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Volumn 12, Issue 2, 2015, Pages 80-90

MicroRNAs and atrial fibrillation: Mechanisms and translational potential

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 1; MICRORNA 133; MICRORNA 208A; MICRORNA 21; MICRORNA 26; MICRORNA 29; MICRORNA 30; MICRORNA 328; MICRORNA 499; MICRORNA 590; NEUROHORMONE; UNCLASSIFIED DRUG; CALCIUM;

EID: 84923126851     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2014.178     Document Type: Review
Times cited : (115)

References (91)
  • 1
    • 84879516150 scopus 로고    scopus 로고
    • Recent developments in understanding epidemiology and risk determinants of atrial fibrillation as a cause of stroke
    • Ahmad, Y., Lip, G. Y. & Lane, D. A. Recent developments in understanding epidemiology and risk determinants of atrial fibrillation as a cause of stroke. Can. J. Cardiol. 29 (Suppl. 7), S4-S13 (2013).
    • (2013) Can. J. Cardiol. , vol.29 , pp. S4-S13
    • Ahmad, Y.1    Lip, G.Y.2    Lane, D.A.3
  • 2
    • 84899623290 scopus 로고    scopus 로고
    • The clinical profile and pathophysiology of atrial fibrillation: Relationships among clinical features, epidemiology, and mechanisms
    • Andrade, J., Khairy, P., Dobrev, D. & Nattel, S. The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circ. Res. 114, 1453-1468 (2014).
    • (2014) Circ. Res. , vol.114 , pp. 1453-1468
    • Andrade, J.1    Khairy, P.2    Dobrev, D.3    Nattel, S.4
  • 3
    • 71649105333 scopus 로고    scopus 로고
    • Increasing prevalence of atrial fibrillation and flutter in the United States
    • Naccarelli, G. V., Varker, H., Lin, J. & Schulman, K. L. Increasing prevalence of atrial fibrillation and flutter in the United States. Am. J. Cardiol. 104, 1534-1539 (2009).
    • (2009) Am. J. Cardiol. , vol.104 , pp. 1534-1539
    • Naccarelli, G.V.1    Varker, H.2    Lin, J.3    Schulman, K.L.4
  • 4
    • 34247885945 scopus 로고    scopus 로고
    • A national survey of the prevalence, incidence, primary care burden and treatment of atrial fibrillation in Scotland
    • Murphy, N. F. et al. A national survey of the prevalence, incidence, primary care burden and treatment of atrial fibrillation in Scotland. Heart 93, 606-612 (2007).
    • (2007) Heart , vol.93 , pp. 606-612
    • Murphy, N.F.1
  • 5
    • 0037050001 scopus 로고    scopus 로고
    • New ideas about atrial fibrillation 50 years on
    • Nattel, S. New ideas about atrial fibrillation 50 years on. Nature 415, 219-226 (2002).
    • (2002) Nature , vol.415 , pp. 219-226
    • Nattel, S.1
  • 6
    • 84899621970 scopus 로고    scopus 로고
    • Atrial fibrillation therapy now and in the future: Drugs, biologicals, and ablation
    • Woods, C. E. & Olgin, J. Atrial fibrillation therapy now and in the future: drugs, biologicals, and ablation. Circ. Res. 114, 1532-1546 (2014).
    • (2014) Circ. Res. , vol.114 , pp. 1532-1546
    • Woods, C.E.1    Olgin, J.2
  • 7
    • 30844452012 scopus 로고    scopus 로고
    • Controversies in atrial fibrillation
    • Nattel, S. & Opie, L. H. Controversies in atrial fibrillation. Lancet 367, 262-272 (2006).
    • (2006) Lancet , vol.367 , pp. 262-272
    • Nattel, S.1    Opie, L.H.2
  • 8
    • 84859357588 scopus 로고    scopus 로고
    • Novel molecular targets for atrial fibrillation therapy
    • Dobrev, D., Carlsson, L. & Nattel, S. Novel molecular targets for atrial fibrillation therapy. Nat. Rev. Drug Discov. 11, 275-291 (2012).
