Analysis of the trajectory of osteoarthritis development in a mouse model by serial near-infrared fluorescence imaging of matrix metalloproteinase activities

Arthritis and Rheumatology

Volumn 67, Issue 2, 2015, Pages 442-453

  Leahy, Averi A ^a   Esfahani, Shadi A ^b   Foote, Andrea T ^a   Hui, Carrie K ^a   Rainbow, Roshni S ^a   Nakamura, Daisy S ^a   Tracey, Brian H ^a   Mahmood, Umar ^b   Zeng, Li ^a  

^a TUFTS UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; FLUORESCENT DYE; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL DEATH; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; ENZYME ACTIVITY; FLUORESCENCE IMAGING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; ILLNESS TRAJECTORY; IN VITRO STUDY; IN VIVO STUDY; INFRARED RADIATION; JOINT DEGENERATION; KNEE; MALE; MOUSE; NEAR INFRARED FLUORESCENCE IMAGING; NONHUMAN; OSTEOARTHRITIS; OSTEOARTHROPATHY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; UPREGULATION; ANIMAL; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; INBRED MOUSE STRAIN; KNEE MENISCUS; KNEE OSTEOARTHRITIS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; SENSITIVITY AND SPECIFICITY; SURGERY; TUMOR MICROENVIRONMENT;

ANIMALS; CELLS, CULTURED; CELLULAR MICROENVIRONMENT; CHONDROCYTES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; IN VITRO TECHNIQUES; INTERLEUKIN-1BETA; MALE; MATRIX METALLOPROTEINASES; MENISCI, TIBIAL; MICE; MICE, INBRED STRAINS; OPTICAL IMAGING; OSTEOARTHRITIS, KNEE; SENSITIVITY AND SPECIFICITY;

EID: 84922768144     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38957     Document Type: Article

References (50)

