Arteether nanoemulsion for enhanced efficacy against Plasmodium yoelii nigeriensis malaria: An approach by enhanced bioavailability

Colloids and Surfaces B: Biointerfaces

Volumn 126, Issue , 2015, Pages 467-475

  Dwivedi, Pankaj ^a,b   Khatik, Renuka ^a   Chaturvedi, Priyanka ^a   Khandelwal, Kiran ^a   Taneja, Isha ^a   Raju, Kanumuri Siva Rama ^a   Dwivedi, Hemlata ^a   Singh, Sunil kumar ^a   Gupta, Pramod Kumar ^a   Shukla, Prashant ^a   Tripathi, Priyanka ^a   Singh, Sarika ^a   Tripathi, Renu ^a   Wahajuddin, ^a   Paliwal, Sarvesh Kumar ^b   Dwivedi, Anil Kumar ^a   Mishra, Prabhat Ranjan ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b BANASTHALI UNIVERSITY   (India)

Author keywords

Antimalarial efficacy; Arteether; High pressure homogenizer; LC MS; Nanoemulsion; Pharmacokinetics

Indexed keywords

BIOCHEMISTRY; CURING; DISEASES; DRUG PRODUCTS; ENZYME INHIBITION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; SIZE DISTRIBUTION;

ANTIMALARIAL EFFICACIES; ARTEETHER; HIGH PRESSURE HOMOGENIZER; LC-MS; NANOEMULSION;

LOADING;

ARACHIS OIL; ARTEETHER; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; EMULSION; NANOMATERIAL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NANOEMULSION; NONHUMAN; PH; PLASMODIUM YOELII; PLASMODIUM YOELII INFECTION; PLASMODIUM YOELII NIGERIENSIS; PLASMODIUM YOELII NIGERIENSIS MALARIA; RAT; SURVIVAL RATE; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY; YOUNG ADULT; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; BLOOD; CACO 2 CELL LINE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG SENSITIVITY; EMULSION; HUMAN; MALARIA; MOUSE; ORAL DRUG ADMINISTRATION; PARASITOLOGY; PARTICLE SIZE; SURFACE PROPERTY;

MUS; NES; PLASMODIUM YOELII NIGERIENSIS; RATTUS;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; ARTEMISININS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CELL LINE; CELL SURVIVAL; EMULSIONS; HUMANS; MALARIA; MICE; NANOSTRUCTURES; PARASITIC SENSITIVITY TESTS; PARTICLE SIZE; PLASMODIUM YOELII; RATS; SURFACE PROPERTIES;

EID: 84923052437     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2014.12.052     Document Type: Article

References (42)

