Hashimoto's thyroiditis and papillary thyroid cancer: Are they immunologically linked?

Trends in Endocrinology and Metabolism

Volumn 25, Issue 12, 2014, Pages 656-664

  Ehlers, Margret ^a   Schott, Matthias ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Cellular immunity; Hashimoto's thyroiditis; Papillary thyroid carcinoma; Thyroid gland

Indexed keywords

ANTIGEN;

AUTOIMMUNITY; CELLULAR IMMUNITY; HASHIMOTO DISEASE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; THYROID CARCINOMA; TUMOR IMMUNITY;

EID: 84922905988     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.09.001     Document Type: Review

References (100)

1. Ahmed R., et al. Hashimoto thyroiditis: a century later. Adv. Anat. Pathol. 2012, 3:181-186.
2. Latina A., et al. Hashimoto's thyroiditis: similar and dissimilar characteristics in neighboring areas. Possible implications for the epidemiology of thyroid cancer. PLoS ONE 2013, 8:e55450.
3. Duntas L.H. Environmental factors and thyroid autoimmunity. Ann. Endocrinol. (Paris) 2011, 2:108-113.
4. Amani H.K. Histopathologic and immunohistochemical features of Hashimoto thyroiditis. Indian J. Pathol. Microbiol. 2011, 3:464-471.
5. Fiore E., et al. Hashimoto's thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine. Endocr. Relat. Cancer 2011, 4:429-437.
6. Shoup M., et al. Prognostic indicators of outcomes in patients with distant metastases from differentiated thyroid carcinoma. J. Am. Coll. Surg. 2003, 2:191-197.
7. Howlader N., et al. SEER Cancer Statistics Review, 1975-2010 2013, National Cancer Institute.
8. Cunha L.L., et al. Infiltration of a mixture of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma. Clin. Endocrinol. (Oxf) 2012, 6:918-925.
9. + T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer. J. Clin. Endocrinol. Metab. 2012, 6:E934-E943.
10. Qing W., et al. Density of tumor-associated macrophages correlates with lymph node metastasis in papillary thyroid carcinoma. Thyroid 2012, 9:905-910.
11. Xu W.C., et al. Expression and distribution of S-100, CD83, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma. Cancer Invest. 2011, 4:286-292.
12. Yu H., et al. Regulatory T cells and plasmacytoid dendritic cells contribute to the immune escape of papillary thyroid cancer coexisting with multinodular non-toxic goiter. Endocrine 2013, 1:172-181.
13. Caturegli P., et al. Hashimoto's thyroiditis: celebrating the centennial through the lens of the Johns Hopkins hospital surgical pathology records. Thyroid 2013, 2:142-150.
14. Chen Y.K., et al. Cancer risk in patients with Hashimoto's thyroiditis: a nationwide cohort study. Br. J. Cancer 2013, 9:2496-2501.
15. + T cell lines/clones derived from autoimmune thyroiditis lesions. They recognize self-thyroid antigens directly on TEC to exhibit T helper cell 1-type lymphokine production and cytotoxicity against TEC. J. Immunol. 1995, 3:1619-1628.
16. Senou M., et al. Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice. Am. J. Physiol. Endocrinol. Metab. 2009, 2:E438-E451.
17. Nielsen C.H., et al. Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*. Clin. Endocrinol. (Oxf) 2008, 4:664-668.
18. McLachlan S.M., Rapoport B. Thyroid peroxidase as an autoantigen. Thyroid 2007, 10:939-948.
19. Liu M., et al. Epitope recognition patterns of thyroglobulin antibody in sera from patients with Hashimoto's thyroiditis on different thyroid functional status. Clin. Exp. Immunol. 2012, 3:283-290.
20. Ehlers M., et al. Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's thyroiditis. J. Clin. Endocrinol. Metab. 2012, 4:1347-1354.
21. Quaratino S., et al. Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice. Nat. Med. 2004, 9:920-926.
