메뉴 건너뛰기




Volumn 24, Issue 3, 2015, Pages 345-362

Investigational therapies currently in Phase II clinical trials for the treatment of pelvic serous carcinomas

Author keywords

Clinical trials; Epithelial ovarian cancer; Fallopian tube carcinoma; Phase II; Therapies

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ANTINEOPLASTIC AGENT; BELINOSTAT; BEVACIZUMAB; CEDIRANIB; CYCLOPHOSPHAMIDE; ENZALUTAMIDE; ENZASTAURIN; ERLOTINIB; EVEROLIMUS; GANETESPIB; GEFITINIB; LURBINECTEDIN; MODIFIED VACCINIA VIRUS ANKARA 5T4 VACCINE; NINTENDANIB; OLAPARIB; PAZOPANIB; PRALATREXATE; PROTEIN TYROSINE KINASE INHIBITOR; RUCAPARIB; SARACATINIB; SERIBANTUMAB; TEMSIROLIMUS; TIVOZANIB; TREBANANIB; UNCLASSIFIED DRUG; VANDENTANIB; VASCULAR TARGETING AGENT; VELIPARIB; WEE1 TYROSINE KINASE INHIBITOR; NEW DRUG;

EID: 84922978163     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2015.999154     Document Type: Review
Times cited : (2)

References (98)
  • 1
    • 84908315018 scopus 로고    scopus 로고
    • The association of serous tubal intraepithelial carcinoma with gynecologic pathologies and its role in pelvic serous cancer
    • Koç N, Ayas S, Uygur L. The association of serous tubal intraepithelial carcinoma with gynecologic pathologies and its role in pelvic serous cancer. Gynecol Oncol 2014;134:486-91
    • (2014) Gynecol Oncol , vol.134 , pp. 486-491
    • Koç, N.1    Ayas, S.2    Uygur, L.3
  • 2
    • 84897018477 scopus 로고    scopus 로고
    • Origin and pathogenesis of pelvic (ovarian tubal and primary peritoneal) serous carcinoma
    • Nik NN, Vang R, Shih IeM, et al. Origin and pathogenesis of pelvic (ovarian tubal and primary peritoneal) serous carcinoma. Annu Rev Pathol 2014;9:27-45
    • (2014) Annu Rev Pathol , vol.9 , pp. 27-45
    • Nik, N.N.1    Vang, R.2    Shih Ie, M.3
  • 3
    • 33846624310 scopus 로고    scopus 로고
    • Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship
    • Kindelberger DW, Lee Y, Miron A, et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 2007;31:161-9
    • (2007) Am J Surg Pathol , vol.31 , pp. 161-169
    • Kindelberger, D.W.1    Lee, Y.2    Miron, A.3
  • 4
    • 62849095422 scopus 로고    scopus 로고
    • Serous tubal intraepithelial carcinoma and the dominant ovarian mass: Clues to serous tumor origin?
    • Roh MH, Kindelberger D, Crum CP. Serous tubal intraepithelial carcinoma and the dominant ovarian mass: clues to serous tumor origin? Am J Surg Pathol 2009;33:376-83
    • (2009) Am J Surg Pathol , vol.33 , pp. 376-383
    • Roh, M.H.1    Kindelberger, D.2    Crum, C.P.3
  • 5
    • 1942469352 scopus 로고    scopus 로고
    • Ovarian tumorigenesis - A proposed model based on morphological and molecular genetic analysis
    • Shih IM, Kurman RJ. Ovarian tumorigenesis-a proposed model based on morphological and molecular genetic analysis. Am J Pathol 2004;164:1511-18
    • (2004) Am J Pathol , vol.164 , pp. 1511-1518
    • Shih, I.M.1    Kurman, R.J.2
  • 6
    • 79957811258 scopus 로고    scopus 로고
    • STICS, SCOUTs and p53 signatures; A new language for pelvic serous carcinogenesis
    • Mehra K, Mehrad M, Ning G, et al. STICS, SCOUTs and p53 signatures; a new language for pelvic serous carcinogenesis. Front Biosci 2011;3:625-34
    • (2011) Front Biosci , vol.3 , pp. 625-634
    • Mehra, K.1    Mehrad, M.2    Ning, G.3
  • 7
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonist in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonist in cancer treatment. N Engl J Med 2008;358:1160-74
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 8
    • 41949100690 scopus 로고    scopus 로고
    • Clinical implications of the Erb/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer
    • Lafky JM, Wilken JA, Baron AT, et al. Clinical implications of the Erb/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochim Biophys Acta 2008;1785:232-65
    • (2008) Biochim Biophys Acta , vol.1785 , pp. 232-265
    • Lafky, J.M.1    Wilken, J.A.2    Baron, A.T.3
  • 9
    • 0030774045 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
    • Moyer CD, Barbacci EG, Iwata KK, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res 1997;57:4838-48
    • (1997) Cancer Res , vol.57 , pp. 4838-4848
    • Moyer, C.D.1    Barbacci, E.G.2    Iwata, K.K.3
  • 10
    • 1842605531 scopus 로고    scopus 로고
    • Insights into ErbB signaling from the structure of the ErbB2 - Pertuzumab complex
    • Franklin MC, Carey KD, Vadjos FF, et al. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 2008;5:317-28
    • (2008) Cancer Cell , vol.5 , pp. 317-328
    • Franklin, M.C.1    Carey, K.D.2    Vadjos, F.F.3
  • 11
    • 23044511620 scopus 로고    scopus 로고
    • Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: A Gynecologic Oncology Group Study
    • Schilder RJ, Sill MW, Chen X, et al. Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study. Clin Cancer Res 2005;11:5539-48
    • (2005) Clin Cancer Res , vol.11 , pp. 5539-5548
    • Schilder, R.J.1    Sill, M.W.2    Chen, X.3
