Do steroid hormones play a role in the etiology of glioma?

Cancer Epidemiology Biomarkers and Prevention

Volumn 19, Issue 10, 2010, Pages 2421-2427

  Kabat, Geoffrey C ^a   Etgen, Anne M ^a   Rohan, Thomas E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; AROMATASE; BENZOPYRAN DERIVATIVE; CC 8490; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR BETA; GENISTEIN; MELATONIN; MIFEPRISTONE; PROGESTERONE; SEX HORMONE; STEROID HORMONE; STEROID RECEPTOR; TAMOXIFEN; TIBOLONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; BRAIN DEVELOPMENT; CANCER EPIDEMIOLOGY; CANCER GROWTH; CANCER INCIDENCE; CANCER INHIBITION; CARCINOGENESIS; CELL DEATH; DRUG EFFECT; DRUG MEGADOSE; GLIA CELL; GLIOBLASTOMA; GLIOMA; GLIOMA CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY;

ANIMALS; ESTROGEN RECEPTOR BETA; FEMALE; GLIOMA; HORMONES; HUMANS; MALE; NEOPLASMS, HORMONE-DEPENDENT; STEROIDS;

EID: 77958036159     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-10-0658     Document Type: Short Survey

References (83)

1. Preston-Martin S, Munir R, Chakrabarti I. Nervous system. In: Schottenfeld D, Fraumeni JF, Jr., editors. Cancer epidemiology and prevention. 3rd ed. New York: Oxford University Press; 2006, p. 1173-95.
2. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2004-2005, 2009. Available from: http://www.cbtrus.org/reports/2009-NPCR-04-05/CBTRUS-NPCR2004-2005-Report-.pdf.
3. Kanu OO, Hughes B, Di C, et al. Glioblastoma multiforme oncogenomics and signaling pathways. Clin Med Oncol 2009;3:39-52.
4. Savitz D, Trichopoulos D. Brain cancer. In: Adami H-O, Hunter D, Trichopoulos D, editors. Textbook of cancer epidemiology. New York: Oxford; 2002, p. 486-503.
5. Inskip PD, Linet MS, Heineman EF. Etiology of brain tumors in adults. Epidemiol Rev 1995;17:382-414.
6. Ohgaki H, Kleihues P. Epidemiology and etiology of gliomas. Acta Neuropathol 2005;109:93-108.
7. McKinley BP, Michalek AM, Fenstermaker RA, Plunkett RJ. The impact of age and sex on the incidence of glial tumors in New York State from 1976 to 1995. J Neurosurg 2000;93:932-9.
8. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB, editors. Cancer incidence in five continents, vol. VIII. Oxford (UK): Oxford University Press; 2003.
9. Fleury A, Menegoz F, Grosclaude P, et al. Descriptive epidemiology of cerebral gliomas in France. Cancer 1997;79:1195-202. (Pubitemid 27118217)
10. Schelhofer B, Blettner M, Wahrendorf J. Association between brain tumors and menopausal status. J Natl Cancer Inst 1992;84:1346-9.
11. Hochberg F, Toniolo P, Cole P. Nonoccupational risk indicators of glioblastoma in adults. J Neuro-Oncol 1990;8:55-60. (Pubitemid 20117354)
12. Cantor KP, Lynch CF, Johnson D. Reproductive factors and risk of brain, colon, and other malignancies in Iowa (United States). Cancer Causes Control 1993;4:505-11.
13. Lambe M, Coogan P, Baron J. Reproductive factors and the risk of brain tumors: a population-based study in Sweden. Int J Cancer 1997;72:389-93. (Pubitemid 27325862)
14. Cicuttini FM, Hurley SF, Forbes A, et al. Association of adult glioma with medical conditions, family and reproductive history. Int J Cancer 1997;71:203-7.
15. Schlehofer B, Blettner M, Preston-Martin S, et al. Role of medical history in brain tumor development. Results from the International Adult Brain Tumor Study. Int J Cancer 1999;82:155-60.
16. Huang K, Whelan EA, Ruder AM, et al. Reproductive factors and risk of glioma in women. Cancer Epidemiol Biomarkers Prev 2004;13:1583-8.
17. Hatch EE, Linet MS, Zhang J, et al. Reproductive and hormonal factors and risk of brain tumors in adult females. Int J Cancer 2005;114:797-805. (Pubitemid 40344441)
18. Silvera SAN, Miller AB, Rohan TE. Hormonal and reproductive factors and risk of glioma: a prospective cohort study. Int J Cancer 2006;118:1321-4.
