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Volumn 3 OCT, Issue , 2013, Pages

The role of PARP inhibitors in the treatment of gynecologic malignancies

Author keywords

Cervical cancer; Endometrial cancer; Niraparib; Olaparib; Ovarian cancer; PARP inhibitor; Rucaparib; Veliparib

Indexed keywords

BEVACIZUMAB; BIOLOGICAL MARKER; BRCA1 PROTEIN; BRCA2 PROTEIN; BUPARLISIB; CARBOPLATIN; CEDIRANIB; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLOXURIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NIRAPARIB; OLAPARIB; PACLITAXEL; PLACEBO; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RUCAPARIB; TEMOZOLOMIDE; TOPOTECAN; VELIPARIB;

EID: 84891068902     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00237     Document Type: Review
Times cited : (58)

References (114)
  • 1
    • 84872967522 scopus 로고    scopus 로고
    • Cancer statistics, 2013
    • doi:10.3322/caac.21166
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin (2013) 63(1):11-30. doi:10.3322/caac.21166
    • (2013) CA Cancer J Clin , vol.63 , Issue.1 , pp. 11-30
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 2
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • doi:10.1038/nature03445
    • Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature (2005) 434(7035):917-21. doi:10.1038/nature03445
    • (2005) Nature , vol.434 , Issue.7035 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6
  • 3
    • 0032938458 scopus 로고    scopus 로고
    • Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage
    • doi:10.1093/carcin/20.2.199
    • Boulton S, Kyle S, Durkacz BW. Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage. Carcinogenesis (1999) 20(2):199-203. doi:10.1093/carcin/20.2.199
    • (1999) Carcinogenesis , vol.20 , Issue.2 , pp. 199-203
    • Boulton, S.1    Kyle, S.2    Durkacz, B.W.3
  • 4
    • 0022415192 scopus 로고
    • Strand breaks arising from the repair of the 5-bromodeoxyuridine-substituted template and methyl methanesulphonate-induced lesions can explain the formation of sister chromatid exchanges
    • doi:10.1007/BF00348697
    • Saffhill R, Ockey CH. Strand breaks arising from the repair of the 5-bromodeoxyuridine-substituted template and methyl methanesulphonate-induced lesions can explain the formation of sister chromatid exchanges. Chromosoma (1985) 92(3):218-24. doi:10.1007/BF00348697
    • (1985) Chromosoma , vol.92 , Issue.3 , pp. 218-224
    • Saffhill, R.1    Ockey, C.H.2
  • 5
    • 84873888067 scopus 로고    scopus 로고
    • Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents
    • doi:10.1016/j.trsl.2012.09.003
    • Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, et al. Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents. Transl Res (2013) 161(3):156-64. doi:10.1016/j.trsl.2012.09.003
    • (2013) Transl Res , vol.161 , Issue.3 , pp. 156-164
    • Duan, W.1    Gao, L.2    Zhao, W.3    Leon, M.4    Sadee, W.5    Webb, A.6
  • 6
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
    • doi:10.1158/0008-5472.CAN-06-0140
    • McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res (2006) 66(16):8109-15. doi:10.1158/0008-5472.CAN-06-0140
    • (2006) Cancer Res , vol.66 , Issue.16 , pp. 8109-8115
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3    Kluzek, K.4    Bialkowska, A.5    Swift, S.6
  • 7
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • doi:10.1038/nrc1457
    • Turner N, Tutt A, Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer (2004) 4(10):814-9. doi:10.1038/nrc1457
    • (2004) Nat Rev Cancer , vol.4 , Issue.10 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 8
    • 34249006299 scopus 로고    scopus 로고
    • ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
    • doi:10.1158/1078-0432.CCR-06-3039
    • Donawho CK, Luo Y, Luo Y, Penning TD, Bauch JL, Bouska JJ, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res (2007) 13(9):2728-37. doi:10.1158/1078-0432.CCR-06-3039
    • (2007) Clin Cancer Res , vol.13 , Issue.9 , pp. 2728-2737
    • Donawho, C.K.1    Luo, Y.2    Luo, Y.3    Penning, T.D.4    Bauch, J.L.5    Bouska, J.J.6
  • 9
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • doi:10.1016/S0092-8674(00)81780-8
    • Stambolic V, Suzuki A, dela Pompa JL, Brothers GM, Mirtsos C, Sasaki T, et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 95(1):29-39. doi:10.1016/S0092-8674(00)81780-8
    • (1998) Cell , vol.95 , Issue.1 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    Dela Pompa, J.L.3    Brothers, G.M.4    Mirtsos, C.5    Sasaki, T.6
  • 10
    • 0032431032 scopus 로고    scopus 로고
    • The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
    • doi:10.1073/pnas.95.26.15587
    • Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1998) 95(26):15587-91. doi:10.1073/pnas.95.26.15587
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.26 , pp. 15587-15591
    • Wu, X.1    Senechal, K.2    Neshat, M.S.3    Whang, Y.E.4    Sawyers, C.L.5
  • 11
    • 77149157867 scopus 로고    scopus 로고
    • Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
    • doi:10.1002/emmm.200900041
    • Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim JS, et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med (2009) 1(6-7):315-22. doi:10.1002/emmm.200900041
    • (2009) EMBO Mol Med , vol.1 , Issue.6-7 , pp. 315-322
    • Mendes-Pereira, A.M.1    Martin, S.A.2    Brough, R.3    McCarthy, A.4    Taylor, J.R.5    Kim, J.S.6
  • 12
    • 77958049428 scopus 로고    scopus 로고
    • PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors
    • doi:10.1126/scitranslmed.3001538
    • Dedes KJ, Wetterskog D, Mendes-Pereira AM, Natrajan R, Lambros MB, Geyer FC, et al. PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. Sci Transl Med (2010) 2(53):53ra75. doi:10.1126/scitranslmed.3001538
    • (2010) Sci Transl Med , vol.2 , Issue.53
    • Dedes, K.J.1    Wetterskog, D.2    Mendes-Pereira, A.M.3    Natrajan, R.4    Lambros, M.B.5    Geyer, F.C.6
  • 13
    • 77954358148 scopus 로고    scopus 로고
    • PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors
    • doi:10.1158/0008-5472.CAN-09-4295
    • McEllin B, Camacho CV, Mukherjee B, Hahm B, Tomimatsu N, Bachoo RM, et al. PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. Cancer Res (2010) 70(13):5457-64. doi:10.1158/0008-5472.CAN-09-4295
    • (2010) Cancer Res , vol.70 , Issue.13 , pp. 5457-5464
    • McEllin, B.1    Camacho, C.V.2    Mukherjee, B.3    Hahm, B.4    Tomimatsu, N.5    Bachoo, R.M.6
  • 14
    • 84876016461 scopus 로고    scopus 로고
    • Mammalian base excision repair: the forgotten archangel
    • doi:10.1093/nar/gkt076
    • Dianov GL, Hubscher U. Mammalian base excision repair: the forgotten archangel. Nucleic Acids Res (2013) 41(6):3483-90. doi:10.1093/nar/gkt076
    • (2013) Nucleic Acids Res , vol.41 , Issue.6 , pp. 3483-3490
    • Dianov, G.L.1    Hubscher, U.2
  • 15
    • 84868035470 scopus 로고    scopus 로고
    • Rules of engagement for base excision repair in chromatin
    • doi:10.1002/jcp.24134
    • Odell ID, Wallace SS, Pederson DS. Rules of engagement for base excision repair in chromatin. J Cell Physiol (2013) 228(2):258-66. doi:10.1002/jcp.24134
    • (2013) J Cell Physiol , vol.228 , Issue.2 , pp. 258-266
