In vivo molecular imaging of cathepsin and matrix metalloproteinase activity discriminates between arthritic and osteoarthritic processes in mice

Molecular Imaging

Volumn 13, Issue 2, 2014, Pages

  Vermeij, Eline A ^a   Koenders, Marije I ^a   Blom, Arjen B ^a   Arntz, Onno J ^a   Bennink, Miranda B ^a   Van Den Berg, Wim B ^a   Van Lent, Peter L E M ^a   Van De Loo, Fons A J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARTILAGE; FLUORESCENCE; GENE EXPRESSION; GLYCOPROTEINS; MAMMALS;

BIOPHOTONIC IMAGING; CARTILAGE DESTRUCTION; COLLAGEN-INDUCED ARTHRITIS; DISEASE PROGRESSION; FLUORESCENCE SIGNALS; MATRIX METALLOPROTEINASES; NEAR-INFRARED FLUORESCENT; RHEUMATOID ARTHRITIS;

MOLECULAR IMAGING;

CATHEPSIN; COLLAGEN TYPE 2; MATRIX METALLOPROTEINASE;

ANIMAL; C57BL MOUSE; CARTILAGE CELL; CELL DEATH; CHEMISTRY; CYTOLOGY; EXPERIMENTAL ARTHRITIS; HINDLIMB; IMMUNOLOGY; MALE; METABOLISM; MOLECULAR IMAGING; MOUSE; OSTEOARTHRITIS; PATHOLOGY; PROCEDURES; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CATHEPSINS; CELL DEATH; CHONDROCYTES; COLLAGEN TYPE II; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MOLECULAR IMAGING; OSTEOARTHRITIS; STIFLE;

EID: 84898045812     PISSN: 15353508     EISSN: None     Source Type: Journal    
DOI: 10.2310/7290.2014.00001     Document Type: Article

References (30)

1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61, doi:10.1038/nature01661.
2. Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone 2012;51:249-57, doi:10.1016/j.bone.2012.02.012.
3. Louboutin H, Debarge R, Richou J, et al. Osteoarthritis in patients with anterior cruciate ligament rupture: a review of risk factors. Knee 2009;16:239-44, doi:10.1016/j.knee.2008.11.004.
4. Peterfy CG, Dicarlo JC, Olech E, et al. Evaluating joint-space narrowing and cartilage loss in rheumatoid arthritis by using MRI. Arthritis Res Ther 2012;14:R131, doi:10.1186/ar3861.
5. Ryu JH, Lee A, Chu JU, et al. Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3-specific polymeric probe. Arthritis Rheum 2011;63:3824-32, doi:10.1002/art.30628.
6. Svelander L, Erlandsson-Harris H, Astner L, et al. Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice. Eur J Pharmacol 2009;613:155-62, doi:10.1016/j.ejphar.2009.03.074.
7. Cunnane G, FitzGerald O, Hummel KM, et al. Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. Rheumatology (Oxford) 1999;38:34-42, doi:10.1093/rheumatology/38.1.34.
8. Itoh T, Matsuda H, Tanioka M, et al. The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibodyinduced arthritis. J Immunol 2002;169:2643-7.
9. Nakagawa TY, Brissette WH, Lira PD, et al. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity 1999;10:207-17, doi:10.1016/S1074-7613(00) 80021-7.
10. Everts V, Korper W, Hoeben KA, et al. Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Miner Res 2006;21:1399-408, doi:10.1359/jbmr.060614.
11. Rengel Y, Ospelt C, Gay S. Proteinases in the joint: clinical relevance of proteinases in joint destruction. Arthritis Res Ther 2007;9:221, doi:10.1186/ar2304.
12. Hou WS, Li W, Keyszer G, et al. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum 2002;46:663-74, doi:10.1002/art.10114.
13. Keyszer G, Redlich A, Haupl T, et al. Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry. Arthritis Rheum 1998;41:1378-87, doi:10.1002/1529- 0131(199808)41:8,1378::AID-ART6.3.0.CO;2-J.
14. Lai WF, Chang CH, Tang Y, et al. Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes. Osteoarthritis Cartilage 2004;12:239-44, doi:10.1016/j.joca.2003.11.005.
15. Singer II, Kawka DW, Bayne EK, et al. DIPEN, a metalloproteinase- generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis. J Clin Invest 1995;95:2178-86, doi:10.1172/JCI117907.
16. Embry Flory JJ, Fosang AJ, Knudson W. The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan. Arthritis Rheum 2006;54:443-54, doi:10.1002/art.21623.
17. Mort JS, Magny MC, Lee ER. Cathepsin B: an alternative protease for the generation of an aggrecan ''metalloproteinase,' cleavage neoepitope. Biochem J 1998;335(Pt 3):491-4.
18. Geurts J, Vermeij EA, Pohlers D, et al. A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts. Ann Rheum Dis 2011;70:1311-9, doi:10.1136/ard.2010.135665.
19. Joosten LA, Helsen MM, van de Loo FA, et al. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra. Arthritis Rheum 1996;39:797-809, doi:10.1002/art.1780390513.
20. van den Berg WB, Joosten LA, Helsen M, et al. Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment. Clin Exp Immunol 1994;95:237-43, doi:10.1111/j.1365-2249.1994.tb06517.x.
21. Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 2007;15:1061-9, doi:10.1016/j.joca.2007.03.006.
22. Nguyen Q, Mort JS, Roughley PJ. Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B. Biochem J 1990;266:569-73.
23. Keyszer G, Redlich A, Haupl T, et al. Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry. Arthritis Rheum 1998;41:1378-87, doi:10.1002/1529- 0131(199808)41:8,1378::AID-ART6.3.0.CO;2-J.
24. van Meurs JB, van Lent PL, Singer II, et al. Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope DIPEN in antigen-induced arthritis. Arthritis Rheum 1998;41:647-56, doi:10.1002/1529-0131(199804)41:4,647::AIDART11.3.0.CO;2-T.
25. Durigova M, Nagase H, Mort JS, et al. MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein. Matrix Biol 2011;30:145-53, doi:10.1016/j.matbio.2010.10.007.
26. Eltawil NM, De Bari C, Achan P, et al. A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury. Osteoarthritis Cartilage 2009;17:695-704, doi:10.1016/j.joca.2008.11. 003.
27. Sandy JD. A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis. Osteoarthritis Cartilage 2006;14:95-100, doi:10.1016/j.joca. 2005.09.004.
28. Dean RA, Cox JH, Bellac CL, et al. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood 2008;112:3455-64, doi:10.1182/blood- 2007-12-129080.
29. Nelson MP, Christmann BS, Dunaway CW, et al. Experimental Pneumocystis lung infection promotes M2a alveolar macrophagederived MMP12 production. Am J Physiol Lung Cell Mol Physiol 2012;303:L469-75, doi:10.1152/ajplung.00158.2012.
30. Tsuneyoshi Y, Tanaka M, Nagai T, et al. Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles. Scand J Rheumatol 2012;41:132-40, doi:10.3109/03009742. 2011.605391.