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 275-291
    • Dobrev, D.1    Carlsson, L.2    Nattel, S.3
  • 9
    • 81355142736 scopus 로고    scopus 로고
    • Atrial fibrillation pathophysiology: Implications for management
    • Iwasaki, Y. K., Nishida, K., Kato, T. & Nattel, S. Atrial fibrillation pathophysiology: Implications for management. Circulation 124, 2264-2274 (2011).
    • (2011) Circulation , vol.124 , pp. 2264-2274
    • Iwasaki, Y.K.1    Nishida, K.2    Kato, T.3    Nattel, S.4
  • 10
    • 50949115126 scopus 로고    scopus 로고
    • Atrial remodeling and atrial fibrillation: Mechanisms and implications
    • Nattel, S., Burstein, B. & Dobrev, D. Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ. Arrhythm. Electrophysiol. 1, 62-73 (2008).
    • (2008) Circ. Arrhythm. Electrophysiol. , vol.1 , pp. 62-73
    • Nattel, S.1    Burstein, B.2    Dobrev, D.3
  • 11
    • 79960985606 scopus 로고    scopus 로고
    • Recent advances in the molecular pathophysiology of atrial fibrillation
    • Wakili, R., Voigt, N., Kaab, S., Dobrev, D. & Nattel, S. Recent advances in the molecular pathophysiology of atrial fibrillation. J. Clin. Invest. 121, 2955-2968 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2955-2968
    • Wakili, R.1    Voigt, N.2    Kaab, S.3    Dobrev, D.4    Nattel, S.5
  • 12
    • 78751681578 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of atrial fibrillation: A translational appraisal
    • Schotten, U., Verheule, S., Kirchhof, P. & Goette, A. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol. Rev. 91, 265-325 (2011).
    • (2011) Physiol. Rev. , vol.91 , pp. 265-325
    • Schotten, U.1    Verheule, S.2    Kirchhof, P.3    Goette, A.4
  • 13
    • 84902108870 scopus 로고    scopus 로고
    • Atrial remodeling and atrial fibrillation: Recent advances and translational perspectives
    • Nattel, S. & Harada, M. Atrial remodeling and atrial fibrillation: recent advances and translational perspectives. J. Am. Coll. Cardiol. 63, 2335-2345 (2014).
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2335-2345
    • Nattel, S.1    Harada, M.2
  • 14
    • 0029099346 scopus 로고
    • Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats
    • Wijffels, M. C., Kirchhof, C. J., Dorland, R. & Allessie, M. A. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 92, 1954-1968 (1995).
    • (1995) Circulation , vol.92 , pp. 1954-1968
    • Wijffels, M.C.1    Kirchhof, C.J.2    Dorland, R.3    Allessie, M.A.4
  • 15
    • 0030765569 scopus 로고    scopus 로고
    • Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation
    • Yue, L. et al. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ. Res. 81, 512-525 (1997).
    • (1997) Circ. Res. , vol.81 , pp. 512-525
    • Yue, L.1
  • 16
    • 23044463854 scopus 로고    scopus 로고
    • Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation
    • Gaborit, N. et al. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation 112, 471-481 (2005).
    • (2005) Circulation , vol.112 , pp. 471-481
    • Gaborit, N.1
  • 17
    • 80054995730 scopus 로고    scopus 로고
    • Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling
    • Makary, S. et al. Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling. Circ. Res. 109, 1031-1043 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 1031-1043
    • Makary, S.1
  • 18
    • 0035814771 scopus 로고    scopus 로고
    • Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation
    • Brundel, B. J. et al. Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation. Circulation 103, 684-690 (2001).
    • (2001) Circulation , vol.103 , pp. 684-690
    • Brundel, B.J.1
  • 19
    • 84856087307 scopus 로고    scopus 로고
    • Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation
    • Igarashi, T. et al. Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation. Circulation 125, 216-225 (2012).