    • Odell, I.D.1    Wallace, S.S.2    Pederson, D.S.3
  • 16
    • 0024197767 scopus 로고
    • Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes
    • doi:10.1016/0065-2571(88)90028-3
    • Carson DA, Carrera CJ, Wasson DB, Yamanaka H. Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes. Adv Enzyme Regul (1988) 27:395-404. doi:10.1016/0065-2571(88)90028-3
    • (1988) Adv Enzyme Regul , vol.27 , pp. 395-404
    • Carson, D.A.1    Carrera, C.J.2    Wasson, D.B.3    Yamanaka, H.4
  • 18
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • doi:10.1093/nar/gkl840
    • Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, et al. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res (2006) 34(21):6170-82. doi:10.1093/nar/gkl840
    • (2006) Nucleic Acids Res , vol.34 , Issue.21 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Wu, W.3    Rosidi, B.4    Zhang, L.5    Wang, H.6
  • 19
    • 38149057387 scopus 로고    scopus 로고
    • PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
    • doi:10.1074/jbc.M706734200
    • Haince JF, McDonald D, Rodrigue A, Dery U, Masson JY, Hendzel MJ, et al. PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem (2008) 283(2):1197-208. doi:10.1074/jbc.M706734200
    • (2008) J Biol Chem , vol.283 , Issue.2 , pp. 1197-1208
    • Haince, J.F.1    McDonald, D.2    Rodrigue, A.3    Dery, U.4    Masson, J.Y.5    Hendzel, M.J.6
  • 20
    • 0142209189 scopus 로고    scopus 로고
    • In vivo reversion to normal of inherited mutations in humans
    • doi:10.1136/jmg.40.10.721
    • Hirschhorn R. In vivo reversion to normal of inherited mutations in humans. J Med Genet (2003) 40(10):721-8. doi:10.1136/jmg.40.10.721
    • (2003) J Med Genet , vol.40 , Issue.10 , pp. 721-728
    • Hirschhorn, R.1
  • 21
    • 0002160618 scopus 로고
    • Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
    • doi:10.1016/0006-291X(63)90024-X
    • Chambon P, Weill JD, Mandel P. Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. Biochem Biophys Res Commun (1963) 11:39-43. doi:10.1016/0006-291X(63)90024-X
    • (1963) Biochem Biophys Res Commun , vol.11 , pp. 39-43
    • Chambon, P.1    Weill, J.D.2    Mandel, P.3
  • 22
    • 0018906390 scopus 로고
    • (ADP-ribose)n participates in DNA excision repair
    • doi:10.1038/283593a0
    • Durkacz BW, Omidiji O, Gray DA, Shall S. (ADP-ribose)n participates in DNA excision repair. Nature (1980) 283(5747):593-6. doi:10.1038/283593a0
    • (1980) Nature , vol.283 , Issue.5747 , pp. 593-596
    • Durkacz, B.W.1    Omidiji, O.2    Gray, D.A.3    Shall, S.4
  • 23
    • 0028989014 scopus 로고
    • trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon
    • Kupper JH, Muller M, Jacobson MK, Tatsumi-Miyajima J, Coyle DL, Jacobson EL, et al. trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon. Mol Cell Biol (1995) 15(6):3154-63.
    • (1995) Mol Cell Biol , vol.15 , Issue.6 , pp. 3154-3163
    • Kupper, J.H.1    Muller, M.2    Jacobson, M.K.3    Tatsumi-Miyajima, J.4    Coyle, D.L.5    Jacobson, E.L.6
  • 24
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • doi:10.1038/nature03443
    • Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature (2005) 434(7035):913-7. doi:10.1038/nature03443
    • (2005) Nature , vol.434 , Issue.7035 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3    Parker, K.M.4    Flower, D.5    Lopez, E.6
  • 25
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • doi:10.1056/NEJMoa0900212
    • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med (2009) 361(2):123-34. doi:10.1056/NEJMoa0900212
    • (2009) N Engl J Med , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 26
    • 23344444636 scopus 로고    scopus 로고
    • Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
    • doi:10.1128/MCB.25.16.7158-7169.2005
    • Saleh-Gohari N, Bryant HE, Schultz N, Parker KM, Cassel TN, Helleday T. Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol (2005) 25(16):7158-69. doi:10.1128/MCB.25.16.7158-7169.2005
    • (2005) Mol Cell Biol , vol.25 , Issue.16 , pp. 7158-7169
    • Saleh-Gohari, N.1    Bryant, H.E.2    Schultz, N.3    Parker, K.M.4    Cassel, T.N.5    Helleday, T.6
  • 27
    • 84872068762 scopus 로고    scopus 로고
    • BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma
    • doi:10.1002/cncr.27720
    • Pennington KP, Walsh T, Lee M, Pennil C, Novetsky AP, Agnew KJ, et al. BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma. Cancer (2013) 119(2):332-8. doi:10.1002/cncr.27720
    • (2013) Cancer , vol.119 , Issue.2 , pp. 332-338
    • Pennington, K.P.1    Walsh, T.2    Lee, M.3    Pennil, C.4    Novetsky, A.P.5    Agnew, K.J.6
  • 28
    • 84868221110 scopus 로고    scopus 로고
    • Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
    • doi:10.1158/0008-5472.CAN-12-2753
    • Murai J, Huang SY, Das BB, Renaud A, Zhang Y, Doroshow JH, et al. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res (2012) 72(21):5588-99. doi:10.1158/0008-5472.CAN-12-2753
    • (2012) Cancer Res , vol.72 , Issue.21 , pp. 5588-5599
    • Murai, J.1    Huang, S.Y.2    Das, B.B.3    Renaud, A.4    Zhang, Y.5    Doroshow, J.H.6
  • 29
    • 30744445981 scopus 로고    scopus 로고
    • Hereditary breast and ovarian cancer: review and future perspectives
    • doi:10.1007/s00109-005-0696-7
    • Lux MP, Fasching PA, Beckmann MW. Hereditary breast and ovarian cancer: review and future perspectives. J Mol Med (Berl) (2006) 84(1):16-28. doi:10.1007/s00109-005-0696-7
    • (2006) J Mol Med (Berl) , vol.84 , Issue.1 , pp. 16-28
    • Lux, M.P.1    Fasching, P.A.2    Beckmann, M.W.3
  • 30
    • 81055126264 scopus 로고    scopus 로고
    • Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing
    • doi:10.1073/pnas.1115052108
    • Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, et al. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc Natl Acad Sci U S A (2011) 108(44):18032-7. doi:10.1073/pnas.1115052108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.44 , pp. 18032-18037
    • Walsh, T.1    Casadei, S.2    Lee, M.K.3    Pennil, C.C.4    Nord, A.S.5    Thornton, A.M.6
  • 31
    • 0028006563 scopus 로고
    • Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
    • doi:10.1126/science.8091231
    • Wooster R, Neuhausen SL, Mangion J, Quirk Y, Ford D, Collins N, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science (1994) 265(5181):2088-90. doi:10.1126/science.8091231
    • (1994) Science , vol.265 , Issue.5181 , pp. 2088-2090
    • Wooster, R.1    Neuhausen, S.L.2    Mangion, J.3    Quirk, Y.4    Ford, D.5    Collins, N.6
  • 32
    • 45149094267 scopus 로고    scopus 로고
    • Basal-like breast cancer: a critical review
    • doi:10.1200/JCO.2007.13.1748
    • Rakha EA, Reis-Filho JS, Ellis IO. Basal-like breast cancer: a critical review. J Clin Oncol (2008) 26(15):2568-81. doi:10.1200/JCO.2007.13.1748
    • (2008) J Clin Oncol , vol.26 , Issue.15 , pp. 2568-2581
    • Rakha, E.A.1    Reis-Filho, J.S.2    Ellis, I.O.3
  • 34
    • 0031881833 scopus 로고    scopus 로고
    • Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1
    • Aida H, Takakuwa K, Nagata H, Tsuneki I, Takano M, Tsuji S, et al. Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1. Clin Cancer Res (1998) 4(1):235-40.
