Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity

Journal of Hepatology

Volumn 61, Issue 6, 2014, Pages 1358-1364

  Yan, Fang ^a,c   Wang, Qi ^b   Lu, Ming ^a,c   Chen, Wenbin ^b   Song, Yongfeng ^a,c   Jing, Fei ^a,c   Guan, Youfei ^d   Wang, Laicheng ^b   Lin, Yanliang ^b   Bo, Tao ^b   Zhang, Jie ^b   Wang, Tingting ^c   Xin, Wei ^b   Yu, Chunxiao ^a,c   Guan, Qingbo ^a,c   Zhou, Xinli ^a,c   Gao, Ling ^b,c   Xu, Chao ^a,c   Zhao, Jiajun ^a,c  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c Shandong Academy of Clinical Medicine   (China)

^d Shenzhen University   (China)

Author keywords

Hepatic steatosis; Peroxisome proliferator activated receptor ; Sterol regulatory element binding protein 1c; Thyrotropin (TSH); Triglyceride

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; THYROTROPIN; THYROTROPIN RECEPTOR; TRIACYLGLYCEROL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; SREBF1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GENE EXPRESSION PROFILING; LIPID DIET; LIPID STORAGE; LIPOGENESIS; LIVER CELL; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; HEPG2 CELL LINE; HUMAN; IN VITRO STUDY; KNOCKOUT MOUSE; LIVER; MALE; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR; SIGNAL TRANSDUCTION;

ANIMALS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; HEP G2 CELLS; HEPATOCYTES; HUMANS; IN VITRO TECHNIQUES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NON-ALCOHOLIC FATTY LIVER DISEASE; PPAR ALPHA; RECEPTORS, THYROTROPIN; RISK FACTORS; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; THYROTROPIN; TRIGLYCERIDES; UP-REGULATION;

EID: 84922762830     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.06.037     Document Type: Article

References (39)

