Folate-decorated hydrophilic three-arm star-block terpolymer as a novel nanovehicle for targeted co-delivery of doxorubicin and Bcl-2 siRNA in breast cancer therapy

Acta Biomaterialia

Volumn 15, Issue , 2015, Pages 102-116

  Qian, Junmin ^a   Xu, Minghui ^a   Suo, Aili ^a   Xu, Weijun ^a   Liu, Ting ^a   Liu, Xuefeng ^a   Yao, Yu ^a   Wang, Hongjie ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Doxorubicin Bcl 2 siRNA; Nanomicelleplex; Star block terpolymer; Targeted co delivery

Indexed keywords

AMINO ACIDS; CELLS; CHEMICAL ANALYSIS; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; CYTOTOXICITY; DISEASES; EFFICIENCY; HYDROPHILICITY; MEDICAL APPLICATIONS; ONCOLOGY; POLYETHYLENE GLYCOLS; RING OPENING POLYMERIZATION; SULFUR COMPOUNDS; TARGETED DRUG DELIVERY;

BLOCK TERPOLYMERS; CO DELIVERIES; DOXORUBICIN; DOXORUBICIN BCL-2 SMALL INTERFERING RNA; FOLATES; HYDROPHILICS; NANOMICELLEPLEX; SMALL INTERFERING RNA; STAR-BLOCK TERPOLYMER; TARGETED CO-DELIVERY;

STARS;

DOXORUBICIN; DRUG VEHICLE; FOLIC ACID; GLUTATHIONE; HYDRAZONE DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; [POLY(L GLUTAMIC ACID GAMMA HYDRAZIDE) B POLY(N,N DIMETHYLAMINOPROPYL METHACRYLAMIDE)]EPSILON G POLY(ETHYLENE GLYCOL); DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MICELLE; NANOPARTICLE; POLYMER; PROTEIN BCL 2;

ARTICLE; BREAST CANCER; CANCER THERAPY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROPHILICITY; IN VITRO STUDY; MCF 7 CELL LINE; MOLECULARLY TARGETED THERAPY; PH; PRIORITY JOURNAL; PROTO ONCOGENE; PROTON NUCLEAR MAGNETIC RESONANCE; RING OPENING; STATIC ELECTRICITY; AGAR GEL ELECTROPHORESIS; APOPTOSIS; BREAST NEOPLASMS; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; HYDRODYNAMICS; METABOLISM; MICELLE; PARTICLE SIZE; PATHOLOGY; SYNTHESIS; ULTRASTRUCTURE;

ANNEXIN A5; APOPTOSIS; BREAST NEOPLASMS; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS, AGAR GEL; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; FOLIC ACID; HUMANS; HYDRODYNAMICS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MCF-7 CELLS; MICELLES; NANOPARTICLES; PARTICLE SIZE; POLYMERS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTON MAGNETIC RESONANCE SPECTROSCOPY; RNA, SMALL INTERFERING; STATIC ELECTRICITY;

EID: 84922729262     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.12.018     Document Type: Article

References (56)

