Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice

Arthritis Research and Therapy

Volumn 16, Issue 1, 2014, Pages

  Zhou, Jingming ^a   Chen, Qian ^a   Lanske, Beate ^b   Fleming, Braden C ^a   Terek, Richard ^a   Wei, Xiaochun ^c   Zhang, Ge ^d   Wang, Shaowei ^a,c   Li, Kai ^a,c   Wei, Lei ^a,c  

^a BROWN UNIVERSITY   (United States)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^c SHANXI MEDICAL UNIVERSITY   (China)

^d HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; COLLAGEN TYPE 10; COLLAGEN TYPE 2; COLLAGENASE 3; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR RUNX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CHONDROPROTECTION; COLLAGEN DEGRADATION; CONTROLLED STUDY; DISEASE COURSE; GENE DELETION; GENOTYPE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INDIAN; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PHENOTYPE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; EXPERIMENTAL ARTHRITIS; LASER CAPTURE MICRODISSECTION; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; DISEASE PROGRESSION; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MICE; MICE, TRANSGENIC; OSTEOARTHRITIS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84893185760     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4437     Document Type: Article

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