Functional and morphological effects of grape seed proanthocyanidins on peripheral neuropathy in rats with type 2 diabetes mellitus

Phytotherapy Research

Volumn 28, Issue 7, 2014, Pages 1082-1087

  Ding, Ye ^a   Dai, Xiaoqian ^a   Jiang, Yanfei ^a   Zhang, Zhaofeng ^a   Li, Yong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

calcium; grape seed proanthocyanidins; pathology; peripheral nervous system diseases; type 2 diabetes mellitus

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCIUM ION; PROANTHOCYANIDIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; ENZYME ACTIVITY; GRAPE; HYPERALGESIA; LUMBAR SPINAL CORD; MALE; MICROSCOPY; NERVE CONDUCTION DISORDER; NERVE FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PERIPHERAL NERVE; PERIPHERAL NEUROPATHY; RAT; SCIATIC NERVE; SPINAL GANGLION; TISSUE STRUCTURE; TREATMENT DURATION;

RATTUS; VITACEAE;

CALCIUM; GRAPE SEED PROANTHOCYANIDINS; PATHOLOGY; PERIPHERAL NERVOUS SYSTEM DISEASES; TYPE 2 DIABETES MELLITUS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CALCIUM; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; GRAPE SEED EXTRACT; MALE; NEURAL CONDUCTION; PAIN THRESHOLD; PERIPHERAL NERVOUS SYSTEM DISEASES; PROANTHOCYANIDINS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; STREPTOZOCIN;

EID: 84904244977     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5104     Document Type: Article

References (29)

1. Asha DS, Sagar CBK, Manjula KR, Ishii N,. 2011. Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats. Exp Gerontol 46: 958-964.
2. Boulton AJ, Vinik AI, Arezzo JC, et al,. 2005. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 28: 956-962. (Pubitemid 40434506)
3. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL,. 1994. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53: 55-56.
4. Cui XP, Li BY, Gao HQ, Wei N, Wang WL, Lu M,. 2008. Effects of grape seed proanthocyanidin extracts on peripheral nerves in streptozocin-induced diabetic rats. J Nutr Sci Vitaminol (Tokyo) 54: 321-328.
5. Ding Y, Dai X, Jiang Y, et al,. 2013a. Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Mol Nutr Food Res 57: 365-369.
6. Ding Y, Zhang Z, Dai X, et al,. 2013. Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress. Nutr Metab (Lond) 10: 51.
7. Fernyhough P, Calcutt NA,. 2010. Abnormal calcium homeostasis in peripheral neuropathies. Cell Calcium 47: 130-139.
8. Fernyhough P, Roy Chowdhury SK, Schmidt RE,. 2010. Mitochondrial stress and the pathogenesis of diabetic neuropathy. Expert Rev Endocrinol Metab 5: 39-49.
9. Hikida T, Kitabatake Y, Pastan I, Nakanishi S,. 2003. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proc Natl Acad Sci U S A 100: 6169-6173. (Pubitemid 36576949)
10. Huang TJ, Sayers NM, Fernyhough P, Verkhratsky A,. 2002. Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin- diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3. Diabetologia 45: 560-570. (Pubitemid 34533836)
11. Kostyuk E, Voitenko N, Kruglikov I, et al,. 2001. Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons. Diabetologia 44: 1302-1309. (Pubitemid 33010507)
12. Lu M, Xu L, Li B, et al,. 2010. Protective effects of grape seed proanthocyanidin extracts on cerebral cortex of streptozotocin-induced diabetic rats through modulating AGEs/RAGE/NF-kappaB pathway. J Nutr Sci Vitaminol (Tokyo) 56: 87-97.
13. Mansouri E, Panahi M, Ghaffari MA, Ghorbani A,. 2011. Effects of grape seed proanthocyanidin extract on oxidative stress induced by diabetes in rat kidney. Iran Biomed J 15: 100-106.
14. Obrosova IG, Ilnytska O, Lyzogubov VV, et al,. 2007. High-fat diet-induced neuropathy of pre-diabetes and obesity: effects of 'healthy' diet and aldose reductase inhibition. Diabetes 56: 2598-2608. (Pubitemid 47523268)
15. Okudan N, Barişkaner H, Gökbel H, Sahin AS, Belviranli M, Baysal H,. 2011. The effect of supplementation of grape seed proanthocyanidin extract on vascular dysfunction in experimental diabetes. J Med Food 14: 1298-1302.
16. Osawa T, Kato Y,. 2005. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann N Y Acad Sci 1043: 440-451. (Pubitemid 41123932)
17. Pande M, Hur J, Hong Y, et al,. 2011. Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetes. Diabetes 60: 1981-1989.
18. Petersen OH, Michalak M, Verkhratsky A,. 2005. Calcium signalling: past, present and future. Cell Calcium 38: 161-169. (Pubitemid 41283257)
19. Ray S, Bagchi D, Lim PM, et al,. 2001. Acute and long-term safety evaluation of a novel IH636 grape seed proanthocyanidin extract. Res Commun Mol Pathol Pharmacol 109: 165-197. (Pubitemid 33095142)
20. Romano B, Pagano E, Montanaro V, Fortunato AL, Milic N, Borrelli F,. 2013. Novel insights into the pharmacology of flavonoids. Phytother Res 27: 1588-1596.
21. Said G,. 2007. Diabetic neuropathy-a review. Nat Clin Pract Neuro 3: 331-340. (Pubitemid 46894936)
22. Selvarajah D, Wilkinson ID, Emery CJ, et al,. 2006. Early involvement of the spinal cord in diabetic peripheral neuropathy. Diabetes Care 29: 2664-2669. (Pubitemid 44912196)
23. Sharma SD, Meeran SM, Katiyar SK,. 2007. Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice. Mol Cancer Ther 6: 995-1005. (Pubitemid 46554569)
24. Sharma SS, Kumar A, Arora M, Kaundal RK,. 2009. Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes. Free Radic Res 43: 400-408.
25. Srinivasan S, Stevens M, Wiley JW,. 2000. Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction. Diabetes 49: 1932-1938.
26. Stavniichuk R, Drel VR, Shevalye H, et al,. 2011. Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation. Exp Neurol 230: 106-113.
27. Sun Q, Tu H, Xing GG, Han JS, Wan Y,. 2005. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation. Exp Neurol 191: 128-136. (Pubitemid 39612398)
28. Tomlinson DR, Gardiner NJ,. 2008. Glucose neurotoxicity. Nat Rev Neurosci 9: 36-45. (Pubitemid 350295687)
29. Wang XH, Huang LL, Yu TT, et al,. 2013. Effects of oligomeric grape seed proanthocyanidins on heart, aorta, kidney in DOCA-salt mice: role of oxidative stress. Phytother Res 27: 869-876.