1. Y.F. Tao, J.L. He, M.Z. Zhang, Y. Hao, J. Liu, and P.H. Ni Galactosylated biodegradable poly(ε-caprolactone-co-phosphoester) random copolymer nanoparticles for potent hepatoma-targeting delivery of doxorubicin Polym Chem 5 2014 3443 3452
2. H.S. Oberoi, N.V. Nukolova, A.V. Kabanov, and T.K. Bronich Nanocarriers for delivery of platinum anticancer drugs Adv Drug Del Rev 65 2013 1667 1685
3. A.C. Childs, S.L. Phaneuf, A.J. Dirks, T. Phillips, and C. Leeuwenburgh Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio Cancer Res 62 2002 4592 4598
4. L. Li, K.M. Huh, Y.K. Lee, and S.Y. Kim Biofunctional self-assembled nanoparticles of folate-PEG-heparin/PBLA copolymers for targeted delivery of doxorubicin J Mater Chem 21 2011 15288 15297
5. F. Greco, and M.J. Vicent Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines Adv Drug Deliv Rev 61 2009 1203 1213
6. P.G. Tardi, R.C. Gallagher, S. Johnstone, N. Harasym, M. Webb, and M.B. Bally Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo Biochim Biophys Acta Biomembr 1768 2007 678 687
7. H.A. Meng, M. Liong, T.A. Xia, Z.X. Li, Z.X. Ji, and J.I. Zink Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line ACS Nano 4 2010 4539 4550
8. F. Bensaid, O.T. du Boullay, A. Amgoune, C. Pradel, L.H. Reddy, and E. Didier Y-shaped mPEG-PLA cabazitaxel conjugates: well-controlled synthesis by organocatalytic approach and self-assembly into interface drug-loaded core-corona nanoparticles Biomacromolecules 14 2013 1189 1198
9. S.D. Li, and L. Huang Surface-modified LPD nanoparticles for tumor targeting Ann N Y Acad Sci 1082 2006 1 8
10. X.F. Yu, X.Q. Yang, S. Horte, J.N. Kizhakkedathu, and D.E. Brooks A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment Biomaterials 35 2014 278 286
11. A. Martinez, E. Muniz, C. Teijon, I. Iglesias, J.M. Teijon, and M.D. Blanco Targeting tamoxifen to breast cancer xenograft tumors: preclinical efficacy of folate-attached nanoparticles based on alginate-cysteine/disulphide-bond-reduced albumin Pharm Res 31 2014 1264 1274
12. J. Adam, M. Yang, T. Soga, and P.J. Pollard Rare insights into cancer biology Oncogene 33 2014 2547 2556
13. H.C. Shin, A.W.G. Alani, D.A. Rao, N.C. Rockich, and G.S. Kwon Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs J Control Release 140 2009 294 300
14. S.M. Lee, T.V. O'Halloran, and S.T. Nguyen Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy J Am Chem Soc 132 2010 17130 17138
15. A.M. Chen, M. Zhang, D.G. Wei, D. Stueber, O. Taratula, and T. Minko Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells Small 5 2009 2673 2677
16. R. Pakunlu, Y. Wang, W. Tsao, V. Pozharov, T. Cook, and T. Minko Enhancement of the efficacy of chemotherapy for lung cancer by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense: novel multicomponent delivery system Cancer Res 64 2004 6214 6224
17. R.J. Youle, and A. Strasser The BCL-2 protein family: opposing activities that mediate cell death Nat Rev Mol Cell Biol 9 2008 47 59
18. D.H. Kim, and J.J. Rossi Strategies for silencing human disease using RNA interference Nat Rev Genet 8 2007 173 184
19. D. Castanotto, and J.J. Rossi The promises and pitfalls of RNA-interference-based therapeutics Nature 457 2009 426 433
20. Y. Wang, S.J. Gao, W.H. Ye, H.S. Yoon, and Y.Y. Yang Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer Nat Mater 5 2006 791 796
21. J. Wang, Z. Lu, B.Z. Yeung, M.G. Wientjes, D.J. Cole, and J.L.S. Au Tumor priming enhances siRNA delivery and transfection in intraperitoneal tumors J Control Release 178 2014 79 85
22. J.M. Li, Y.Y. Wang, M.X. Zhao, C.P. Tan, Y.Q. Li, and X.Y. Le Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking Biomaterials 33 2012 2780 2790
23. T.M. Sun, J.Z. Du, Y.D. Yao, C.Q. Mao, S. Dou, and S.Y. Huang Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression ACS Nano 5 2011 1483 1494
24. R.G. Qi, S. Liu, J. Chen, H.H. Xiao, L.S. Yan, and Y.B. Huang Biodegradable copolymers with identical cationic segments and their performance in siRNA delivery J Control Release 159 2012 251 260
25. D. Cheng, N. Cao, J.F. Chen, X.S. Yu, and X.T. Shuai Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat Biomaterials 33 2012 1170 1179
26. S.X. Lv, M.Q. Li, Z.H. Tang, W.T. Song, H. Sun, and H.Y. Liu Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy Acta Biomater 9 2013 9330 9342
27. D.J. Gary, N. Puri, and Y.Y. Won Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery J Control Release 121 2007 64 73
28. Y.Q. Yang, B. Zhao, Z.D. Li, W.J. Lin, C.Y. Zhang, and X.D. Guo PH-sensitive micelles self-assembled from multi-arm star triblock copolymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery Acta Biomater 9 2013 7679 7690
29. P.F. Gou, W.P. Zhu, and Z.Q. Shen Calixarene-centered amphiphilic A(2)B(2) miktoarm star copolymers based on poly(ε-caprolactone) and poly(ethylene glycol) synthesis and self-assembly behaviors in water J Polym Sci Part A Polym Chem 48 2010 5643 5651
30. W.W. He, H.J. Jiang, L.F. Zhang, Z.P. Cheng, and X.L. Zhu Atom transfer radical polymerization of hydrophilic monomers and its applications Polym Chem 4 2013 2919 2938
