Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 2, 2010, Pages 953-962

  Figueroa Vega, Nicté ^a,b   Alfonso Pérez, Manuel ^b   Benedicto, Ignacio ^b,c   Sánchez Madrid, Francisco ^b   González Amaro, Roberto ^a   Marazuela, Mónica ^b  

^a UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE INDUCTION; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; IMMUNOPATHOGENESIS; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; MALE; PRIORITY JOURNAL; TH17 CELL;

EID: 76149084482     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1719     Document Type: Article

References (54)

1. Druet P, Sheela R, Pelletier L 1996 Th1 and Th2 cells in autoimmunity. Chem Immunol 63:138-170
2. Tato CM, Laurence A, O'Shea JJ 2006 Helper T cell differentiation enters a new era: le roi est mort; vive le roi! J Exp Med 203:809-812
3. Shevach EM 2000 Suppressor T cells: rebirth, function and homeostasis. Curr Biol 10:R572-R5
4. Soroosh P, Doherty TA 2009 Th9 and allergic disease. Immunology 127:450-458
5. Harrington LE, Mangan PR, Weaver CT 2006 Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 18:349-356
6. Dong C 2006 Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 6:329-333
7. Bettelli E, Korn T, Kuchroo VK 2007 Th17: the third member of the effector T cell trilogy. Curr Opin Immunol 19:652-657
8. Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R 2007 Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8:903-905
9. Unutmaz D 2009 RORC2: the master of human Th17 cell programming. Eur J Immunol 39:1452-1455
10. Crome SQ, Wang AY, Kang CY, Levings MK 2009 The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells. Eur J Immunol 39:1480-1493
11. Ouyang W, Kolls JK, Zheng Y 2008 The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28:454-467
12. Traves SL, Donnelly LE 2008 Th17 cells in airway diseases. Curr Mol Med 8:416-426
13. Nistala K, Moncrieffe H, Newton KR, Varsani H, Hunter P, Wedderburn LR 2008 Interleukin-17-producingTcells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum 58:875-887
14. Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L, Szeliga W, Wang Y, Liu Y, Welling TH, Elder JT, Zou W 2008 Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 181:4733-4741
15. Garrett-Sinha LA, John S, Gaffen SL 2008 IL-17 and the Th17 lineage in systemic lupus erythematosus. Curr Opin Rheumatol 20: 519-525
16. Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ 2007 Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 56:2936-2946
17. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F 2007 Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8:942-949
18. Liu Z, Yang L, Cui Y, Wang X, Guo C, Huang Z 2009 IL-21 and TGF-β are required for differentiation of human T(H)17 cells. Inflamm Bowel Dis 15:1133-1144
19. Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR 2007 IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8:967-974
20. Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA 2006 Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7:937-945
21. Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT 2006 Transforming growth factor-β induces development of the T(H)17 lineage. Nature 441:231-234
22. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B 2006 TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-189
23. Hwang SY, Kim HY 2005 Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients. Mol Cells 19:180-184
24. Weaver CT, Hatton RD, Mangan PR, Harrington LE 2007 IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821-852
25. Korn T, Oukka M, Kuchroo V, Bettelli E 2007 Th17 cells: effector T cells with inflammatory properties. Semin Immunol 19:362-371
26. Lubberts E, Joosten LA, van de Loo FA, Schwarzenberger P, Kolls J, van den Berg WB 2002 Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction. Inflamm Res 51:102-104
27. Paradowska A, Maślińiski W, Grzybowska-Kowalczyk A, Łacki J 2007 The function of interleukin 17 in the pathogenesis of rheumatoid arthritis. Arch Immunol Ther Exp (Warsz) 55:329-334
28. Kurasawa K, Hirose K, Sano H, Endo H, Shinkai H, Nawata Y, Takabayashi K, Iwamoto I 2000 Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum 43:2455-2463
