Behavioral and neural toxicity of arteether in rats

Pharmacology Biochemistry and Behavior

Volumn 60, Issue 2, 1998, Pages 449-458

  Genovese, Raymond F ^a,b   Newman, Donald B ^a,b   Petras, J M ^a,b   Brewer, Thomas G ^a,b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Antimalarial; Artemisinin; Audition; Discrimination; Neuropathology; Safety assessment

Indexed keywords

ARTEETHER; ARTEMISININ;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY DISCRIMINATION; BEHAVIOR DISORDER; CONTROLLED STUDY; DRUG SAFETY; HISTOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACOUSTIC STIMULATION; ANIMALS; ANTIMALARIALS; ARTEMISININS; BEHAVIOR, ANIMAL; BRAIN STEM; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; MALE; NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES;

EID: 0032100512     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(98)00019-7     Document Type: Article

References (27)

1. Brewer T.G., Grate S.J., Peggins J.O., Weina P.J., Petras J.M., Levine B.S., Heiffer M.H., Schuster B.G. Fatal neurotoxicity of arteether and artemether. Am. J. Trop. Med. Hyg. 51:1994;251-259.
2. Brewer T.G., Peggins J.O., Grate S.J., Petras J.M., Levine B.S., Weina P.J., Swearengen J., Heiffer M.H., Schuster B.G. Neurotoxicity in animals due to arteether and artemether. Trans. R. Soc. Trop. Med. Hyg. 88(Suppl. 1):1994;33-36.
3. Buser P., Imbert M., translated by Kay R.H. Audition. 1992;MIT Press, Cambridge.
4. Cammemeyer J. The importance of avoiding dark neurons in experimental neuropathology. Acta Neuropathol. 1:1961;245-270.
5. Cammemeyer J. An evaluation of the significance of the "dark" neuron. Ergebn. Anat. Entwickl-Gesch. 36:1962;1-61.
6. China Cooperative Research Group on Qinghaosu and Its Derivatives as Antimalarials: Studies on the toxicity of qinghaosu and its derivatives. J. Trad. Chin. Med. 2:31-38; 1982.
7. Davidson D.E. Role of arteether in the treatment of malaria and plans for further development. Trans. R. Soc. Trop. Med. Hyg. 88(Suppl. 1):1994;51-52.
8. Dykstra L.A., Genovese R.F. Measurement of drug effects on stimulus control. Greenshaw A.J., Dourish C.T. Experimental psychopharmacology. 1987;393-431 Humana Press, Clifton, NJ.
9. Genovese, R. F.; Newman, D. B.; Li, Q.; Peggins, J. O.; Brewer, T. G.: Dose-dependent brainstem neuropathology following re-peated arteether administration in rats (submitted).
10. Genovese R.F., Petras J.M., Brewer T.G. Arteether neurotoxicity in the absence of deficits in behavioral performance in rats. Ann. Trop. Med. Parastol. 89:1995;447-449.
11. Gourevitch G. Auditory masking in the rat. J. Acoust. Soc. Am. 37:1965;439-443.
12. Gourevitch G., Hack M.H. Audibility in the rat. J. Comp. Physiol. Psychol. 62:1966;289-291.
13. Green D.M., Swets J.A. Signal detection theory and psychophysics. 1966;John Wiley, New York.
14. Hien T.T. An overview of the clinical use of artemisinin and its derivatives in the treatment of falciparum in Viet Nam. Trans. R. Soc. Trop. Med. Hyg. 88(Suppl. 1):1994;7-8.
15. Hien T.T., White N.J. Qinghaosu. Lancet. 341:1993;603-608.
16. Kager P.A., Schultz M.J., Zijlstra E.E., van den Berg B., van Boxtel Ch. Arteether administration in humans. Preliminary studies of pharmacokinetics, safety and tolerance Trans. R. Soc. Trop. Med. Hyg. 88(Suppl. 1):1994;53-54.
17. Kamchonwongpaisan S., McKeever P., Hossler P., Ziffer H., Meshnick S.R. Artemisinin neurotoxicity. Neuropathology in rats and mechanistic studies in vitro Am. J. Trop. Med. Hyg. 56:1997;7-12.
18. Klayman D.L. Qinghaosu (Artemisinin). An antimalarial drug from China Science. 228:1985;1049-1055.
19. Looareesuwan S. Overview of clinical studies on artemisinin derivatives in Thailand. Trans. R. Soc. Trop. Med. Hyg. 88(Suppl. 1):1994;9-11.
20. Meshnick S.R. The mode of action of antimalarial endoperoxides. Trans R. Soc. Trop. Med. Hyg. 88(Suppl. 1):1994;31-32.
21. Meshnick S.R., Yang Y.-Z., Lima V., Kuypers F., Kamchonwongpaisan S., Yuthavong Y. lron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu). Antimicrob. Agents Chemother. 37:1993;1108-1114.
22. Petras J.M., Brewer T.G., Peggins J.O. Brain injury induced in Rattus rattus by the antimalarial drug arteether (Ae). a neuroanatomical and neuropathological analysis Anat. Rec. 237(Suppl. 1):1993;95.
23. Petras J.M., Kyle D.E., Gettayacamin G.D., Young G.D., Bauman R.A., Webster H.K., Corcoran K.D., Peggins J.O., Vane M.A., Brewer T.G. Arteether. Risks of two-week administration in Macaca mulatta Am. J. Trop. Med. Hyg. 56:1997;390-396.
24. Shmuklarsky M.J., Klayman D.L., Milhous W.K., Kyle D.E., Rossan R.N., Ager A.L.J. Jr., Tang D.B., Heiffer M.H., Canfield C.J., Schuster B.G. Comparison of β-artemether and β-arteether against malaria parasites in vitro and in vivo. Am. J. Trop. Med. Hyg. 48:1993;377-384.
25. Webster H.K., Lehnert E.K. Chemistry of artemisinin. An overview Trans. R. Soc. Trop. Med. Hyg. 88(Suppl. 1):1994;27-29.
26. White N.J. Artemisinin. Current status Trans R. Soc. Trop. Med. Hyg. 88(Suppl. 1):1994;3-4.
27. Zahm D.S., Munger B.L. The innervation of the primate fungiform papilla. Development, distribution, and changes following selective ablation Brain Res. 356:1985;147-186.