19. Wigertz A, Lönn S, Mathiesen T, Ahlbom A, Hall P, Feychting M. Swedish Interphone Study Group. Risk of brain tumors associated with exposure to female sex hormones. Am J Epidemiol 2006;164:629-36.
20. Benson VS, Pirie K, Green J, Casabonne D, Beral V, Million Women Study Collaborators. Lifestyle factors and primary glioma and meningioma tumors in the Million Women Study cohort. Br J Cancer 2008;99:185-90.
21. Wigertz A, Lönn S, Hall P, et al. Reproductive factors and risk of meningioma and glioma. Cancer Epidemiol Biomarkers Prev 2008;17:2663-70.
22. Felini MJ, Olshan AF, Schroeder JC, et al. Reproductive factors and hormone use and risk of adult glioma. Cancer Causes Control 2009;20:87-96.
23. Benson VS, Pirie K, Green J, et al. Hormone replacement therapy and incidence of central nervous system tumors in the Million Women Study. Int J Cancer 2010;127:1692-98, DOI 10.1002/ijc.25184.
24. Kabat GC, Park Y, Hollenbeck A, Schatzkin A, Rohan TE. Reproductive factors and exogenous hormone use and risk of adult glioma in women in the NIH-AARP Diet and Health Study. Int J Cancer. Epub ahead of print 2010.
25. Carroll RS, Zhang J, Dashner K, Sar M, Black PM. Steroid hormone receptors in astrocytic neoplasms. Neurosurgery 1995;37:496-503.
26. Santagati S, Melcangi RC, Celotti F, Martini L, Maggi A. Estrogen receptor is expressed in different types of glial cells in culture. J Neurochem 1994;63:2058-64.
27. Garcia-Segura LM, Azocoitia I, DonCarlos LL. Neuroprotection by estradiol. Prog Neurobiol 2001;63:29-60.
28. Behl C. Estrogen as a neuroprotective hormone. Nat Rev Neurosci 2002;3:433-42.
29. Dhandapani KM, Brann DW. Protective effects of estrogen and selective estrogen receptor modulators in the brain. Biol Reprod 2002;67:1379-85.
30. Mhyre AJ, Dorsa DM. Estrogen activates rapid signaling in the brain: role of estrogen receptor α and estrogen receptor β in neurons and glia. Neuroscience 2006;138:851-8.
31. Gilles GE, McArthur S. Independent influences of sex steroids of systematic and central origin in a rat model of Parkinson's disease: a contribution to sex-specific neuroprotection by estrogens. Horm Behav 2010;57:23-34.
32. Arevalo M-A, Santos-Galindo M, Bellini M-J, Azcoitia I, Garcia-Segura LM. Actions of estrogens on glial cells: implications for neuroprotection. Biochem Biophys Acta. Epub ahead of print 2009.
33. Green S, Chambon P. A superfamily of potentially oncogenic hormone receptors. Nature 1986;324:615-7. (Pubitemid 17206346)
34. Lonard DM, Smith CL. Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions. Steroid 2002;67:15-24.
35. Batistatou A, Kyzas PA, Goussia A, et al. Estrogen receptor beta (ERβ) protein expression correlates with BAG-1 and prognosis in brain glial tumors. J Neuro-Oncol 2006;77:17-23.
36. Batistatou A, Stefanou D, Goussia A, Arkoumani E, Papavassiliou A, Agnantis NJ. Estrogen receptor beta (ERβ) is expressed in brain astrocytic tumors and declines with dedifferentiation of the neoplasm. J Cancer Res Clin Oncol 2004;130:405-10.
37. Norman AW, Mizwicki MT, Norman DP. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 2004;3:27-41.
38. Prossnitz ER, Maggiolini M. Mechanisms of estrogen signaling and gene expression via GPR30. Mol Cell Endocrinol 2009;308:32-8.
39. Goya L. Steroid and protein regulators of glial cell proliferation. In: Filogama G, Vernadakis A, Gremo F, Privat AM, Timiras PS, editors. Brain plasticity: development and aging. New York: Plenum Press; 1997, p. 249-60.
40. Bardin A, Boulle N, Lazennec G, Vignon F, Pujol P. Loss of ERβ expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer 2004;11:537-51.
