Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum

Science

Volumn 323, Issue 5922, 2009, Pages 1693-1697

  Jonikas, Martin C ^a,b,c   Collins, Sean R ^a,b,c   Denic, Vladimir ^a,b,c   Oh, Eugene ^a,b,c   Quan, Erin M ^a,b,c   Schmid, Volker ^d   Weibezahn, Jimena ^a,b,c   Schwappach, Blanche ^d   Walter, Peter ^b   Weissman, Jonathan S ^a,b,c,e   Schuldiner, Maya ^a,b,c,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e HARVARD UNIVERSITY   (United States)

^f WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; MEMBRANE PROTEIN; PROTEIN; TAIL ANCHORED PROTEIN; UNCLASSIFIED DRUG;

DISEASE; GENE; GENETIC ANALYSIS; PROTEIN; QUANTITATIVE ANALYSIS; YEAST;

ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; COMPLEX FORMATION; ENDOPLASMIC RETICULUM; GENE FUNCTION; GENE INSERTION; GENETIC ANALYSIS; GENETIC TRAIT; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SECRETION; YEAST;

ENDOPLASMIC RETICULUM; EPISTASIS, GENETIC; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GENES, REPORTER; MEMBRANE PROTEINS; MUTATION; PHENOTYPE; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SECRETORY PATHWAY;

EID: 63449128473     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1167983     Document Type: Article

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38. We thank C.-S. Chin for flow cytometry software development; C. Boone, D. Breslow, N. Krogan, D. Ng, and C. Wang for reagents; K. Thorn for microscopy assistance; S. Zhou, D. King, G. Cagney, and N. Krogan for mass spectrometry analyses; J. Metz, P. Nittler, A. Carroll, J. Hill, J. Ihmels, S. Wang, and C. Chu for technical help; R. Andino, T. Aragon, A. Battle, N. Bradshaw, J. DeRisi, N. Friedman, J. Hollien, J. Newman, D. Koller, R. Kupferman, H. Madhani, L. Osherovich, F. Papa, and members of the Weissman, Walter, and Schwappach labs for stimulating discussion; B. Toyama for graphics; and M. Bassik, D. Breslow, O. Brandman, S. Churchman, and S. Neher for comments on the manuscript. This work was supported by the Howard Hughes Medical Institute (J.S.W. and P.W.), the NSF (M.C.J. and E.M.Q.), the International Human Frontier Science Program (M.S. and J.W.), an NIH K99/R00 award (M.S.), a European Molecular Biology Organization long-term fellowship (J.W.), the Deutsche Forschungsgemeinschaft (V.S.), and the Wellcome Trust (B.S.).