-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA: a cancer journal for clinicians. 2005; 55:74-108.
-
(2005)
CA: a cancer journal for clinicians
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
2
-
-
4444244978
-
International variation
-
Parkin DM. International variation. Oncogene. 2004; 23:6329-6340.
-
(2004)
Oncogene
, vol.23
, pp. 6329-6340
-
-
Parkin, D.M.1
-
4
-
-
0035542950
-
Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue
-
Sasaki N, Morisaki T, Hashizume K, Yao T, Tsuneyoshi M, Noshiro H, Nakamura K, Yamanaka T, Uchiyama A, Tanaka M, Katano M. Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. Clinical cancer research: an official journal of the American Association for Cancer Research. 2001; 7:4136-4142.
-
(2001)
Clinical cancer research: an official journal of the American Association for Cancer Research
, vol.7
, pp. 4136-4142
-
-
Sasaki, N.1
Morisaki, T.2
Hashizume, K.3
Yao, T.4
Tsuneyoshi, M.5
Noshiro, H.6
Nakamura, K.7
Yamanaka, T.8
Uchiyama, A.9
Tanaka, M.10
Katano, M.11
-
5
-
-
77953908026
-
Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression
-
Sakamoto K, Hikiba Y, Nakagawa H, Hayakawa Y, Yanai A, Akanuma M, Ogura K, Hirata Y, Kaestner KH, Omata M, Maeda S. Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression. Gastroenterology. 2010; 139:226-238 e226.
-
(2010)
Gastroenterology
, vol.139
, pp. 226-238
-
-
Sakamoto, K.1
Hikiba, Y.2
Nakagawa, H.3
Hayakawa, Y.4
Yanai, A.5
Akanuma, M.6
Ogura, K.7
Hirata, Y.8
Kaestner, K.H.9
Omata, M.10
Maeda, S.11
-
6
-
-
84859834841
-
First evidence that gamma-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-kappaB pathway
-
Manu KA, Shanmugam MK, Ramachandran L, Li F, Fong CW, Kumar AP, Tan P, Sethi G. First evidence that gamma-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-kappaB pathway. Clinical cancer research: an official journal of the American Association for Cancer Research. 2012; 18:2220-2229.
-
(2012)
Clinical cancer research: an official journal of the American Association for Cancer Research
, vol.18
, pp. 2220-2229
-
-
Manu, K.A.1
Shanmugam, M.K.2
Ramachandran, L.3
Li, F.4
Fong, C.W.5
Kumar, A.P.6
Tan, P.7
Sethi, G.8
-
7
-
-
23844524758
-
Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway
-
Lin MT, Zuon CY, Chang CC, Chen ST, Chen CP, Lin BR, Wang MY, Jeng YM, Chang KJ, Lee PH, Chen WJ, Kuo ML. Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway. Clinical cancer research: an official journal of the American Association for Cancer Research. 2005; 11:5809-5820.
-
(2005)
Clinical cancer research: an official journal of the American Association for Cancer Research
, vol.11
, pp. 5809-5820
-
-
Lin, M.T.1
Zuon, C.Y.2
Chang, C.C.3
Chen, S.T.4
Chen, C.P.5
Lin, B.R.6
Wang, M.Y.7
Jeng, Y.M.8
Chang, K.J.9
Lee, P.H.10
Chen, W.J.11
Kuo, M.L.12
-
8
-
-
78650915537
-
Deubiquitinases in the regulation of NF-kappaB signaling
-
Harhaj EW, Dixit VM. Deubiquitinases in the regulation of NF-kappaB signaling. Cell research. 2011; 21:22-39.
-
(2011)
Cell research
, vol.21
, pp. 22-39
-
-
Harhaj, E.W.1
Dixit, V.M.2
-
9
-
-
78650903043
-
Expanding role of ubiquitination in NF-kappaB signaling
-
Liu S, Chen ZJ. Expanding role of ubiquitination in NF-kappaB signaling. Cell research. 2011; 21:6-21.
-
(2011)
Cell research
, vol.21
, pp. 6-21
-
-
Liu, S.1
Chen, Z.J.2
-
10
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003; 114:181-190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
11
-
-
33646034316
-
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
-
Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Molecular cell. 2006; 22:245-257.