22. Watanabe H., et al. Experimental autoimmune thyroiditis induced by thyroglobulin-pulsed dendritic cells. Autoimmunity 1999, 4:273-282.
23. Drugarin D., et al. The pattern of a T(H)1 cytokine in autoimmune thyroiditis. Immunol. Lett. 2000, 2:73-77.
24. Kemp E.H., et al. Detection and localization of chemokine gene expression in autoimmune thyroid disease. Clin. Endocrinol. (Oxf) 2003, 2:207-213.
25. Kabel P.J., et al. Intrathyroidal dendritic cells. J. Clin. Endocrinol. Metab. 1988, 1:199-207.
26. Figueroa-Vega N., et al. Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis. J. Clin. Endocrinol. Metab. 2010, 2:953-962.
27. + regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen. J. Autoimmun. 2009, 1:68-76.
28. Glick A.B., et al. Impairment of regulatory T-cell function in autoimmune thyroid disease. Thyroid 2013, 7:871-878.
29. Domberg J., et al. Circulating chemokines in patients with autoimmune thyroid diseases. Horm. Metab. Res. 2008, 6:416-421.
30. Antonelli A., et al. Circulating chemokine (CXC motif) ligand (CXCL)9 is increased in aggressive chronic autoimmune thyroiditis, in association with CXCL10. Cytokine 2011, 2:288-293.
31. del Prete G.F., et al. High potential to tumor necrosis factor alpha (TNF-alpha) production of thyroid infiltrating T lymphocytes in Hashimoto's thyroiditis: a peculiar feature of destructive thyroid autoimmunity. Autoimmunity 1989, 4:267-276.
32. Akeno N., et al. IFN-alpha mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms. J. Immunol. 2011, 8:4693-4706.
33. Rebuffat S.A., et al. IL-1beta and TSH disturb thyroid epithelium integrity in autoimmune thyroid diseases. Immunobiology 2013, 3:285-291.
34. Salzano M., et al. Interferon-gamma inhibits integrin-mediated adhesion to fibronectin and survival signaling in thyroid cells. J. Endocrinol. 2012, 3:439-444.
35. Vural P., et al. The relationship between transforming growth factor-beta1, vascular endothelial growth factor, nitric oxide and Hashimoto's thyroiditis. Int. Immunopharmacol. 2009, 2:212-215.
36. Rotondi M., et al. Interferon-gamma and tumor necrosis factor-alpha sustain secretion of specific CXC chemokines in human thyrocytes: a first step toward a differentiation between autoimmune and tumor-related inflammation?. J. Clin. Endocrinol. Metab. 2013, 1:308-313.
37. Bossowski A., et al. Cytometric evaluation of intracellular IFN-gamma and IL-4 levels in thyroid follicular cells from patients with autoimmune thyroid diseases. Thyroid Res. 2011, 4:13.
38. Mariotti S., et al. Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet 1992, 8808:1506-1508.
39. Hollowell J.G., et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J. Clin. Endocrinol. Metab. 2002, 2:489-499.
40. Vanderpump M.P., et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin. Endocrinol. (Oxf) 1995, 1:55-68.
41. Wick G. Spontaneous autoimmune thyroiditis in chickens. Hautarzt 1970, 8:383-385. in German.
42. Braley-Mullen H., et al. Spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J. Autoimmun. 1999, 3:157-165.
43. Ng H.P., et al. Development of a murine model of autoimmune thyroiditis induced with homologous mouse thyroid peroxidase. Endocrinology 2004, 2:809-816.
44. Velicky J., et al. Experimental thyroiditis in guinea pigs and rabbits. Immunization with thyroglobulin and bovine thyroid gland suspension. Funct. Dev. Morphol. 1993, 4:259-267.
45. Volpe R., et al. The use of the severe combined immunodeficient mouse and the athymic 'nude' mouse as models for the study of human autoimmune thyroid disease. Clin. Immunol. Immunopathol. 1993, 2:93-99.
46. Vladutiu A.O., Rose N.R. Autoimmune murine thyroiditis relation to histocompatibility (H-2) type. Science 1971, 4014:1137-1139.
