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Volumn 156, Issue 5, 2014, Pages 249-257

Targeting histone methyltransferase EZH2 as cancer treatment

Author keywords

Cancer; Epigenetics; EZH2; Polycomb; Treatment

Indexed keywords

POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR EZH2; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; EZH2 PROTEIN, HUMAN; MOLECULAR LIBRARY;

EID: 84923109013     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvu054     Document Type: Review
Times cited : (75)

References (60)
  • 1
    • 2442577021 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation
    • Kondo, Y., Shen, L., Yan, P.S., Huang, T.H., and Issa, J.P. (2004) Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Proc. Natl Acad. Sci. USA 101, 7398-7403
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 7398-7403
    • Kondo, Y.1    Shen, L.2    Yan, P.S.3    Huang, T.H.4    Issa, J.P.5
  • 2
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • Sparmann, A. and van Lohuizen, M. (2006) Polycomb silencers control cell fate, development and cancer. Nat. Rev. Cancer 6, 846-856
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 4
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA methylation and histone modification: Patterns and paradigms
    • Cedar, H. and Bergman, Y. (2009) Linking DNA methylation and histone modification: patterns and paradigms. Nat. Rev. Genet. 10, 295-304
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 9
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron, R. and Reinberg, D. (2011) The Polycomb complex PRC2 and its mark in life. Nature 469, 343-349
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 12
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer, C.J., Scott, M.P., Kuntz, K.W., Knutson, S.K., Pollock, R.M., Richon, V.M., and Copeland, R.A. (2010) Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc. Natl Acad. Sci. USA 107, 20980-20985
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1    Scott, M.P.2    Kuntz, K.W.3    Knutson, S.K.4    Pollock, R.M.5    Richon, V.M.6    Copeland, R.A.7
  • 22
    • 77956222562 scopus 로고    scopus 로고
    • Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer
    • Sauvageau, M. and Sauvageau, G (2010) Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 7, 299-313
    • (2010) Cell Stem Cell , vol.7 , pp. 299-313
    • Sauvageau, M.1    Sauvageau, G.2
  • 24
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • Gupta, P.B., Chaffer, C.L., and Weinberg, R.A. (2009) Cancer stem cells: mirage or reality? Nat. Med. 15, 1010-1012
    • (2009) Nat. Med. , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 25
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak, K. and Weinberg, R.A. (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer 9, 265-273
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 26
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta, P.B., Fillmore, CM, Jiang, G, Shapira, S.D., Tao, K., Kuperwasser, C, and Lander, E.S. (2011) Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146, 633-644
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 27
  • 28
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen, J., Li, Y., Yu, T.S., McKay, R.M., Burns, D.K., Kernie, S.G, and Parada, L.F. (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488, 522-526
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6    Parada, L.F.7
  • 30
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • Lee, J., Kotliarova, S., Kotliarov, Y., Li, A., Su, Q., Donin, N.M., Pastorino, S., Purow, B.W., Christopher, N., Zhang, W., Park, J.K., and Fine, H.A. (2006) Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9, 391-403
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotliarov, Y.3    Li, A.4    Su, Q.5    Donin, N.M.6    Pastorino, S.7    Purow, B.W.8    Christopher, N.9    Zhang, W.10    Park, J.K.11    Fine, H.A.12
  • 36
    • 80052222327 scopus 로고    scopus 로고
    • Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers
    • Lee, S.T., Li, Z., Wu, Z., Aau, M., Guan, P., Karuturi, R.K., Liou, Y.C., and Yu, Q. (2011) Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers. Mol. Cell 43, 798-810
    • (2011) Mol. Cell , vol.43 , pp. 798-810
    • Lee, S.T.1    Li, Z.2    Wu, Z.3    Aau, M.4    Guan, P.5    Karuturi, R.K.6    Liou, Y.C.7    Yu, Q.8
  • 39
    • 26844520965 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3
    • Cha, T.L., Zhou, B.P., Xia, W., Wu, Y., Yang, C.C., Chen, C.T., Ping, B., Otte, A.P., and Hung, M.C. (2005) Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 310, 306-310
    • (2005) Science , vol.310 , pp. 306-310
    • Cha, T.L.1    Zhou, B.P.2    Xia, W.3    Wu, Y.4    Yang, C.C.5    Chen, C.T.6    Ping, B.7    Otte, A.P.8    Hung, M.C.9
  • 42
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan, J., Yang, X., Zhuang, L., Jiang, X., Chen, W., Lee, P.L., Karuturi, R.K., Tan, P.B., Liu, E.T., and Yu, Q. (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21, 1050-1063
    • (2007) Genes Dev. , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6    Karuturi, R.K.7    Tan, P.B.8    Liu, E.T.9    Yu, Q.10
  • 51
    • 79954471872 scopus 로고    scopus 로고
    • EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression
    • Fan, T., Jiang, S., Chung, N, Alikhan, A., Ni, C, Lee, C.C., and Hornyak, T.J. (2011) EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. Mol. Cancer Res. 9, 418-429
    • (2011) Mol. Cancer Res. , vol.9 , pp. 418-429
    • Fan, T.1    Jiang, S.2    Chung, N.3    Alikhan, A.4    Ni, C.5    Lee, C.C.6    Hornyak, T.J.7
  • 54
    • 82155186923 scopus 로고    scopus 로고
    • The emergence of lncRNAs in cancer biology
    • Prensner, J.R. and Chinnaiyan, A.M. (2011) The emergence of lncRNAs in cancer biology. Cancer Discov. 1, 391-407
    • (2011) Cancer Discov. , vol.1 , pp. 391-407
    • Prensner, J.R.1    Chinnaiyan, A.M.2
  • 55
    • 84868683051 scopus 로고    scopus 로고
    • Regulation of mammalian cell differentiation by long non-coding RNAs
    • Hu, W., Alvarez-Dominguez, J.R., and Lodish, H.F. (2012) Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep. 13, 971-983
    • (2012) EMBO Rep. , vol.13 , pp. 971-983
    • Hu, W.1    Alvarez-Dominguez, J.R.2    Lodish, H.F.3
  • 59
    • 84890031914 scopus 로고    scopus 로고
    • Poly-combing the genome for RNA
    • Goff, L.A. and Rinn, J.L. (2013) Poly-combing the genome for RNA. Nat. Struct. Mol. Biol. 20, 1344-1346
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 1344-1346
    • Goff, L.A.1    Rinn, J.L.2
  • 60
    • 84857066786 scopus 로고    scopus 로고
    • Modular regulatory principles of large non-coding RNAs
    • Guttman, M. and Rinn, J.L. (2012) Modular regulatory principles of large non-coding RNAs. Nature 482, 339-346
    • (2012) Nature , vol.482 , pp. 339-346
    • Guttman, M.1    Rinn, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.