1. Felson DT,. Osteoarthritis. In:, Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, editors. Harrison's principles of internal medicine. 18th ed. New York: McGraw-Hill; 2012.
2. Lafeber FP, van Spil EW,. Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time. Osteoarthritis Cartilage 2013; 21: 1452-64.
3. Patra D, Sandell LJ,. Evolving biomarkers in osteoarthritis. J Knee Surg 2011; 24: 241-9.
4. Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, et al. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage 2011; 19: 515-42.
5. Goldring MB, Berenbaum F,. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clin Orthop Relat Res 2004; 427 Suppl: S37-46.
6. Leong DJ, Hardin JA, Cobelli NJ, Sun HB,. Mechanotransduction and cartilage integrity. Ann N Y Acad Sci 2011; 1240: 32-7.
7. Ryu JH, Lee A, Huh MS, Chu J, Kim K, Kim BS, et al. Measurement of MMP activity in synovial fluid in cases of osteoarthritis and acute inflammatory conditions of the knee joints using a aluorogenic peptide probe-immobilized diagnostic kit. Theranostics 2012; 2: 198-206.
8. Swingler TE, Waters JG, Davidson RK, Pennington CJ, Puente XS, Darrah C, et al. Degradome expression profiling in human articular cartilage. Arthritis Res Ther 2009; 11: R96.
9. Glasson SS, Blanchet TJ, Morris EA,. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 2007; 15: 1061-9.
10. Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan M, Ferguson C, et al. Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis. PLoS One 2013; 8: e54633.
11. Bateman JF, Rowley L, Belluoccio D, Chan B, Bell K, Fosang AJ, et al. Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. Arthritis Rheum 2013; 65: 1547-60.
12. Poole AR,. Osteoarthritis as a whole joint disease. HSS J 2012; 8: 4-6.
13. Zhen G, Wen C, Jia X, Li Y, Crane JL, Mears SC, et al. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Medicine 2013; 19: 704-12.
14. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2-Δ Δ C T method. Methods 2001; 25: 402-8.
15. McNulty MA, Loeser RF, Davey C, Callahan M, Ferguson C, Carlson CS,. A comprehensive histological assessment of osteoarthritis lesions in mice. Cartilage 2011; 2: 354-63.
16. Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum 2009; 60: 3723-33.
17. Galazka G, Windsor LJ, Birkedal-Hansen H, Engler JA,. APMA (4-aminophenylmercuric acetate) activation of stromelysin-1 involves protein interactions in addition to those with cysteine-75 in the propeptide. Biochemistry 1996; 35: 11221-7.
18. Cortial D, Gouttenoire J, Rousseau CF, Ronziere MC, Piccardi N, Msika P, et al. Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold: an in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis. Osteoarthritis Cartilage 2006; 14: 631-40.
19. 2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis. Arthritis Rheumatol 2014; 66: 1843-53.
20. Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y,. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 2008; 67 Suppl 3: iii75-82.
21. Freemont AJ, Byers RJ, Taiwo YO, Hoyland JA,. In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage. Ann Rheum Dis 1999; 58: 357-65.
22. Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, et al. Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arterioscler Thromb Vasc Biol 2011; 31: 2464-72.
23. Klohs J, Baeva N, Steinbrink J, Bourayou R, Boettcher C, Royl G, et al. In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia. J Cereb Blood Flow Metab 2009; 29: 1284-92.
24. McNulty MA, Loeser RF, Davey C, Callahan MF, Ferguson CM, Carlson CS,. Histopathology of naturally occurring and surgically induced osteoarthritis in mice. Osteoarthritis Cartilage 2012; 20: 949-56.
25. Glasson SS, Chambers MG, Van Den Berg WB, Little CB,. The OARSI histopathology initiative: recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010; 18 Suppl 3: S17-23.
26. Sevick-Muraca EM,. Translation of near-infrared fluorescence imaging technologies: emerging clinical applications. Annu Rev Med 2012; 63: 217-31.
27. Gounaris E, Martin J, Ishihara Y, Khan MW, Lee G, Sinh P, et al. Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis. Inflamm Bowel Dis 2013; 19: 1339-45.
28. Turk BE, Huang LL, Piro ET, Cantley LC,. Determination of protease cleavage site motifs using mixture-based oriented peptide libraries. Nat Biotechnol 2001; 19: 661-7.
29. Hills R, Mazzarella R, Fok K, Liu M, Nemirovskiy O, Leone J, et al. Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. J Biol Chem 2007; 282: 11101-9.
30. Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Bromme D, et al. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. J Biol Chem 2006; 281: 12824-32.
31. Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U,. In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. Arthritis Rheum 2004; 50: 2459-65.
32. Hansch A, Frey O, Hilger I, Sauner D, Haas M, Schmidt D, et al. Diagnosis of arthritis using near-infrared fluorochrome Cy5.5. Invest Radiol 2004; 39: 626-32.
33. Hansch A, Frey O, Sauner D, Hilger I, Haas M, Malich A, et al. In vivo imaging of experimental arthritis with near-infrared fluorescence. Arthritis Rheum 2004; 50: 961-7.
34. Ryu JH, Lee A, Chu JU, Koo H, Ko CY, Kim HS, et al. Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3-specific polymeric probe. Arthritis Rheum 2011; 63: 3824-32.
35. Chen WT, Mahmood U, Weissleder R, Tung CH,. Arthritis imaging using a near-infrared fluorescence folate-targeted probe. Arthritis Res Ther 2005; 7: R310-7.
36. Ibarra JM, Jimenez F, Martinez HG, Clark K, Ahuja SS,. MMP-activated fluorescence imaging detects early joint inflammation in collagen-antibody-induced arthritis in CC-chemokine receptor-2-null mice, in-vivo. Int J Inflam 2011; 2011: 691587.
37. Galligan CL, Fish EN,. Circulating fibrocytes contribute to the pathogenesis of collagen antibody-induced arthritis. Arthritis Rheum 2012; 64: 3583-93.
38. Lai WF, Chang CH, Tang Y, Bronson R, Tung CH,. Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes. Osteoarthritis Cartilage 2004; 12: 239-44.
39. fl mice. Arthritis Res Ther 2014; 16: R11.
40. Vermeij EA, Koenders MI, Blom AB, Arntz OJ, Bennink MB, van den Berg WB, et al. In vivo molecular imaging of cathepsin and matrix metalloproteinase activity discriminates between arthritic and osteoarthritic processes in mice. Mol Imaging 2014; 13: 1-10.
41. Ryu JH, Lee A, Na JH, Lee S, Ahn HJ, Park JW, et al. Optimization of matrix metalloproteinase fluorogenic probes for osteoarthritis imaging. Amino Acids 2011; 41: 1113-22.
42. Lee S, Park K, Lee SY, Ryu JH, Park JW, Ahn HJ, et al. Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo. Bioconjug Chem 2008; 19: 1743-7.
43. Jones EF, Schooler J, Miller DC, Drake CR, Wahnishe H, Siddiqui S, et al. Characterization of human osteoarthritic cartilage using optical and magnetic resonance imaging. Mol Imaging Biol 2012; 14: 32-9.
44. Frangioni JV,. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol 2003; 7: 626-34.
45. Oh H, Chun CH, Chun JS,. Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum 2012; 64: 2568-78.
46. Ma HL, Blanchet TJ, Peluso D, Hopkins B, Morris EA, Glasson SS,. Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage 2007; 15: 695-700.
47. Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, et al. Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum 2009; 60: 1372-80.
48. Buck RJ, Wyman BT, Le Graverand MP Hellio, Hudelmaier M, Wirth W, Eckstein F, for the A9001140 Investigators. Does the use of ordered values of subregional change in cartilage thickness improve the detection of disease progression in longitudinal studies of osteoarthritis? Arthritis Rheum 2009; 61: 917-24.
49. Hayashi D, Guermazi A, Hunter DJ,. Osteoarthritis year 2010 in review: imaging. Osteoarthritis Cartilage 2011; 19: 354-60.
50. Lakin BA, Grasso DJ, Stewart RC, Freedman JD, Snyder BD, Grinstaff MW,. Contrast enhanced CT attenuation correlates with the GAG content of bovine meniscus. J Orthop Res 2013; 31: 1765-71.