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Volumn 31, Issue , 2015, Pages 36-42

Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways

Author keywords

Ape1 Ref 1; Cancer stem cells; DNA repair; Intracellular signalling; MRN complex

Indexed keywords

ABC TRANSPORTER; CISPLATIN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; MRE11 PROTEIN; NIBRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAC1 PROTEIN; RAD50 PROTEIN; REACTIVE OXYGEN METABOLITE; REDOX EFFECTOR FACTOR 1; ANTINEOPLASTIC AGENT; APEX1 PROTEIN, HUMAN;

EID: 84923221727     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2014.06.002     Document Type: Review
Times cited : (90)

References (63)
  • 1
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: premises, promises and challenges
    • Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med 2011, 17:313-319.
    • (2011) Nat Med , vol.17 , pp. 313-319
    • Clevers, H.1
  • 2
    • 63449100206 scopus 로고    scopus 로고
    • Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers
    • Kinsella T.J. Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers. Clin Cancer Res 2009, 15:1853-1859.
    • (2009) Clin Cancer Res , vol.15 , pp. 1853-1859
    • Kinsella, T.J.1
  • 3
    • 0034905642 scopus 로고    scopus 로고
    • Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer
    • Kelley M.R., Cheng L., Foster R., Tritt R., Jiang J., Broshears J., et al. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer. Clin Cancer Res 2001, 7:824-830.
    • (2001) Clin Cancer Res , vol.7 , pp. 824-830
    • Kelley, M.R.1    Cheng, L.2    Foster, R.3    Tritt, R.4    Jiang, J.5    Broshears, J.6
  • 6
    • 55849153134 scopus 로고    scopus 로고
    • Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells
    • Skvortsova I., Skvortsov S., Stasyk T., Raju U., Popper B.A., Schiestl B., et al. Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells. Proteomics 2008, 8:4521-4533.
    • (2008) Proteomics , vol.8 , pp. 4521-4533
    • Skvortsova, I.1    Skvortsov, S.2    Stasyk, T.3    Raju, U.4    Popper, B.A.5    Schiestl, B.6
  • 7
    • 70449585523 scopus 로고    scopus 로고
    • Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) in human ovarian cancer and indentification of the therapeutic potential of APE1/Ref-1 inhibitor
    • Zhang Y., Wang J., Xiang D., Wang D., Xin X. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) in human ovarian cancer and indentification of the therapeutic potential of APE1/Ref-1 inhibitor. Int J Oncol 2009, 35:1069-1079.
    • (2009) Int J Oncol , vol.35 , pp. 1069-1079
    • Zhang, Y.1    Wang, J.2    Xiang, D.3    Wang, D.4    Xin, X.5
  • 9
    • 84875902088 scopus 로고    scopus 로고
    • Redox homeostasis: the linchpin in stem cell self-renewal and differentiation
    • Wang K., Zhang T., Dong Q., Nice E.C., Huang C., Wei Y. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis 2013, 4:e537.
    • (2013) Cell Death Dis , vol.4 , pp. e537
    • Wang, K.1    Zhang, T.2    Dong, Q.3    Nice, E.C.4    Huang, C.5    Wei, Y.6
  • 10
    • 84887043495 scopus 로고    scopus 로고
    • Redox regulation in stem-like cancer cells by CD44 variant isoforms
    • Nagano O., Okazaki S., Saya H. Redox regulation in stem-like cancer cells by CD44 variant isoforms. Oncogene 2013, 32:5191-5198.
    • (2013) Oncogene , vol.32 , pp. 5191-5198
    • Nagano, O.1    Okazaki, S.2    Saya, H.3
  • 12
    • 84895860688 scopus 로고    scopus 로고
    • The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate
    • Domenis R., Bergamin N., Gianfranceschi G., Vascotto C., Romanello M., Rigo S., et al. The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. PLoS ONE 2014, 9:e89232.
