Development of a Murine Model of Autoimmune Thyroiditis Induced with Homologous Mouse Thyroid Peroxidase

Endocrinology

Volumn 145, Issue 2, 2004, Pages 809-816

  Ng, H P ^a   Banga, J Paul ^b   Kung, Annie W C ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AUTOANTIBODY; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; FREUND ADJUVANT; RECOMBINANT PROTEIN; THYROID PEROXIDASE; THYROID PEROXIDASE ANTIBODY;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL COUNT; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; ESCHERICHIA COLI; EUTHANASIA; FEMALE; HASHIMOTO DISEASE; IMMUNIZATION; IMMUNOSTIMULATION; INJECTION; LYMPH NODE CELL; MONONUCLEAR CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PURIFICATION; T LYMPHOCYTE; THYROID FOLLICLE; THYROIDITIS;

ANIMALS; AUTOANTIBODIES; CELL DIVISION; DISEASE MODELS, ANIMAL; FEMALE; IMMUNIZATION; IODIDE PEROXIDASE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; RECOMBINANT PROTEINS; T-LYMPHOCYTES; THYROID GLAND; THYROIDITIS, AUTOIMMUNE; THYROXINE;

EID: 0842291558     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0656     Document Type: Article

References (41)

1. Wang C, Crapo LM 1997 The epidemiology of thyroid disease and implication for screening. Endocrinol Metab Clin North Am 26:189-218
2. Jacobson DL, Gange SJ, Rosa NR, Garaham NMH 1997 Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 84:223-243
3. Weetman AP, McGregor AM 1994 Autoimmune thyroid disease: further developments in our understanding. Endocr Rev 15:788-830
4. Rapoport B, McLachlan S 1994 Thyroid peroxidase as an autoantigen in autoimmune thyroid disease: update. Endocr Rev 3:96-102
5. Banga JP 1998 Thyroid peroxidase: developments in our understanding of its structure and the relevance of these findings to autoimmunity. Curr Opin Endocrinol Diabetes 5:275-281
6. Dayan CM, Daniels GH 1996 Chronic autoimmune thyroiditis. N Engl J Med 335:99-107
7. Calder AE, Penhale WJ, McLeman D, Barnes EW, Irvine WJ 1973 Lymphocyte-dependent antibody-mediated cytotoxicity in Hashimoto thyroiditis. Clin Exp Immunol 14:153-158
8. Suzuki S, Mitsunuga M, Miyoshi M, Hivakawa S, Nakagawa O, Miuva H, Ofuji T 1980 Cytophilic anti-thyroglobulin antibody and antibody-dependent monocyte-mediated cytotoxicity in Hashimoto's thyroiditis. J Clin Endocrinol Metab 51:446-453
9. Rodien P, Madec AM, Ruf J, Rajas F, Bornet H, Carayon P, Orgiazzi J 1996 Antibody-dependent cell-mediated cytotoxicity in autoimmune thyroid disease: relationship to antithyroperoxidase antibodies. J Clin Endocrinol Metab 81:2595-2600
10. Jin G, Juan CJ, Rapoport B, McLachlan S 1997 Recombinant thyroid peroxidase-specific Fab converted to immunoglobulin G (IgG) molecules: evidence for thyroid cell damage by IgG1, but not IgG4, autoantibodies. J Clin Endocrinol Metab 82:925-931
11. Kong YC, Lomo LC, Mott RW, Giraldo AA, Baisch J, Strauss G, Hammerling GJ 1996 HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA- DRB1*0301(DR3) gene. J Exp Med 184:1167-1172
12. Dai Y, Carayanniotis KA, Eliades P, Lymberi P, Shepherd P, Kong YC, Carayanniotis G 1991 Enhancing or suppressive effects of antibodies on processing of a pathogenic T cell epitope in thyroglobulin. J Immunol 162:6987-6992
13. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM 1998 The thyrotropin (TSH) receptor interaction with TSH and autoantibodies. Endocr Rev 19:673-716
14. Stassi G, De Maria R 2002 Autoimmune thyroid disease: new models of cell death in autoimmunity. Nat Rev Immunol 2:195-204
15. Kotani T, Umeki K, Hirai K, Ohtaki S 1990 Experimental murine thyroiditis induced by porcine thyroid peroxidase and its transfer by the antigen specific T cell line. Clin Exp Immunol 80:11-18
16. Kotani T, Umeki K, Yagihashi S, Hirai K, Ohtaki S 1992 Identification of thyroiditogenic epitope on porcine thyroid peroxidase for C57BL/6 mice. J Immunol 148:2084-2089
17. McLachlan SM, Atherton MC, Nakajima Y, Napier J, Jordan RK, Clark F, Rees Smith B 1990 Thyroid peroxidase and the induction of autoimmune thyroid disease. Clin Exp Immunol 79:182-188
