Placing a disrupted degradation motif at the C terminus of proteasome substrates attenuates degradation without impairing ubiquitylation

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 12645-12653

  Alfassy, Omri S ^a   Cohen, Itamar ^a   Reiss, Yuval ^a   Tirosh, Boaz ^b   Ravid, Tommer ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL REGIONS; DEGRADATION SIGNALS; HYDROPHOBIC MOTIFS; HYDROPHOBIC NATURE; HYDROPHOBIC SEQUENCES; PATHOLOGICAL EFFECTS; PROTEASOMAL DEGRADATION; UBIQUITIN-PROTEASOME SYSTEM;

HYDROPHOBICITY; PROTEINS; YEAST;

SUBSTRATES;

FUNGAL PROTEIN; MUTANT PROTEIN; PROTEASOME; PROTEIN DEGB; PROTEIN NDC10; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MAMMAL CELL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STABILITY; PROTEIN STRUCTURE; UBIQUITINATION; YEAST CELL;

DEGRADATION INITIATION SITE; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; PROTEASOME; PROTEIN DEGRADATION; UBIQUITIN; UBIQUITIN LIGASE;

AMINO ACID MOTIFS; DNA-BINDING PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETOCHORES; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITINATION;

MAMMALIA;

EID: 84877155002     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.453027     Document Type: Article

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