47. Bonita R.E., et al. Kinetics of mononuclear cell infiltration and cytokine expression in iodine-induced thyroiditis in the NOD-H2h4 mouse. Exp. Mol. Pathol. 2003, 1:1-12.
48. Yu S., et al. Dual roles for IFN-gamma, but not for IL-4, in spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J. Immunol. 2002, 7:3999-4007.
49. Braley-Mullen H., et al. Role of TGFbeta in development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J. Immunol. 2001, 12:7111-7118.
50. Bonita R.E., et al. Adhesion molecules as susceptibility factors in spontaneous autoimmune thyroiditis in the NOD-H2h4 mouse. Exp. Mol. Pathol. 2002, 3:155-163.
51. + T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis. J. Exp. Med. 2006, 2:349-358.
52. + regulatory T cells results in multiple autoimmune diseases in wild-type and B-cell-deficient NOD mice. Immunology 2013, 2:179-186.
53. Wick G., et al. No development of experimental autoimmune thyroiditis in nude mice. Z. Immunitatsforsch. Immunobiol. 1978, 2:162-168.
54. Cooper D.S., et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009, 11:1167-1214.
55. Pusztaszeri M.P., et al. Association of CD1a-positive dendritic cells with papillary thyroid carcinoma in thyroid fine-needle aspirations: a cytologic and immunocytochemical evaluation. Cancer Cytopathol. 2013, 4:206-213.
56. + T cells. Eur. J. Immunol. 2010, 5:1396-1407.
57. Todaro M., et al. Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells. Cancer Res. 2006, 3:1491-1499.
58. Gogali F., et al. Phenotypical analysis of lymphocytes with suppressive and regulatory properties (Tregs) and NK cells in the papillary carcinoma of thyroid. J. Clin. Endocrinol. Metab. 2012, 5:1474-1482.
59. Imam S., et al. Lymphocytic profiling in thyroid cancer provides clues for failure of tumor immunity. Endocr. Relat. Cancer 2014, 3:505-516.
60. bright immunoregulatory NK cells are increased in the tumor microenvironment and inversely correlate with advanced stages in patients with papillary thyroid cancer. Thyroid 2013, 12:1561-1568.
61. Ghiringhelli F., et al. The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression. Immunol. Rev. 2006, 229-238.
62. Cunha L.L., et al. Differentiated thyroid carcinomas may elude the immune system by B7H1 upregulation. Endocr. Relat. Cancer 2013, 1:103-110.
63. Mitsiades N., et al. Fas ligand expression in thyroid carcinomas: a potential mechanism of immune evasion. J. Clin. Endocrinol. Metab. 1999, 8:2924-2932.
64. Nunes L.M., et al. Association between the HLA-G molecule and lymph node metastasis in papillary thyroid cancer. Hum. Immunol. 2012, 4:447-451.
65. Dong H., et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 2002, 8:793-800.
66. Moretti S., et al. Indoleamine 2,3-dioxygenase 1 (IDO1) is up-regulated in thyroid carcinoma and drives the development of an immunosuppressant tumor microenvironment. J. Clin. Endocrinol. Metab. 2014, 5:E832-E840.
67. Rouas-Freiss N., et al. Expression of tolerogenic HLA-G molecules in cancer prevents antitumor responses. Semin. Cancer Biol. 2007, 6:413-421.
68. Paparodis R., et al. Hashimoto's thyroiditis pathology and risk for thyroid cancer. Thyroid 2014, 7:1107-1114.
69. Weetman A.P. Autoimmune thyroid disease. Autoimmunity 2004, 4:337-340.
70. Rebuffat S.A., et al. Antithyroperoxidase antibody-dependent cytotoxicity in autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 2008, 3:929-934.
71. Vasileiadis I., et al. Thyroglobulin antibodies could be a potential predictive marker for papillary thyroid carcinoma. Ann. Surg. Oncol. 2014, 8:2725-2732.
72. Grani G., et al. Thyroid autoimmunity and risk of malignancy in thyroid nodules submitted to fine-needle aspiration cytology. Head Neck 2013, 10.1002/hed.23587.