1. WHO World Malaria Report 2013 2013.
2. Krishna S., Bustamante L., Haynes R.K., Staines H.M. Artemisinins: their growing importance in medicine. Trends Pharmacol. Sci. 2008, 29:520-527.
3. Cui L., Su X.Z. Discovery, mechanisms of action and combination therapy of artemisinin. Expert. Rev. Anti Infect. Ther. 2009, 7:999-1013.
4. Agnandji S.T., Kurth F., Belard S., Mombo-Ngoma G., Basra A., Fernandes J.F., Soulanoudjingar S.S., Adegnika A.A., Ramharter M. Current status of the clinical development and implementation of paediatric artemisinin combination therapies in Sub-Saharan Africa. Wien Klin. Wochenschr. 2011, 1:7-9.
5. O'Brien C., Henrich P.P., Passi N., Fidock D.A. Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum. Curr. Opin. Infect. Dis. 2011, 24:570-577.
6. Noedl H., Se Y., Schaecher K., Smith B.L., Socheat D., Fukuda M.M. Evidence of artemisinin-resistant malaria in Western Cambodia. N. Engl. J. Med. 2008, 359:2619-2620.
7. Witkowski B., Amaratunga C., Khim N., Sreng S., Chim P., Kim S., Lim P., Mao S., Sopha C., Sam B., Anderson J.M., Duong S., Chuor C.M., Taylor W.R.J., Suon S., Mercereau-Puijalon O., Fairhurst R.M., Menard D. Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. Lancet Infect. Dis. 2013, 13:1043-1049.
8. Jiang J.-B., Guo X.-B., Li G.-Q., Cheung Kong Y., Arnold K. Antimalarial activity of mefloquine and qinghasu. Lancet 1982, 320:285-288.
9. Posner G.H., Cumming J.N., Ploypradith P., Oh C.H. Evidence for Fe(IV):O in the molecular mechanism of action of the trioxane antimalarial artemisinin. J. Am. Chem. Soc. 1995, 117:5885-5886.
10. Borstnik K., Paik I.-h., Shapiro T.A., Posner G.H. Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds. Int. J. Parasitol. 2002, 32:1661-1667.
11. White N.J. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob. Agents Chemother. 1997, 41:1413-1422.
12. Wells T.N.C., Alonso P.L., Gutteridge W.E. New medicines to improve control and contribute to the eradication of malaria. Nat. Rev. Drug Discov. 2009, 8:879-891.
13. Olliaro P., Nair N., Sathasivam K., Mansor S., Navaratnam V. Pharmacokinetics of artesunate after single oral administration to rats. BMC Pharmacol. 2001, 1:12.
14. Baker J.K., McChesney J.D., Chi H.T. Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity. Pharm. Res. 1993, 10:662-666.
15. Brewer T.G., Genovese R.F., Newman D.B., Li Q. Factors relating to neurotoxicity of artemisinin antimalarial drugs "listening to arteether". Med. Trop. (Mars) 1998, 58:22-27.
16. Genovese R.F., Newman D.B., Li Q., Peggins J.O., Brewer T.G. Dose-dependent brainstem neuropathology following repeated arteether administration in rats. Brain Res. Bull. 1998, 45:199-202.
17. Genovese R.F., Newman D.B., Petras J.M., Brewer T.G. Behavioral and neural toxicity of arteether in rats. Pharmacol. Biochem. Behav. 1998, 60:449-458.
18. Bouchemal K., Briancon S., Perrier E., Fessi H. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. Int. J. Pharm. 2004, 280:241-251.
19. Solans C., Izquierdo P., Nolla J., Azemar N., Garcia-Celma M.J. Nano-emulsions. Curr. Opin. Colloid Interface Sci. 2005, 10:102-110.
20. Vyas T.K., Shahiwala A., Amiji M.M. Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations. Int. J. Pharm. 2008, 347:93-101.
21. Baluom M., Friedman D.I., Rubinstein A. Absorption enhancement of calcitonin in the rat intestine by carbopol-containing submicron emulsions. Int. J. Pharm. 1997, 154:235-243.
22. Meleson K., Graves S., Mason T.G. Formation of concentrated nanoemulsions by extreme shear. Soft Mater. 2004, 2:109-123.
23. Floury J., Desrumaux A., Axelos M.A.V., Legrand J. Effect of high pressure homogenisation on methylcellulose as food emulsifier. J. Food Eng. 2003, 58:227-238.
24. Qian C., McClements D.J. Formation of nanoemulsions stabilized by model food-grade emulsifiers using high-pressure homogenization: factors affecting particle size. Food Hydrocoll. 2011, 25:1000-1008.