    • (2012) Circulation , vol.125 , pp. 216-225
    • Igarashi, T.1
  • 20
    • 80054116111 scopus 로고    scopus 로고
    • Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model
    • Bikou. O. et al. Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model. Cardiovasc. Res. 92, 218-225 (2011).
    • (2011) Cardiovasc. Res. , vol.92 , pp. 218-225
    • Bikou, O.1
  • 21
    • 5344224031 scopus 로고    scopus 로고
    • The association of left atrial size and occurrence of atrial fibrillation: A prospective cohort study from the Canadian Registry of Atrial Fibrillation
    • Parkash, R. et al. The association of left atrial size and occurrence of atrial fibrillation: a prospective cohort study from the Canadian Registry of Atrial Fibrillation. Am. Heart J. 148, 649-654 (2004).
    • (2004) Am. Heart J. , vol.148 , pp. 649-654
    • Parkash, R.1
  • 22
    • 23944471114 scopus 로고    scopus 로고
    • Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium
    • Zou, R., Kneller, J., Leon, L. J. & Nattel, S. Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium. Am. J. Physiol. Heart Circ. Physiol. 289, H1002-H1012 (2005).
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289 , pp. H1002-H1012
    • Zou, R.1    Kneller, J.2    Leon, L.J.3    Nattel, S.4
  • 23
    • 0030763103 scopus 로고    scopus 로고
    • Histological substrate of atrial biopsies in patients with lone atrial fibrillation
    • Frustaci, A. et al. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation 96, 1180-1184 (1997).
    • (1997) Circulation , vol.96 , pp. 1180-1184
    • Frustaci, A.1
  • 24
    • 84867878969 scopus 로고    scopus 로고
    • Markers of collagen synthesis, atrial fibrosis, and the mechanisms underlying atrial fibrillation
    • Kalman, J. M., Kumar, S. & Sanders, P. Markers of collagen synthesis, atrial fibrosis, and the mechanisms underlying atrial fibrillation. J. Am. Coll. Cardiol. 60, 1807-1808 (2012).
    • (2012) J. Am. Coll. Cardiol. , vol.60 , pp. 1807-1808
    • Kalman, J.M.1    Kumar, S.2    Sanders, P.3
  • 25
    • 0037446573 scopus 로고    scopus 로고
    • Atrial ischemia promotes atrial fibrillation in dogs
    • Sinno, H. et al. Atrial ischemia promotes atrial fibrillation in dogs. Circulation 107, 1930-1936 (2003).
    • (2003) Circulation , vol.107 , pp. 1930-1936
    • Sinno, H.1
  • 26
    • 22744433256 scopus 로고    scopus 로고
    • Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation
    • Anne, W. et al. Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation. Cardiovasc. Res. 67, 655-666 (2005).
    • (2005) Cardiovasc. Res. , vol.67 , pp. 655-666
    • Anne, W.1
  • 27
    • 35548983906 scopus 로고    scopus 로고
    • Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: A novel consideration in atrial remodeling
    • Burstein, B., Qi, X. Y., Yeh, Y. H., Calderone, A. & Nattel, S. Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling. Cardiovasc. Res. 76, 442-452 (2007).
    • (2007) Cardiovasc. Res. , vol.76 , pp. 442-452
    • Burstein, B.1    Qi, X.Y.2    Yeh, Y.H.3    Calderone, A.4    Nattel, S.5
  • 28
    • 41649102599 scopus 로고    scopus 로고
    • Differential behaviors of atrial versus ventricular fibroblasts: A potential role for platelet-derived growth factor in atrial-ventricular remodeling differences
    • Burstein, B., Libby, E., Calderone, A. & Nattel, S. Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences. Circulation 117, 1630-1641 (2008).