-
(2006)
Molecular cell
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
Deng, L.2
Xia, Z.P.3
Pineda, G.4
Chen, Z.J.5
-
12
-
-
33744951304
-
Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation
-
Li H, Kobayashi M, Blonska M, You Y, Lin X. Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. The Journal of biological chemistry. 2006; 281:13636-13643.
-
(2006)
The Journal of biological chemistry
, vol.281
, pp. 13636-13643
-
-
Li, H.1
Kobayashi, M.2
Blonska, M.3
You, Y.4
Lin, X.5
-
14
-
-
0030004897
-
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity
-
Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell. 1996; 84:853-862.
-
(1996)
Cell
, vol.84
, pp. 853-862
-
-
Chen, Z.J.1
Parent, L.2
Maniatis, T.3
-
15
-
-
0025266685
-
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B
-
Ghosh S, Baltimore D. Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature. 1990; 344:678-682.
-
(1990)
Nature
, vol.344
, pp. 678-682
-
-
Ghosh, S.1
Baltimore, D.2
-
16
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
-
Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature. 2003; 424:801-805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
Israel, A.4
Wallach, D.5
Courtois, G.6
-
17
-
-
0042467558
-
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
-
Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature. 2003; 424:793-796.
-
(2003)
Nature
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
Hatzivassiliou, E.2
Tsichritzis, T.3
Farmer, H.4
Ashworth, A.5
Mosialos, G.6
-
18
-
-
77449150629
-
CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes
-
Sun SC. CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell death and differentiation. 2010; 17:25-34.
-
(2010)
Cell death and differentiation
, vol.17
, pp. 25-34
-
-
Sun, S.C.1
-
19
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
-
Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature. 2004; 430:694-699.
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
O'Rourke, K.M.2
Zhou, H.3
Eby, M.4
Aravind, L.5
Seshagiri, S.6
Wu, P.7
Wiesmann, C.8
Baker, R.9
Boone, D.L.10
Ma, A.11
Koonin, E.V.12
Dixit, V.M.13
-
20
-
-
1642423503
-
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
-
Evans PC, Ovaa H, Hamon M, Kilshaw PJ, Hamm S, Bauer S, Ploegh HL, Smith TS. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. The Biochemical journal. 2004; 378:727-734.
-
(2004)
The Biochemical journal
, vol.378
, pp. 727-734
-
-
Evans, P.C.1
Ovaa, H.2
Hamon, M.3
Kilshaw, P.J.4
Hamm, S.5
Bauer, S.6
Ploegh, H.L.7
Smith, T.S.8
-
21
-
-
34548405689
-
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1-and LPS-mediated NF-kappaB and JNK signaling
-
Shembade N, Harhaj NS, Liebl DJ, Harhaj EW. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1-and LPS-mediated NF-kappaB and JNK signaling. The EMBO journal. 2007; 26:3910-3922.
-
(2007)
The EMBO journal
, vol.26
, pp. 3910-3922
-
-
Shembade, N.1
Harhaj, N.S.2
Liebl, D.J.3
Harhaj, E.W.4
-
22
-
-
43749122598
-
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling
-
Enesa K, Zakkar M, Chaudhury H, Luong le A, Rawlinson L, Mason JC, Haskard DO, Dean JL, Evans PC. NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. The Journal of biological chemistry. 2008; 283:7036-7045.
-
(2008)
The Journal of biological chemistry
, vol.283
, pp. 7036-7045
-
-
Enesa, K.1
Zakkar, M.2
Chaudhury, H.3
Luong le, A.4
Rawlinson, L.5
Mason, J.C.6
Haskard, D.O.7
Dean, J.L.8
Evans, P.C.9
-
23
-
-
84873729426
-
miR-486 sustains NF-kappaB activity by disrupting multiple NF-kappaB-negative feedback loops
-
Song L, Lin C, Gong H, Wang C, Liu L, Wu J, Tao S, Hu B, Cheng SY, Li M, Li J. miR-486 sustains NF-kappaB activity by disrupting multiple NF-kappaB-negative feedback loops. Cell research. 2013; 23:274-289.
