Inhibition of Ref-1 stimulates the production of reactive oxygen species and induces differentiation in adult cardiac stem cells

Antioxidants and Redox Signaling

Volumn 11, Issue 3, 2009, Pages 589-599

  Gurusamy, Narasimman ^a   Mukherjee, Subhendu ^a   Lekli, Istvan ^a   Bearzi, Claudia ^b   Bardelli, Silvana ^b   Das, Dipak K ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; HYDROGEN PEROXIDE; PROTEIN P22; PROTEIN P47; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDOX EFFECTOR FACTOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR MEF2C; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG; APEX1 PROTEIN, HUMAN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; PRIMER DNA;

APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; CONCENTRATION (PARAMETERS); ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEM CELL; ADULT; ANTAGONISTS AND INHIBITORS; CYTOLOGY; HEART MUSCLE; HUMAN; METABOLISM; NICK END LABELING; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; BASE SEQUENCE; CELL DIFFERENTIATION; DNA PRIMERS; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; IN SITU NICK-END LABELING; MYOCARDIUM; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS;

EID: 58849122683     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2008.2195     Document Type: Article

References (53)

1. Allen RG and Venkatraj VS. Oxidants and antioxidants in development and differentiation. J Nutr 122: 631-635, 1992.
2. Almog N and Rotter V. Involvement of p53 in cell differentiation and development. Biochim Biophys Acta 1333: F1-F27, 1997.
3. Angkeow P, Deshpande SS, Qi B, Liu YX, Park YC, Jeon BH, Ozaki M, and Irani K. Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis. Cell Death Differ 9: 717-725, 2002.
4. Bachelder RE, Ribick MJ, Marchetti A, Falcioni R, Soddu S, Davis KR, and Mercurio AM. p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. J Cell Biol 147: 1063-1072, 1999.
5. Beckman BS, Balin AK, and Allen RG. Superoxide dismutase induces differentiation of Friend erythroleukemia cells. J Cell Physiol 139: 370-376, 1989.
6. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, and Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114: 763-776, 2003.
7. Brand T. Heart development: molecular insights into cardiac specification and early morphogenesis. Dev Biol 258: 1-19, 2003.
8. Buggisch M, Ateghang B, Ruhe C, Strobel C, Lange S, Wartenberg M, and Sauer H. Stimulation of ES-cell-derived cardiomyogenesis and neonatal cardiac cell proliferation by reactive oxygen species and NADPH oxidase. J Cell Sci 120: 885-894, 2007.
9. Chénais B, Andriollo M, Guiraud P, Belhoussine R, and Jeannesson P. Oxidative stress involvement in chemically induced differentiation of K562 cells. Free Radic Biol Med 28: 18-27, 2000.
10. Chiarini LB, Freitas FG, Petrs-Silva H, and Linden R. Evidence that the bifunctional redox factor/AP endonuclease Ref-1 is an anti-apoptotic protein associated with differentiation in the developing retina. Cell Death Differ 7: 272-281, 2000.
11. Chiarini LB and Linden R. Tissue biology of apoptosis: Ref-1 and cell differentiation in the developing retina. Ann N Y Acad Sci 926: 64-78, 2000.
12. Decatur AL and Losick R: Three sites of contact between the Bacillus subtilis transcription factor sigmaF and its antisigma factor SpoIIAB. Genes Dev 10: 2348-2358, 1996.
13. Eizenberg O, Faber-Elman A, Gottlieb E, Oren M, Rotter V, and Schwartz M. p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells. Mol Cell Biol 16: 5178-5185, 1996.
14. Evans AR, Limp-Foster M, and Kelley MR. Going APE over ref-1. Mutat Res 461: 83-108, 2000.
15. Finkel T and Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 408: 239-247, 2000.
16. Gottlieb TM, Leal JF, Seger R, Taya Y, and Oren M. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene 21: 1299-1303, 2002.
17. Gupta S, Das B, and Sen S. Cardiac hypertrophy: mechanisms and therapeutic opportunities. Antioxid Redox Signal 9: 623-652, 2007.
18. Haneline LS. Redox regulation of stem and progenitor cells. Antioxid Redox Signal 11: 1849-1852, 2008.
19. Henderson S, Allsopp R, Spector D, Wang SS, and Harley C. In situ analysis of changes in telomere size during replicative aging and cell transformation. J Cell Biol 134: 1-12, 1996.
20. Hosokawa K, Arai F, Yoshihara H, Nakamura Y, Gomei Y, Iwasaki H, Miyamoto K, Shima H, Ito K, and Suda T. Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. Biochem Biophys Res Commun 363: 578-583, 2007.
21. Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, and Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev 11: 558-570, 1997.
22. Kamata H and Hirata H. Redox regulation of cellular signalling. Cell Signal 11:1-14, 1999.
