Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction

Biomaterials

Volumn 46, Issue , 2015, Pages 26-34

  Peña, James R ^a   Pinney, James R ^b   Ayala, Perla ^b   Desai, Tejal A ^b   Goldspink, Paul H ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiac tissue repair; Drug delivery; Growth factors; Hydrogel; Peptide; Polyethylene glycol dimethacrylate

Indexed keywords

ALIPHATIC COMPOUNDS; CARDIOLOGY; CONTROLLED DRUG DELIVERY; DRUG DELIVERY; GENE EXPRESSION; HEMODYNAMICS; HYDROGELS; MAMMALS; MICROSTRUCTURE; PATHOLOGY; PEPTIDES; POLYETHYLENE GLYCOLS; STIFFNESS; TARGETED DRUG DELIVERY; TISSUE REGENERATION;

CARDIAC TISSUES; DIMETHACRYLATES; GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR-I; INTRAMUSCULAR INJECTIONS; MYOCARDIAL INFARCTION; POLY(ETHYLENE GLYCOL) DIMETHACRYLATE; POLYMERIC MICROSTRUCTURES;

HEART;

ATRIAL NATRIURETIC FACTOR; MECHANO GROWTH FACTOR E; MYOSIN HEAVY CHAIN BETA; POLY(ETHYLENE GLYCOL) DIMETHACRYLATE; POLYMER; SOMATOMEDIN C; UNCLASSIFIED DRUG; MECHANO-GROWTH FACTOR E, HUMAN; PEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CONTRACTILITY; HEMODYNAMICS; MALE; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEART CONTRACTION; HEART FUNCTION TEST; HUMAN; KAPLAN MEIER METHOD; MYOCARDIAL INFARCTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGAN SIZE; PATHOPHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

MUS;

ANIMALS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; HEART FUNCTION TESTS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; KAPLAN-MEIER ESTIMATE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; ORGAN SIZE; PEPTIDES; POLYMERS; PROTEIN STRUCTURE, TERTIARY;

EID: 84922778332     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.12.050     Document Type: Article

References (40)

