Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 7, 2015, Pages E625-E632

  Cohen, Itamar ^a   Wiener, Reuven ^a   Reiss, Yuval ^a   Ravid, Tommer ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

ER associated degradation; Protein quality control; Ubiquitin conjugating enzyme; Ubiquitin E3 ligase; Ubiquitin proteasome degradation system

Indexed keywords

CYCLOHEXIMIDE; ENZYME; UBC7 ENZYME; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; LYSINE; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONJUGATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEGRADATION KINETICS; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME DEGRADATION; HYDROGEN BOND; IMMUNOBLOTTING; IN VITRO STUDY; MUTAGENESIS; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; RING FINGER MOTIF; SITE DIRECTED MUTAGENESIS; STEADY STATE; UBIQUITINATION; BIOCATALYSIS; METABOLISM;

BIOCATALYSIS; ENZYME ACTIVATION; LYSINE; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES;

EID: 84923201324     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415621112     Document Type: Article

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