18. Rowley MJ, Maeda T, Mackay IR, Loveland BE, McMullen GL, Tribbick G, Bernard CC 1992 Differing epitope selection of experimentally induced and natural antibodies to a disease-specific autoantigen, the E2 subunit of pyruvate dehydrogenese complex (PDC-E2). Int Immunol 4:1245-1253
19. Jaume JC, Guo J, Wang Y, Rapoport B, McLachlan SM 1999 Cellular thyroid peroxidase, unlike purified TPO and adjuvant induces antibodies in mice that resemble autoantibodies in human autoimmune thyroid disease. J Clin Endocrinol Metab 84:1651-1657
20. Guo J, Pinchurin P, Nagayama Y, Rapoport B, McLachlan SM 2003 Insight into the antibody response induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. Clin Exp Immunol 132:408-415
21. Kotani T, Umeki K, Yamamoto I, Takeuchi M, Takechi S, Nakayama T, Ohtaki S 1993 Nucleotide sequence of the cDNA encoding mouse thyroid peroxidase. Gene 123:289-290
22. Frangioni JV, Neel BG 1993 Solubilization and purification of enzymatically active glutathione-S-transferase (pGEX) fusion proteins. Anal Biochem 210:179-187
23. Gardas A, Lewartowska A, Sutton BJ, Pasieka Z, McGregor AM, Banga JP 1997 Human thyroid peroxidase (TPO) isoform, TPO-1 and TPO-2: analysis of protein expression in Graves' thyroid tissue. J Clin Endocrinol Metab 82:3752-3757
24. Ewins DL, Barnett PS, Tomlinson RW, McGregor AM, Banga JP 1992 Mapping epitope specificities of monoclonal antibodies to thyroidase using recombinant antigen preparations. Autoimmunity 11:1141-1149
25. Gardas A, Sohi MK, Sutton BJ, McGregor AM, Banga JP 1997 Purification and crystallization of the autoantigen thyroid peroxidase from human Graves' thyroid tissue. Biochem Biophys Res Commun 234:366-370
26. Vladutiu AO, Rose NR 1971 Autoimmune murine thyroiditis: relation to histocompatibility (H-2) type. Science 174:1137-1139
27. Esquivel PS, Rose NR, Kong YC 1977 Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide. J Exp Med 145:1250-1263
28. Rasmussen AK, Feldt-Rasmussen U, Brandt M, Hartoft, Nielsen ML, Carayon P, Buschard K 1999 Thyrotropin stimulates specifically the expression of the autoantibody binding domains of the thyroperoxidase molecule. Autoimmunity 29:323-331
29. Kimura S, Kotani T, McBride OW, Umeki K, Hirai K, Nakayoma T, Ohtaki S 1987 Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping and identification of two alternately spliced mRNAs. Proc Natl Acad Sci USA 84:5555-5559
30. Ruf J, Toubert ME, Czarnocka B, Durand-Gorde JM, Ferrand M, Carayon P 1989 Relationship between immunological structures and biochemical properties of human thyroid peroxidase. Endocrinology 125:1211-1218
31. McLachlan S, Rapoport B 1995 Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response. Clin Exp Immunol 101:200-206
32. Weetman AP, McGregor AM, Lazarus JH, Hall R 1982 Thyroid antibodies are produced by thyroid-derived lymphocytes Clin Exp Immunol 48:196-200
33. McLachlan SM, Dickinson AM, Malcolm A, Farndon JR, Young E, Proctor SJ, Smith BR 1983 Thyroid autoantibody synthesis by cultures of thyroid and peripheral blood lymphocytes. I. Lymphocyte makers and response to pokeweed mitogen. Clin Exp Immunol 52:45-53
34. Iwatani Y, Hidaka Y, Matsuzuka F, Kuma K, Amino N 1993 Intrathyroidal lymphocyte subsets, including unusual CD4+CD8+ cells and CD3loTCRα β lo/-CD4-CD8-cells, in autoimmune thyroid disease. Clin Exp Immunol 93:430-436
35. Maron R, Zerubavel R, Fiedman A, Cohen IR 1983 T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice. J Immunol 131:2316-2322
36. Romball CG, Weigle WO 1987 Transfer of experimental autoimmune thyroiditis with T cell clones. J Immunol 138:1092-1098
37. Vladutiu AO, Rose NR 1975 Cellular basis of the genetic control of immune responsiveness to murine thyroglobulin in mice. Cell Immunol 17:106-127
38. Bennet SR, Carbone FR, Karamalis F, Miller JF, Heath WR 1997 Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J Exp Med 186:65-70
39. Heath WR, Carbone FR 2001 Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol 19:47-64
40. Lewis M, Gialdo AA, Kong YM 1987 Resistance to experimental autoimmune thyroiditis induced by physiologic manipulation of thyroglubulin level. Clin Immunol Immunopathol 45:92-104
41. Alejandro RA, Danese MD, Ladenson PW 2000 When to treat mild hypothyroidism. Endocrinol Metab Clin North Am 29:399-415