-
(2013)
Cell research
, vol.23
, pp. 274-289
-
-
Song, L.1
Lin, C.2
Gong, H.3
Wang, C.4
Liu, L.5
Wu, J.6
Tao, S.7
Hu, B.8
Cheng, S.Y.9
Li, M.10
Li, J.11
-
24
-
-
33847192750
-
Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors
-
L'Esperance S, Popa I, Bachvarova M, Plante M, Patten N, Wu L, Tetu B, Bachvarov D. Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors. International journal of oncology. 2006; 29:5-24.
-
(2006)
International journal of oncology
, vol.29
, pp. 5-24
-
-
L'Esperance, S.1
Popa, I.2
Bachvarova, M.3
Plante, M.4
Patten, N.5
Wu, L.6
Tetu, B.7
Bachvarov, D.8
-
25
-
-
84862143812
-
Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer
-
Nikolaou K, Tsagaratou A, Eftychi C, Kollias G, Mosialos G, Talianidis I. Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer. Cancer cell. 2012; 21:738-750.
-
(2012)
Cancer cell
, vol.21
, pp. 738-750
-
-
Nikolaou, K.1
Tsagaratou, A.2
Eftychi, C.3
Kollias, G.4
Mosialos, G.5
Talianidis, I.6
-
26
-
-
4644309196
-
The functions of animal microRNAs
-
Ambros V. The functions of animal microRNAs. Nature. 2004; 431:350-355.
-
(2004)
Nature
, vol.431
, pp. 350-355
-
-
Ambros, V.1
-
27
-
-
0347444723
-
MicroRNAs: genomics, biogenesis, mechanism, and function
-
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116:281-297.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
28
-
-
39449129941
-
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation
-
Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. The EMBO journal. 2008; 27:629-641.
-
(2008)
The EMBO journal
, vol.27
, pp. 629-641
-
-
Iha, H.1
Peloponese, J.M.2
Verstrepen, L.3
Zapart, G.4
Ikeda, F.5
Smith, C.D.6
Starost, M.F.7
Yedavalli, V.8
Heyninck, K.9
Dikic, I.10
Beyaert, R.11
Jeang, K.T.12
-
31
-
-
77956511912
-
The Notch/Hes1 pathway sustains NF-kappaB activation through CYLD repression in T cell leukemia
-
Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Ingles-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun SC, Song G, Mullighan CC, et al. The Notch/Hes1 pathway sustains NF-kappaB activation through CYLD repression in T cell leukemia. Cancer cell. 2010; 18:268-281.
-
(2010)
Cancer cell
, vol.18
, pp. 268-281
-
-
Espinosa, L.1
Cathelin, S.2
D'Altri, T.3
Trimarchi, T.4
Statnikov, A.5
Guiu, J.6
Rodilla, V.7
Ingles-Esteve, J.8
Nomdedeu, J.9
Bellosillo, B.10
Besses, C.11
Abdel-Wahab, O.12
Kucine, N.13
Sun, S.C.14
Song, G.15
Mullighan, C.C.16
-
32
-
-
60549102324
-
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
-
Massoumi R, Kuphal S, Hellerbrand C, Haas B, Wild P, Spruss T, Pfeifer A, Fassler R, Bosserhoff AK. Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. The Journal of experimental medicine. 2009; 206:221-232.
-
(2009)
The Journal of experimental medicine
, vol.206
, pp. 221-232
-
-
Massoumi, R.1
Kuphal, S.2
Hellerbrand, C.3
Haas, B.4
Wild, P.5
Spruss, T.6
Pfeifer, A.7
Fassler, R.8
Bosserhoff, A.K.9
-
33
-
-
33845679104
-
Reduced expression of CYLD in human colon and hepatocellular carcinomas
-
Hellerbrand C, Bumes E, Bataille F, Dietmaier W, Massoumi R, Bosserhoff AK. Reduced expression of CYLD in human colon and hepatocellular carcinomas. Carcinogenesis. 2007; 28:21-27.
-
(2007)
Carcinogenesis
, vol.28
, pp. 21-27
-
-
Hellerbrand, C.1
Bumes, E.2
Bataille, F.3
Dietmaier, W.4
Massoumi, R.5
Bosserhoff, A.K.6
-
34
-
-
18844464056
-
Identification of the familial cylindromatosis tumour-suppressor gene
-
Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C, Biggs PJ, Lakhani SR, Jones C, Hansen J, Blair E, Hofmann B, Siebert R, Turner G, et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nature genetics. 2000; 25:160-165.