1. H. Perazzo, T. Poynard, and J.F. Dufour The interactions of nonalcoholic fatty liver disease and cardiovascular diseases Clin Liver Dis 18 2014 233 248
2. B.Q. Starley, C.J. Calcagno, and S.A. Harrison Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection Hepatology 51 2010 1820 1832
3. M. Lazo, R. Hernaez, S. Bonekamp, I.R. Kamel, F.L. Brancati, and E. Guallar Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study BMJ 343 2011 d6891
4. S. Liangpunsakul, and N. Chalasani Is hypothyroidism a risk factor for non-alcoholic steatohepatitis? J Clin Gastroenterol 37 2003 340 343
5. S. Petta, C. Muratore, and A. Craxi Non-alcoholic fatty liver disease pathogenesis: the present and the future Dig Liver Dis 41 2009 615 625
6. G.E. Chung, D. Kim, W. Kim, J.Y. Yim, M.J. Park, and Y.J. Kim Non-alcoholic fatty liver disease across the spectrum of hypothyroidism J Hepatol 57 2012 150 156
7. L. Xu, H. Ma, M. Miao, and Y. Li Impact of subclinical hypothyroidism on the development of non-alcoholic fatty liver disease: a prospective case-control study J Hepatol 57 2012 1153 1154
8. C. Martinez-Gonzalez, H.L. Wang, B.R. Micklem, J.P. Bolam, and J. Mena-Segovia Subpopulations of cholinergic, GABAergic and glutamatergic neurons in the pedunculopontine nucleus contain calcium-binding proteins and are heterogeneously distributed Eur J Neurosci 35 2012 723 734
9. X. Wanjia, W. Chenggang, W. Aihong, Y. Xiaomei, Z. Jiajun, and Y. Chunxiao A high normal TSH level is associated with an atherogenic lipid profile in euthyroid non-smokers with newly diagnosed asymptomatic coronary heart disease Lipids Health Dis 11 2012 44
10. P. Ferre, and F. Foufelle Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c Diabetes Obes Metab 12 2010 83 92
11. N. Ikarashi, T. Toda, T. Okaniwa, K. Ito, W. Ochiai, and K. Sugiyama Anti-obesity and anti-diabetic effects of acacia polyphenol in obese diabetic KKAy mice fed high-fat diet Evid Based Complement Alternat Med 2011 2011 952031
12. T. Yokozawa, E.J. Cho, C.H. Park, and J.H. Kim Protective effect of proanthocyanidin against diabetic oxidative stress Evid Based Complement Alternat Med 2012 2012 623879
13. D. Eberle, B. Hegarty, P. Bossard, P. Ferre, and F. Foufelle SREBP transcription factors: master regulators of lipid homeostasis Biochimie 86 2004 839 848
14. M.H. Oosterveer, A. Grefhorst, T.H. van Dijk, R. Havinga, B. Staels, and F. Kuipers Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice J Biol Chem 284 2009 34036 34044
15. D.D. Patel, B.L. Knight, D. Wiggins, S.M. Humphreys, and G.F. Gibbons Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice J Lipid Res 42 2001 328 337
16. A. Fernandez-Alvarez, M.S. Alvarez, R. Gonzalez, C. Cucarella, J. Muntane, and M. Casado Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) J Biol Chem 286 2011 21466 21477
17. Y. Li, S. Xu, M.M. Mihaylova, B. Zheng, X. Hou, and B. Jiang AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice Cell Metab 13 2011 376 388
18. J.E. Dumont The action of thyrotropin on thyroid metabolism Vitam Horm 29 1971 287 412
19. W. Zhang, L.M. Tian, Y. Han, H.Y. Ma, L.C. Wang, and J. Guo Presence of thyrotropin receptor in hepatocytes: not a case of illegitimate transcription J Cell Mol Med 13 2009 4636 4642
20. M. Kohjima, M. Enjoji, N. Higuchi, M. Kato, K. Kotoh, and T. Yoshimoto Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease Int J Mol Med 20 2007 351 358
21. B.L. Knight, A. Hebbachi, D. Hauton, A.M. Brown, D. Wiggins, and D.D. Patel A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver Biochem J 389 2005 413 421
22. S. Ducheix, N. Podechard, F. Lasserre, A. Polizzi, A. Pommier, and S. Murzilli A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARalpha Biochimie 95 2013 556 567
23. K.A. Burns, and J.P. Vanden Heuvel Modulation of PPAR activity via phosphorylation Biochim Biophys Acta 1771 2007 952 960
24. L. Tian, Y. Song, M. Xing, W. Zhang, G. Ning, and X. Li A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway Hepatology 52 2010 1401 1409
25. M.D. Fullerton, S. Galic, K. Marcinko, S. Sikkema, T. Pulinilkunnil, and Z.P. Chen Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin Nat Med 19 2013 1649 1654
26. E.E. Cable, P.D. Finn, J.W. Stebbins, J. Hou, B.R. Ito, and P.D. van Poelje Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist Hepatology 49 2009 407 417
27. M. Heimberg, J.O. Olubadewo, and H.G. Wilcox Plasma lipoproteins and regulation of hepatic metabolism of fatty acids in altered thyroid states Endocr Rev 6 1985 590 607
28. A. Garg, and M.P. Vanderpump Subclinical thyroid disease Br Med Bull 107 2013 101 116
29. R.C. Marians, L. Ng, H.C. Blair, P. Unger, P.N. Graves, and T.F. Davies Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice Proc Natl Acad Sci U S A 99 2002 15776 15781
30. T. Wang, J. Xu, T. Bo, X. Zhou, X. Jiang, and L. Gao Decreased fasting blood glucose is associated with impaired hepatic glucose production in thyroid-stimulating hormone receptor knockout mice Endocr J 60 2013 941 950
31. G.V. Gnoni, A. Rochira, A. Leone, F. Damiano, S. Marsigliante, and L. Siculella 3,5,3′triiodo-L-thyronine induces SREBP-1 expression by non-genomic actions in human HEP G2 cells J Cell Physiol 227 2012 2388 2397
32. A. Rochira, F. Damiano, S. Marsigliante, G.V. Gnoni, and L. Siculella 3,5-Diiodo-L-thyronine induces SREBP-1 proteolytic cleavage block and apoptosis in human hepatoma (Hepg2) cells Biochim Biophys Acta 1831 2013 1679 1689
33. P. de Lange, F. Cioffi, R. Senese, M. Moreno, A. Lombardi, and E. Silvestri Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-L-thyronine in rats Diabetes 60 2011 2730 2739
34. G. Lazennec, L. Canaple, D. Saugy, and W. Wahli Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators Mol Endocrinol 14 2000 1962 1975
35. E.S. Buhl, N. Jessen, R. Pold, T. Ledet, A. Flyvbjerg, and S.B. Pedersen Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome Diabetes 51 2002 2199 2206
36. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 2002 1125 1131
37. H. Shimano Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism Vitam Horm 65 2002 167 194
38. T. Porstmann, C.R. Santos, B. Griffiths, M. Cully, M. Wu, and S. Leevers SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth Cell Metab 8 2008 224 236
39. S. Balzan, S. Frascarelli, G. Nicolini, V. Lubrano, F. Forini, and G. Iervasi Acute infusion of recombinant human thyrotropin in Langendorff-rat hearts: role of a thyrotropin receptor Int J Cardiol 144 2010 85 86