    • (2014) PLoS ONE , vol.9 , pp. e89232
    • Domenis, R.1    Bergamin, N.2    Gianfranceschi, G.3    Vascotto, C.4    Romanello, M.5    Rigo, S.6
  • 13
    • 58849122683 scopus 로고    scopus 로고
    • Inhibition of ref-1 stimulates the production of reactive oxygen species and induces differentiation in adult cardiac stem cells
    • Gurusamy N., Mukherjee S., Lekli I., Bearzi C., Bardelli S., Das D.K. Inhibition of ref-1 stimulates the production of reactive oxygen species and induces differentiation in adult cardiac stem cells. Antioxid Redox Signal 2009, 11:589-600.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 589-600
    • Gurusamy, N.1    Mukherjee, S.2    Lekli, I.3    Bearzi, C.4    Bardelli, S.5    Das, D.K.6
  • 15
    • 61549109882 scopus 로고    scopus 로고
    • Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
    • Vascotto C., Cesaratto L., Zeef L.A., Deganuto M., D'Ambrosio C., Scaloni A., et al. Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells. Proteomics 2009, 9:1058-1074.
    • (2009) Proteomics , vol.9 , pp. 1058-1074
    • Vascotto, C.1    Cesaratto, L.2    Zeef, L.A.3    Deganuto, M.4    D'Ambrosio, C.5    Scaloni, A.6
  • 16
    • 84879301722 scopus 로고    scopus 로고
    • Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy
    • Wang L., Huang X., Zheng X., Wang X., Li S., Zhang L., et al. Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy. Int J Biol Sci 2013, 9:472-479.
    • (2013) Int J Biol Sci , vol.9 , pp. 472-479
    • Wang, L.1    Huang, X.2    Zheng, X.3    Wang, X.4    Li, S.5    Zhang, L.6
  • 17
    • 84895923229 scopus 로고    scopus 로고
    • Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-kappaB downregulation
    • Liu L., Salnikov A.V., Bauer N., Aleksandrowicz E., Labsch S., Nwaeburu C., et al. Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-kappaB downregulation. Int J Cancer 2014, 34:2489-2503.
    • (2014) Int J Cancer , vol.34 , pp. 2489-2503
    • Liu, L.1    Salnikov, A.V.2    Bauer, N.3    Aleksandrowicz, E.4    Labsch, S.5    Nwaeburu, C.6
  • 18
    • 84855822330 scopus 로고    scopus 로고
    • APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1
    • Kelley M.R., Georgiadis M.M., Fishel M.L. APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1. Curr Mol Pharmacol 2012, 5:36-53.
    • (2012) Curr Mol Pharmacol , vol.5 , pp. 36-53
    • Kelley, M.R.1    Georgiadis, M.M.2    Fishel, M.L.3
  • 19
    • 34347389461 scopus 로고    scopus 로고
    • Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies
    • Chan N., Milosevic M., Bristow R.G. Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies. Future Oncol 2007, 3:329-341.
    • (2007) Future Oncol , vol.3 , pp. 329-341
    • Chan, N.1    Milosevic, M.2    Bristow, R.G.3
  • 20
    • 14044269479 scopus 로고    scopus 로고
    • The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
    • Tell G., Damante G., Caldwell D., Kelley M.R. The intracellular localization of APE1/Ref-1: more than a passive phenomenon?. Antioxid Redox Signal 2005, 7:367-384.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 367-384
    • Tell, G.1    Damante, G.2    Caldwell, D.3    Kelley, M.R.4
  • 22
    • 84896942587 scopus 로고    scopus 로고
    • Putative biomarkers and therapeutic targets associated with radiation resistance
    • Skvortsov S., Debbage P., Cho W.C., Lukas P., Skvortsova I. Putative biomarkers and therapeutic targets associated with radiation resistance. Expert Rev Proteomics 2014, 11(2):207-214.
    • (2014) Expert Rev Proteomics , vol.11 , Issue.2 , pp. 207-214
    • Skvortsov, S.1    Debbage, P.2    Cho, W.C.3    Lukas, P.4    Skvortsova, I.5
  • 23
    • 79960364956 scopus 로고    scopus 로고
    • The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells
    • Yoon C.H., Hyun K.H., Kim R.K., Lee H., Lim E.J., Chung H.Y., et al. The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells. FEBS Lett 2011, 585:2331-2338.