    • (1998) Clin Cancer Res , vol.4 , Issue.1 , pp. 235-240
    • Aida, H.1    Takakuwa, K.2    Nagata, H.3    Tsuneki, I.4    Takano, M.5    Tsuji, S.6
  • 35
    • 0032608379 scopus 로고    scopus 로고
    • A population-based study of BRCA1 and BRCA2 mutations in Jewish women with epithelial ovarian cancer
    • doi:10.1016/S0029-7844(98)00362-7
    • Lu KH, Cramer DW, Muto MG, Li EY, Niloff J, Mok SC. A population-based study of BRCA1 and BRCA2 mutations in Jewish women with epithelial ovarian cancer. Obstet Gynecol (1999) 93(1):34-7. doi:10.1016/S0029-7844(98)00362-7
    • (1999) Obstet Gynecol , vol.93 , Issue.1 , pp. 34-37
    • Lu, K.H.1    Cramer, D.W.2    Muto, M.G.3    Li, E.Y.4    Niloff, J.5    Mok, S.C.6
  • 36
    • 10544220023 scopus 로고    scopus 로고
    • Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1
    • doi:10.1056/NEJM199611073351901
    • Rubin SC, Benjamin I, Behbakht K, Takahashi H, Morgan MA, LiVolsi VA, et al. Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1. N Engl J Med (1996) 335(19):1413-6. doi:10.1056/NEJM199611073351901
    • (1996) N Engl J Med , vol.335 , Issue.19 , pp. 1413-1416
    • Rubin, S.C.1    Benjamin, I.2    Behbakht, K.3    Takahashi, H.4    Morgan, M.A.5    LiVolsi, V.A.6
  • 37
    • 0031803226 scopus 로고    scopus 로고
    • Response to radiation therapy and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations
    • doi:10.1016/S0167-8140(98)00023-1
    • Gaffney DK, Brohet RM, Lewis CM, Holden JA, Buys SS, Neuhausen SL, et al. Response to radiation therapy and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations. Radiother Oncol (1998) 47(2):129-36. doi:10.1016/S0167-8140(98)00023-1
    • (1998) Radiother Oncol , vol.47 , Issue.2 , pp. 129-136
    • Gaffney, D.K.1    Brohet, R.M.2    Lewis, C.M.3    Holden, J.A.4    Buys, S.S.5    Neuhausen, S.L.6
  • 38
    • 17444448154 scopus 로고    scopus 로고
    • Survival of BRCA1 breast and ovarian cancer patients: a population-based study from southern Sweden
    • Johannsson OT, Ranstam J, Borg A, Olsson H. Survival of BRCA1 breast and ovarian cancer patients: a population-based study from southern Sweden. J Clin Oncol (1998) 16(2):397-404.
    • (1998) J Clin Oncol , vol.16 , Issue.2 , pp. 397-404
    • Johannsson, O.T.1    Ranstam, J.2    Borg, A.3    Olsson, H.4
  • 40
    • 17344392776 scopus 로고    scopus 로고
    • Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1
    • doi:10.1016/S0140-6736(97)07065-7
    • Verhoog LC, Brekelmans CT, Seynaeve C, van den Bosch LM, Dahmen G, van Geel AN, et al. Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1. Lancet (1998) 351(9099):316-21. doi:10.1016/S0140-6736(97)07065-7
    • (1998) Lancet , vol.351 , Issue.9099 , pp. 316-321
    • Verhoog, L.C.1    Brekelmans, C.T.2    Seynaeve, C.3    Van Den Bosch, L.M.4    Dahmen, G.5    Van Geel, A.N.6
  • 41
    • 33847668823 scopus 로고    scopus 로고
    • Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1-and non-BRCA1/2 families as compared to sporadic breast cancer cases
    • doi:10.1016/j.ejca.2006.12.009
    • Brekelmans CT, Tilanus-Linthorst MM, Seynaeve C, vd Ouweland A, Menke-Pluymers MB, Bartels CC, et al. Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1-and non-BRCA1/2 families as compared to sporadic breast cancer cases. Eur J Cancer (2007) 43(5):867-76. doi:10.1016/j.ejca.2006.12.009
    • (2007) Eur J Cancer , vol.43 , Issue.5 , pp. 867-876
    • Brekelmans, C.T.1    Tilanus-Linthorst, M.M.2    Seynaeve, C.3    Vd Ouweland, A.4    Menke-Pluymers, M.B.5    Bartels, C.C.6
  • 42
    • 34447303102 scopus 로고    scopus 로고
    • Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations
    • doi:10.1056/NEJMoa070608
    • Rennert G, Bisland-Naggan S, Barnett-Griness O, Bar-Joseph N, Zhang S, Rennert HS, et al. Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. N Engl J Med (2007) 357(2):115-23. doi:10.1056/NEJMoa070608
    • (2007) N Engl J Med , vol.357 , Issue.2 , pp. 115-123
    • Rennert, G.1    Bisland-Naggan, S.2    Barnett-Griness, O.3    Bar-Joseph, N.4    Zhang, S.5    Rennert, H.S.6
  • 43
    • 68949127264 scopus 로고    scopus 로고
    • Sensitivity to first-line chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers
    • doi:10.1200/JCO.2008.19.9067
    • Kriege M, Seynaeve C, Meijers-Heijboer H, Collee JM, Menke-Pluymers MB, Bartels CC, et al. Sensitivity to first-line chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol (2009) 27(23):3764-71. doi:10.1200/JCO.2008.19.9067
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3764-3771
    • Kriege, M.1    Seynaeve, C.2    Meijers-Heijboer, H.3    Collee, J.M.4    Menke-Pluymers, M.B.5    Bartels, C.C.6
  • 44
    • 62649111685 scopus 로고    scopus 로고
    • Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia
    • doi:10.1186/1471-2407-9-62
    • Budroni M, Cesaraccio R, Coviello V, Sechi O, Pirino D, Cossu A, et al. Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia. BMC Cancer (2009) 9:62. doi:10.1186/1471-2407-9-62
    • (2009) BMC Cancer , vol.9 , pp. 62
    • Budroni, M.1    Cesaraccio, R.2    Coviello, V.3    Sechi, O.4    Pirino, D.5    Cossu, A.6
  • 45
    • 55949089955 scopus 로고    scopus 로고
    • New insights into the pathogenesis of serous ovarian cancer and its clinical impact
    • doi:10.1200/JCO.2008.18.1107
    • Levanon K, Crum C, Drapkin R. New insights into the pathogenesis of serous ovarian cancer and its clinical impact. J Clin Oncol (2008) 26(32):5284-93. doi:10.1200/JCO.2008.18.1107
    • (2008) J Clin Oncol , vol.26 , Issue.32 , pp. 5284-5293
    • Levanon, K.1    Crum, C.2    Drapkin, R.3
  • 46
    • 57149093237 scopus 로고    scopus 로고
    • "BRCAness" syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations
    • doi:10.1200/JCO.2008.16.1703
    • Tan DS, Rothermundt C, Thomas K, Bancroft E, Eeles R, Shanley S, et al. "BRCAness" syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations. J Clin Oncol (2008) 26(34):5530-6. doi:10.1200/JCO.2008.16.1703
    • (2008) J Clin Oncol , vol.26 , Issue.34 , pp. 5530-5536
    • Tan, D.S.1    Rothermundt, C.2    Thomas, K.3    Bancroft, E.4    Eeles, R.5    Shanley, S.6
  • 47
    • 0037403380 scopus 로고    scopus 로고
    • Improved survival in women with BRCA-associated ovarian carcinoma
    • doi:10.1002/cncr.11310