    • (2008) Circulation , vol.117 , pp. 1630-1641
    • Burstein, B.1    Libby, E.2    Calderone, A.3    Nattel, S.4
  • 29
    • 84883233816 scopus 로고    scopus 로고
    • Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1
    • Rahmutula, D. et al. Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1. Cardiovasc. Res. 99, 769-779 (2013).
    • (2013) Cardiovasc. Res. , vol.99 , pp. 769-779
    • Rahmutula, D.1
  • 30
    • 84899622741 scopus 로고    scopus 로고
    • Role of the autonomic nervous system in atrial fibrillation: Pathophysiology and therapy
    • Chen, P. S., Chen, L. S., Fishbein, M. C., Lin, S. F. & Nattel, S. Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy. Circ. Res. 114, 1500-1515 (2014).
    • (2014) Circ. Res. , vol.114 , pp. 1500-1515
    • Chen, P.S.1    Chen, L.S.2    Fishbein, M.C.3    Lin, S.F.4    Nattel, S.5
  • 31
    • 0027751663 scopus 로고
    • The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854 (1993).
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 32
    • 0035966319 scopus 로고    scopus 로고
    • MicroRNAs: Tiny regulators with great potential
    • Ambros, V. MicroRNAs: tiny regulators with great potential. Cell 107, 823-826 (2001).
    • (2001) Cell , vol.107 , pp. 823-826
    • Ambros, V.1
  • 33
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman, R. C., Farh, K. K., Burge, C. B. & Bartel, D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19, 92-105 (2009).
    • (2009) Genome Res. , vol.19 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3    Bartel, D.P.4
  • 34
    • 84868475728 scopus 로고    scopus 로고
    • MicroRNA therapeutics for cardiovascular disease: Opportunities and obstacles
    • van Rooij, E. & Olson, E. N. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat. Rev. Drug Discov. 11, 860-872 (2012).
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 860-872
    • Van Rooij, E.1    Olson, E.N.2
  • 35
  • 36
    • 9144224451 scopus 로고    scopus 로고
    • Processing of primary microRNAs by the Microprocessor complex
    • Denli, A. M., Tops, B. B., Plasterk, R. H., Ketting, R. F. & Hannon, G. J. Processing of primary microRNAs by the Microprocessor complex. Nature 432, 231-235 (2004).
    • (2004) Nature , vol.432 , pp. 231-235
    • Denli, A.M.1    Tops, B.B.2    Plasterk, R.H.3    Ketting, R.F.4    Hannon, G.J.5
  • 37
    • 81355123438 scopus 로고    scopus 로고
    • Evolution of microRNA diversity and regulation in animals
    • Berezikov, E. Evolution of microRNA diversity and regulation in animals. Nat. Rev. Genet. 12, 846-860 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 846-860
    • Berezikov, E.1
  • 39
    • 27744537851 scopus 로고    scopus 로고
    • Human RISC couples microRNA biogenesis and posttranscriptional gene silencing
    • Gregory, R. I., Chendrimada, T. P., Cooch, N. & Shiekhattar, R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 123, 631-640 (2005).
    • (2005) Cell , vol.123 , pp. 631-640
    • Gregory, R.I.1    Chendrimada, T.P.2    Cooch, N.3    Shiekhattar, R.4
  • 40
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • Carthew, R. W. & Sontheimer, E. J. Origins and mechanisms of miRNAs and siRNAs. Cell 136, 642-655 (2009).
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 41
    • 33846277696 scopus 로고    scopus 로고
    • Repression of protein synthesis by miRNAs: How many mechanisms?
    • Pillai, R. S., Bhattacharyya, S. N. & Filipowicz, W. Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol. 17, 118-126 (2007).
    • (2007) Trends Cell Biol. , vol.17 , pp. 118-126
    • Pillai, R.S.1    Bhattacharyya, S.N.2    Filipowicz, W.3
  • 42
    • 34347376692 scopus 로고    scopus 로고
    • Characterization of microRNA expression profiles in normal human tissues
    • Liang, Y., Ridzon, D., Wong, L. & Chen, C. Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 8, 166 (2007).