41. Klinge CM. Estrogen receptor interaction with co-activators and co-repressors. Steroids 2000;65:227-51.
42. Poisson M, Pertuiset BF, Moguilewsky M, Magdenlenat H, Martin PM. Les récepteurs de stéroides du système nerveux central: implications en neurologie. Rev Neurol (Paris) 1984;140:233-48.
43. Brentani MM, Lopes MTP, Martins VR, Plese JPP. Steroid receptors in intracranial tumors. Clin Neuropharmacol 1984;7:347-50.
44. Fujimoto M, Yoshino E, Hirakawa K, Fujimoto J, Tamaya T. Estrogen receptors in brain tumors. Clin Neuropharmacol 1984;7:357-62.
45. Whittle IR, Hawkins RA, Miller JD. Sex hormone receptors in intracranial tumors and normal brain. Eur J Surg Oncol 1987;13:303-7.
46. Stojković RR, Jovanèević M, Šantel DJ, Grèević N, Gamulin S. Sex steroid receptors in intracranial tumors. Cancer 1990;65:1968-70.
47. Paoletti P, Butti G, Zibera C, et al. Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors. J Neurosurg 1990;73:736-42. (Pubitemid 20364490)
48. Jung-Testas I, Renoir M, Bugnard H, Greene GL, Baulieu E-E. Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells. J Steroid Biochem Mol Biol 1992;41:3-8.
49. Leslie KK, Keefe D, Powell S, Naftolin F. Estrogen receptors are identified in the glioblastoma cell line U138MG. J Soc Gynecol Investig 1994;1:238-44.
50. Khalid MH, Shibata S, Furukawa K, Nadel A, Ammerman MD, Caputy AJ. Role of estrogen receptor-related antigen in initiating the growth of human glioma cells. J Neurosurg 2004;100:923-30.
51. Gandhari MK, Frazier CR, Hartenstein JS, Cloix J-F, Bernier M, Wainer IW. Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells. Mol Cell Endocrinol 2010;315:314-8.
52. Yague JG, Lavaque E, Carretero J, Azcoitia I, Garcia-Segura LM. Aromatase, the enzyme responsible for estrogen biosynthesis, is expressed by human and rat glioblastomas. Neurosci Lett 2004;368:279-84.
53. Gonzalez-Agüero G, Ondarza R, Gamboa-Dominguez A, Cerbon MA, Camacho-Arroyo I. Progesterone receptor isoforms expression pattern in human astrocytomas. Brain Res Bull 2001;56:43-8. (Pubitemid 32962937)
54. Giraud SN, Caron CM, Pham-Dinh D, Kitabgi P, Nicot AB. Estradiol inhibits ongoing autoimmune neuroinflammation and NFκB-dependent CCL2 expresssion in reactive astrocytes. PNAS 2010;107:8416-21.
55. Takao T, Flint N, Lee L, Ying X, Merrill J, Chandross KJ. 17β-estradiol protects oligodendrocytes from cytotoxicity induced cell death. J Neurochem 2004;89:660-73.
56. Allred DC, Carlson RW, Berry DA, et al. NCCN Task Force Report: Estrogen Receptor and Progesterone Receptor Testing in Breast Cancer by Immunohistochemistry. J Natl Compr Canc Netw 2009;7 Suppl 6:S1-21.
57. Rhodes A, Jasani B, Balaton AJ, et al. Study of interlaboratory reliability and reproducibility of estrogen and progesterone receptor assays in Europe. Documentation of poor reliability and identification of insufficient microwave antigen retrieval time as a major contributory element of unreliable assays. Am J Clin Pathol 2001;115:44-58.
58. Deyrup AT, Tretiakova M, Khramtsov A, Montag AG. Estrogen receptor β expression in vascular neoplasia: an analysis of 53 benign and malignant cases. Mod Pathol 2004;17:1372-7. (Pubitemid 39472992)
59. Konstantinopoulos PA, Kominea A, Vandoros G, et al. Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation. Eur J Cancer 2003;39:1251-8.
60. Pujol P, Rey JM, Nirde P, et al. Differential expression of estrogen receptor-α and -β messenger RNAs as a potential marker of ovarian carcinogenesis. Cancer Res 1998;58:5367-73.
61. Speirs V. Oestrogen receptor β in breast cancer: good, bad, or still too early to tell? J Pathol 2002;197:143-7.
62. Verzat C, Belisle M-B, Courriere P, Hollande E. Influence of host sex on growth of human glioblastoma line in athymic mice. Neuropathol Appl Neurobiol 1990;16:141-51. (Pubitemid 20146623)