  • 12
    • 33947523019 scopus 로고    scopus 로고
    • A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer
    • Posadas EM, Liel MS, Kiwitkowki V, et al. A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer. Cancer 2007;109:1323-30
    • (2007) Cancer , vol.109 , pp. 1323-1330
    • Posadas, E.M.1    Liel, M.S.2    Kiwitkowki, V.3
  • 13
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 14
    • 63549126247 scopus 로고    scopus 로고
    • The contribution of BRCA1 and BRCA2 to ovarian cancer
    • Ramus SJ, Gayther SA. The contribution of BRCA1 and BRCA2 to ovarian cancer. Mol Oncol 2009;3:138-50
    • (2009) Mol Oncol , vol.3 , pp. 138-150
    • Ramus, S.J.1    Gayther, S.A.2
  • 15
    • 84903547236 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial
    • Ledermann J, Harter P, Gourley C, et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol 2014;15:852-61
    • (2014) Lancet Oncol , vol.15 , pp. 852-861
    • Ledermann, J.1    Harter, P.2    Gourley, C.3
  • 16
    • 84898466302 scopus 로고    scopus 로고
    • Novel therapies, including enzastaurin, in the treatment of ovarian cancer
    • Vergote I. Novel therapies, including enzastaurin, in the treatment of ovarian cancer. Expert Opin Investig Drugs 2014;23:579-98
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 579-598
    • Vergote, I.1
  • 17
    • 84891068902 scopus 로고    scopus 로고
    • The role of PARP inhibitors in the treatment of gynecologic malignancies
    • Reinbolt RE, Hays JL. The role of PARP inhibitors in the treatment of gynecologic malignancies. Front Oncol 2013;3:237
    • (2013) Front Oncol , vol.3 , pp. 237
    • Reinbolt, R.E.1    Hays, J.L.2
  • 18
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly-ADP-rybose polymerase inhibitor olaparib in patients with BRCA1 and BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh MW, Carmichael J, Penson RT, et al. Oral poly-ADP-rybose polymerase inhibitor olaparib in patients with BRCA1 and BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010;376:245-51
    • (2010) Lancet , vol.376 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3
  • 19
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple negative breast cancer: A phase 2, multicentre, open-label, non-randomized study
    • Gelmon KA, Tischkowitz M, Mackay H, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple negative breast cancer: a phase 2, multicentre, open-label, non-randomized study. Lancet Oncol 2011;12:852-61
    • (2011) Lancet Oncol , vol.12 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3
  • 20
    • 84863010984 scopus 로고    scopus 로고
    • Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly(ADPribose) polymerase inhibitor, and pegylated liposomal soxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer
    • Kaye SB, Lubinsky J, Matulonis U, et al. Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly(ADPribose) polymerase inhibitor, and pegylated liposomal soxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. J Clin Oncol 2012;30:372-9
    • (2012) J Clin Oncol , vol.30 , pp. 372-379
    • Kaye, S.B.1    Lubinsky, J.2    Matulonis, U.3
  • 21
    • 84859523588 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
    • Ledermann J, Harter P, Gourley C, et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med 2012;366:1382-92
    • (2012) N Engl J Med , vol.366 , pp. 1382-1392
    • Ledermann, J.1    Harter, P.2    Gourley, C.3
  • 22
    • 84908134454 scopus 로고    scopus 로고
    • Combination of cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: A randomized phase 2 study
    • Liu JF, Barry WT, Birrer M, et al. Combination of cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomized phase 2 study. Lancet Oncol 2014;15:1207-14
    • (2014) Lancet Oncol , vol.15 , pp. 1207-1214
    • Liu, J.F.1    Barry, W.T.2    Birrer, M.3
  • 23
    • 84863236347 scopus 로고    scopus 로고
    • A phase i study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas
    • Kummar S, Ji J, Morgan R, et al. A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin Cancer Res 2012;18:1726-34
    • (2012) Clin Cancer Res , vol.18 , pp. 1726-1734
    • Kummar, S.1    Ji, J.2    Morgan, R.3
  • 24
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumors with inhibitors of poly(ADPribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumors with inhibitors of poly(ADPribose) polymerase. Nature 2005;434:913-17
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 25
    • 84899650704 scopus 로고    scopus 로고
    • PARP inhibitors in ovarian cancer: Current status and future promise
    • Liu JF, Konstantinopoulos PA, Matulonis UA. PARP inhibitors in ovarian cancer: current status and future promise. Gynecol Oncol 2014;133:362-9
    • (2014) Gynecol Oncol , vol.133 , pp. 362-369
    • Liu, J.F.1    Konstantinopoulos, P.A.2    Matulonis, U.A.3
  • 26
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-49
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 27