    • Cass I, Baldwin RL, Varkey T, Moslehi R, Narod SA, Karlan BY. Improved survival in women with BRCA-associated ovarian carcinoma. Cancer (2003) 97(9):2187-95. doi:10.1002/cncr.11310
    • (2003) Cancer , vol.97 , Issue.9 , pp. 2187-2195
    • Cass, I.1    Baldwin, R.L.2    Varkey, T.3    Moslehi, R.4    Narod, S.A.5    Karlan, B.Y.6
  • 48
    • 19744368302 scopus 로고    scopus 로고
    • Cancer of the ovary
    • doi:10.1056/NEJMra041842
    • Cannistra SA. Cancer of the ovary. N Engl J Med (2004) 351(24):2519-29. doi:10.1056/NEJMra041842
    • (2004) N Engl J Med , vol.351 , Issue.24 , pp. 2519-2529
    • Cannistra, S.A.1
  • 49
    • 77954032829 scopus 로고    scopus 로고
    • Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
    • doi:10.1200/JCO.2009.26.9589
    • Fong PC, Yap TA, Boss DS, Carden CP, Mergui-Roelvink M, Gourley C, et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J Clin Oncol (2010) 28(15):2512-9. doi:10.1200/JCO.2009.26.9589
    • (2010) J Clin Oncol , vol.28 , Issue.15 , pp. 2512-2519
    • Fong, P.C.1    Yap, T.A.2    Boss, D.S.3    Carden, C.P.4    Mergui-Roelvink, M.5    Gourley, C.6
  • 50
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
    • doi:10.1016/S0140-6736(10)60893-8
    • Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet (2010) 376(9737):245-51. doi:10.1016/S0140-6736(10)60893-8
    • (2010) Lancet , vol.376 , Issue.9737 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3    Friedlander, M.4    Powell, B.5    Bell-McGuinn, K.M.6
  • 51
    • 84863010984 scopus 로고    scopus 로고
    • Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer
    • doi:10.1200/JCO.2011.36.9215
    • Kaye SB, Lubinski J, Matulonis U, Ang JE, Gourley C, Karlan BY, et al. Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. J Clin Oncol (2012) 30(4):372-9. doi:10.1200/JCO.2011.36.9215
    • (2012) J Clin Oncol , vol.30 , Issue.4 , pp. 372-379
    • Kaye, S.B.1    Lubinski, J.2    Matulonis, U.3    Ang, J.E.4    Gourley, C.5    Karlan, B.Y.6
  • 52
    • 0035879099 scopus 로고    scopus 로고
    • Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan
    • Gordon AN, Fleagle JT, Guthrie D, Parkin DE, Gore ME, Lacave AJ. Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan. J Clin Oncol (2001) 19(14):3312-22.
    • (2001) J Clin Oncol , vol.19 , Issue.14 , pp. 3312-3322
    • Gordon, A.N.1    Fleagle, J.T.2    Guthrie, D.3    Parkin, D.E.4    Gore, M.E.5    Lacave, A.J.6
  • 53
    • 84869109927 scopus 로고    scopus 로고
    • Randomized, open-label, phase III study comparing patupilone (EPO906) with pegylated liposomal doxorubicin in platinum-refractory or-resistant patients with recurrent epithelial ovarian, primary fallopian tube, or primary peritoneal cancer
    • doi:10.1200/JCO.2011.38.8082
    • Colombo N, Kutarska E, Dimopoulos M, Bae DS, Rzepka-Gorska I, Bidzinski M, et al. Randomized, open-label, phase III study comparing patupilone (EPO906) with pegylated liposomal doxorubicin in platinum-refractory or-resistant patients with recurrent epithelial ovarian, primary fallopian tube, or primary peritoneal cancer. J Clin Oncol (2012) 30(31):3841-7. doi:10.1200/JCO.2011.38.8082
    • (2012) J Clin Oncol , vol.30 , Issue.31 , pp. 3841-3847
    • Colombo, N.1    Kutarska, E.2    Dimopoulos, M.3    Bae, D.S.4    Rzepka-Gorska, I.5    Bidzinski, M.6
  • 54
    • 84856731422 scopus 로고    scopus 로고
    • Comparing poly (ADP-ribose) polymerase inhibitors with standard chemotherapy in BRCA-mutated, recurrent ovarian cancer: lessons learned from a negative trial
    • doi:10.1200/JCO.2011.40.1489
    • Konstantinopoulos PA, Cannistra SA. Comparing poly (ADP-ribose) polymerase inhibitors with standard chemotherapy in BRCA-mutated, recurrent ovarian cancer: lessons learned from a negative trial. J Clin Oncol (2012) 30(4):347-50. doi:10.1200/JCO.2011.40.1489
    • (2012) J Clin Oncol , vol.30 , Issue.4 , pp. 347-350
    • Konstantinopoulos, P.A.1    Cannistra, S.A.2
  • 55
    • 49249138928 scopus 로고    scopus 로고
    • Sporadic epithelial ovarian cancer: clinical relevance of BRCA1 inhibition in the DNA damage and repair pathway
    • doi:10.1200/JCO.2007.11.3902
    • Weberpals JI, Clark-Knowles KV, Vanderhyden BC. Sporadic epithelial ovarian cancer: clinical relevance of BRCA1 inhibition in the DNA damage and repair pathway. J Clin Oncol (2008) 26(19):3259-67. doi:10.1200/JCO.2007.11.3902
    • (2008) J Clin Oncol , vol.26 , Issue.19 , pp. 3259-3267
    • Weberpals, J.I.1    Clark-Knowles, K.V.2    Vanderhyden, B.C.3
  • 56
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
    • doi:10.1016/S1470-2045(11)70214-5
    • Gelmon KA, Tischkowitz M, Mackay H, Swenerton K, Robidoux A, Tonkin K, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol (2011) 12(9):852-61. doi:10.1016/S1470-2045(11)70214-5
    • (2011) Lancet Oncol , vol.12 , Issue.9 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3    Swenerton, K.4    Robidoux, A.5    Tonkin, K.6
  • 57
    • 70949086814 scopus 로고    scopus 로고
    • Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and-2 mutant tumors
    • doi:10.1021/jm901188v
    • Jones P, Altamura S, Boueres J, Ferrigno F, Fonsi M, Giomini C, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and-2 mutant tumors. J Med Chem (2009) 52(22):7170-85. doi:10.1021/jm901188v
    • (2009) J Med Chem , vol.52 , Issue.22 , pp. 7170-7185
    • Jones, P.1    Altamura, S.2    Boueres, J.3    Ferrigno, F.4    Fonsi, M.5    Giomini, C.6
  • 58
    • 77958458006 scopus 로고    scopus 로고
    • First-in-human trial of a poly(ADP-ribose) polymerase (PARP) inhibitor MK-4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers (ASCO Meeting Abstracts)
    • [Accessed 2013 Jun 16]
    • Sandhu SK, Wenham RM, Wilding G, McFadden M, Sun L, Toniatti C, et al. First-in-human trial of a poly(ADP-ribose) polymerase (PARP) inhibitor MK-4827 in advanced cancer patients (pts) with antitumor activity in BRCA-deficient and sporadic ovarian cancers (ASCO Meeting Abstracts). J Clin Oncol (2010) 28(15):3001. [Accessed 2013 Jun 16]. Available at: http://meeting.ascopubs.org/cgi/content/abstract/28/15_suppl/3001
    • (2010) J Clin Oncol , vol.28 , Issue.15 , pp. 3001
    • Sandhu, S.K.1    Wenham, R.M.2    Wilding, G.3    McFadden, M.4    Sun, L.5    Toniatti, C.6