23. Katoh S, Mitsui Y, Kitani K, and Suzuki T. Hyperoxia induces the neuronal differentiated phenotype of PC12 cells via a sustained activity of mitogen-activated protein kinase induced by Bcl-2. Biochem J 338: 465-470, 1999.
24. Keren-Tal I, Suh BS, Dantes A, Lindner S, Oren M, and Amsterdam A. Involvement of p53 expression in cAMP-mediated apoptosis in immortalized granulosa cells. Exp Cell Res 218: 283-295, 1995.
25. Kondoh H, Lleonart ME, Nakashima Y, Yokode M, Tanaka M, Bernard D, Gil J, and Beach D. A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxid Redox Signal 9: 293-299, 2007.
26. Li J, Stouffs M, and Serrander L, et al. The NADPH oxidase NOX4 drives cardiac differentiation: role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell 17: 3978-3988, 2006.
27. Liu B, Chen Y, and St Clair DK. ROS and p53: a versatile partnership. Free Radic Biol Med 44: 1529-1535, 2008.
28. Luo M, Delaplane S, Jiang A, Reed A, He Y, Fishel M, Nyland Ii RL, Borch RF, Qiao X, Georgiadis MM, and Kelley MR. Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1. Antioxid Redox Signal, 2008.
29. 2 mimic stem cell factor effects? Antioxid Redox Signal 9: 271-279, 2007.
30. Mofarrahi M, Brandes RP, Gorlach A, Hanze J, Terada LS, Quinn MT, Mayaki D, Petrof B, and Hussain SN. Regulation of proliferation of skeletal muscle precursor cells by NADPH oxidase. Antioxid Redox Signal 10: 559-574, 2008.
31. Morita-Fujimura Y, Fujimura M, Kawase M, et al Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice. Neuroscience 93: 1465-1473, 1999.
32. Naka K, Muraguchi T, Hoshii T, and Hirao A. Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells. Antioxid Redox Signal, 2008.
33. Nose K. Role of reactive oxygen species in the regulation of physiological functions. Biol Pharm Bull 23: 897-903, 2000.
34. Ostrakhovitch EA and Cherian MG. Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. Apoptosis 10: 111-121, 2005.
35. Ozaki M, Suzuki S, and Irani K. Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase. FASEB J 16: 889-890, 2002.
36. Ramana CV, Boldogh I, Izumi T, and Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc Natl Acad Sci U S A 95: 5061-5066, 1998.
37. Sabapathy K, Klemm M, and Jaenisch R, et al. Regulation of ES cell differentiation by functional and conformational modulation of p53. EMBO J 16: 6217-6229, 1997.
38. Sarkar SA and Sharma RP. All-trans-retinoic acid-mediated modulation of p53 during neural differentiation in murine embryonic stem cells. Cell Biol Toxicol 18: 243-257, 2002.
39. Sauer H, Rahimi G, Hescheler J, and Wartenberg M. Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells. J Cell Biochem 75: 710-723, 1999.
40. Sauer H, Rahimi G, Hescheler J, and Wartenberg M. Role of reactive oxygen species and phosphatidylinositol 3-kinase in cardiomyocyte differentiation of embryonic stem cells. FEBS Lett 476: 218-223, 2000.
41. Sauer H, Wartenberg M, and Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 11:173-186, 2001.
42. Spradling A, Drummond-Barbosa D, Kai T. Stem cells find their niche. Nature 414: 98-104, 2001.
43. Steinbeck MJ, Kim JK, Trudeau MJ, Hauschka PV, and Karnovsky MJ. Involvement of hydrogen peroxide in the differentiation of clonal HD-11EM cells into osteoclast-like cells. J Cell Physiol 176: 574-587, 1998.
44. Sussman MA and Anversa P. Myocardial aging and senescence: where have the stem cells gone? Annu Rev Physiol 66: 29-48, 2004.
45. Tell G, Damante G, Caldwell D, and Kelley MR. The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxid Redox Signal 7: 367-384, 2005.
46. Vasko MR, Guo C, and Kelley MR. The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair (Amst) 4: 367-379, 2005.
47. Walker LJ, Craig RB, Harris AL, and Hickson ID. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res 22: 4884-4889, 1994.
48. Walker LJ, Robson CN, Black E, Gillespie D, and Hickson ID. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol Cell Biol 13: 5370-5376, 1993.
49. Walton M, Lawlor P, Sirimanne E, Williams C, Gluckman P, and Dragunow M. Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons. Brain Res Mol Brain Res 44: 167-170, 1997.
50. Watson T, Goon PK, and Lip GY. Endothelial progenitor cells, endothelial dysfunction, inflammation, and oxidative stress in hypertension. Antioxid Redox Signal 10: 1079-1088, 2008.
51. Weinberg WC, Azzoli CG, Chapman K, Levine AJ, and Yuspa SH. p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein. Oncogene 10: 2271-2279, 1995.
52. Yang KD and Shaio MF. Hydroxyl radicals as an early signal involved in phorbol ester-induced monocytic differentiation of HL60 cells. Biochem Biophys Res Commun 200: 1650-1657, 1994.
53. Zhu D, Qu L, Zhang X, and Lou Y. Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells. Eur J Pharmacol 514: 99-110, 2005.