    • (2011) FEBS Lett , vol.585 , pp. 2331-2338
    • Yoon, C.H.1    Hyun, K.H.2    Kim, R.K.3    Lee, H.4    Lim, E.J.5    Chung, H.Y.6
  • 24
    • 84901609325 scopus 로고    scopus 로고
    • Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)
    • Skvortsov S., Dudas J., Eichberger P., Witsch-Baumgartner M., Loeffler-Ragg J., Pritz C., et al. Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC). Br J Cancer 2014, 110(11):2677-2687.
    • (2014) Br J Cancer , vol.110 , Issue.11 , pp. 2677-2687
    • Skvortsov, S.1    Dudas, J.2    Eichberger, P.3    Witsch-Baumgartner, M.4    Loeffler-Ragg, J.5    Pritz, C.6
  • 25
    • 84883552929 scopus 로고    scopus 로고
    • CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signalling
    • Kato T., Fujita Y., Nakane K., Mizutani K., Terazawa R., Ehara H., et al. CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signalling. Cytokine 2013, 64(1):251-257.
    • (2013) Cytokine , vol.64 , Issue.1 , pp. 251-257
    • Kato, T.1    Fujita, Y.2    Nakane, K.3    Mizutani, K.4    Terazawa, R.5    Ehara, H.6
  • 27
    • 80655149141 scopus 로고    scopus 로고
    • Radioresistant head and neck squamous cell carcinoma cells: intracellular signaling, putative biomarkers for tumor recurrences and possible therapeutic targets
    • Skvortsov S., Jimenez C.R., Knol J.C., Eichberger P., Schiestl B., Debbage P., et al. Radioresistant head and neck squamous cell carcinoma cells: intracellular signaling, putative biomarkers for tumor recurrences and possible therapeutic targets. Radiother Oncol 2011, 101:177-182.
    • (2011) Radiother Oncol , vol.101 , pp. 177-182
    • Skvortsov, S.1    Jimenez, C.R.2    Knol, J.C.3    Eichberger, P.4    Schiestl, B.5    Debbage, P.6
  • 28
    • 84885376540 scopus 로고    scopus 로고
    • Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair
    • German P., Szaniszlo P., Hajas G., Radak Z., Bacsi A., Hazra T.K., et al. Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair. DNA Repair (Amst) 2013, 12:856-863.
    • (2013) DNA Repair (Amst) , vol.12 , pp. 856-863
    • German, P.1    Szaniszlo, P.2    Hajas, G.3    Radak, Z.4    Bacsi, A.5    Hazra, T.K.6
  • 29
    • 84878009944 scopus 로고    scopus 로고
    • 8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1
    • Hajas G., Bacsi A., Guilera-Aguirre L., Hegde M.L., Tapas K.H., Sur S., et al. 8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1. Free Radic Biol Med 2013, 61C:384-394.
    • (2013) Free Radic Biol Med , vol.61 C , pp. 384-394
    • Hajas, G.1    Bacsi, A.2    Guilera-Aguirre, L.3    Hegde, M.L.4    Tapas, K.H.5    Sur, S.6
  • 30
    • 43149116339 scopus 로고    scopus 로고
    • Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division
    • Michaelson D., Abidi W., Guardavaccaro D., Zhou M., Ahearn I., Pagano M., et al. Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. J Cell Biol 2008, 181:485-496.
    • (2008) J Cell Biol , vol.181 , pp. 485-496
    • Michaelson, D.1    Abidi, W.2    Guardavaccaro, D.3    Zhou, M.4    Ahearn, I.5    Pagano, M.6
  • 31
    • 84859513105 scopus 로고    scopus 로고
    • RAC1 GTPase plays an important role in gamma-irradiation induced G2/M checkpoint activation
    • Yan Y., Greer P.M., Cao P.T., Kolb R.H., Cowan K.H. RAC1 GTPase plays an important role in gamma-irradiation induced G2/M checkpoint activation. Breast Cancer Res 2012, 14:R60.
    • (2012) Breast Cancer Res , vol.14 , pp. R60
    • Yan, Y.1    Greer, P.M.2    Cao, P.T.3    Kolb, R.H.4    Cowan, K.H.5
  • 32
    • 84880159982 scopus 로고    scopus 로고
    • Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress
    • Johnson M.A., Sharma M., Mok M.T., Henderson B.R. Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress. Biochim Biophys Acta 2013, 1833:2334-2347.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 2334-2347
    • Johnson, M.A.1    Sharma, M.2    Mok, M.T.3    Henderson, B.R.4
  • 33
    • 4444336712 scopus 로고    scopus 로고
    • Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone
    • Luo M., Kelley M.R. Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. Anticancer Res 2004, 24:2127-2134.
