Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction

Biomaterials

Volumn 35, Issue 31, 2014, Pages 8820-8828

  Pinney, James R ^a   Du, Kim T ^b   Ayala, Perla ^a,c   Fang, Qizhi ^b   Sievers, Richard E ^b   Chew, Patrick ^d   Delrosario, Lawrence ^b   Lee, Randall J ^a,b   Desai, Tejal A ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d UCSF Schools of Pharmacy and Medicine   (United States)

Author keywords

Cardiac tissue engineering; Collagen; ECM; Fibrosis; Photolithography; Polyethylene glycol dimethacrylate

Indexed keywords

COLLAGEN; FUNCTIONAL POLYMERS; GENE EXPRESSION; MICROSTRUCTURE; MILITARY ELECTRONIC COUNTERMEASURES; PHOTOLITHOGRAPHY; TISSUE ENGINEERING;

ACUTE MYOCARDIAL INFARCTION; CARDIAC TISSUE ENGINEERING; DIMETHACRYLATES; FIBROSIS; MICROSTRUCTURED MATERIALS; POLYMERIC MICROSTRUCTURES; THERAPEUTIC MATERIALS; THREE-DIMENSIONAL CULTURE MODEL;

GENE EXPRESSION REGULATION;

COLLAGEN; ELASTIN; MACROGOL; METHACRYLIC ACID; POLYETHYLENE GLYCOL DIMETHACRYLATE MICROROD; POLYETHYLENE GLYCOL DIMETHACRYLATE MICROTUBE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; BIOMATERIAL; MACROGOL DERIVATIVE; METHACRYLIC ACID DERIVATIVE; POLY(ETHYLENE GLYCOL)-DIMETHACRYLATE;

3T3 CELL LINE; ACUTE HEART INFARCTION; ADULT; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CONTROLLED STUDY; DOWN REGULATION; EXPERIMENTAL CORONARY OCCLUSION; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE; HEART MUSCLE FIBROSIS; HISTOLOGY; IN VITRO STUDY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; TISSUE ENGINEERING; TRANSTHORACIC ECHOCARDIOGRAPHY; VASCULARIZATION; ANIMAL; CYTOLOGY; FIBROBLAST; FIBROSIS; MICROTECHNOLOGY; MYOCARDIAL INFARCTION; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

3T3 CELLS; ANIMALS; BIOCOMPATIBLE MATERIALS; COLLAGEN; FEMALE; FIBROBLASTS; FIBROSIS; METHACRYLATES; MICE; MICROTECHNOLOGY; MYOCARDIAL INFARCTION; MYOCARDIUM; POLYETHYLENE GLYCOLS; RATS, SPRAGUE-DAWLEY; TISSUE ENGINEERING;

EID: 84905501367     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.07.005     Document Type: Article

References (45)

