Dose-dependent brainstem neuropathology following repeated arteether administration in rats

Brain Research Bulletin

Volumn 45, Issue 2, 1998, Pages 199-202

  Genovese, Raymond F ^a   Newman, Donald B ^b   Li, Qigui ^a   Peggins, James O ^a   Brewer, Thomas G ^c  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Dept Anat Cell Biol Uniformed S ^*  (United States)

^c ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

Author keywords

Antimalarial; Arteether; Artemisinin; Neurotoxicity; Rats

Indexed keywords

ARTEETHER; ARTEMISININ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM INJURY; COCHLEAR NUCLEUS; CONTROLLED STUDY; DENTATE NUCLEUS; DOSE TIME EFFECT RELATION; HISTOPATHOLOGY; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SUPERIOR OLIVARY NUCLEUS; VESTIBULAR NUCLEUS;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BEHAVIOR, ANIMAL; BRAIN DISEASES; BRAIN STEM; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES;

EID: 0031984387     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(97)00339-0     Document Type: Article

References (11)

1. Brewer T. G., Grate S. J., Peggins J. O., Weina P. J., Petras J. M., Levine B. S., Heiffer M. H., Schuster B. G. Fatal neurotoxicity of arteether and artemether. Am. J. Trop. Med. Hyg. 51:1994;251-259.
2. Brewer T. G., Peggins J. O., Grate S. J., Petras J. M., Levine B. S., Weina P. J., Swearengen J., Heiffer M. H., Schuster B. G. Neurotoxicity in animals due to arteether and artemether. Trans. R. Soc. Trop. Med. Hyg. 88:(Suppl. 1):1994;33-36.
3. China Cooperative Research Group on Qinghaosu and Its Derivatives as Antimalarials. Studies on the toxicity of qinghaosu and its derivatives. J. Trad. Chin. Med. 2:31-38; 1982.
4. Davidson D. E. Role of arteether in the treatment of malaria and plans for further development. Trans. R. Soc. Trop. Med. Hyg. 88:(Suppl. 1):1994;51-52.
5. Genovese R. F., Petras J. M., Brewer T. G. Arteether neurotoxicity in the absence of deficits in behavioral performance in rats. Ann. Trop. Med. Parastol. 89:1995;447-449.
6. Hien, T. T.; White, N. J. Qinghaosu, Lancet 341:603-608; 1993.
7. Kager P. A., Schultz M. J., Zijlstra E. E., van den Berg B., van Boxtel C. J. Arteether administration in humans Preliminary studies of pharmacokinetics, safety and tolerance . Trans. R. Soc. Trop. Med. Hyg. 88:(Suppl. 1):1994;53-54.
8. Klayman D. L. Qinghaosu (Artemisinin) An antimalarial drug from China . Science. 228:1985;1049-1055.
9. Mishra S. K., Asthana O. P., Mohanty S., Patnaik J. K., Das B. S., Srivastava J. S., Satpathy S. K., Dash S., Rath P. K., Varghese K. Effectiveness of α, β-arteether in acute falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 89:1995;299-301.
10. Petras J. M., Kyle D. E., Ngampochjana; M.; Young G. D., Bauman R. A., Webster H. K., Corcoran J. D., Peggins J. O., Vane M. A., Brewer T. G. Arteether Risks of two-week administration in macaca mulatta . Am. J. Trop. Med. 56:1997;390-396.
11. Shmuklarsky M. J., Klayman D. L., Milhous W. K., Kyle D. E., Rossan R. N., Ager A. L. jr., Tang D. B., Heiffer M. H., Canfield C. J., Schuster B. G. Comparison of β-artemether and β-arteether against malaria parasites in vitro and in vivo. Am. J. Trop. Med. Hyg. 48:1993;377-384.