31. S.V. Lale, R.G. Aswathy, A. Aravind, D.S. Kumar, and V. Koul AS1411 aptamer and folic acid functionalized pH-responsive ATRP fabricated pPEGMA-PCL-pPEGMA polymeric nanoparticles for targeted drug delivery in cancer therapy Biomacromolecules 15 2014 1737 1752
32. H.L. Sun, F.H. Meng, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong α-Amino acid containing degradable polymers as functional biomaterials: rational design, synthetic pathway, and biomedical applications Biomacromolecules 12 2011 1937 1955
33. Z.F. Yuan, X.Q. Yi, J. Zhang, S.X. Cheng, R.X. Zhuo, and F. Li A prodrug nanoassembly entrapping drugs as a tumor-targeted delivery system Chem Commun 49 2013 801 803
34. E.G. Kelley, J.N.L. Albert, M.O. Sullivan, and T.H. Epps Stimuli-responsive copolymer solution and surface assemblies for biomedical applications Chem Soc Rev 42 2013 7057 7071
35. G. Filomeni, G. Rotilio, and M.R. Ciriolo Cell signalling and the glutathione redox system Biochem Pharmacol 64 2002 1057 1064
36. Y. Teramura, Y. Kaneda, and H. Iwata Islet-encapsulation in ultra-thin layer-by-layer membranes of poly(vinyl alcohol) anchored to poly(ethylene glycol)-lipids in the cell membrane Biomaterials 28 2007 4818 4825
37. J.M. Qian, X.Q. Yong, W.J. Xu, and X.X. Jin Preparation and characterization of bimodal porous poly(γ-benzyl-l-glutamate) scaffolds for bone tissue engineering Mater Sci Eng C Mater Biol Appl 33 2013 4587 4593
38. C.Y. Hong, and C.Y. Pan Direct synthesis of biotinylated stimuli-responsive polymer and diblock copolymer by RAFT polymerization using biotinylated trithiocarbonate as RAFT agent Macromolecules 39 2006 3517 3524
39. Y.A. Vasilieva, D.B. Thomas, C.W. Scales, and C.L. McCormick Direct controlled polymerization of a cationic methacrylamido monomer in aqueous media via the RAFT process Macromolecules 37 2004 2728 2737
40. D. Popescu, H. Keul, and M. Moller Functional and reactive polymethacrylates suitable for preparation of peptide/protein-polymer conjugates React Funct Polym 70 2010 767 774
41. X.L. Hu, S. Liu, Y.B. Huang, X.S. Chen, and X.B. Jing Biodegradable block copolymer-doxorubicin conjugates via different linkages: preparation, characterization, and in vitro evaluation Biomacromolecules 11 2010 2094 2102
42. N.V. Cuong, Y.L. Li, and M.F. Hsieh Targeted delivery of doxorubicin to human breast cancers by folate-decorated star-shaped PEG-PCL micelle J Mater Chem 22 2012 1006 1020
43. J.X. Ding, C.S. Xiao, Y.C. Li, Y.L. Cheng, N.N. Wang, and C.L. He Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions J Control Release 169 2013 193 203
44. Z.X. Zhao, S.Y. Gao, J.C. Wang, C.J. Chen, E.Y. Zhao, and W.J. Hou Self-assembly nanomicelles based on cationic mPEG-PLA-b-polyarginine(R15) triblock copolymer for siRNA delivery Biomaterials 33 2012 6793 6807
45. Y.Z. Song, Q.J. Tian, Z.J. Huang, D. Fan, Z.N. She, and X.R. Liu Self-assembled micelles of novel amphiphilic copolymer cholesterol-coupled F68 containing cabazitaxel as a drug delivery system Int J Nanomed 9 2014 2307 2317
46. M. Bradley, and B.S. Garcia-Risueño Symmetric and asymmetric adsorption of pH-responsive gold nanoparticles onto microgel particles and dispersion characterization J Colloid Interface Sci 355 2011 321 327
47. J.F. Kukowska-Latallo, K.A. Candido, Z.Y. Cao, S.S. Nigavekar, I.J. Majoros, and T.P. Thomas Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer Cancer Res 65 2005 5317 5324
48. M. Hruby, C. Konak, and K. Ulbrich Polymeric micellar pH-sensitive drug delivery system for doxorubicin J Control Release 103 2005 137 148
49. K. Kataoka, T. Matsumoto, M. Yokoyama, T. Okano, Y. Sakurai, and S. Fukushima Doxorubicin-loaded poly(ethylene glycol)-poly(β-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance J Control Release 64 2000 143 153
50. L. Gu, L.M. Nusblat, N. Tishbi, S.C. Noble, C.M. Pinson, and E. Mintzer Cationic amphiphilic macromolecule (CAM)-lipid complexes for efficient siRNA gene silencing J Control Release 184 2014 28 35
51. S.H. Pun, N.C. Bellocq, A.J. Liu, G. Jensen, T. Machemer, and E. Quijano Cyclodextrin-modified polyethylenimine polymers for gene delivery Bioconjugate Chem 15 2004 831 840
52. M.E.H. El-Sayed, A.S. Hoffman, and P.S. Stayton Rational design of composition and activity correlations for pH-sensitive and glutathione-reactive polymer therapeutics J Control Release 101 2005 47 58
53. S. Biswas, N.S. Dodwadkar, P.P. Deshpande, S. Parab, and V.P. Torchilin Surface functionalization of doxorubicin-loaded liposomes with octa-arginine for enhanced anticancer activity Eur J Pharm Biopharm 84 2013 517 525
54. J.X. Gu, W.P. Cheng, J.G. Liu, S.Y. Lo, D. Smith, and X.Z. Qu PH-triggered reversible "stealth" polycationic micelles Biomacromolecules 9 2008 255 262
55. D.W. Pack, A.S. Hoffman, S. Pun, and P.S. Stayton Design and development of polymers for gene delivery Nat Rev Drug Discov 4 2005 581 593
56. C.J. Bishop, S.Y. Tzeng, and J.J. Green Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA Acta Biomater 11 2015 393 403