    • 84882238405 scopus 로고    scopus 로고
    • Anti-angiogenic drugs currently in Phase II clinical trials for gynecological cancer treatment
    • Wei XW, Zhang ZR, Wei YQ. Anti-angiogenic drugs currently in Phase II clinical trials for gynecological cancer treatment. Expert Opin Investig Drugs 2013;22:1181-92
    • (2013) Expert Opin Investig Drugs , vol.22 , pp. 1181-1192
    • Wei, X.W.1    Zhang, Z.R.2    Wei, Y.Q.3
  • 28
    • 84873619713 scopus 로고    scopus 로고
    • Targeted anti-vascular therapies for ovarian cancer: Current evidence
    • Hall M, Goulrley C, McNeish I, et al. Targeted anti-vascular therapies for ovarian cancer: current evidence. Br J Cancer 2013;108:250-8
    • (2013) Br J Cancer , vol.108 , pp. 250-258
    • Hall, M.1    Goulrley, C.2    McNeish, I.3
  • 29
    • 79957947131 scopus 로고    scopus 로고
    • Clinical significance of VEGFR-2 and VEGFR-3 expression in ovarian cancer patients
    • Klasa-Mazurkiewicz D, Jarzab M, Milczek T, et al. Clinical significance of VEGFR-2 and VEGFR-3 expression in ovarian cancer patients. Pol J Pathol 2008;62:31-40
    • (2008) Pol J Pathol , vol.62 , pp. 31-40
    • Klasa-Mazurkiewicz, D.1    Jarzab, M.2    Milczek, T.3
  • 30
    • 79959999859 scopus 로고    scopus 로고
    • Immunohistochemical expression of VEGF predicts response to platinum based chemotherapy in patients with epithelial ovarian cancer
    • Siddiqui GK, Maclean AB, Elmasry K, et al. Immunohistochemical expression of VEGF predicts response to platinum based chemotherapy in patients with epithelial ovarian cancer. Angiogenesis 2011;14:155-61
    • (2011) Angiogenesis , vol.14 , pp. 155-161
    • Siddiqui, G.K.1    Maclean, A.B.2    Elmasry, K.3
  • 31
    • 84855425106 scopus 로고    scopus 로고
    • Incorporation of Bevacizumab in the primary treatment of ovarian cancer
    • Burger RA, Brady MF, Bookman MA, et al. Incorporation of Bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 2011;365:2473-83
    • (2011) N Engl J Med , vol.365 , pp. 2473-2483
    • Burger, R.A.1    Brady, M.F.2    Bookman, M.A.3
  • 32
    • 84855466019 scopus 로고    scopus 로고
    • A phase 3 trial of bevacizumab in ovarian cancer
    • Perren TJ, Swart AM, Pfisterer J, et al. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 2011;365:2484-96
    • (2011) N Engl J Med , vol.365 , pp. 2484-2496
    • Perren, T.J.1    Swart, A.M.2    Pfisterer, J.3
  • 33
    • 79951983770 scopus 로고    scopus 로고
    • Disease course patterns after discontinuation of bevacizumab: Pooled analysis of randomized phase III trials
    • Miles D, Harbeck N, Escudier B, et al. Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials. J Clin Oncol 2011;29:83-8
    • (2011) J Clin Oncol , vol.29 , pp. 83-88
    • Miles, D.1    Harbeck, N.2    Escudier, B.3
  • 34
    • 84861736119 scopus 로고    scopus 로고
    • OCEANS: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinumsensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
    • Aghajanian C, Blank SV, Goff BA, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinumsensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 2012;30:2039-45
    • (2012) J Clin Oncol , vol.30 , pp. 2039-2045
    • Aghajanian, C.1    Blank, S.V.2    Goff, B.A.3
  • 35
    • 84899837376 scopus 로고    scopus 로고
    • Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial
    • Pujade-Lauraine E, Hilpert F, Weber B, et al. Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: the AURELIA open-label randomized phase III trial. J Clin Oncol 2014;32:1302-8
    • (2014) J Clin Oncol , vol.32 , pp. 1302-1308
    • Pujade-Lauraine, E.1    Hilpert, F.2    Weber, B.3
  • 36
    • 79953208074 scopus 로고    scopus 로고
    • Bevacizumab in the treatment of ovarian cancer
    • Eskander RN, Randall LM. Bevacizumab in the treatment of ovarian cancer. Biologics 2011;5:1-5
    • (2011) Biologics , vol.5 , pp. 1-5
    • Eskander, R.N.1    Randall, L.M.2
  • 37
    • 70249114453 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and antitumor activity of AMG386 a selective angiopoietin inhibitor in adult patients with advanced solid tumors
    • Herbst RS, Hong D, Chap L, et al. Safety, pharmacokinetics and antitumor activity of AMG386 a selective angiopoietin inhibitor in adult patients with advanced solid tumors. J Clin Oncol 2009;27:3557-65
    • (2009) J Clin Oncol , vol.27 , pp. 3557-3565
    • Herbst, R.S.1    Hong, D.2    Chap, L.3
  • 38
    • 84863012011 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer
    • Karlan BY, Oza AM, Richardson GE, et al. Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer. J Clin Oncol 2012;30:362-71
    • (2012) J Clin Oncol , vol.30 , pp. 362-371
    • Karlan, B.Y.1    Oza, A.M.2    Richardson, G.E.3
  • 39
    • 84903517779 scopus 로고    scopus 로고
    • Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): A randomized, multicentre, double-blind, placebocontrolled phase 3 trial