  • 59
    • 80355136313 scopus 로고    scopus 로고
    • Phase II trial of the poly(ADP-ribose) polymerase (PARP) inhibitor AG-014699 in BRCA 1 and 2-mutated, advanced ovarian and/or locally advanced or metastatic breast cancer (ASCO Meeting Abstracts)
    • [Accessed 2013 Jun 16]
    • Drew Y, Ledermann JA, Jones A, Hall G, Jayson GC, Highley M, et al. Phase II trial of the poly(ADP-ribose) polymerase (PARP) inhibitor AG-014699 in BRCA 1 and 2-mutated, advanced ovarian and/or locally advanced or metastatic breast cancer (ASCO Meeting Abstracts). J Clin Oncol (2011) 29(15):3104. [Accessed 2013 Jun 16]. Available at: http://meeting.ascopubs.org/cgi/content/short/29/15_suppl/3104?rss=1
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 3104
    • Drew, Y.1    Ledermann, J.A.2    Jones, A.3    Hall, G.4    Jayson, G.C.5    Highley, M.6
  • 60
    • 84859523588 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
    • doi:10.1056/NEJMoa1105535
    • Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G, et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med (2012) 366(15):1382-92. doi:10.1056/NEJMoa1105535
    • (2012) N Engl J Med , vol.366 , Issue.15 , pp. 1382-1392
    • Ledermann, J.1    Harter, P.2    Gourley, C.3    Friedlander, M.4    Vergote, I.5    Rustin, G.6
  • 62
    • 69249162912 scopus 로고    scopus 로고
    • Systemic therapy for recurrent endometrial cancer: a review of North American trials
    • doi:10.1586/era.09.54
    • Dellinger TH, Monk BJ. Systemic therapy for recurrent endometrial cancer: a review of North American trials. Expert Rev Anticancer Ther (2009) 9(7):905-16. doi:10.1586/era.09.54
    • (2009) Expert Rev Anticancer Ther , vol.9 , Issue.7 , pp. 905-916
    • Dellinger, T.H.1    Monk, B.J.2
  • 63
    • 34447536870 scopus 로고    scopus 로고
    • Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant
    • doi:10.1200/JCO.2007.10.8431
    • Fleming GF. Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant. J Clin Oncol (2007) 25(20):2983-90. doi:10.1200/JCO.2007.10.8431
    • (2007) J Clin Oncol , vol.25 , Issue.20 , pp. 2983-2990
    • Fleming, G.F.1
  • 64
    • 84861527676 scopus 로고    scopus 로고
    • Molecular bases of endometrial cancer: new roles for new actors in the diagnosis and the therapy of the disease
    • doi:10.1016/j.mce.2011.10.003
    • Llaurado M, Ruiz A, Majem B, Ertekin T, Colas E, Pedrola N, et al. Molecular bases of endometrial cancer: new roles for new actors in the diagnosis and the therapy of the disease. Mol Cell Endocrinol (2012) 358(2):244-55. doi:10.1016/j.mce.2011.10.003
    • (2012) Mol Cell Endocrinol , vol.358 , Issue.2 , pp. 244-255
    • Llaurado, M.1    Ruiz, A.2    Majem, B.3    Ertekin, T.4    Colas, E.5    Pedrola, N.6
  • 65
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • doi:10.1038/ng0597-64
    • Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet (1997) 16(1):64-7. doi:10.1038/ng0597-64
    • (1997) Nat Genet , vol.16 , Issue.1 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3    Dahia, P.L.4    Wang, S.I.5    Zheng, Z.6
  • 66
    • 70350238781 scopus 로고    scopus 로고
    • PTEN hamartoma tumor syndrome: an overview
    • doi:10.1097/GIM.0b013e3181ac9aea
    • Hobert JA, Eng C. PTEN hamartoma tumor syndrome: an overview. Genet Med (2009) 11(10):687-94. doi:10.1097/GIM.0b013e3181ac9aea
    • (2009) Genet Med , vol.11 , Issue.10 , pp. 687-694
    • Hobert, J.A.1    Eng, C.2
  • 67
    • 61449282506 scopus 로고    scopus 로고
    • The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies
    • Bansal N, Yendluri V, Wenham RM. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Cancer Control (2009) 16(1):8-13.
    • (2009) Cancer Control , vol.16 , Issue.1 , pp. 8-13
    • Bansal, N.1    Yendluri, V.2    Wenham, R.M.3
  • 68
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • doi:10.1093/jnci/92.11.924
    • Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JP, Lees JA, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst (2000) 92(11):924-30. doi:10.1093/jnci/92.11.924
    • (2000) J Natl Cancer Inst , vol.92 , Issue.11 , pp. 924-930
    • Mutter, G.L.1    Lin, M.C.2    Fitzgerald, J.T.3    Kum, J.B.4    Baak, J.P.5    Lees, J.A.6
  • 69
    • 61449307070 scopus 로고    scopus 로고
    • Current treatment of metastatic endometrial cancer
    • Temkin SM, Fleming G. Current treatment of metastatic endometrial cancer. Cancer Control (2009) 16(1):38-45.
    • (2009) Cancer Control , vol.16 , Issue.1 , pp. 38-45
    • Temkin, S.M.1    Fleming, G.2
  • 70
    • 84856000440 scopus 로고    scopus 로고
    • Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?
    • doi:10.1016/j.ygyno.2011.10.011
    • Ioffe YJ, Chiappinelli KB, Mutch DG, Zighelboim I, Goodfellow PJ. Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis? Gynecol Oncol (2012) 124(2):340-6. doi:10.1016/j.ygyno.2011.10.011
    • (2012) Gynecol Oncol , vol.124 , Issue.2 , pp. 340-346
    • Ioffe, Y.J.1    Chiappinelli, K.B.2    Mutch, D.G.3    Zighelboim, I.4    Goodfellow, P.J.5
  • 71
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • Cancer Genome Atlas Research Network, doi:10.1038/nature12113
    • Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Cancer Genome Atlas Research Network, et al. Integrated genomic characterization of endometrial carcinoma. Nature (2013) 497(7447):67-73. doi:10.1038/nature12113
    • (2013) Nature , vol.497 , Issue.7447 , pp. 67-73
    • Kandoth, C.1    Schultz, N.2    Cherniack, A.D.3    Akbani, R.4    Liu, Y.5
  • 72
    • 79955589677 scopus 로고    scopus 로고
    • A phase I study to determine the comparative bioavailability of two different oral formulations of the PARP inhibitor, olaparib (AZD2281), in patients with advanced solid tumors (ASCO Meeting Abstracts)
    • [Accessed 2013 Jun 7]
    • Molife LR, Forster MD, Krebs M, Pwint T, Middleton MR, Kaye SB, et al. A phase I study to determine the comparative bioavailability of two different oral formulations of the PARP inhibitor, olaparib (AZD2281), in patients with advanced solid tumors (ASCO Meeting Abstracts). J Clin Oncol (2010) 28(15):2599. [Accessed 2013 Jun 7]. Available at: http://meeting.ascopubs.org/cgi/content/abstract/28/15_suppl/2599
    • (2010) J Clin Oncol , vol.28 , Issue.15 , pp. 2599