63. Plunkett RJ, Lis A, Barone TA, Fronckowiak MD, Greenberg SJ. Hormonal effects on glioblastoma multiforme in the nude rat model. J Neurosurg 1999;90:1072-7.
64. Barone TA, Gorski JW, Greenberg SJ, Plunkett RJ. Estrogen increases survival in an orthotopic model of glioblastoma. J Neurooncol 2009;95:37-48.
65. Lis A, CiesielskiMJ, Barone TA, Scott BE, Fenstermaker RA, Plunkett RJ. 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death, in vitro. Cancer Lett 2004;213:57-65.
66. Chamaon K, Stojek J, Kanakis D, et al. Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton. J Neuro-Oncol 2005;72:11-6. (Pubitemid 41149171)
67. Kirches E, Warich-Kirches M. 2-Methoxyestradiol as a potential cytostatic drug in gliomas? Anti-Cancer Agents Med Chem 2009;9:55-65.
68. Kang SH, Cho HT, Devi S, et al. Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Cancer Res 2006;66:11991-7.
69. Altinoz MA, Albayrak SB, Karasu A, Sabanci PA, Imer M, Bilir A. The effects of tibolone on the human primary gliobastoma multiforme cell culture and the rat C6 glioma model. Neurol Res 2009;31:923-7.
70. Gonzalez A, Martinez-Campa C, Mediavilla MD, Alonso-Gonzalez C, Sanchez-Barceló, Cos S. Inhibitory effects of pharmacological doses of melatonin on aromatase activity and expression in rat glioma cells. Brit J Cancer 2007;97:755-60.
71. Yakisich JS, Lindblom IO, Siden A, Cruz MH. Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein. Oncol Rep 2009;22:569-74.
72. Pollack IF, Randall MS, Kristofik MP, Kelly RH, Selker RG, Vertosick FT, Jr. Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro. Cancer Res 1990;50:7134-8.
73. Zhang W, Couldwell WT, Song H, Takano T, Lin JH, Nedergaard M. Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells. Cancer Res 2000;60:5395-400.
74. Kim Y-J, Lee C-J, Lee U, Yoo Y-M. Tamoxifen-induced cell death and expression of neurotrophic factors in cultured C6 glioma cells. J Neuro-Oncol 2005;71:121-5. (Pubitemid 40796292)
75. Hui A-M, Zhang W, Chen W, et al. Agents with selective estrogen receptor (ER) modulator activity induce apoptosis in vitro and in vivo in ER-negative glioma cells. Cancer Res 2004;64:9115-23.
76. Liu Z, Kokunai T, Tamaki N. Tamoxifen interacts with neu/c-erbB-2 receptor and inhibits growth of human malignant glioma cell lines. Kobe J Med Sci 2001;47:131-40.
77. Lu T, Achari Y, Rattner JB, Hart DA. Evidence that estrogen receptor beta enhances MMP-13 promoter activity in HIG-82 cells and that this enhancement can be influenced by ligands and involves specific promoter sites. Biochem Cell Biol 2007;85:326-36. (Pubitemid 47025912)
78. de Medina P, Favre G, Poirot M. Multiple targeting by the antitumor drug tamoxifen: a structure-activity study. Curr Med Chem Anticancer Agents 2004;4:491-508.
79. da Rocha AB, Mans DR, Bernard EA, et al. Tamoxifen inhibits particulate-associated protein kinase C activity, and sensitises cultured human glioblastoma cells not to etoposide but to gammaradiation and BCNU. Eur J Cancer 1999;35:833-9.
80. Ramos-Mandujano G, Vázquez-Juárez E, Hernández- Benítez R, Pasantes-Morales H. Thrombin potentially enhances swelling-sensitive glutamate influx from cultured astrocytes. Glia 2007;55:917-25.
81. Pinski J, Halmos G, Shirahige Y, Wittliff JL, Schally AV. Inhibition of growth of the human malignant glioma cell line (U87MG) by the steroid hormone antagonist RU486. J Clin Endocrinol Metab 1993;77:1388-92. (Pubitemid 23345502)
82. Pardridge WM. Transport of nutrients and hormones through the blood-brain barrier. Diabetologia 1981;20:246-54.
83. Pardridge WM, Moeller TL, Mietus LJ, Oldendorf WH. Blood-brain barrier and brain sequestration of steroid hormones. Am J Physiol 1980;239:E96-102.