    • Monk B, Poveda A, Vergote I, et al. Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomized, multicentre, double-blind, placebocontrolled phase 3 trial. Lancet Oncol 2014;15:799-808
    • (2014) Lancet Oncol , vol.15 , pp. 799-808
    • Monk, B.1    Poveda, A.2    Vergote, I.3
  • 40
    • 49649083397 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis
    • Heckman CA, Holopainen T, Wirzenius M, et al. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res 2008;68:4758-62
    • (2008) Cancer Res , vol.68 , pp. 4758-4762
    • Heckman, C.A.1    Holopainen, T.2    Wirzenius, M.3
  • 41
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005;65:4389-400
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 42
    • 84894050019 scopus 로고    scopus 로고
    • Randomised double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum sensitive ovarian cancer: Results of the ICON6 trial [abstract 10]
    • 13 September 2013; Amsterdam, Netherlands
    • Ledermann J, Perren TJ, Raja FA, et al. Randomised double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum sensitive ovarian cancer: results of the ICON6 trial [abstract 10]. 2013 European Cancer Congress; 13 September 2013; Amsterdam, Netherlands
    • (2013) European Cancer Congress
    • Ledermann, J.1    Perren, T.J.2    Raja, F.A.3
  • 43
    • 77956649079 scopus 로고    scopus 로고
    • A Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer
    • Friedlander M, Hancock KC, Rischin D. A Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer. Gynecol Oncol 2010;119:32-7
    • (2010) Gynecol Oncol , vol.119 , pp. 32-37
    • Friedlander, M.1    Hancock, K.C.2    Rischin, D.3
  • 44
    • 84908334026 scopus 로고    scopus 로고
    • Incorporation of pazopanib in maintenance therapy of ovarian cancer
    • duBois A, Floquet A, Kim JW, et al. Incorporation of pazopanib in maintenance therapy of ovarian cancer. J Clin Oncol 2014;32:3374-82
    • (2014) J Clin Oncol , vol.32 , pp. 3374-3382
    • Dubois, A.1    Floquet, A.2    Kim, J.W.3
  • 45
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericytemediated endothelial cell survival mechanisms
    • Erber R, Thurnher A, Katsen AD, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericytemediated endothelial cell survival mechanisms. FASEB J 2004;18:338-40
    • (2004) FASEB J , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 46
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008;68:4774-82
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 47
    • 80053561888 scopus 로고    scopus 로고
    • Randomized phase II placebocontrolled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer
    • Ledermann JA, Hackshaw A, Kaye S, et al. Randomized phase II placebocontrolled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. J Clin Oncol 2011;29:3798-804
    • (2011) J Clin Oncol , vol.29 , pp. 3798-3804
    • Ledermann, J.A.1    Hackshaw, A.2    Kaye, S.3
  • 48
    • 84894046261 scopus 로고    scopus 로고
    • AGO-OVAR 12: A randomized placebo-controlled CGIG/ENGOT - INTERGROUP phase III trial of standard frontline chemotherapy ± nintendanib for advanced ovarian cancer [abstract]
    • du Bois A, Kristensen G, Ray-Coquard I, et al. AGO-OVAR 12: a randomized placebo-controlled CGIG/ENGOT - INTERGROUP phase III trial of standard frontline chemotherapy ± nintendanib for advanced ovarian cancer [abstract]. Int J Gynecol Cancer 2013;23:LBA1
    • (2013) Int J Gynecol Cancer , vol.23 , pp. LBA1
    • Du Bois, A.1    Kristensen, G.2    Ray-Coquard, I.3
  • 49
    • 74549205168 scopus 로고    scopus 로고
    • Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2
    • Annunziata CM, Walker AJ, Minasian L, et al. Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. Clin Cancer Res 2010;16:664-72
    • (2010) Clin Cancer Res , vol.16 , pp. 664-672
    • Annunziata, C.M.1    Walker, A.J.2    Minasian, L.3
  • 50
    • 84893055861 scopus 로고    scopus 로고
    • Novel tyrosine kinase inhibitors for renal cell carcinoma
    • Doff TB, Pal SK, Quinn DI. Novel tyrosine kinase inhibitors for renal cell carcinoma. Expert Rev Clin Pharmacol 2014;7:67-73
    • (2014) Expert Rev Clin Pharmacol , vol.7 , pp. 67-73
    • Doff, T.B.1    Pal, S.K.2    Quinn, D.I.3
  • 51
    • 33748869678 scopus 로고    scopus 로고
    • Pathophysiologic effects of vascular targeting agents and the implications for combination with conventional therapies
    • Horsman MR, Sieman DW. Pathophysiologic effects of vascular targeting agents and the implications for combination with conventional therapies. Cancer Res 2006;66:11520-39
    • (2006) Cancer Res , vol.66 , pp. 11520-11539
    • Horsman, M.R.1    Sieman, D.W.2
  • 52
    • 84873619713 scopus 로고    scopus 로고
    • Targeted anti-vascular therapies for ovarian cancer: Current evidence
    • Hall M, Gourley C, McNeish I, et al. Targeted anti-vascular therapies for ovarian cancer: current evidence. Br J Cancer 2013;108:250
    • (2013) Br J Cancer , vol.108 , pp. 250
    • Hall, M.1    Gourley, C.2    McNeish, I.3