    • Molife, L.R.1    Forster, M.D.2    Krebs, M.3    Pwint, T.4    Middleton, M.R.5    Kaye, S.B.6
  • 73
    • 79955610372 scopus 로고    scopus 로고
    • Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer
    • doi:10.1038/nrclinonc.2011.42
    • Forster MD, Dedes KJ, Sandhu S, Frentzas S, Kristeleit R, Ashworth A, et al. Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer. Nat Rev Clin Oncol (2011) 8(5):302-6. doi:10.1038/nrclinonc.2011.42
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.5 , pp. 302-306
    • Forster, M.D.1    Dedes, K.J.2    Sandhu, S.3    Frentzas, S.4    Kristeleit, R.5    Ashworth, A.6
  • 74
    • 84874228825 scopus 로고    scopus 로고
    • Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma
    • doi:10.1073/pnas.1222577110
    • Zhao S, Choi M, Overton JD, Bellone S, Roque DM, Cocco E, et al. Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma. Proc Natl Acad Sci U S A (2013) 110(8):2916-21. doi:10.1073/pnas.1222577110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.8 , pp. 2916-2921
    • Zhao, S.1    Choi, M.2    Overton, J.D.3    Bellone, S.4    Roque, D.M.5    Cocco, E.6
  • 76
    • 84855792427 scopus 로고    scopus 로고
    • Cancer statistics, 2012
    • doi:10.3322/caac.21149
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin (2012) 62(1):10-29. doi:10.3322/caac.21149
    • (2012) CA Cancer J Clin , vol.62 , Issue.1 , pp. 10-29
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 77
    • 0030826230 scopus 로고    scopus 로고
    • International incidence rates of invasive cervical cancer after introduction of cytological screening
    • doi:10.1023/A:1018435522475
    • Gustafsson L, Ponten J, Zack M, Adami HO. International incidence rates of invasive cervical cancer after introduction of cytological screening. Cancer Causes Control (1997) 8(5):755-63. doi:10.1023/A:1018435522475
    • (1997) Cancer Causes Control , vol.8 , Issue.5 , pp. 755-763
    • Gustafsson, L.1    Ponten, J.2    Zack, M.3    Adami, H.O.4
  • 78
    • 8444249386 scopus 로고    scopus 로고
    • Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial
    • doi:10.1016/S0140-6736(04)17398-4
    • Harper DM, Franco EL, Wheeler C, Ferris DG, Jenkins D, Schuind A, et al. Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet (2004) 364(9447):1757-65. doi:10.1016/S0140-6736(04)17398-4
    • (2004) Lancet , vol.364 , Issue.9447 , pp. 1757-1765
    • Harper, D.M.1    Franco, E.L.2    Wheeler, C.3    Ferris, D.G.4    Jenkins, D.5    Schuind, A.6
  • 79
    • 33646058566 scopus 로고    scopus 로고
    • Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial
    • doi:10.1016/S0140-6736(06)68439-0
    • Harper DM, Franco EL, Wheeler CM, Moscicki AB, Romanowski B, Roteli-Martins CM, et al. Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial. Lancet (2006) 367(9518):1247-55. doi:10.1016/S0140-6736(06)68439-0
    • (2006) Lancet , vol.367 , Issue.9518 , pp. 1247-1255
    • Harper, D.M.1    Franco, E.L.2    Wheeler, C.M.3    Moscicki, A.B.4    Romanowski, B.5    Roteli-Martins, C.M.6
  • 80
    • 0037153042 scopus 로고    scopus 로고
    • A controlled trial of a human papillomavirus type 16 vaccine
    • doi:10.1056/NEJMoa020586
    • Koutsky LA, Ault KA, Wheeler CM, Brown DR, Barr E, Alvarez FB, et al. A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med (2002) 347(21):1645-51. doi:10.1056/NEJMoa020586
    • (2002) N Engl J Med , vol.347 , Issue.21 , pp. 1645-1651
    • Koutsky, L.A.1    Ault, K.A.2    Wheeler, C.M.3    Brown, D.R.4    Barr, E.5    Alvarez, F.B.6
  • 81
    • 33644849136 scopus 로고    scopus 로고
    • Efficacy of human papillomavirus-16 vaccine to prevent cervical intraepithelial neoplasia: a randomized controlled trial
    • doi:10.1097/01.AOG.0000192397.41191.fb
    • Mao C, Koutsky LA, Ault KA, Wheeler CM, Brown DR, Wiley DJ, et al. Efficacy of human papillomavirus-16 vaccine to prevent cervical intraepithelial neoplasia: a randomized controlled trial. Obstet Gynecol (2006) 107(1):18-27. doi:10.1097/01.AOG.0000192397.41191.fb
    • (2006) Obstet Gynecol , vol.107 , Issue.1 , pp. 18-27
    • Mao, C.1    Koutsky, L.A.2    Ault, K.A.3    Wheeler, C.M.4    Brown, D.R.5    Wiley, D.J.6
  • 82
    • 20944448032 scopus 로고    scopus 로고
    • Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
    • doi:10.1016/S1470-2045(05)70101-7
    • Villa LL, Costa RL, Petta CA, Andrade RP, Ault KA, Giuliano AR, et al. Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol (2005) 6(5):271-8. doi:10.1016/S1470-2045(05)70101-7
    • (2005) Lancet Oncol , vol.6 , Issue.5 , pp. 271-278
    • Villa, L.L.1    Costa, R.L.2    Petta, C.A.3    Andrade, R.P.4    Ault, K.A.5    Giuliano, A.R.6
  • 84
    • 84875163620 scopus 로고    scopus 로고
    • Cisplatin resistance associated with PARP hyperactivation
    • doi:10.1158/0008-5472.CAN-12-3000
    • Michels J, Vitale I, Galluzzi L, Adam J, Olaussen KA, Kepp O, et al. Cisplatin resistance associated with PARP hyperactivation. Cancer Res (2013) 73(7):2271-80. doi:10.1158/0008-5472.CAN-12-3000
    • (2013) Cancer Res , vol.73 , Issue.7 , pp. 2271-2280
    • Michels, J.1    Vitale, I.2    Galluzzi, L.3    Adam, J.4    Olaussen, K.A.5    Kepp, O.6
  • 85
    • 19444375973 scopus 로고    scopus 로고
    • Chemopotentiation by PARP inhibitors in cancer therapy
    • doi:10.1016/j.phrs.2005.02.010
    • Tentori L, Graziani G. Chemopotentiation by PARP inhibitors in cancer therapy. Pharmacol Res (2005) 52(1):25-33. doi:10.1016/j.phrs.2005.02.010
    • (2005) Pharmacol Res , vol.52 , Issue.1 , pp. 25-33
    • Tentori, L.1    Graziani, G.2
  • 86
    • 0033941729 scopus 로고    scopus 로고
    • Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines
    • Delaney CA, Wang LZ, Kyle S, White AW, Calvert AH, Curtin NJ, et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res (2000) 6(7):2860-7.
    • (2000) Clin Cancer Res , vol.6 , Issue.7 , pp. 2860-2867
    • Delaney, C.A.1    Wang, L.Z.2    Kyle, S.3    White, A.W.4    Calvert, A.H.5    Curtin, N.J.6
  • 87
    • 10744233684 scopus 로고    scopus 로고
    • Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
    • Tentori L, Leonetti C, Scarsella M, D'Amati G, Vergati M, Portarena I, et al. Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clin Cancer Res (2003) 9(14):5370-9.
