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Volumn 19, Issue 24, 2013, Pages 6657-6661

Pralatrexate pharmacology and clinical development

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CYANOCOBALAMIN; CYTARABINE; DIHYDROFOLATE REDUCTASE; FOLIC ACID; FOLYLPOLYGLUTAMATE SYNTHASE; GEMCITABINE; METHOTREXATE; PRALATREXATE; REDUCED FOLATE CARRIER; ROMIDEPSIN;

EID: 84890631534     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-2251     Document Type: Review
Times cited : (31)

References (22)
  • 1
    • 59849093173 scopus 로고    scopus 로고
    • Membrane transporters and folate homeostasis: Intestinal absorption and transport into systemic compartments and tissues
    • Zhao R, Matherly LH, Goldman ID. Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med 2009;11:e4.
    • (2009) Expert Rev Mol Med , vol.11
    • Zhao, R.1    Matherly, L.H.2    Goldman, I.D.3
  • 3
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid
    • Farber S, Diamond LK. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl J Med 1948;238:787-93.
    • (1948) N Engl J Med , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2
  • 4
    • 0020068096 scopus 로고
    • Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice
    • Sirotnak FM, DeGraw JI, Chello PL, Moccio DM, Dorick DM. Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice. Cancer Treat Rep 1982;66:351-8. (Pubitemid 12169669)
    • (1982) Cancer Treatment Reports , vol.66 , Issue.2 , pp. 351-358
    • Sirotnak, F.M.1    DeGraw, J.I.2    Chello, P.L.3
  • 5
    • 0027304579 scopus 로고
    • Synthesis and antitu-mor activity of 10-propargyl-10-deazaaminopterin
    • DeGraw JI, Colwell WT, Piper JR, Sirotnak FM. Synthesis and antitu-mor activity of 10-propargyl-10-deazaaminopterin. J Med Chem 1993;36:2228-31.
    • (1993) J Med Chem , vol.36 , pp. 2228-2231
    • Degraw, J.I.1    Colwell, W.T.2    Piper, J.R.3    Sirotnak, F.M.4
  • 6
    • 0022406905 scopus 로고
    • Transport of folates at maternal and fetal sides of the placenta: Lack of inhibition by methotrexate
    • DOI 10.1016/0005-2736(85)90055-0
    • Sweiry JH, Yudilevich DL. Transport of folates at maternal and fetal sides of the placenta: lack of inhibition by methotrexate. Biochim Biophys Acta 1985;821:497-501. (Pubitemid 16172510)
    • (1985) Biochimica et Biophysica Acta - Biomembranes , vol.821 , Issue.3 , pp. 497-501
    • Sweiry, J.H.1    Yudilevich, D.L.2
  • 7
    • 0036987083 scopus 로고    scopus 로고
    • Molecular, biochemical, and cellular pharmacology of pemetrexed
    • DOI 10.1053/sonc.2002.37421
    • Goldman ID, Zhao R. Molecular, biochemical, and cellular pharmacology of pemetrexed. Semin Oncol 2002;29(6 Suppl 18):3-17. (Pubitemid 36176669)
    • (2002) Seminars in Oncology , vol.29 , Issue.6 SUPPL. 18 , pp. 3-17
    • Goldman, I.D.1    Zhao, R.2
  • 8
    • 67650569093 scopus 로고    scopus 로고
    • Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions
    • Marneros AG, Grossman ME, Silvers DN, Husain S, Nuovo GJ, Mac-Gregor-Cortelli B, et al. Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions. Blood 2009;113:6338-41.
    • (2009) Blood , vol.113 , pp. 6338-6341
    • Marneros, A.G.1    Grossman, M.E.2    Silvers, D.N.3    Husain, S.4    Nuovo, G.J.5    Mac-Gregor-Cortelli, B.6
  • 10
    • 0037409795 scopus 로고    scopus 로고
    • Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression
    • DOI 10.1080/1042819031000077124
    • Wang ES, O'Connor O, She Y, Zelenetz AD, Sirotnak FM, Moore MA. Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminop-terin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression. Leuk Lymphoma 2003;44:1027-35. (Pubitemid 36417003)
    • (2003) Leukemia and Lymphoma , vol.44 , Issue.6 , pp. 1027-1035
    • Wang, E.S.1    O'Connor, O.2    She, Y.3    Zelenetz, A.D.4    Sirotnak, F.M.5    Moore, M.A.S.6
  • 11
    • 84890602495 scopus 로고    scopus 로고
    • Pralatrexate has potent activity against multiple myeloma in vitro and in vivo and activity correlates with tumor RFC-1 and DHFR expression [abstract]
    • 2011 Dec 10-13; San Antonio TX. Washington DC: ASH, Abstract nr 1831
    • Mangone M, Scotto L, Marchi E, O'Connor OA, Cho HJ. Pralatrexate has potent activity against multiple myeloma in vitro and in vivo, and activity correlates with tumor RFC-1 and DHFR expression [abstract]. In: Proceedings of the 53rd ASH Annual Meeting and Exposition; 2011 Dec 10-13; San Antonio, TX. Washington, DC: ASH; 2011. Abstract nr 1831.
    • (2011) Proceedings of the 53rd ASH Annual Meeting and Exposition
    • Mangone, M.1    Scotto, L.2    Marchi, E.3    O'Connor, O.A.4    Cho, H.J.5
  • 12
    • 32944480860 scopus 로고    scopus 로고
    • The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-hodgkin's lymphoma
    • DOI 10.1158/1078-0432.CCR-05-0331