  • 53
    • 79953648492 scopus 로고    scopus 로고
    • Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum resistant ovarian cancer
    • Zweifel M, Jayson GC, Reed NS, et al. Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum resistant ovarian cancer. Ann Oncol 2011;22:2036-41
    • (2011) Ann Oncol , vol.22 , pp. 2036-2041
    • Zweifel, M.1    Jayson, G.C.2    Reed, N.S.3
  • 54
    • 0029127042 scopus 로고
    • Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
    • Bellacosa A, de Feo D, Godwin AK, et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 1995;64:280-5
    • (1995) Int J Cancer , vol.64 , pp. 280-285
    • Bellacosa, A.1    De Feo, D.2    Godwin, A.K.3
  • 55
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 56
    • 77950519173 scopus 로고    scopus 로고
    • Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells
    • Peng DJ, Wang J, Zhou JY, et al. Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells. Biochem Biophys Res Commun 2010;394:600-5
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 600-605
    • Peng, D.J.1    Wang, J.2    Zhou, J.Y.3
  • 57
    • 4143111260 scopus 로고    scopus 로고
    • AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
    • Altomare DA, Wang HQ, Skele KL, et al. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene 2004;25:5853-7
    • (2004) Oncogene , vol.25 , pp. 5853-5857
    • Altomare, D.A.1    Wang, H.Q.2    Skele, K.L.3
  • 58
    • 84863338519 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
    • Janku F, Wheler JJ, Westin SN, et al. PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 2012;30:777-82
    • (2012) J Clin Oncol , vol.30 , pp. 777-782
    • Janku, F.1    Wheler, J.J.2    Westin, S.N.3
  • 59
    • 84922979418 scopus 로고    scopus 로고
    • Phase II trial of the mTOR inhibitor temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: A Gynecologic Oncology Group study
    • Behbakht K, Sill MW, Darcy KM, et al. Phase II trial of the mTOR inhibitor temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study. Gynecol Oncol 2011;115:215-20
    • (2011) Gynecol Oncol , vol.115 , pp. 215-220
    • Behbakht, K.1    Sill, M.W.2    Darcy, K.M.3
  • 60
    • 77954615408 scopus 로고    scopus 로고
    • MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
    • Hirai H, Sootome H, Nakatsuru Y, et al. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 2010;9:1956-67
    • (2010) Mol Cancer Ther , vol.9 , pp. 1956-1967
    • Hirai, H.1    Sootome, H.2    Nakatsuru, Y.3
  • 61
    • 84879607314 scopus 로고    scopus 로고
    • WEE1 tyrosine kinase, a novel epigenetic modifier
    • Mahajan K, Mahajan NP. WEE1 tyrosine kinase, a novel epigenetic modifier. Trends Genet 2013;29:394-402
    • (2013) Trends Genet , vol.29 , pp. 394-402
    • Mahajan, K.1    Mahajan, N.P.2
  • 62
    • 84875980902 scopus 로고    scopus 로고
    • Effect of histone deacetylase inhibitors on cell apoptosis and expression of the tumor suppressor genes RUNX3 and ARHI in ovarian tumors
    • Zhang L, Liu P, Li H. Effect of histone deacetylase inhibitors on cell apoptosis and expression of the tumor suppressor genes RUNX3 and ARHI in ovarian tumors. Mol Med Rep 2013;7:1705-9
    • (2013) Mol Med Rep , vol.7 , pp. 1705-1709
    • Zhang, L.1    Liu, P.2    Li, H.3
  • 63
    • 84863615068 scopus 로고    scopus 로고
    • Phase II activity of belinostat (PXD-101), carboplatin, and paclitaxel in women with previously treated ovarian cancer
    • Dizon S, Damstrup L, Finkler NJ, et al. Phase II activity of belinostat (PXD-101), carboplatin, and paclitaxel in women with previously treated ovarian cancer. Int J Gynecol Cancer 2012;22:979-86
    • (2012) Int J Gynecol Cancer , vol.22 , pp. 979-986
    • Dizon, S.1    Damstrup, L.2    Finkler, N.J.3
  • 64
    • 14644392093 scopus 로고    scopus 로고
    • Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    • Parker N, Turk MJ, Westrick E, et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005;338:284-93
    • (2005) Anal Biochem , vol.338 , pp. 284-293
    • Parker, N.1    Turk, M.J.2    Westrick, E.3
  • 65
    • 0030976709 scopus 로고    scopus 로고
    • Simultaneous activity of two different mechanism of folate transport in ovarian carcinoma cell lines
    • Miotti S, Bagnoli M, Ottone F, et al. Simultaneous activity of two different mechanism of folate transport in ovarian carcinoma cell lines. J Cell Biochem 1997;65:479-91
    • (1997) J Cell Biochem , vol.65 , pp. 479-491
    • Miotti, S.1    Bagnoli, M.2    Ottone, F.3
  • 66
    • 84886092119 scopus 로고    scopus 로고
    • Folate and folate receptor alpha antagonist mechanism of action in ovarian cancer
    • Walters CL, Arend RC, Armstrong DK, et al. Folate and folate receptor alpha antagonist mechanism of action in ovarian cancer. Gynecol Oncol 2013;131:493-8
    • (2013) Gynecol Oncol , vol.131 , pp. 493-498
    • Walters, C.L.1    Arend, R.C.2    Armstrong, D.K.3
  • 67
    • 84891854386 scopus 로고    scopus 로고