    • (2007) BMC Genomics , vol.8 , pp. 166
    • Liang, Y.1    Ridzon, D.2    Wong, L.3    Chen, C.4
  • 43
    • 77952961808 scopus 로고    scopus 로고
    • Regulation of human cardiac ion channel genes by microRNAs: Theoretical perspective and pathophysiological implications
    • Luo, X., Zhang, H., Xiao, J. & Wang, Z. Regulation of human cardiac ion channel genes by microRNAs: theoretical perspective and pathophysiological implications. Cell. Physiol. Biochem. 25, 571-586 (2010).
    • (2010) Cell. Physiol. Biochem. , vol.25 , pp. 571-586
    • Luo, X.1    Zhang, H.2    Xiao, J.3    Wang, Z.4
  • 44
    • 77649253288 scopus 로고    scopus 로고
    • MicroRNAs add a new dimension to cardiovascular disease
    • Small, E. M., Frost, R. J. & Olson, E. N. MicroRNAs add a new dimension to cardiovascular disease. Circulation 121, 1022-1032 (2010).
    • (2010) Circulation , vol.121 , pp. 1022-1032
    • Small, E.M.1    Frost, R.J.2    Olson, E.N.3
  • 45
    • 78650701405 scopus 로고    scopus 로고
    • MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation
    • Lu, Y. et al. MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation. Circulation 122, 2378-2387 (2010).
    • (2010) Circulation , vol.122 , pp. 2378-2387
    • Lu, Y.1
  • 46
    • 79959291579 scopus 로고    scopus 로고
    • MicroRNA expression signature in atrial fibrillation with mitral stenosis
    • Xiao, J. et al. MicroRNA expression signature in atrial fibrillation with mitral stenosis. Physiol. Genomics 43, 655-664 (2011).
    • (2011) Physiol. Genomics , vol.43 , pp. 655-664
    • Xiao, J.1
  • 47
    • 84863401788 scopus 로고    scopus 로고
    • Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease
    • Cooley, N. et al. Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease. Physiol. Genomics 44, 211-219 (2012).
    • (2012) Physiol. Genomics , vol.44 , pp. 211-219
    • Cooley, N.1
  • 48
    • 84884179441 scopus 로고    scopus 로고
    • Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery
    • Nishi, H. et al. Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery. PLoS ONE 8, e73397 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e73397
    • Nishi, H.1
  • 49
    • 84892725707 scopus 로고    scopus 로고
    • Atrial fibrillation alters the microRNA expression profiles of the left atria of patients with mitral stenosis
    • Liu, H. et al. Atrial fibrillation alters the microRNA expression profiles of the left atria of patients with mitral stenosis. BMC Cardiovasc. Disord. 14, 10 (2014).
    • (2014) BMC Cardiovasc. Disord. , vol.14 , pp. 10
    • Liu, H.1
  • 50
    • 52349083651 scopus 로고    scopus 로고
    • Serum microRNAs are promising novel biomarkers
    • Gilad, S. et al. Serum microRNAs are promising novel biomarkers. PLoS ONE 3, e3148 (2008).
    • (2008) PLoS ONE , vol.3 , pp. e3148
    • Gilad, S.1
  • 51
    • 84866490126 scopus 로고    scopus 로고
    • The expression levels of plasma microRNAs in atrial fibrillation patients
    • Liu, Z. et al. The expression levels of plasma microRNAs in atrial fibrillation patients. PLoS ONE 7, e44906 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e44906
    • Liu, Z.1
  • 52
    • 84896709217 scopus 로고    scopus 로고
    • Relation of reduced expression of MiR-150 in platelets to atrial fibrillation in patients with chronic systolic heart failure
    • Goren, Y. et al. Relation of reduced expression of MiR-150 in platelets to atrial fibrillation in patients with chronic systolic heart failure. Am. J. Cardiol. 113, 976-981 (2014).