25. Al-Angary A.A., Al-Meshal M.A., Bayomi M.A., Khidr S.H. Evaluation of liposomal formulations containing the antimalarial agent, arteether. Int. J. Pharm. 1996, 128:163-168.
26. Chidambaram N., Burgess D.J. A novel in vitro release method for submicron sized dispersed systems. AAPS PharmSci. 1999, 1:E11.
27. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
28. Sabarinath S., Singh R.P., Gupta R.C. Simultaneous quantification of alpha-/beta-diastereomers of arteether, sulfadoxine and pyrimethamine: a promising anti-relapse antimalarial therapeutic combination, by liquid chromatography tandem mass spectrometry. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2006, 842:36-42.
29. Rajanikanth M., Madhusudanan K.P., Gupta R.C. Liquid chromatographic-mass spectrometric method for the determination of alpha-, beta-arteether in rat serum. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2003, 783:391-399.
30. Dwivedi P., Khatik R., Khandelwal K., Taneja I., Raju K.S.R., Wahajuddin, Paliwal S.K., Dwivedi A.K., Mishra P.R. Pharmacokinetics study of arteether loaded solid lipid nanoparticles: an improved oral bioavailability in rats. Int. J. Pharm. 2014, 466:321-327.
31. Li J., Pattaradilokrat S., Zhu F., Jiang H., Liu S., Hong L., Fu Y., Koo L., Xu W., Pan W., Carlton J.M., Kaneko O., Carter R., Wootton J.C., Su X.Z. Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:20.
32. Walker D.J., Pitsch J.L., Peng M.M., Robinson B.L., Peters W., Bhisutthibhan J., Meshnick S.R. Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii. Antimicrob. Agents Chemother. 2000, 44:344-347.
33. Carlton J.M., Angiuoli S.V., Suh B.B., Kooij T.W., Pertea M., Silva J.C., Ermolaeva M.D., Allen J.E., Selengut J.D., Koo H.L., Peterson J.D., Pop M., Kosack D.S., Shumway M.F., Bidwell S.L., Shallom S.J., van Aken S.E., Riedmuller S.B., Feldblyum T.V., Cho J.K., Quackenbush J., Sedegah M., Shoaibi A., Cummings L.M., Florens L., Yates J.R., Raine J.D., Sinden R.E., Harris M.A., Cunningham D.A., Preiser P.R., Bergman L.W., Vaidya A.B., van Lin L.H., Janse C.J., Waters A.P., Smith H.O., White O.R., Salzberg S.L., Venter J.C., Fraser C.M., Hoffman S.L., Gardner M.J., Carucci D.J. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature 2002, 419:512-519.
34. Elwell M.W., Roberts R.F., Coupland J.N. Effect of homogenization and surfactant type on the exchange of oil between emulsion droplets. Food Hydrocolloids 2004, 18:413-418.
35. Mishra P.R., Shaal L.A., Müller R.H., Keck C.M. Production and characterization of Hesperetin nanosuspensions for dermal delivery. Int. J. Pharm. 2009, 371:182-189.
36. Perrechil F.A., Cunha R.L. Oil-in-water emulsions stabilized by sodium caseinate: influence of pH, high-pressure homogenization and locust bean gum addition. J. Food Eng. 2010, 97:441-448.
37. Salvia-Trujillo L., Qian C., Martin-Belloso O., McClements D.J. Influence of particle size on lipid digestion and beta-carotene bioaccessibility in emulsions and nanoemulsions. Food Chem. 2013, 141:1472-1480.
38. Hur S.J., Decker E.A., McClements D.J. Influence of initial emulsifier type on microstructural changes occurring in emulsified lipids during in vitro digestion. Food Chem. 2009, 114:253-262.
39. Hsieh C.W., Li P.H., Lu I.C., Wang T.H. Preparing glabridin-in-water nanoemulsions by high pressure homogenization with response surface methodology. J. Oleo Sci. 2012, 61:483-489.
40. Liu W., Sun D., Li C., Liu Q., Xu J. Formation and stability of paraffin oil-in-water nano-emulsions prepared by the emulsion inversion point method. J. Colloid Interface Sci. 2006, 303:557-563.
41. Sabarinath S., Madhusudanan K.P., Gupta R.C. Pharmacokinetics of the diastereomers of arteether, a potent antimalarial drug, in rats. Biopharm. Drug Dispos. 2005, 26:211-223.
42. Tripathi R., Jefford C.W., Dutta G.P. Blood schizontocidal activity of selected 1,2,4-trioxanes (Fenozans) against the multidrug-resistant strain of Plasmodium yoelii nigeriensis (MDR) in vivo. Parasitology 2006, 133:1-9.