Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

Journal of Medicinal Chemistry

Volumn 58, Issue 3, 2015, Pages 1184-1194

  Paterni, Ilaria ^a   Bertini, Simone ^a   Granchi, Carlotta ^a   Tuccinardi, Tiziano ^a   Macchia, Marco ^a   Martinelli, Adriano ^a   Caligiuri, Isabella ^b   Toffoli, Giuseppe ^b   Rizzolio, Flavio ^b   Carlson, Kathryn E ^c   Katzenellenbogen, Benita S ^d   Katzenellenbogen, John A ^c   Minutolo, Filippo ^a  

^a UNIVERSITY OF PISA   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [6 HYDROXY 3 (3 CHLORO 4 HYDROXYPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (3 CHLORO 4 METHOXYPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (3 FLUORO 4 HYDROXYPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (3 FLUORO 4 HYDROXYPHENYL)PHENYL]PROPAN 1 ONE OXIME; 1 [6 HYDROXY 3 (3 FLUORO 4 METHOXYPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (4 CHLOROPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (4 FLUOROPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (4 HYDROXY 3 METHYLPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (4 HYDROXYPHENYL)PHENYL] 2,2,2 TRIFLUOROETHANONE OXIME; 1 [6 HYDROXY 3 (4 HYDROXYPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (4 HYDROXYPHENYL)PHENYL]PROPAN 1 ONE OXIME; 1 [6 HYDROXY 3 (4 METHOXY 3 METHYLPHENYL)PHENYL]ETHANONE OXIME; 1 [6 HYDROXY 3 (4 METHOXYPHENYL)PHENYL]ETHANONE OXIME; ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR BETA AGONIST; HORMONE RECEPTOR STIMULATING AGENT; LIQUIRITIGENIN; OXIME DERIVATIVE; SALICYLKETOXIME DERIVATIVE; UNCLASSIFIED DRUG; BIPHENYL DERIVATIVE; OXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CELL ASSAY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CROSS COUPLING REACTION; DOSE RESPONSE; EC50; FEMALE; GENE EXPRESSION ASSAY; GLIOMA; GLIOMA CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MODEL; MOUSE; NONHUMAN; RECEPTOR BINDING; TRANSACTIVATION; TRANSCRIPTION INITIATION; TUMOR VOLUME; TUMOR XENOGRAFT; AGONISTS; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; MCF 7 CELL LINE; METABOLISM; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ESTROGEN RECEPTOR BETA; FEMALE; GLIOMA; HUMANS; MCF-7 CELLS; MICE; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; OXIMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922830995     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501829f     Document Type: Article

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