    • (2003) Clin Cancer Res , vol.9 , Issue.14 , pp. 5370-5379
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3    D'Amati, G.4    Vergati, M.5    Portarena, I.6
  • 88
    • 10744226451 scopus 로고    scopus 로고
    • Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361
    • doi:10.1093/jnci/djh005
    • Calabrese CR, Almassy R, Barton S, Batey MA, Calvert AH, Canan-Koch S, et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. J Natl Cancer Inst (2004) 96(1):56-67. doi:10.1093/jnci/djh005
    • (2004) J Natl Cancer Inst , vol.96 , Issue.1 , pp. 56-67
    • Calabrese, C.R.1    Almassy, R.2    Barton, S.3    Batey, M.A.4    Calvert, A.H.5    Canan-Koch, S.6
  • 89
    • 10744233628 scopus 로고    scopus 로고
    • Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells
    • doi:10.1158/1078-0432.CCR-1144-3
    • Curtin NJ, Wang LZ, Yiakouvaki A, Kyle S, Arris CA, Canan-Koch S, et al. Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells. Clin Cancer Res (2004) 10(3):881-9. doi:10.1158/1078-0432.CCR-1144-3
    • (2004) Clin Cancer Res , vol.10 , Issue.3 , pp. 881-889
    • Curtin, N.J.1    Wang, L.Z.2    Yiakouvaki, A.3    Kyle, S.4    Arris, C.A.5    Canan-Koch, S.6
  • 90
    • 33644675410 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft
    • doi:10.1158/1535-7163.MCT-05-0128
    • Cheng CL, Johnson SP, Keir ST, Quinn JA, Ali-Osman F, Szabo C, et al. Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. Mol Cancer Ther (2005) 4(9):1364-8. doi:10.1158/1535-7163.MCT-05-0128
    • (2005) Mol Cancer Ther , vol.4 , Issue.9 , pp. 1364-1368
    • Cheng, C.L.1    Johnson, S.P.2    Keir, S.T.3    Quinn, J.A.4    Ali-Osman, F.5    Szabo, C.6
  • 91
    • 0027223526 scopus 로고
    • Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment
    • doi:10.1093/carcin/14.4.559
    • Burkle A, Chen G, Kupper JH, Grube K, Zeller WJ. Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment. Carcinogenesis (1993) 14(4):559-61. doi:10.1093/carcin/14.4.559
    • (1993) Carcinogenesis , vol.14 , Issue.4 , pp. 559-561
    • Burkle, A.1    Chen, G.2    Kupper, J.H.3    Grube, K.4    Zeller, W.J.5
  • 92
    • 28544441999 scopus 로고    scopus 로고
    • The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks
    • doi:10.1158/1078-0432.CCR-05-1224
    • Smith LM, Willmore E, Austin CA, Curtin NJ. The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. Clin Cancer Res (2005) 11(23):8449-57. doi:10.1158/1078-0432.CCR-05-1224
    • (2005) Clin Cancer Res , vol.11 , Issue.23 , pp. 8449-8457
    • Smith, L.M.1    Willmore, E.2    Austin, C.A.3    Curtin, N.J.4
  • 93
    • 0242588748 scopus 로고    scopus 로고
    • Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor
    • Miknyoczki SJ, Jones-Bolin S, Pritchard S, Hunter K, Zhao H, Wan W, et al. Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. Mol Cancer Ther (2003) 2(4):371-82.
    • (2003) Mol Cancer Ther , vol.2 , Issue.4 , pp. 371-382
    • Miknyoczki, S.J.1    Jones-Bolin, S.2    Pritchard, S.3    Hunter, K.4    Zhao, H.5    Wan, W.6
  • 94
    • 84866768008 scopus 로고    scopus 로고
    • Olaparib plus paclitaxel plus carboplatin (P/C) followed by olaparib maintenance treatment in patients (pts) with platinum-sensitive recurrent serous ovarian cancer (PSR SOC): a randomized, open-label phase II study (ASCO Meeting Abstracts)
    • [Accessed 2013 Jun 18]
    • Oza AM, Cibula D, Oaknin A, Poole CJ, Mathijssen RHJ, Sonke GS, et al. Olaparib plus paclitaxel plus carboplatin (P/C) followed by olaparib maintenance treatment in patients (pts) with platinum-sensitive recurrent serous ovarian cancer (PSR SOC): a randomized, open-label phase II study (ASCO Meeting Abstracts). J Clin Oncol (2012) 30(15):5001. [Accessed 2013 Jun 18]. Available at: http://meeting.ascopubs.org/cgi/content/abstract/30/15_suppl/5001?sid=35889604-a227-482d-96ff-5d349c7e1856
    • (2012) J Clin Oncol , vol.30 , Issue.15 , pp. 5001
    • Oza, A.M.1    Cibula, D.2    Oaknin, A.3    Poole, C.J.4    Mathijssen, R.H.J.5    Sonke, G.S.6
  • 95
    • 80355136310 scopus 로고    scopus 로고
    • Phase I study of the PARP inhibitor olaparib (O) in combination with carboplatin (C) in BRCA1/2 mutation carriers with breast (Br) or ovarian (Ov) cancer (Ca) (ASCO Meeting Abstracts)
    • [Accessed 2013 Jun 10]
    • Lee J, Annunziata CM, Minasian LM, Zujewski J, Prindiville SA, Kotz HL, et al. Phase I study of the PARP inhibitor olaparib (O) in combination with carboplatin (C) in BRCA1/2 mutation carriers with breast (Br) or ovarian (Ov) cancer (Ca) (ASCO Meeting Abstracts). J Clin Oncol (2011) 29(15):2520. [Accessed 2013 Jun 10]. Available at: http://meeting.ascopubs.org/cgi/content/short/29/15_suppl/2520?rss=1
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 2520
    • Lee, J.1    Annunziata, C.M.2    Minasian, L.M.3    Zujewski, J.4    Prindiville, S.A.5    Kotz, H.L.6
  • 96
    • 84871715837 scopus 로고    scopus 로고
    • Sorafenib potentiates irradiation effect in hepatocellular carcinoma in vitro and in vivo
    • doi:10.1016/j.canlet.2012.10.024
    • Yu W, Gu K, Yu Z, Yuan D, He M, Ma N, et al. Sorafenib potentiates irradiation effect in hepatocellular carcinoma in vitro and in vivo. Cancer Lett (2013) 329(1):109-17. doi:10.1016/j.canlet.2012.10.024
    • (2013) Cancer Lett , vol.329 , Issue.1 , pp. 109-117
    • Yu, W.1    Gu, K.2    Yu, Z.3    Yuan, D.4    He, M.5    Ma, N.6
  • 97
    • 79960148154 scopus 로고    scopus 로고
    • Sorafenib enhances the antitumor effects of chemoradiation treatment by downregulating ERCC-1 and XRCC-1 DNA repair proteins
    • doi:10.1158/1535-7163.MCT-11-0004
    • Yadav A, Kumar B, Teknos TN, Kumar P. Sorafenib enhances the antitumor effects of chemoradiation treatment by downregulating ERCC-1 and XRCC-1 DNA repair proteins. Mol Cancer Ther (2011) 10(7):1241-51. doi:10.1158/1535-7163.MCT-11-0004
    • (2011) Mol Cancer Ther , vol.10 , Issue.7 , pp. 1241-1251
    • Yadav, A.1    Kumar, B.2    Teknos, T.N.3    Kumar, P.4
  • 98
    • 33749347804 scopus 로고    scopus 로고
    • Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis
    • doi:10.1016/j.bbrc.2006.09.160
    • Rajesh M, Mukhopadhyay P, Batkai S, Godlewski G, Hasko G, Liaudet L, et al. Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis. Biochem Biophys Res Commun (2006) 350(2):352-7. doi:10.1016/j.bbrc.2006.09.160
    • (2006) Biochem Biophys Res Commun , vol.350 , Issue.2 , pp. 352-357
    • Rajesh, M.1    Mukhopadhyay, P.2    Batkai, S.3    Godlewski, G.4    Hasko, G.5    Liaudet, L.6
  • 99
    • 46749119301 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34
    • Pyriochou A, Olah G, Deitch EA, Szabo C, Papapetropoulos A. Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34. Int J Mol Med (2008) 22(1):113-8.