29. Arican O, Aral M, Sasmaz S, Ciragil P 2005 Serum levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm 2005:273-279
30. Wong CK, Lit LC, Tam LS, Li EK, Wong PT, Lam CW 2008 Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol 127:385-393
31. Ikeuchi H, Kuroiwa T, Hiramatsu N, Kaneko Y, Hiromura K, Ueki K, Nojima Y 2005 Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum 52:1037-1046
32. Weetman AP 2004 Autoimmune thyroid disease. Autoimmunity 3:337-340
33. Weetman AP 2004 Cellular immune responses in autoimmune thyroid disease. Clin Endocrinol 61:405-413
34. MarazuelaM1999 Lymphocyte traffic and homing in autoimmune thyroid disorders. Eur J Endocrinol 140:287-290
35. Liblau RS, Singer SM, McDevitt HO 1995 Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16:34-38
36. Paschke R, Schuppert F, Taton M, Velu T 1994 Intrathyroidal cytokine gene expression profiles in autoimmune thyroiditis. J Endocrinol 141:309-315
37. García-López MA, Sancho D, Sánchez-Madrid F, Marazuela M 2001 Thyrocytes from autoimmune thyroid disorders produce the chemokines IP-10 and Mig and attract CXCR3+ lymphocytes. J Clin Endocrinol Metab 86:5008-5016
38. Ajjan RA, Weetman AP 2003 Cytokines in thyroid autoimmunity. Autoimmunity 36:351-359
39. Marazuela M, García-López MA, Figueroa-Vega N, de la Fuente H, Alvarado-Sánchez B, Monsiváis-Urenda A, Sánchez-Madrid F, González-Amaro R 2006 Regulatory T cells in human autoimmune thyroid disease. J Clin Endocrinol Metab 91:3639-3646
40. Figueroa-Vega N, Sanz-Cameno P, Moreno-Otero R, Sánchez-Madrid F, González-Amaro R, Marazuela M 2009 Serum levels of angiogenic molecules in autoimmune thyroid diseases and their correlation with laboratory and clinical features. J Clin Endocrinol Metab 94:1145-1153
41. Acevedo A, del Pozo MA, Arroyo AG, Sánchez-Mateos P, González-Amaro R, Sánchez-Madrid F 1993 Distribution of ICAM-3-bearing cells in normal human tissues. Expression of a novel counter-receptor for LFA-1 in epidermal Langerhans cells. Am J Pathol 143:774-783
42. Stockinger B, Veldhoen M, Martin B 2007 Th17 T cells: linking innate and adaptive immunity. Semin Immunol 19:353-361
43. Pène J, Chevalier S, Preisser L, Vénéreau E, Guilleux MH, Ghannam S, Molès JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H 2008 Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 180:7423-7430
44. Gu Y, Yang J, Ouyang X, Liu W, Li H, Yang J, Bromberg J, Chen SH, Mayer L, Unkeless JC, XiongH2008 Interleukin 10 suppresses Th17 cytokines secreted by macrophages andTcells. Eur J Immunol 38:1807-1813
45. Rachitskaya AV, Hansen AM, Horai R, Li Z, Villasmil R, Luger D, Nussenblatt RB, Caspi RR 2008 Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 180:5167-5171
46. O'Brien RL, Roark CL, Born WK 2009 IL-17-producing γΔ T cells. Eur J Immunol 39:662-666
47. Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hünig T, Mittrücker HW, Brüstle A, Kamradt T, Lohoff M 2009 A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur J Immunol 39:1716-1725
48. Nakae S, Iwakura Y, Suto H, Galli SJ 2007 Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol 81:1258-1268
49. Li MO, Wan YY, Flavell RA 2007 T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26:579-591
50. Voo KS, Wang YH, Santori FR, Boggiano C, Wang YH, Arima K, Bover L, Hanabuchi S, Khalili J, Marinova E, Zheng B, Littman DR, Liu YJ 2009 Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci USA 106:4793-4798
51. Mathers AR, Janelsins BM, Rubin JP, Tkacheva OA, Shufesky WJ, Watkins SC, Morelli AE, Larregina AT 2009 Differential capability ofhumancutaneous dendritic cell subsets to initiate Th17 responses. J Immunol 182:921-933
52. Inoue N, Watanabe M, Nanba T, Wada M, Akamizu T, Iwatani Y 2009 Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody. Clin Exp Immunol 156:199-204
53. Nanba T, Watanabe M, Inoue N, Iwatani Y 2009 Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease. Thyroid 19:495-501
54. Kocjan T, Wraber B, Repnik U, Hojker S 2000 Changes in Th1/Th2 cytokine balance in Graves' disease. Pflugers Arch 440(Suppl 5): R94-R95