Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats

Phytotherapy Research

Volumn 29, Issue 2, 2015, Pages 228-240

  Yu, Hao ^a   Zheng, Lingli ^a   Xu, Lina ^a   Yin, Lianhong ^a   Lin, Yuan ^a   Li, Hua ^a   Liu, Kexin ^a   Peng, Jinyong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

D. nipponica Makino; Natural product; Total saponins; Type 2 diabetes mellitus

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ANTIDIABETIC AGENT; DIOSCOREA NIPPONICA EXTRACT; GLIBENCLAMIDE; GLUCOSE 6 PHOSPHATASE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE TRANSPORTER 4; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PLANT EXTRACT; PROTEIN KINASE B; SAPONIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; LIPID; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIOSCOREA NIPPONICA; DOWN REGULATION; DRUG EFFECT; DRUG POTENCY; G6PASE GENE; GENE ACTIVITY; GENE EXPRESSION; GENE TARGETING; GLYCOGEN LIVER LEVEL; GSK 3BETA GENE; HISTOPATHOLOGY; IL 6 GENE; INSULIN BLOOD LEVEL; LIVER INJURY; MALE; MEDICINAL PLANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSSIFICATION; PEPCK GENE; PHYTOCHEMISTRY; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; RENAL PROTECTION; TNF ALPHA GENE; UPREGULATION; WEIGHT GAIN; ANALYSIS; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; LIPID DIET; LIVER; METABOLISM; PATHOLOGY; WISTAR RAT; YAM;

DIOSCOREA NIPPONICA; RATTUS;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DIOSCOREA; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; LIPIDS; LIVER; LIVER GLYCOGEN; MALE; RATS; RATS, WISTAR; SAPONINS; STREPTOZOCIN;

EID: 84922769766     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5243     Document Type: Article

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