    • (2008) Int J Mol Med , vol.22 , Issue.1 , pp. 113-118
    • Pyriochou, A.1    Olah, G.2    Deitch, E.A.3    Szabo, C.4    Papapetropoulos, A.5
  • 100
    • 34548514842 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis
    • doi:10.1016/j.ejca.2007.07.010
    • Tentori L, Lacal PM, Muzi A, Dorio AS, Leonetti C, Scarsella M, et al. Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis. Eur J Cancer (2007) 43(14):2124-33. doi:10.1016/j.ejca.2007.07.010
    • (2007) Eur J Cancer , vol.43 , Issue.14 , pp. 2124-2133
    • Tentori, L.1    Lacal, P.M.2    Muzi, A.3    Dorio, A.S.4    Leonetti, C.5    Scarsella, M.6
  • 101
    • 80355145583 scopus 로고    scopus 로고
    • A phase I trial of the PARP inhibitor olaparib (AZD2281) in combination with the antiangiogenic cediranib (AZD2171) in recurrent ovarian or triple-negative breast cancer (ASCO Meeting Abstracts)
    • [Accessed 2013 Jun 10]
    • Liu J, Fleming GF, Tolaney SM, Birrer MJ, Penson RT, Berlin ST, et al. A phase I trial of the PARP inhibitor olaparib (AZD2281) in combination with the antiangiogenic cediranib (AZD2171) in recurrent ovarian or triple-negative breast cancer (ASCO Meeting Abstracts). J Clin Oncol (2011) 29(15):5028. [Accessed 2013 Jun 10]. Available at: http://meeting.ascopubs.org/cgi/content/abstract/29/15_suppl/5028?sid=a88c5b0a-3c23-4d7b-893a-877d2132a7db
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 5028
    • Liu, J.1    Fleming, G.F.2    Tolaney, S.M.3    Birrer, M.J.4    Penson, R.T.5    Berlin, S.T.6
  • 102
    • 0141619287 scopus 로고    scopus 로고
    • Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1
    • Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res (2003) 63(18):6008-15.
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 6008-6015
    • Veuger, S.J.1    Curtin, N.J.2    Richardson, C.J.3    Smith, G.C.4    Durkacz, B.W.5
  • 103
    • 0040984333 scopus 로고    scopus 로고
    • Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
    • doi:10.1073/pnas.94.14.7303
    • de Murcia JM, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 94(14):7303-7. doi:10.1073/pnas.94.14.7303
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.14 , pp. 7303-7307
    • de Murcia, J.M.1    Niedergang, C.2    Trucco, C.3    Ricoul, M.4    Dutrillaux, B.5    Mark, M.6
  • 104
    • 0032917607 scopus 로고    scopus 로고
    • Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice
    • doi:10.1023/A:1006941016799
    • Masutani M, Nozaki T, Nishiyama E, Shimokawa T, Tachi Y, Suzuki H, et al. Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice. Mol Cell Biochem (1999) 193(1-2):149-52. doi:10.1023/A:1006941016799
    • (1999) Mol Cell Biochem , vol.193 , Issue.1-2 , pp. 149-152
    • Masutani, M.1    Nozaki, T.2    Nishiyama, E.3    Shimokawa, T.4    Tachi, Y.5    Suzuki, H.6
  • 107
    • 77950974130 scopus 로고    scopus 로고
    • Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
    • doi:10.1158/1078-0432.CCR-09-2758
    • Mukhopadhyay A, Elattar A, Cerbinskaite A, Wilkinson SJ, Drew Y, Kyle S, et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin Cancer Res (2010) 16(8):2344-51. doi:10.1158/1078-0432.CCR-09-2758
    • (2010) Clin Cancer Res , vol.16 , Issue.8 , pp. 2344-2351
    • Mukhopadhyay, A.1    Elattar, A.2    Cerbinskaite, A.3    Wilkinson, S.J.4    Drew, Y.5    Kyle, S.6
  • 108
    • 84869210797 scopus 로고    scopus 로고
    • Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival
    • doi:10.1158/0008-5472.CAN-12-0324
    • Mukhopadhyay A, Plummer ER, Elattar A, Soohoo S, Uzir B, Quinn JE, et al. Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival. Cancer Res (2012) 72(22):5675-82. doi:10.1158/0008-5472.CAN-12-0324
    • (2012) Cancer Res , vol.72 , Issue.22 , pp. 5675-5682
    • Mukhopadhyay, A.1    Plummer, E.R.2    Elattar, A.3    Soohoo, S.4    Uzir, B.5    Quinn, J.E.6
  • 109
    • 80053911243 scopus 로고    scopus 로고
    • Modeling pharmacodynamic response to the poly(ADP-ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells
    • doi:10.1371/journal.pone.0026152
    • Ji J, Kinders RJ, Zhang Y, Rubinstein L, Kummar S, Parchment RE, et al. Modeling pharmacodynamic response to the poly(ADP-ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells. PLoS ONE (2011) 6(10):e26152. doi:10.1371/journal.pone.0026152
    • (2011) PLoS ONE , vol.6 , Issue.10
    • Ji, J.1    Kinders, R.J.2    Zhang, Y.3    Rubinstein, L.4    Kummar, S.5    Parchment, R.E.6
  • 110
    • 84863236347 scopus 로고    scopus 로고
    • A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas
    • doi:10.1158/1078-0432.CCR-11-2821
    • Kummar S, Ji J, Morgan R, Lenz HJ, Puhalla SL, Belani CP, et al. A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin Cancer Res (2012) 18(6):1726-34. doi:10.1158/1078-0432.CCR-11-2821
    • (2012) Clin Cancer Res , vol.18 , Issue.6 , pp. 1726-1734
    • Kummar, S.1    Ji, J.2    Morgan, R.3    Lenz, H.J.4    Puhalla, S.L.5    Belani, C.P.6
  • 111
    • 84874832925 scopus 로고    scopus 로고
    • Molecular pathways: targeting PARP in cancer treatment
    • doi:10.1158/1078-0432.CCR-12-0163
    • Do K, Chen AP. Molecular pathways: targeting PARP in cancer treatment. Clin Cancer Res (2013) 19(5):977-84. doi:10.1158/1078-0432.CCR-12-0163
    • (2013) Clin Cancer Res , vol.19 , Issue.5 , pp. 977-984
    • Do, K.1    Chen, A.P.2
  • 112
    • 79951549627 scopus 로고    scopus 로고
    • Preliminary experience with the use of chemotherapy (CT) following treatment with olaparib, a poly(ADP-ribose) polymerase inhibitor (PARPi), in patients with BRCA1/2-deficient ovarian cancer (BDOC) (ASCO Meeting Abstracts)
    • [Accessed 6/10/2013]
    • Ang J, Yap TA, Fong P, Carden CP, Tan DS, Hanwell J, et al. Preliminary experience with the use of chemotherapy (CT) following treatment with olaparib, a poly(ADP-ribose) polymerase inhibitor (PARPi), in patients with BRCA1/2-deficient ovarian cancer (BDOC) (ASCO Meeting Abstracts). J Clin Oncol (2010) 28(15):5041. [Accessed 6/10/2013]. Available from: http://meeting.ascopubs.org/cgi/content/abstract/28/15_suppl/5041
    • (2010) J Clin Oncol , vol.28 , Issue.15 , pp. 5041
    • Ang, J.1    Yap, T.A.2    Fong, P.3    Carden, C.P.4    Tan, D.S.5    Hanwell, J.6
  • 113
    • 55949092708 scopus 로고    scopus 로고
    • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
    • doi:10.1073/pnas.0806092105
    • Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A (2008) 105(44):17079-84. doi:10.1073/pnas.0806092105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.44 , pp. 17079-17084
    • Rottenberg, S.1    Jaspers, J.E.2    Kersbergen, A.3    van der Burg, E.4    Nygren, A.O.5    Zander, S.A.6


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