An efficient synthesis of a dual PPAR α/γ agonist and the formation of a sterically congested α-aryloxyisobutyric acid via a Bargellini reaction

Journal of Organic Chemistry

Volumn 70, Issue 21, 2005, Pages 8560-8563

  Cvetovich, Raymond J ^a   Chung, John Y L ^a   Kress, Michael H ^a   Amato, Joseph S ^a   Matty, Louis ^a   Weingarten, M David ^a,b   Tsay, Fuh Rong ^a   Li, Zhen ^a   Zhou, George ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b AtheroGenics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; SODIUM COMPOUNDS; STEREOCHEMISTRY; SULFUR COMPOUNDS; SYNTHESIS (CHEMICAL);

BARGELLINI REACTION; BENZISOXAZOLE 1; CHLORETONE HEMIHYDRATE; CYCLIC SUFIDE;

ORGANIC ACIDS;

BENZISOXAZOLE; CHLORBUTOL; ISOBUTYRIC ACID DERIVATIVE; METHANE; METHANESULFONYL CHLORIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PHENOL DERIVATIVE; SODIUM HYDROXIDE; SULFITE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BARGELLINI REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; HALF LIFE TIME; REACTION ANALYSIS; STRUCTURE ANALYSIS;

BUTYRIC ACIDS; ISOXAZOLES; MOLECULAR STRUCTURE; PPAR ALPHA; PPAR GAMMA; PROPIONIC ACIDS;

EID: 26844443331     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo051027+     Document Type: Article

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