    • PRECEDENT: A randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer
    • Naumann RW, Coleman RL, Burger RA, et al. PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer. J Clin Oncol 2013;31:4400-6
    • (2013) J Clin Oncol , vol.31 , pp. 4400-4406
    • Naumann, R.W.1    Coleman, R.L.2    Burger, R.A.3
  • 68
    • 84897043920 scopus 로고    scopus 로고
    • Phase II study of treatment of advanced ovarian cancer with folatereceptor.-targeted therapeutic (vintafolide) and companion SPECTbased imaging agent (99mTc-ertafolide)
    • Morris R, Joyrich RN, Naumann RW, et al. Phase II study of treatment of advanced ovarian cancer with folatereceptor.-targeted therapeutic (vintafolide) and companion SPECTbased imaging agent (99mTc-ertafolide). Ann Oncol 2014;25:852-8
    • (2014) Ann Oncol , vol.25 , pp. 852-858
    • Morris, R.1    Joyrich, R.N.2    Naumann, R.W.3
  • 69
    • 84890631534 scopus 로고    scopus 로고
    • Pralatrexate pharmacology and clinical development
    • Marchi E, Mangone M, Zullo K, et al. Pralatrexate pharmacology and clinical development. Clin Cancer Res 2013;19:6657-61
    • (2013) Clin Cancer Res , vol.19 , pp. 6657-6661
    • Marchi, E.1    Mangone, M.2    Zullo, K.3
  • 70
    • 84858159292 scopus 로고    scopus 로고
    • Heat shock protein 90 is a putative therapeutic target in patients with recurrent advanced-stage ovarian carcinoma with serous effusions
    • Elstrand MB, Stavnes HT, Tropè CG, et al. Heat shock protein 90 is a putative therapeutic target in patients with recurrent advanced-stage ovarian carcinoma with serous effusions. Hum Pathol 2012;43:529-35
    • (2012) Hum Pathol , vol.43 , pp. 529-535
    • Elstrand, M.B.1    Stavnes, H.T.2    Tropè, C.G.3
  • 71
    • 0038377853 scopus 로고    scopus 로고
    • Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries
    • Elpek GO, Karaveli S, Simsek T, et al. Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries. APMIS 2003;111:523-30
    • (2003) APMIS , vol.111 , pp. 523-530
    • Elpek, G.O.1    Karaveli, S.2    Simsek, T.3
  • 72
    • 84896511103 scopus 로고    scopus 로고
    • Ganetespib and HSP90: Translating preclinical activity into clinical promise
    • Proia DA, Bates RC. Ganetespib and HSP90: translating preclinical activity into clinical promise. Cancer Res 2014;74:1294-300
    • (2014) Cancer Res , vol.74 , pp. 1294-1300
    • Proia, D.A.1    Bates, R.C.2
  • 73
    • 23844521568 scopus 로고    scopus 로고
    • The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615. HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
    • Graff JR, McNulty AM, Hanna KR, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005;65:7462-9
    • (2005) Cancer Res , vol.65 , pp. 7462-7469
    • Graff, J.R.1    McNulty, A.M.2    Hanna, K.R.3
  • 74
    • 77953398189 scopus 로고    scopus 로고
    • Combination of enzastaurin and pemetrexed inhibits cell growth and induces apoptosis of chemoresistant ovarian cancer cells regulating extracellular signal-regulated kinase 1/2 phosphorylation
    • Bräutigam K, Bauerschlag DO, Weigel MT, et al. Combination of enzastaurin and pemetrexed inhibits cell growth and induces apoptosis of chemoresistant ovarian cancer cells regulating extracellular signal-regulated kinase 1/2 phosphorylation. Transl Oncol 2009;2:164-73
    • (2009) Transl Oncol , vol.2 , pp. 164-173
    • Bräutigam, K.1    Bauerschlag, D.O.2    Weigel, M.T.3
  • 75
    • 36549083728 scopus 로고    scopus 로고
    • A phase i safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors
    • Camidge DR, Gail Eckhardt S, Gore L, et al. A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors. Anticancer Drugs 2008;19:77-84
    • (2008) Anticancer Drugs , vol.19 , pp. 77-84
    • Camidge, D.R.1    Gail Eckhardt, S.2    Gore, L.3
  • 76
    • 85026149526 scopus 로고    scopus 로고
    • Carboplatin and paclitaxel in combination with oral enzastaurin in advanced ovarian or primary peritoneal cancer: Results from a safety lead-in study
    • Vergote I, Amant F, Oskay-Oezcelik G, et al. Carboplatin and paclitaxel in combination with oral enzastaurin in advanced ovarian or primary peritoneal cancer: results from a safety lead-in study. Int J Gynecol Cancer 2009;19:1505-10
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 1505-1510
    • Vergote, I.1    Amant, F.2    Oskay-Oezcelik, G.3
  • 77
    • 84964313307 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of weekly paclitaxel and saracatinib (AZD0530) in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer
    • McNeish IA, Ledermann JA, Webber L, et al. A randomized, placebo-controlled trial of weekly paclitaxel and saracatinib (AZD0530) in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer. Ann Oncol 2014;25:1988-95
    • (2014) Ann Oncol , vol.25 , pp. 1988-1995
    • McNeish, I.A.1    Ledermann, J.A.2    Webber, L.3
  • 78
    • 84893363781 scopus 로고    scopus 로고
    • Antibody-based immunotherapy for ovarian cancer: Where are we at?