1. Go A.S., Mozaffarian D., Roger V.L., Benjamin E.J., Berry J.D., Borden W.B., et al. Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation 2013, 127:e6-e245.
2. Wilson P, Douglas P, Alpert JS, Simons M, Breall JA. Prognosis after myocardial infarction. UpToDate, Last updated 2013. accessed 2014. Available from URL: http://www.uptodate.com/contents/prognosis-after-myocardial-infarction.
3. Camelliti P., Borg T.K., Kohl P. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res 2005, 65:40-51.
4. Sun Y. Myocardial repair/remodelling following infarction: roles of local factors. Cardiovasc Res 2009, 81:482-490.
5. Brown R.D., Ambler S.K., Mitchell M.D., Long C.S. The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol 2005, 45:657-687.
6. Creemers E.E., Pinto Y.M. Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc Res 2011, 89:265-272.
7. Hinz B. Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 2007, 127:526-537.
8. Hinz B. The myofibroblast: paradigm for a mechanically active cell. J Biomech 2010, 43:146-155.
9. Beltrami A.P., Barlucchi L., Torella D., Baker M., Limana F., Chimenti S., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003, 114:763-776.
10. Ieda M., Fu J.-D., Delgado-Olguin P., Vedantham V., Hayashi Y., Bruneau B.G., et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010, 142:375-386.
11. Johnston P.V., Sasano T., Mills K., Evers R., Lee S.-T., Smith R.R., et al. Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation 2009, 120:1075-1083.
12. Chugh A.R., Beache G.M., Loughran J.H., Mewton N., Elmore J.B., Kajstura J., et al. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation 2012, 126:S54-S64.
13. Plotkin M., Vaibavi S.R., Rufaihah A.J., Nithya V., Wang J., Shachaf Y., et al. The effect of matrix stiffness of injectable hydrogels on the preservation of cardiac function after a heart attack. Biomaterials 2014, 35:1429-1438.
14. Kichula E.T., Wang H., Dorsey S.M., Szczesny S.E., Elliott D.M., Burdick J.A., et al. Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection. Ann Biomed Eng 2013, 42(7):1546-1556.
15. Rane A.a., Chuang J.S., Shah A., Hu D.P., Dalton N.D., Gu Y., et al. Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction. PLoS One 2011, 6:e21571.
16. Seif-Naraghi S.B., Salvatore M.A., Schup-Magoffin P.J., Hu D.P., Christman K.L. Design and characterization of an injectable pericardial matrix gel: a potentially autologous scaffold for cardiac tissue engineering. Tissue Eng Part A 2010, 16:2017-2027.
17. Christman K.L., Vardanian A.J., Fang Q., Sievers R.E., Fok H.H., Lee R.J. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. J Am Coll Cardiol 2004, 44:654-660.
18. Sun Y., Kiani M.F., Postlethwaite A.E., Weber K.T. Infarct scar as living tissue. Basic Res Cardiol 2002, 97:343-347.
19. Rosenzweig A. Cardiac cell therapy-mixed results from mixed cells. N Engl J Med 2006, 355:1274-1277.
20. Weber K.T. Fibrosis in hypertensive heart disease: focus on cardiac fibroblasts. J Hypertens 2004, 47-50.
21. Camelliti P., Green C.R., Kohl P. Structural and functional coupling of cardiac myocytes and fibroblasts. Adv Cardiol 2006, 42:132-149.
22. Bryant J.E., Shamhart P.E., Luther D.J., Olson E.R., Koshy J.C., Costic D.J., et al. Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling. J Mol Cell Cardiol 2009, 46:186-192.
23. Asazuma-Nakamura Y., Dai P., Harada Y., Jiang Y., Hamaoka K., Takamatsu T. Cx43 contributes to TGF-beta signaling to regulate differentiation of cardiac fibroblasts into myofibroblasts. Exp Cell Res 2009, 315:1190-1199.
24. Ayala P., Lopez J., Desai T. Microtopographical cues in 3D attenuate fibrotic phenotype and extracellular matrix deposition: implications for tissue regeneration. Tissue Eng Part A 2010, 16:2519-2527.
25. Ayala P., Desai T.A. Integrin α3 blockade enhances microtopographical down-regulation of α-smooth muscle actin: role of microtopography in ECM regulation. Integr Biol (Camb) 2011, 3:733-741.
26. Boateng S.Y., Hartman T.J., Ahluwalia N., Vidula H., Desai T.A., Russell B. Inhibition of fibroblast proliferation in cardiac myocyte cultures by surface microtopography. Am J Physiol Cell Physiol 2003, 285:C171-C182.
27. Norman J.J., Collins J.M., Sharma S., Russell B., Desai T.A. Microstructures in 3D biological gels affect cell proliferation. Tissue Eng Part A 2008, 14:379-390.
28. Thakar R.G., Chown M.G., Patel A., Peng L., Kumar S., Desai T.A. Contractility-dependent modulation of cell proliferation and adhesion by microscale topographical cues. Small 2008, 4:1416-1424.
29. Huang N.F., Sievers R.E., Park J.S., Fang Q., Li S., Lee R.J. A rodent model of myocardial infarction for testing the efficacy of cells and polymers for myocardial reconstruction. Nat Protoc 2006, 1:1596-1609.
30. Yu J., Christman K.L., Chin E., Sievers R.E., Saeed M., Lee R.J. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. J Thorac Cardiovasc Surg 2009, 137:180-187.
31. Leask A. Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res 2010, 106:1675-1680.
32. Akhmetshina A., Palumbo K., Dees C., Bergmann C., Venalis P., Zerr P., et al. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun 2012, 3:735.
33. Yang Y., Zhe X., Phan S.H., Ullenbruch M., Schuger L. Involvement of serum response factor isoforms in myofibroblast differentiation during bleomycin-induced lung injury. Am J Respir Cell Mol Biol 2003, 29:583-590.
34. Mendez M.G., Janmey P.A. Transcription factor regulation by mechanical stress. Int J Biochem Cell Biol 2012, 44:728-732.
35. Khan R., Sheppard R. Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 2006, 118:10-24.
36. Dupont S., Morsut L., Aragona M., Enzo E., Giulitti S., Cordenonsi M., et al. Role of YAP/TAZ in mechanotransduction. Nature 2011, 474:179-183.
37. Swift J., Ivanovska I.L., Buxboim A., Harada T., Dingal P.C.D.P., Pinter J., et al. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science 2013, 341:1240104.
38. Bainer R., Weaver V. Cell biology. Strength under tension. Science 2013, 341:965-966.
39. Sun Y., Zhang J.Q., Zhang J., Lamparter S. Cardiac remodeling by fibrous tissue after infarction in rats. J Lab Clin Med 2000, 135:316-323.
40. Stanton L.W., Garrard L.J., Damm D., Garrick B.L., Lam A., Kapoun A.M., et al. Altered patterns of gene expression in response to myocardial infarction. Circ Res 2000, 86:939-945.
41. Rehfeldt F., Engler A.J., Eckhardt A., Ahmed F., Discher D.E. Cell responses to the mechanochemical microenvironment-implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev 2007, 59:1329-1339.
42. Patel A.A., Thakar R.G., Chown M., Ayala P., Desai T.A., Kumar S. Biophysical mechanisms of single-cell interactions with microtopographical cues. Biomed Microdevices 2010, 12:287-296.
43. Gould S.T., Anseth K.S. Role of cell-matrix interactions on VIC phenotype and tissue deposition in 3D PEG hydrogels. J Tissue Eng Regen Med 2013, [Epub ahead of print].
44. Kirschner C.M., Anseth K.S. Hydrogels in healthcare: from static to dynamic material microenvironments. Acta Mater 2013, 61:931-944.
45. Tibbitt M.W., Kloxin A.M., Sawicki L.A., Anseth K.S. Mechanical properties and degradation of chain and step-polymerized photodegradable hydrogels. Macromolecules 2013, 46:2785-2792.