    • (2014) Am. J. Cardiol. , vol.113 , pp. 976-981
    • Goren, Y.1
  • 53
    • 84876116399 scopus 로고    scopus 로고
    • MicroRNA29: A mechanistic contributor and potential biomarker in atrial fibrillation
    • Dawson, K. et al. MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation. Circulation 127, 1466-1475 (2013).
    • (2013) Circulation , vol.127 , pp. 1466-1475
    • Dawson, K.1
  • 54
    • 84896986437 scopus 로고    scopus 로고
    • Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study
    • McManus, D. D. et al. Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study. Heart Rhythm 11, 663-669 (2014).
    • (2014) Heart Rhythm , vol.11 , pp. 663-669
    • McManus, D.D.1
  • 55
    • 34147095310 scopus 로고    scopus 로고
    • The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    • Yang, B. et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat. Med. 13, 486-491 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 486-491
    • Yang, B.1
  • 56
    • 70549111002 scopus 로고    scopus 로고
    • Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation
    • Girmatsion, Z. et al. Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation. Heart Rhythm 6, 1802-1809 (2009).
    • (2009) Heart Rhythm , vol.6 , pp. 1802-1809
    • Girmatsion, Z.1
  • 57
    • 80052758502 scopus 로고    scopus 로고
    • PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis
    • Chinchilla, A. et al. PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis. Circ. Cardiovasc. Genet. 4, 269-279 (2011).
    • (2011) Circ. Cardiovasc. Genet. , vol.4 , pp. 269-279
    • Chinchilla, A.1
  • 58
    • 84877132387 scopus 로고    scopus 로고
    • MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation
    • Luo, X. et al. MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. J. Clin. Invest. 123, 1939-1951 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 1939-1951
    • Luo, X.1
  • 59
    • 84893532294 scopus 로고    scopus 로고
    • MicroRNA-1 accelerates the shortening of atrial effective refractory period by regulating KCNE1 and KCNB2 expression: An atrial tachypacing rabbit model
    • Jia, X. et al. MicroRNA-1 accelerates the shortening of atrial effective refractory period by regulating KCNE1 and KCNB2 expression: an atrial tachypacing rabbit model. PLoS ONE 8, e85639 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e85639
    • Jia, X.1
  • 60
    • 0141565359 scopus 로고    scopus 로고
    • Molecular basis of species-specific expression of repolarizing K+ currents in the heart
    • Zicha, S. et al. Molecular basis of species-specific expression of repolarizing K+ currents in the heart. Am. J. Physiol. Heart Circ. Physiol. 285, H1641-H1649 (2003).
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.285 , pp. H1641-H1649
    • Zicha, S.1
  • 61
    • 84894473134 scopus 로고    scopus 로고
    • MicroRNA regulation and cardiac calcium signaling: Role in cardiac disease and therapeutic potential
    • Harada, M. et al. MicroRNA regulation and cardiac calcium signaling: role in cardiac disease and therapeutic potential. Circ. Res. 114, 689-705 (2014).
    • (2014) Circ. Res. , vol.114 , pp. 689-705
    • Harada, M.1
  • 62
    • 22244453703 scopus 로고    scopus 로고
    • Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation
    • Pandit, S. V. et al. Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys. J. 88, 3806-3821 (2005).
    • (2005) Biophys. J. , vol.88 , pp. 3806-3821
    • Pandit, S.V.1
  • 63
    • 70349202176 scopus 로고    scopus 로고
    • MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
    • Callis, T. E. et al. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J. Clin. Invest. 119, 2772-2786 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 2772-2786
    • Callis, T.E.1
  • 64
    • 84879500344 scopus 로고    scopus 로고
    • Regulation of the SK3 channel by microRNA-499-potential role in atrial fibrillation
    • Ling, T. Y. et al. Regulation of the SK3 channel by microRNA-499-potential role in atrial fibrillation. Heart Rhythm 10, 1001-1009 (2013).