    • Tse CW, Collins A, Oelher MK, et al. Antibody-based immunotherapy for ovarian cancer: where are we at? Ann Oncol 2014;25:322-31
    • (2014) Ann Oncol , vol.25 , pp. 322-331
    • Tse, C.W.1    Collins, A.2    Oelher, M.K.3
  • 79
    • 84896845396 scopus 로고    scopus 로고
    • Therapeutic vaccines and cancer: Focus on DPX-0907
    • Karkada M, Berinstein N, Mansour M, et al. Therapeutic vaccines and cancer: focus on DPX-0907. Biologics 2014;8:27-38
    • (2014) Biologics , vol.8 , pp. 27-38
    • Karkada, M.1    Berinstein, N.2    Mansour, M.3
  • 80
    • 33749256649 scopus 로고    scopus 로고
    • Structural, functional and therapeutic biology of survivin
    • Sah NK, Khan Z, Khan GJ, Bisen PS. Structural, functional and therapeutic biology of survivin. Cancer Lett 2006;244:164-71
    • (2006) Cancer Lett , vol.244 , pp. 164-171
    • Sah, N.K.1    Khan, Z.2    Khan, G.J.3    Bisen, P.S.4
  • 81
    • 78649369270 scopus 로고    scopus 로고
    • Trovax, a recombinant modified vaccinia Ankara virus encoding 5T4. Lesson learned and future development
    • Won Kim D, Krishnamurthy V, Bines SD, et al. Trovax, a recombinant modified vaccinia Ankara virus encoding 5T4. Lesson learned and future development. Hum Vaccin 2010;6:784-91
    • (2010) Hum Vaccin , vol.6 , pp. 784-791
    • Won Kim, D.1    Krishnamurthy, V.2    Bines, S.D.3
  • 82
    • 84977097620 scopus 로고    scopus 로고
    • A phase 2, single-arm study of an autologus dendritic cell treatment against mucin 1 in patients with advanced epithelial ovarian cancer
    • Mitchell PL, Quinn MA, Grant PT, et al. A phase 2, single-arm study of an autologus dendritic cell treatment against mucin 1 in patients with advanced epithelial ovarian cancer. J Immunother Cancer 2014;2:16
    • (2014) J Immunother Cancer , vol.2 , pp. 16
    • Mitchell, P.L.1    Quinn, M.A.2    Grant, P.T.3
  • 83
    • 79251472492 scopus 로고    scopus 로고
    • Review of catumaxomab in the treatment of malignant ascites
    • Sebastian M. Review of catumaxomab in the treatment of malignant ascites. Cancer Manag Res 2010;2:283-6
    • (2010) Cancer Manag Res , vol.2 , pp. 283-286
    • Sebastian, M.1
  • 84
    • 77954676136 scopus 로고    scopus 로고
    • The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial
    • Heiss MM, Murawa P, Koralewski P. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: results of a prospective randomized phase II/III trial. Int J Cancer 2010;127:2209-21
    • (2010) Int J Cancer , vol.127 , pp. 2209-2221
    • Heiss, M.M.1    Murawa, P.2    Koralewski, P.3
  • 85
    • 34447132202 scopus 로고    scopus 로고
    • Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti-CD3 antibody: A phase I/II study
    • Burges A, Wimberger P, Kumper C, et al. Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti-CD3 antibody: a phase I/II study. Clin Cancer Res 2007;13:3899-905
    • (2007) Clin Cancer Res , vol.13 , pp. 3899-3905
    • Burges, A.1    Wimberger, P.2    Kumper, C.3
  • 86
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 87
    • 84905753981 scopus 로고    scopus 로고
    • Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum resistant ovarian cancer
    • abstract 5511
    • Hamanishi J, Mandani M, Ikeda T, et al. Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum resistant ovarian cancer. J Clin Oncol 2014;32(5s Suppl):abstract 5511
    • (2014) J Clin Oncol , vol.32 , Issue.5 S
    • Hamanishi, J.1    Mandani, M.2    Ikeda, T.3
  • 88
    • 84901236250 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase mediates immuneindependent human tumor cell resistance to olaparib, gamma radiation, and cisplatin
    • Maleki Vareki S, Rytelewski M, Figueredo R, et al. Indoleamine 2,3-dioxygenase mediates immuneindependent human tumor cell resistance to olaparib, gamma radiation, and cisplatin. Oncotarget 2014;5:2778-91
    • (2014) Oncotarget , vol.5 , pp. 2778-2791
    • Maleki Vareki, S.1    Rytelewski, M.2    Figueredo, R.3
  • 89
    • 84920267480 scopus 로고    scopus 로고