    • (2004) Anticancer Res , vol.24 , pp. 2127-2134
    • Luo, M.1    Kelley, M.R.2
  • 34
    • 4444327784 scopus 로고    scopus 로고
    • Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition
    • Wang D., Luo M., Kelley M.R. Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. Mol Cancer Ther 2004, 3:679-686.
    • (2004) Mol Cancer Ther , vol.3 , pp. 679-686
    • Wang, D.1    Luo, M.2    Kelley, M.R.3
  • 35
    • 84872495141 scopus 로고    scopus 로고
    • DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity
    • Nagaria P., Robert C., Rassool F.V. DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity. Biochim Biophys Acta 2013, 1830:2345-2353.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 2345-2353
    • Nagaria, P.1    Robert, C.2    Rassool, F.V.3
  • 36
    • 34250377983 scopus 로고    scopus 로고
    • Therapeutic potential of drugs to modulate DNA repair in cancer
    • Curtin N. Therapeutic potential of drugs to modulate DNA repair in cancer. Expert Opin Ther Targets 2007, 11:783-799.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 783-799
    • Curtin, N.1
  • 37
    • 78649445307 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks
    • Williams G.J., Lees-Miller S.P., Tainer J.A. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst) 2010, 9:1299-1306.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 1299-1306
    • Williams, G.J.1    Lees-Miller, S.P.2    Tainer, J.A.3
  • 38
    • 84892491008 scopus 로고    scopus 로고
    • The essential function of the MRN complex in the resolution of endogenous replication intermediates
    • Bruhn C., Zhou Z.W., Ai H., Wang Z.Q. The essential function of the MRN complex in the resolution of endogenous replication intermediates. Cell Rep 2014, 6:182-195.
    • (2014) Cell Rep , vol.6 , pp. 182-195
    • Bruhn, C.1    Zhou, Z.W.2    Ai, H.3    Wang, Z.Q.4
  • 39
    • 84864746641 scopus 로고    scopus 로고
    • Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization
    • Kuroda S., Urata Y., Fujiwara T. Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization. Acta Med Okayama 2012, 66:83-92.
    • (2012) Acta Med Okayama , vol.66 , pp. 83-92
    • Kuroda, S.1    Urata, Y.2    Fujiwara, T.3
  • 40
    • 4544355447 scopus 로고    scopus 로고
    • Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm
    • Cerosaletti K., Concannon P. Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. J Biol Chem 2004, 279:38813-38819.
    • (2004) J Biol Chem , vol.279 , pp. 38813-38819
    • Cerosaletti, K.1    Concannon, P.2
  • 41
    • 33847385008 scopus 로고    scopus 로고
    • Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer
    • Yang M.H., Chang S.Y., Chiou S.H., Liu C.J., Chi C.W., Chen P.M., et al. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene 2007, 26:1459-1467.
    • (2007) Oncogene , vol.26 , pp. 1459-1467
    • Yang, M.H.1    Chang, S.Y.2    Chiou, S.H.3    Liu, C.J.4    Chi, C.W.5    Chen, P.M.6
  • 42
    • 31544465282 scopus 로고    scopus 로고
    • Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation
    • Yang M.H., Chiang W.C., Chou T.Y., Chang S.Y., Chen P.M., Teng S.C., et al. Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation. Clin Cancer Res 2006, 12:507-515.
    • (2006) Clin Cancer Res , vol.12 , pp. 507-515
    • Yang, M.H.1    Chiang, W.C.2    Chou, T.Y.3    Chang, S.Y.4    Chen, P.M.5    Teng, S.C.6
  • 43
    • 25444455323 scopus 로고    scopus 로고
    • Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt
    • Chen Y.C., Su Y.N., Chou P.C., Chiang W.C., Chang M.C., Wang L.S., et al. Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. J Biol Chem 2005, 280:32505-32511.