    • (2013) Heart Rhythm , vol.10 , pp. 1001-1009
    • Ling, T.Y.1
  • 65
    • 77649191092 scopus 로고    scopus 로고
    • Common variants in KCNN3 are associated with lone atrial fibrillation
    • Ellinor, P. T. et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat. Genet. 42, 240-244 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 240-244
    • Ellinor, P.T.1
  • 66
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum, T. et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456, 980-984 (2008).
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1
  • 67
    • 78049432896 scopus 로고    scopus 로고
    • Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice
    • Patrick, D. M. et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J. Clin. Invest. 120, 3912-3916 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 3912-3916
    • Patrick, D.M.1
  • 68
    • 84871569496 scopus 로고    scopus 로고
    • Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure
    • Cardin, S. et al. Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure. Circ. Arrhythm. Electrophysiol. 5, 1027-1035 (2012).
    • (2012) Circ. Arrhythm. Electrophysiol. , vol.5 , pp. 1027-1035
    • Cardin, S.1
  • 69
    • 84863114983 scopus 로고    scopus 로고
    • Role of miR-21 in the pathogenesis of atrial fibrosis
    • Adam, O. et al. Role of miR-21 in the pathogenesis of atrial fibrosis. Basic Res. Cardiol. 107, 278 (2012).
    • (2012) Basic Res. Cardiol. , vol.107 , pp. 278
    • Adam, O.1
  • 70
    • 84867767699 scopus 로고    scopus 로고
    • Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
    • Harada, M. et al. Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation 126, 2051-2064 (2012).
    • (2012) Circulation , vol.126 , pp. 2051-2064
    • Harada, M.1
  • 71
    • 51349141401 scopus 로고    scopus 로고
    • Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
    • van Rooij, E. et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc. Natl Acad. Sci. USA 105, 13027-13032 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13027-13032
    • Van Rooij, E.1
  • 72
    • 59849128881 scopus 로고    scopus 로고
    • MiR-133 and miR-30 regulate connective tissue growth factor: Implications for a role of microRNAs in myocardial matrix remodeling
    • Duisters, R. F. et al. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ. Res. 104, 170-178 (2009).
    • (2009) Circ. Res. , vol.104 , pp. 170-178
    • Duisters, R.F.1
  • 73
    • 84860716719 scopus 로고    scopus 로고
    • Expression of miR-133 and miR-30 in chronic atrial fibrillation in canines
    • Li, H., Li, S., Yu, B. & Liu, S. Expression of miR-133 and miR-30 in chronic atrial fibrillation in canines. Mol. Med. Rep. 5, 1457-1460 (2012).
    • (2012) Mol. Med. Rep. , vol.5 , pp. 1457-1460
    • Li, H.1    Li, S.2    Yu, B.3    Liu, S.4
  • 74
    • 67651111989 scopus 로고    scopus 로고
    • Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines
    • Shan, H. et al. Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovasc. Res. 83, 465-472 (2009).
    • (2009) Cardiovasc. Res. , vol.83 , pp. 465-472
    • Shan, H.1
  • 75
    • 84899482237 scopus 로고    scopus 로고
    • Inhibition of miR-25 improves cardiac contractility in the failing heart
    • Wahlquist, C. et al. Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature 508, 531-535 (2014).
    • (2014) Nature , vol.508 , pp. 531-535
    • Wahlquist, C.1
  • 76
    • 84880816481 scopus 로고    scopus 로고
    • Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling
    • Karakikes, I. et al. Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling. J. Am. Heart Assoc. 2, e000078 (2013).
    • (2013) J. Am. Heart Assoc. , vol.2 , pp. e000078
    • Karakikes, I.1
  • 77
    • 33645135862 scopus 로고    scopus 로고
    • Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in human disease?
    • Weiler, J., Hunziker, J. & Hall, J. Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther. 13, 496-502 (2006).