    • Toner LE, Vrhovac R, Smith EA, Gardner J, Heaney M, Gonen M, et al. The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma. Clin Cancer Res 2006; 12(3 Pt 1):924-32. (Pubitemid 43259875)
    • (2006) Clinical Cancer Research , vol.12 , Issue.3 , pp. 924-932
    • Toner, L.E.1    Vrhovac, R.2    Smith, E.A.3    Gardner, J.4    Heaney, M.5    Gonen, M.6    Teruya-Feldstein, J.7    Sirotnak, F.8    O'Connor, O.A.9
  • 14
    • 77954755959 scopus 로고    scopus 로고
    • Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies
    • Marchi E, Paoluzzi L, Scotto L, Seshan VE, Zain JM, Zinzani PL, et al. Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies. Clin Cancer Res 2010;16:3648-58.
    • (2010) Clin Cancer Res , vol.16 , pp. 3648-3658
    • Marchi, E.1    Paoluzzi, L.2    Scotto, L.3    Seshan, V.E.4    Zain, J.M.5    Zinzani, P.L.6
  • 15
    • 34247871454 scopus 로고    scopus 로고
    • Phase II trial of pralatrexate (10-propargyl-10-deazaaminopterin, PDX) in patients with unresectable malignant pleural mesothelioma
    • DOI 10.1097/01.JTO.0000263715.84567.5f, PII 0124389420070400000012
    • Krug LM, Heelan RT, Kris MG, Venkatraman E, Sirotnak FM. Phase II trial of pralatrexate (10-propargyl-10-deazaaminopterin, PDX) in patients with unresectable malignant pleural mesothelioma. J Thorac Oncol 2007;2:317-20. (Pubitemid 47181715)
    • (2007) Journal of Thoracic Oncology , vol.2 , Issue.4 , pp. 317-320
    • Krug, L.M.1    Heelan, R.T.2    Kris, M.G.3    Venkatraman, E.4    Sirotnak, F.M.5
  • 16
    • 67651202352 scopus 로고    scopus 로고
    • A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin's or Hodgkin's lymphoma
    • Mould DR, Sweeney K, Duffull SB, Neylon E, Hamlin P, Horwitz S, et al. A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin's or Hodgkin's lymphoma. Clin Pharmacol Ther 2009;86:190-6.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 190-196
    • Mould, D.R.1    Sweeney, K.2    Duffull, S.B.3    Neylon, E.4    Hamlin, P.5    Horwitz, S.6
  • 17
    • 70349310325 scopus 로고    scopus 로고
    • Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies
    • O'Connor OA, Horwitz S, Hamlin P, Portlock C, Moskowitz CH, Sarasohn D, et al. Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies. J Clin Oncol 2009; 27:4357-64.
    • (2009) J Clin Oncol , vol.27 , pp. 4357-4364
    • O'Connor, O.A.1    Horwitz, S.2    Hamlin, P.3    Portlock, C.4    Moskowitz, C.H.5    Sarasohn, D.6
  • 19
    • 79952749741 scopus 로고    scopus 로고
    • Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: Results from the pivotal PROPEL study
    • O'Connor OA, Pro B, Pinter-Brown L, Bartlett N, Popplewell L, Coiffier B, et al. Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL study. J Clin Oncol 2011;29:1182-9.
    • (2011) J Clin Oncol , vol.29 , pp. 1182-1189
    • O'Connor, O.A.1    Pro, B.2    Pinter-Brown, L.3    Bartlett, N.4    Popplewell, L.5    Coiffier, B.6
  • 20
    • 84864191691 scopus 로고    scopus 로고
    • Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: A subgroup efficacy analysis from the PROPEL study
    • Foss F, Horwitz SM, Coiffier B, Bartlett N, Popplewell L, Pro B, et al. Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study. Clin Lymphoma Myeloma Leuk 2012;12:238-43.
    • (2012) Clin Lymphoma Myeloma Leuk , vol.12 , pp. 238-243
    • Foss, F.1    Horwitz, S.M.2    Coiffier, B.3    Bartlett, N.4    Popplewell, L.5    Pro, B.6
  • 21
    • 84860775360 scopus 로고    scopus 로고
    • Identification of an active, well tolerated dose of pralatrexate in patients with relasped or refractory cutaneous T-cell lymphoma (CTCL)
    • Horwitz SM, Kim Y, Foss F, Zain JM, Myskowski P, Lechowicz MJ, et al. Identification of an active, well tolerated dose of pralatrexate in patients with relasped or refractory cutaneous T-cell lymphoma (CTCL). Blood 2012;119:4115-22.
    • (2012) Blood , vol.119 , pp. 4115-4122
    • Horwitz, S.M.1    Kim, Y.2    Foss, F.3    Zain, J.M.4    Myskowski, P.5    Lechowicz, M.J.6
  • 22
    • 84890701092 scopus 로고    scopus 로고
    • Validation of a novel bioluminescent mouse model of sezary syndrome for preclinical drug screening [abstract]
    • 2011 Dec 10-13; San Antonio TX. Washington DC: ASH, Abstract nr 2725
    • Jain S, Scotto L, Marchi E, Kalac M, Amengual J, Buitrago JB, et al. Validation of a novel bioluminescent mouse model of sezary syndrome for preclinical drug screening [abstract]. In: Proceedings of the 53rd ASH Annual Meeting and Exposition; 2011 Dec 10-13; San Antonio, TX. Washington, DC: ASH; 2011. Abstract nr 2725.
    • (2011) Proceedings of the 53rd ASH Annual Meeting and Exposition
    • Jain, S.1    Scotto, L.2    Marchi, E.3    Kalac, M.4    Amengual, J.5    Buitrago, J.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.