-
(2000)
Nature genetics
, vol.25
, pp. 160-165
-
-
Bignell, G.R.1
Warren, W.2
Seal, S.3
Takahashi, M.4
Rapley, E.5
Barfoot, R.6
Green, H.7
Brown, C.8
Biggs, P.J.9
Lakhani, S.R.10
Jones, C.11
Hansen, J.12
Blair, E.13
Hofmann, B.14
Siebert, R.15
Turner, G.16
-
35
-
-
84894281222
-
Treatment of gastric cancer
-
Orditura M, Galizia G, Sforza V, Gambardella V, Fabozzi A, Laterza MM, Andreozzi F, Ventriglia J, Savastano B, Mabilia A, Lieto E, Ciardiello F, De Vita F. Treatment of gastric cancer. World journal of gastroenterology: WJG. 2014; 20:1635-1649.
-
(2014)
World journal of gastroenterology: WJG
, vol.20
, pp. 1635-1649
-
-
Orditura, M.1
Galizia, G.2
Sforza, V.3
Gambardella, V.4
Fabozzi, A.5
Laterza, M.M.6
Andreozzi, F.7
Ventriglia, J.8
Savastano, B.9
Mabilia, A.10
Lieto, E.11
Ciardiello, F.12
De Vita, F.13
-
36
-
-
84879420939
-
Phase II 2-arm trial of the proteasome inhibitor, PS-341 (bortezomib) in combination with irinotecan or PS-341 alone followed by the addition of irinotecan at time of progression in patients with locally recurrent or metastatic squamous cell carcinoma of the head and neck (E1304): a trial of the Eastern Cooperative Oncology Group
-
Gilbert J, Lee JW, Argiris A, Haigentz M Jr., Feldman LE, Jang M, Arun P, Van Waes C, Forastiere AA. Phase II 2-arm trial of the proteasome inhibitor, PS-341 (bortezomib) in combination with irinotecan or PS-341 alone followed by the addition of irinotecan at time of progression in patients with locally recurrent or metastatic squamous cell carcinoma of the head and neck (E1304): a trial of the Eastern Cooperative Oncology Group. Head & neck. 2013; 35:942-948.
-
(2013)
Head & neck
, vol.35
, pp. 942-948
-
-
Gilbert, J.1
Lee, J.W.2
Argiris, A.3
Haigentz, M.4
Feldman, L.E.5
Jang, M.6
Arun, P.7
Van Waes, C.8
Forastiere, A.A.9
-
37
-
-
84887052280
-
Phase I-II study of the farnesyl transferase inhibitor tipifarnib plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in HER2/neu-negative inflammatory carcinoma and non-inflammatory estrogen receptor-positive breast carcinoma
-
Andreopoulou E, Vigoda IS, Valero V, Hershman DL, Raptis G, Vahdat LT, Han HS, Wright JJ, Pellegrino CM, Cristofanilli M, Alvarez RH, Fehn K, Fineberg S, Sparano JA. Phase I-II study of the farnesyl transferase inhibitor tipifarnib plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in HER2/neu-negative inflammatory carcinoma and non-inflammatory estrogen receptor-positive breast carcinoma. Breast cancer research and treatment. 2013; 141:429-435.
-
(2013)
Breast cancer research and treatment
, vol.141
, pp. 429-435
-
-
Andreopoulou, E.1
Vigoda, I.S.2
Valero, V.3
Hershman, D.L.4
Raptis, G.5
Vahdat, L.T.6
Han, H.S.7
Wright, J.J.8
Pellegrino, C.M.9
Cristofanilli, M.10
Alvarez, R.H.11
Fehn, K.12
Fineberg, S.13
Sparano, J.A.14
-
38
-
-
0036020941
-
NF-kappaB as a therapeutic target in cancer
-
Orlowski RZAS Jr. NF-kappaB as a therapeutic target in cancer. Trends in molecular medicine. 2002; 8:385-389.
-
(2002)
Trends in molecular medicine
, vol.8
, pp. 385-389
-
-
Orlowski, R.Z.A.S.1
|