Decreased fasting blood glucose is associated with impaired hepatic glucose production in thyroid-stimulating hormone receptor knockout mice

Endocrine Journal

Volumn 60, Issue 8, 2013, Pages 941-950

  Wang, Tingting ^a,b   Xu, Jin ^a   Bo, Tao ^a   Zhou, Xiaoming ^a   Jiang, Xiuyun ^a,b   Gao, Ling ^a,b   Zhao, Jiajun ^a,b  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b Shandong Academy of Clinical Medicine   (China)

Author keywords

AMP activated protein kinase (AMPK); cAMP regulatory element binding protein (CREB); Gluconeogenesis; Thyroid stimulating hormone receptors (TSHR)

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYLASE; THYROTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DIET RESTRICTION; DOWN REGULATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE DELETION; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCOGEN SYNTHESIS; HISTOPATHOLOGY; HORMONE ACTION; HUMAN; HUMAN CELL; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIVER METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOOD GLUCOSE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOWN-REGULATION; FASTING; GLUCONEOGENESIS; GLUCOSE; GLUCOSE-6-PHOSPHATASE; HEP G2 CELLS; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; LIVER GLYCOGEN; MICE; MICE, KNOCKOUT; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); RECEPTORS, THYROTROPIN; THYROTROPIN;

EID: 84883345439     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ12-0462     Document Type: Article

References (32)

1. Turhan S, Sezer S, Erden G, Guctekin A, Ucar F, et al. (2008) Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism. Ann Saudi Med 28: 96-101.
2. Asvold BO, Bjoro T, Platou C, Vatten LJ (2012) Thyroid function and the risk of coronary heart disease: 12-year follow-up of the HUNT Study in Norway. Clin Endocrinol (Oxf) 77: 911-917.
3. Dessein PH, Joffe BI, Stanwix AE (2004) Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis. Thyroid 14: 443-446.
4. Al Sayed A, Al Ali N, Bo Abbas Y, Alfadhli E (2006) Subclinical hypothyroidism is associated with early insulin resistance in Kuwaiti women. Endocr J 53: 653-657.
5. Maratou E, Hadjidakis DJ, Kollias A, Tsegka K, Peppa M, et al. (2009) Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol 160: 785-790.
6. Tuzcu A, Bahceci M, Gokalp D, Tuzun Y, Gunes K (2005) Subclinical hypothyroidism may be associated with elevated high-sensitive c-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocr J 52: 89-94.
7. Amati F, Dube JJ, Stefanovic-Racic M, Toledo FG, Goodpaster BH (2009) Improvements in insulin sensitivity are blunted by subclinical hypothyroidism. Med Sci Sports Exerc 41: 265-269.
8. Velija-Asimi Z, Karamehic J (2007) The effects of treatment of subclinical hypothyroidism on metabolic control and hyperinsulinemia. Med Arh 61: 20-21.
9. Kowalska I, Borawski J, Nikolajuk A, Budlewski T, Otziomek E, et al. (2011) Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy. Endocrine 40: 95-101.
10. Peeters RP, van der Deure WM, van den Beld AW, van Toor H, Lamberts SW, et al. (2007) TheAsp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Clin Endocrinol 66: 808-815.
11. Davies T, Marians R, Latif R (2002) The TSH receptor reveals itself. J Clin Invest 110: 161-164.
12. Zhang W, Tian LM, Han Y, Ma HY, Wang LC, et al. (2009) Presence of thyrotropin receptor in hepatocytes: not a case of illegitimate transcription. J Cell Mol Med 13: 4636-4642.
13. Tian L, Song Y, Xing M, Zhang W, Ning G, et al. (2010) A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway. Hepatology 52: 1401-1409.
14. Staehr P, Hother-Nielsen O, Beck-Nielsen H (2004) The role of the liver in type 2 diabetes. Rev Endocr Metab Disord 5: 105-110.
15. Viollet B, Lantier L, Devin-Leclerc J, Hebrard S, Amouyal C, et al. (2009) Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front Biosci 14: 3380-3400.
16. Horike N, Sakoda H, Kushiyama A, Ono H, Fujishiro M, et al. (2008) AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J Biol Chem 283: 33902-33910.
17. Andrade BM, Araujo RL, Perry RL, Souza EC, Cazarin JM, et al. (2011) A novel role for AMP-kinase in the regulation of the Na+/I--symporter and iodide uptake in the rat thyroid gland. Am J Physiol Cell Physiol 300: C1291-1297.
18. Marians RC, Ng L, Blair HC, Unger P, Graves PN, et al. (2002) Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A 99: 15776-15781.
19. Li GW, Pan XR (1993) A new insulin-sensitivity index for the population-based study. Zhonghua Nei Ke Za Zhi 32: 656-660 (In Chinese).
20. Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, et al. (2006) Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab 3:343-353.
21. Miyake K, Ogawa W, Matsumoto M, Nakamura T, Sakaue H, et al. (2002) Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. J Clin Invest 110: 1483-1491.
22. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
23. Seifter S, Dayton S, et al. (1950) The estimation of glycogen with the anthrone reagent. Arch Biochem 25:191-200.
24. Rodgers JT, Puigserver P (2007) Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A 104: 12861-12866.
25. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, et al. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119: 121-135.
26. Jitrapakdee S (2012) Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis. Int J Biochem Cell Biol 44: 33-45.
27. Xing W, Govoni KE, Donahue LR, Kesavan C, Wergedal J, et al. (2012) Genetic evidence that thyroid hormone is indispensable for prepubertal insulinlike growth factor-I expression and bone acquisition in mice. J Bone Miner Res 27: 1067-1079.
28. Pilkis SJ, Granner DK (1992) Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 54: 885-909.
29. Goto M, Yoshioka T, Battelino T, Ravindranath T, Zeller WP (2001) TNFalpha decreases gluconeogenesis in hepatocytes isolated from 10-day-old rats. Pediatr Res 49: 552-557.
30. Viollet B, Foretz M, Guigas B, Horman S, Dentin R, et al. (2006) Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol 574: 41-53.
31. Brehm A, Thomaseth K, Bernroider E, Nowotny P, Waldhausl W, et al. (2006) The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests. J Clin Endocrinol Metab 91: 2272-2278.
32. Comte B, Vidal H, Laville M, Riou JP (1990) Influence of thyroid hormones on gluconeogenesis from glycerol in rat hepatocytes: a dose-response study. Metabolism 39: 259-263.