1. Reiss K., Kajstura J., Zhang X., Li P., Szoke E., Olivetti G., et al. Acute myocardial infarction leads to upregulation of the IGF-1 autocrine system, DNA replication, and nuclear mitotic division in the remaining viable cardiac myocytes. Exp Cell Res 1994, 213:463-472.
2. Duerr R.L., Huang S., Miraliakbar H.R., Clark R., Chien K.R., Ross J. Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. JClin Invest 1995, 95:619-627.
3. Froesch E.R., Schmid C., Schwander J., Zapf J. Actions of insulin-like growth factors. Annu Rev Physiol 1985, 47:443-467.
4. Russell S.M., Spencer E.M. Local injections of human or rat growth hormone or of purified human somatomedin-C stimulates unilateral tibial epiphyseal growth in hypophysectomized rats. Endocrinology 1985, 116:2563-2567.
5. Vetter U., Zapf J., Heit W., Helbing G., Heinze E., Froesch E.R., et al. Human fetal and adult chondrocytes. Effect of insulin like growth factors I and II, insulin, and growth hormone on clonal growth. JClin Invest 1989, 77:1903-1908.
6. Shimatsu A., Rotwein P. Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene. JBiol Chem 1987, 262:7894-7900.
7. Oberbauer A.M. The regulation of IGF-1 gene transcription and splicing during development and aging. Front Endocrinol 2013, 4:39.
8. Mavrommatis E., Shioura K.M., Los T., Goldspink P.H. The E-domain region of mechano-growth factor inhibits cellular apoptosis and preserves cardiac function during myocardial infarction. Mol Cell Biochem 2013, 381:69-83.
9. Philippou A., Papageorgiou E., Bogdanis G., Halapas A., Sourla A., Maridaki M., et al. Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions invitro. InVivo 2002, 23:567-575.
10. Hill M.A., Goldspink G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. JPhysiol 2003, 549:409-418.
11. Carpenter V.A., Matthews K.G., Devlin G.P., Stuart S.P., Jensen J.A., Conaglen J.V., et al. Mechano-growth factor ameliorates loss of cardiac function in acute myocardial infarction. Heart Lung Circ 2008, 17:33-39.
12. Dluzniewska J., Sarnowska A., Beresewicz M., Johnsomn I., Srai S.K., Ramesh B., et al. Astrong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB J 2005, 19:1896-1898.
13. Quesada A., Ogi J., Schultz J., Handforth A. C-terminal mechano-growth factor induces heme oxygenase-1-mediated neuroprotection of SH-SY5Y cells via the protein kinase C/Nrf2 pathway. JNeurosci Res 2011, 89:394-405.
14. Shioura K.M., Peña J.R., Goldspink P.H. Administration of a synthetic peptide derived from the E-domain region of mechano-growth factor delays decompensation following myocardial infarction. Int J Cardiovasc Res 2014, 3:3. 10.4172/2324-8602.1000169.
15. Shioura K.M., Geenen D.L., Goldspink P.H. Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice. Am J Physiol Heart Circ Physiol 2007, 293:H2870-H2877.
16. Shioura K.M., Geenen D.L., Goldspink P.H. Sex related differences in cardiac function during the progression to heart failure following myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol 2008, 5:R528-R534.
17. Ayala P., Lopez J.I., Desai T.A. Microtopographical cues in 3D attenuate fibrotic phenotype and extracellular matrix deposition: implications for tissue regeneration. Tissue Eng Part A 2010, 16:2519-2527.
18. Doroudian G., Pinney J., Ayala P., Los T., Desai T.A., Russell B. Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes. Biomed Microdev 2014, 16:705-715.
19. Suga H. Total mechanical energy of a ventricle model and cardiac oxygen consumption. Am J Physiol 1979, 236:H498-H505.
20. Matthews K.G., Devlin G.P., Conaglen J.V., Stuart S.P., Mervyn Aitken W., Bass J.J. Changes in IGFs in cardiac tissue following myocardial infarction. JEndocrinol 1999, 163:433-445.
21. Loennechen J.P., Støylen A., Beisvag V., Wisløff U., Ellingsen O. Regional expression of endothelin-1, ANP, IGF-1, and LV wall stress in the infarcted rat heart. Am J Physiol Heart Circ Physiol 2001, 280:H2902-H2910.
22. Li Q., Li B., Wang X., Leri A., Jana K.P., Liu Y., et al. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. JClin Invest 1997, 100:1991-1999.
23. Santini M.P., Tsao L., Monassier L., Theodoropoulos C., Carter J., Lara-Pezzi E., et al. Enhancing repair of the mammalian heart. Circ Res 2007, 100:1732-1740.
24. McMullen J.R., Shioi T., Huang W.Y., Zhang L., Tarnavski O., Bisping E., et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. JBiol Chem 2004, 279:4782-4793.
25. Lin R.C., Weeks K.L., Gao X.M., Williams R.B., Bernardo B.C., Kiriazis H., et al. McMullen JR.PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA. Arterioscler Thromb Vasc Biol 2010, 30:724-732.
26. Durzyńska J., Philippou A., Brisson B.K., Nguyen-McCarty M., Barton E.R. The pro-forms of insulin-like growth factor I (IGF-I) are predominant in skeletal muscle and alter IGF-I receptor activation. Endocrinology 2013, 154:1215-1224.
27. Brisson B.K., Barton E.R. Insulin-like growth factor-I E-peptide activity is dependent on the IGF-I receptor. PLoS One 2012, 7:e45588.
28. Hede M.S., Salimova E., Piszczek A., Perlas E., Winn N., Nastasi T., et al. E-peptides control bioavailability of IGF-1. PLoS One 2012, 7:e51152.
29. Barton E.R., DeMeo J., Lei H. The insulin-like growth factor (IGF)-I E-peptides are required for isoform-specific gene expression and muscle hypertrophy after local IGF-I production. JAppl Physiol 2010, 108:1069-1076.
30. Brisson B.K., Spinazzola J., Park S., Barton E.R. Viral expression of insulin-like growth factor I E-peptides increases skeletal muscle mass but at the expense of strength. Am J Physiol Endocrinol Metab 2014, 306:E965-E974.
31. Wallis M New insulin-like growth factor (IGF)-precursor sequences from mammalian genomes: the molecular evolution of IGFs and associated peptides in primates. Growth Horm IGF Res 2009, 1:12-23.
32. Pinney J.R., Du K.T., Ayala P., Fang Q., Sievers R.E., Chew P., et al. Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction. Biomaterials 2014, 35:8820-8828.
33. Curtis M.W., Sharma S., Desai T.A., Russell B. Hypertrophy, gene expression, and beating of neonatal cardiac myocytes are affected by microdomain heterogeneity in 3D. Biomed Microdev 2010, 12:1073-1085.
34. Curtis M.W., Budyn E., Desai T.A., Samarel A.M., Russell B. Microdomain heterogeneity in 3D affects the mechanics of neonatal cardiac myocyte contraction. Biomech Model Mechanobiol 2013, 12:95-109.
35. Kloxin A.M., Kasko A.M., Salinas C.N., Anseth K.S. Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science 2009, 324:59-63.
36. Lin C.C. Anseth KS.PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm Res 2009, 26:631-643.
37. Lin C.C., Anseth K.S. Glucagon-like peptide-1 functionalized PEG hydrogels promote survival and function of encapsulated pancreatic beta-cells. Biomacromolecules 2009, 10:2460-2467.
38. Deng M., Zhang B., Wang K., Liu F., Xiao H., Zhao J., et al. Mechano growth factor E peptide promotes osteoblasts proliferation and bone-defect healing in rabbits. Int Orthop 2011, 35:1099-1106.
39. Li Y., Zhang B., Ruan C., Wang P., Sun J., Pan J., et al. Synthesis, characterization, and biocompatibility of a novel biomimetic material based on MGF-Ct24E modified poly(d, l-lactic acid). JBiomed Mater Res A 2012, 100:3496-3502.
40. Malhotra M, Tomaro-Duchesneau C, Saha S, Prakash S. Intranasal, siRNA delivery to the brain by TAT/MGF tagged PEGylated chitosan nanoparticles. J Pharm 2013:10. Article ID 812387. http://dx.doi.org/10.1155/2013/812387.