    • (2005) J Biol Chem , vol.280 , pp. 32505-32511
    • Chen, Y.C.1    Su, Y.N.2    Chou, P.C.3    Chiang, W.C.4    Chang, M.C.5    Wang, L.S.6
  • 44
    • 79952281817 scopus 로고    scopus 로고
    • L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1
    • Cheng L., Wu Q., Huang Z., Guryanova O.A., Huang Q., Shou W., et al. L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. EMBO J 2011, 30:800-813.
    • (2011) EMBO J , vol.30 , pp. 800-813
    • Cheng, L.1    Wu, Q.2    Huang, Z.3    Guryanova, O.A.4    Huang, Q.5    Shou, W.6
  • 45
    • 33751170901 scopus 로고    scopus 로고
    • Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma
    • Li X.R., Ji F., Ouyang J., Wu W., Qian L.Y., Yang K.Y. Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma. Eur J Surg Oncol 2006, 32:1130-1134.
    • (2006) Eur J Surg Oncol , vol.32 , pp. 1130-1134
    • Li, X.R.1    Ji, F.2    Ouyang, J.3    Wu, W.4    Qian, L.Y.5    Yang, K.Y.6
  • 46
    • 84862155618 scopus 로고    scopus 로고
    • The role of Rac1 in the regulation of NF-kappaB activity, cell proliferation, and cell migration in non-small cell lung carcinoma
    • Gastonguay A., Berg T., Hauser A.D., Schuld N., Lorimer E., Williams C.L. The role of Rac1 in the regulation of NF-kappaB activity, cell proliferation, and cell migration in non-small cell lung carcinoma. Cancer Biol Ther 2012, 13:647-656.
    • (2012) Cancer Biol Ther , vol.13 , pp. 647-656
    • Gastonguay, A.1    Berg, T.2    Hauser, A.D.3    Schuld, N.4    Lorimer, E.5    Williams, C.L.6
  • 47
    • 79952187822 scopus 로고    scopus 로고
    • Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells
    • Koh M.S., Moon A. Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells. Biochem Biophys Res Commun 2011, 406:25-29.
    • (2011) Biochem Biophys Res Commun , vol.406 , pp. 25-29
    • Koh, M.S.1    Moon, A.2
  • 48
    • 66649121354 scopus 로고    scopus 로고
    • Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma
    • Ma Q., Cavallin L.E., Yan B., Zhu S., Duran E.M., Wang H., et al. Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. Proc Natl Acad Sci USA 2009, 106:8683-8688.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8683-8688
    • Ma, Q.1    Cavallin, L.E.2    Yan, B.3    Zhu, S.4    Duran, E.M.5    Wang, H.6
  • 49
    • 77957748289 scopus 로고    scopus 로고
    • BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair
    • Ismail I.H., Andrin C., McDonald D., Hendzel M.J. BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J Cell Biol 2010, 191:45-60.
    • (2010) J Cell Biol , vol.191 , pp. 45-60
    • Ismail, I.H.1    Andrin, C.2    McDonald, D.3    Hendzel, M.J.4
  • 51
    • 84870618348 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-mediated activation of AKT-beta-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells
    • Mavila N., James D., Utley S., Cu N., Coblens O., Mak K., et al. Fibroblast growth factor receptor-mediated activation of AKT-beta-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells. PLoS ONE 2012, 7:e50401.
    • (2012) PLoS ONE , vol.7 , pp. e50401
    • Mavila, N.1    James, D.2    Utley, S.3    Cu, N.4    Coblens, O.5    Mak, K.6
  • 52
    • 84875720608 scopus 로고    scopus 로고
    • Clinical implications of Girdin and PI3K protein expression in breast cancer
    • Jin F., Liu C., Guo Y., Chen H., Wu Y. Clinical implications of Girdin and PI3K protein expression in breast cancer. Oncol Lett 2013, 5:1549-1553.
    • (2013) Oncol Lett , vol.5 , pp. 1549-1553
    • Jin, F.1    Liu, C.2    Guo, Y.3    Chen, H.4    Wu, Y.5
  • 53
    • 77953960942 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and c-myc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse
    • Skvortsova I., Skvortsov S., Raju U., Stasyk T., Riesterer O., Schottdorf E.M., et al. Epithelial-to-mesenchymal transition and c-myc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse. Radiother Oncol 2010, 96:108-115.