    • (2006) Gene Ther. , vol.13 , pp. 496-502
    • Weiler, J.1    Hunziker, J.2    Hall, J.3
  • 78
    • 83255194160 scopus 로고    scopus 로고
    • Chemical modification and design of anti-miRNA oligonucleotides
    • Lennox, K. A. & Behlke, M. A. Chemical modification and design of anti-miRNA oligonucleotides. Gene Ther. 18, 1111-1120 (2011).
    • (2011) Gene Ther. , vol.18 , pp. 1111-1120
    • Lennox, K.A.1    Behlke, M.A.2
  • 79
    • 34249279050 scopus 로고    scopus 로고
    • MicroRNA-133 controls cardiac hypertrophy
    • Carè, A. et al. MicroRNA-133 controls cardiac hypertrophy. Nat. Med. 13, 613-618 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 613-618
    • Carè, A.1
  • 80
    • 80053567152 scopus 로고    scopus 로고
    • Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure
    • Montgomery, R. L. et al. Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation 124, 1537-1547 (2011).
    • (2011) Circulation , vol.124 , pp. 1537-1547
    • Montgomery, R.L.1
  • 81
    • 84855350458 scopus 로고    scopus 로고
    • Inhibition of miR-15 protects against cardiac ischemic injury
    • Hullinger, T. G. et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ. Res. 110, 71-81 (2012).
    • (2012) Circ. Res. , vol.110 , pp. 71-81
    • Hullinger, T.G.1
  • 82
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Lanford, R. E. et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327, 198-201 (2010).
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1
  • 83
    • 42249093319 scopus 로고    scopus 로고
    • LNA-mediated microRNA silencing in non-human primates
    • Elmen, J. et al. LNA-mediated microRNA silencing in non-human primates. Nature 452, 896-899 (2008).
    • (2008) Nature , vol.452 , pp. 896-899
    • Elmen, J.1
  • 85
    • 54249096193 scopus 로고    scopus 로고
    • MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths
    • Sayed, D. et al. MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Mol. Biol. Cell 19, 3272-3282 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3272-3282
    • Sayed, D.1
  • 86
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • Ebert, M. S., Neilson, J. R. & Sharp, P. A. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat. Methods 4, 721-726 (2007).
    • (2007) Nat. Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 87
    • 35348914716 scopus 로고    scopus 로고
    • Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430
    • Choi, W. Y., Giraldez, A. J. & Schier, A. F. Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science 318, 271-274 (2007).
    • (2007) Science , vol.318 , pp. 271-274
    • Choi, W.Y.1    Giraldez, A.J.2    Schier, A.F.3
  • 88
    • 79952201745 scopus 로고    scopus 로고
    • The principles of MiRNA-masking antisense oligonucleotides technology
    • Wang, Z. The principles of MiRNA-masking antisense oligonucleotides technology. Methods Mol. Biol. 676, 43-49 (2011).
    • (2011) Methods Mol. Biol. , vol.676 , pp. 43-49
    • Wang, Z.1
  • 89
    • 84873661316 scopus 로고    scopus 로고
    • Functions of microRNAs in cardiovascular biology and disease
    • Hata, A. Functions of microRNAs in cardiovascular biology and disease. Annu. Rev. Physiol. 75, 69-93 (2013).
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 69-93
    • Hata, A.1
  • 90
    • 70349254444 scopus 로고    scopus 로고
    • Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure
    • Rao, P. K. et al. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ. Res. 105, 585-594 (2009).
    • (2009) Circ. Res. , vol.105 , pp. 585-594
    • Rao, P.K.1
  • 91
    • 84870359499 scopus 로고    scopus 로고
    • Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs
    • Hu, Y. et al. Epitranscriptional orchestration of genetic reprogramming is an emergent property of stress-regulated cardiac microRNAs. Proc. Natl Acad. Sci. USA 109, 19864-19869 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 19864-19869
    • Hu, Y.1


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