Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains

EMBO Journal

Volumn 33, Issue 1, 2014, Pages 46-61

  Liu, Weixiao ^a   Shang, Yongliang ^a   Zeng, Yan ^b   Liu, Chao ^a   Li, Yanchang ^c   Zhai, Linhui ^c   Wang, Pan ^a   Lou, Jizhong ^b   Xu, Ping ^c   Ye, Yihong ^d   Li, Wei ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

^c BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

E2 dimerization; ER associated degradation ERAD; K48 linked ubiquitin chain; Linkage specificity; Ubiquitination mechanism

Indexed keywords

ARGININE; ASPARTIC ACID; HOMODIMER; UBE2G2 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; LYSINE; MUTANT PROTEIN; POLYUBIQUITIN; UBE2G2 PROTEIN, HUMAN; UBIQUITIN CONJUGATING ENZYME;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STATIC ELECTRICITY; UBIQUITINATION; BIOSYNTHESIS; CELL LINE; CHEMICAL STRUCTURE; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

AMINO ACID SEQUENCE; CELL LINE; DNA MUTATIONAL ANALYSIS; HUMANS; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; POLYUBIQUITIN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84894652172     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1002/embj.201385315     Document Type: Article

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