    • Lurbinectedin (PM01183), an active compound in platinum-resistant/refractory ovarian cancer (PRROC) patients: Results of a two-stage, controlled phase II study
    • abstract 5505
    • Poveda A, Berton-Rigaud D, Ray-Coquard IR, et al. Lurbinectedin (PM01183), an active compound in platinum-resistant/refractory ovarian cancer (PRROC) patients: results of a two-stage, controlled phase II study. J Clin Oncol 2014;32(5s Suppl):abstract 5505
    • (2014) J Clin Oncol , vol.32 , Issue.5 S
    • Poveda, A.1    Berton-Rigaud, D.2    Ray-Coquard, I.R.3
  • 90
    • 36048974673 scopus 로고    scopus 로고
    • Lessons from BRCA: The tubal fimbria emerges an origin for pelvic serous cancer
    • Crum CP, Drapkin R, Kindelberger D, et al. Lessons from BRCA: the tubal fimbria emerges an origin for pelvic serous cancer. Clin Med Res 2007;5:35-44
    • (2007) Clin Med Res , vol.5 , pp. 35-44
    • Crum, C.P.1    Drapkin, R.2    Kindelberger, D.3
  • 92
    • 84893636462 scopus 로고    scopus 로고
    • New perspectives in ovarian cancer treatment
    • Schmid BC, Oehler MK. New perspectives in ovarian cancer treatment. Maturitas 2014;77:128-36
    • (2014) Maturitas , vol.77 , pp. 128-136
    • Schmid, B.C.1    Oehler, M.K.2
  • 93
    • 84964314560 scopus 로고    scopus 로고
    • The combination of circulating ang1 and tie2 levels predicts progression-free survival advantage in bevacizumab-treated patients with ovarian cancer
    • Backen A, Renehan AG, Clamp AR. The combination of circulating ang1 and tie2 levels predicts progression-free survival advantage in bevacizumab-treated patients with ovarian cancer. Clin Cancer Res 2014;20:4549-58
    • (2014) Clin Cancer Res , vol.20 , pp. 4549-4558
    • Backen, A.1    Renehan, A.G.2    Clamp, A.R.3
  • 94
    • 84908319663 scopus 로고    scopus 로고
    • Molecular subgroup of high-grade serous ovarian cancer (HGSOC) as a predictor of outcome following bevacizumab
    • abstract 5502
    • Gourley C, McCavigan A, Perren T, et al. Molecular subgroup of high-grade serous ovarian cancer (HGSOC) as a predictor of outcome following bevacizumab. J Clin Oncol 2014;32(5s Suppl):abstract 5502
    • (2014) J Clin Oncol , vol.32 , Issue.5 S
    • Gourley, C.1    McCavigan, A.2    Perren, T.3
  • 95
    • 84876323703 scopus 로고    scopus 로고
    • Aberrant lipid metabolism: An emerging diagnostic and therapeutic target in ovarian cancer
    • Pyragius CE, Fuller M, Ricciardelli C, et al. Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer. Int J Mol Sci 2013;14:7742-56
    • (2013) Int J Mol Sci , vol.14 , pp. 7742-7756
    • Pyragius, C.E.1    Fuller, M.2    Ricciardelli, C.3
  • 96
    • 84898448687 scopus 로고    scopus 로고
    • A phase II study of pazopanib in recurrent or persistent ovarian (EOC), peritoneal (PPC), or Fallopian tube cancer (FTC): A Spanish Ovarian Cancer Group (GEICO) study
    • abstract 5068
    • Oaknin A, Gonzalez-Martin A, García Y, et al. A phase II study of pazopanib in recurrent or persistent ovarian (EOC), peritoneal (PPC), or Fallopian tube cancer (FTC): A Spanish Ovarian Cancer Group (GEICO) study. J Clin Oncol 2012;30(Suppl):abstract 5068
    • (2012) J Clin Oncol , vol.30
    • Oaknin, A.1    Gonzalez-Martin, A.2    García, Y.3
  • 97
    • 73949123481 scopus 로고    scopus 로고
    • Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer
    • Matulonis UM, Berlin S, Ivy P, et al. Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer. J Clin Oncol 2009;27:5601-6
    • (2009) J Clin Oncol , vol.27 , pp. 5601-5606
    • Matulonis, U.M.1    Berlin, S.2    Ivy, P.3
  • 98
    • 79951988792 scopus 로고    scopus 로고
    • Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: A gynecologic oncology group trial
    • Matei D, Sill MW, Lankes HA, et al. Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trial. J Clin Oncol 2011;29:69-75
    • (2011) J Clin Oncol , vol.29 , pp. 69-75
    • Matei, D.1    Sill, M.W.2    Lankes, H.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.