73. Latrofa F., et al. Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies. J. Clin. Endocrinol. Metab. 2008, 2:591-596.
74. Liotti F., et al. Inflammation in thyroid oncogenesis. Am. J. Cancer Res. 2012, 3:286-297.
75. Colotta F., et al. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009, 7:1073-1081.
76. Antonelli A., et al. Thyroid cancer in HCV-related chronic hepatitis patients: a case-control study. Thyroid 2007, 5:447-451.
77. Bartolome J., et al. Detection of hepatitis C virus in thyroid tissue from patients with chronic HCV infection. J. Med. Virol. 2008, 9:1588-1594.
78. Blackard J.T., et al. Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis. Thyroid 2013, 7:863-870.
79. Akeno N., et al. HCV E2 protein binds directly to thyroid cells and induces IL-8 production: a new mechanism for HCV induced thyroid autoimmunity. J. Autoimmun. 2008, 4:339-344.
80. Landskron G., et al. Chronic inflammation and cytokines in the tumor microenvironment. J. Immunol. Res. 2014, 2014:149185.
81. He D., et al. IL-17 mediated inflammation promotes tumor growth and progression in the skin. PLoS ONE 2012, 7:e32126.
82. Zhu G., et al. TNF-alpha promotes gallbladder cancer cell growth and invasion through autocrine mechanisms. Int. J. Mol. Med. 2014, 6:1431-1440.
83. Fajardo L.F., et al. Dual role of tumor necrosis factor-alpha in angiogenesis. Am. J. Pathol. 1992, 3:539-544.
84. Ji B., et al. COX-2 expression and tumor angiogenesis in thyroid carcinoma patients among northeast Chinese population-result of a single-center study. Int. J. Med. Sci. 2012, 3:237-242.
85. Mardente S., et al. Cross-talk between NO and HMGB1 in lymphocytic thyroiditis and papillary thyroid cancer. Oncol. Rep. 2010, 6:1455-1461.
86. Mardente S., et al. HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells. Oncol. Rep. 2012, 6:2285-2289.
87. Wang Z., et al. Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression. Curr. Stem Cell Res. Ther. 2010, 1:74-80.
88. Ohye H., Sugawara M. Dual oxidase, hydrogen peroxide and thyroid diseases. Exp. Biol. Med. (Maywood) 2010, 4:424-433.
89. Duntas L.H. Environmental factors and autoimmune thyroiditis. Nat. Clin. Pract. Endocrinol. Metab. 2008, 8:454-460.
90. Borrello M.G., et al. Inflammation and cancer: the oncogene-driven connection. Cancer Lett. 2008, 2:262-270.
91. Muzza M., et al. The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: clinical and molecular studies. Clin. Endocrinol. (Oxf) 2010, 5:702-708.
92. Amos S.M., et al. Autoimmunity associated with immunotherapy of cancer. Blood 2011, 3:499-509.
93. Kong Y.C., et al. Opportunistic autoimmune disorders: from immunotherapy to immune dysregulation. Ann. N. Y. Acad. Sci. 2010, 222-236.
94. +) T cells in melanoma-associated vitiligo. J. Invest. Dermatol. 2001, 6:1464-1470.
95. Byrne K.T., Turk M.J. New perspectives on the role of vitiligo in immune responses to melanoma. Oncotarget 2011, 9:684-694.
96. Kari S., et al. Enhanced autoimmunity associated with induction of tumor immunity in thyroiditis-susceptible mice. Thyroid 2013, 12:1590-1599.
97. Lee J.H., et al. The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis. Eur. J. Endocrinol. 2013, 3:343-349.
98. Spencer C.A. Clinical review: clinical utility of thyroglobulin antibody (TgAb) measurements for patients with differentiated thyroid cancers (DTC). J. Clin. Endocrinol. Metab. 2011, 12:3615-3627.
99. Kim H.Y., et al. Comparative analysis of gene expression profiles of papillary thyroid microcarcinoma and papillary thyroid carcinoma. J. Cancer Res. Ther. 2010, 4:452-457.
100. Saranac L., et al. Why is the thyroid so prone to autoimmune disease?. Horm. Res. Paediatr. 2011, 3:157-165.