    • (2010) Radiother Oncol , vol.96 , pp. 108-115
    • Skvortsova, I.1    Skvortsov, S.2    Raju, U.3    Stasyk, T.4    Riesterer, O.5    Schottdorf, E.M.6
  • 55
    • 84892432945 scopus 로고    scopus 로고
    • Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation
    • Yoshida G.J., Saya H. Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation. Biochem Biophys Res Commun 2014, 443:622-627.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 622-627
    • Yoshida, G.J.1    Saya, H.2
  • 56
    • 84872107486 scopus 로고    scopus 로고
    • Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells
    • Musha A., Yoshida Y., Takahashi T., Ando K., Funayama T., Kobayashi Y., et al. Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells. J Radiat Res 2012, 53:545-550.
    • (2012) J Radiat Res , vol.53 , pp. 545-550
    • Musha, A.1    Yoshida, Y.2    Takahashi, T.3    Ando, K.4    Funayama, T.5    Kobayashi, Y.6
  • 57
    • 84875806802 scopus 로고    scopus 로고
    • Tumor dormancy: long-term survival in a hostile environment
    • Quesnel B. Tumor dormancy: long-term survival in a hostile environment. Adv Exp Med Biol 2013, 734:181-200.
    • (2013) Adv Exp Med Biol , vol.734 , pp. 181-200
    • Quesnel, B.1
  • 58
    • 84859450097 scopus 로고    scopus 로고
    • Cancer stem cells and drug resistance: the potential of nanomedicine
    • Vinogradov S., Wei X. Cancer stem cells and drug resistance: the potential of nanomedicine. Nanomedicine (Lond) 2012, 7:597-615.
    • (2012) Nanomedicine (Lond) , vol.7 , pp. 597-615
    • Vinogradov, S.1    Wei, X.2
  • 59
    • 84879063194 scopus 로고    scopus 로고
    • Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells
    • Pawlowski K.M., Mucha J., Majchrzak K., Motyl T., Krol M. Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells. BMC Vet Res 2013, 9:119.
    • (2013) BMC Vet Res , vol.9 , pp. 119
    • Pawlowski, K.M.1    Mucha, J.2    Majchrzak, K.3    Motyl, T.4    Krol, M.5
  • 60
    • 80052214545 scopus 로고    scopus 로고
    • Novel insights into targeting ATP-binding cassette transporters for antitumor therapy
    • Gatti L., Cossa G., Beretta G.L., Zaffaroni N., Perego P. Novel insights into targeting ATP-binding cassette transporters for antitumor therapy. Curr Med Chem 2011, 18:4237-4249.
    • (2011) Curr Med Chem , vol.18 , pp. 4237-4249
    • Gatti, L.1    Cossa, G.2    Beretta, G.L.3    Zaffaroni, N.4    Perego, P.5
  • 61
    • 84978025993 scopus 로고    scopus 로고
    • ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma
    • Ingram W.J., Crowther L.M., Little E.B., Freeman R., Harliwong I., Veleva D., et al. ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma. Exp Hematol Oncol 2013, 2:26.
    • (2013) Exp Hematol Oncol , vol.2 , pp. 26
    • Ingram, W.J.1    Crowther, L.M.2    Little, E.B.3    Freeman, R.4    Harliwong, I.5    Veleva, D.6
  • 62
    • 33751075186 scopus 로고    scopus 로고
    • ABC transporters, neural stem cells and neurogenesis - a different perspective
    • Lin T., Islam O., Heese K. ABC transporters, neural stem cells and neurogenesis - a different perspective. Cell Res 2006, 16:857-871.
    • (2006) Cell Res , vol.16 , pp. 857-871
    • Lin, T.1    Islam, O.2    Heese, K.3
  • 63
    • 79551602468 scopus 로고    scopus 로고
    • Critical appraisal of the side population assay in stem cell and cancer stem cell research
    • Golebiewska A., Brons N.H., Bjerkvig R., Niclou S.P. Critical appraisal of the side population assay in stem cell and cancer stem cell research. Cell Stem Cell 2011, 8:136-147.
    • (2011) Cell Stem Cell , vol.8 , pp. 136-147
    • Golebiewska, A.1    Brons, N.H.2    Bjerkvig, R.3    Niclou, S.P.4


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