537-2541.
39. Shimada K, Nakamura M, Ispida E, Kishi M, Konishi N. 2003. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24:1067-1075.
40. Song RX, Santen RJ. 2003. Apoptotic action of estrogen. Apoptosis 8:55-60.
41. Song RX, Mor G, Naftolin F, McPherson RA, Song J, Zhang Z, Yue W, Wang J, Santen RJ. 2001. Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17β-estradiol. J Nat Cancer Institute 93:1714-1723.
42. Song YS, Park HJ, Kim SY, Lee SH, Yoo HS, Lee HS, Lee MK, Oh KW, Kang SK, Lee SE, Hong JT. 2004. Protective role of Bcl-2 on β-amyloid-induced cell death of differentiated PC12 cells: Reduction of NF-κB and p38 MAP kinase activation. Neurosci Res 49:69-80.
43. Strom A, Hartman J, Foster JS, Kietz S, Wimalasena J, Gustafsson J-Å. 2004. Estrogen receptor beta inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci USA 101:1566-1571.
44. Sutherland RL, Reddel RR, Green MD. 1983. Effects of estrogens on cell proliferation and cell cycle kinetics: A hypothesis on the cell cycle effects of antiestrogens. Eur J Cancer Clin Oncol 19:307-318.
45. Talapatra S, Thompson CB. 2001. Growth factor signaling in cell survival: Implications for cancer treatment. J Pharmacol Exp Ther 298:873-878.
46. Tamura Y, Simizu S, Osada H. 2004. The phosphorylation status and antiapoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria. FEBS Lett 569:249-255.
47. Weihua Z, Andersson S, Cheng G, Simpson ER, Warner M, Gustafsson J-Å. 2003. Update on estrogen signaling. FEBS Lett 46:17-24.
48. Zhang CC, Shapiro DJ. 2000. Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis. J Biol Chem 275:479-486.
49. Zhang HM, Rao JN, Guo X, Liu L, Zou T, Turner DJ, Wang JY. 2004. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. J Biol Chem 279:22539-22547.
50. Zheng J, Ali A, Ramirez VD. 1996. Steroids conjugated to bovine serum albumin as tools to demonstrate specific steroid neuronal membrane binding sites. J Psych Neurosci 21:187-197.