A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment

Biomaterials

Volumn 35, Issue 1, 2014, Pages 278-286

  Yu, Xifei ^a   Yang, Xiaoqiang ^a   Horte, Sonja ^a   Kizhakkedathu, Jayachandran N ^a   Brooks, Donald E ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cell adhesion; Choline phosphate; Drug delivery; Thermal and pH sensitive; Tumor

Indexed keywords

ACIDIC MICROENVIRONMENT; LINEAR COPOLYMERS; LOWER CRITICAL SOLUTION TEMPERATURE; PH SENSITIVE; PHOSPHATIDYL CHOLINE; POLYMERIC ADHESIVE; TEMPERATURE SENSITIVE; TUMOR MICROENVIRONMENT;

CELL ADHESION; COPOLYMERS; DRUG DELIVERY; PH SENSORS; TUMORS;

POLYMERS;

COPOLYMER; FLUORESCENT DYE; METHACRYLIC ACID DERIVATIVE; PHOSPHATIDYLCHOLINE; PHOSPHORYLCHOLINE; TRITIUM;

ACIDITY; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL AGGREGATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TARGETING; HEAT SENSITIVITY; HIGH TEMPERATURE; HUMAN; HUMAN CELL; HYDROPHILICITY; LOW TEMPERATURE; MAMMAL CELL; MEMBRANE BINDING; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; TUMOR MICROENVIRONMENT;

MAMMALIA;

CELL ADHESION; CHOLINE PHOSPHATE; DRUG DELIVERY; THERMAL AND PH SENSITIVE; TUMOR;

ACIDS; ANIMALS; CELL ADHESION; CHROMATOGRAPHY, GEL; ERYTHROCYTE MEMBRANE; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, CONFOCAL; PHOSPHORYLCHOLINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TUMOR MICROENVIRONMENT;

EID: 84887018744     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.09.052     Document Type: Article

References (37)

1. Catenby R.A., Gillies R.J. Amicroenvironmental model of carcinogenesis. Nat Rev Cancer 2008, 8:56-61.
2. Gillies R.J., Raghunand N., Karczmar G.S., Bhujwalla Z.M. MRI of the tumor microenvironment. JMagn Reson Imaging 2002, 16:430-450.
3. Zhang X., Lin Y., Gillies R.J. Tumor pH and its measurement. JNucl Med 2010, 51:1167-1170.
4. Hashimay A.I., Zhangay X., Wojtkowiaka J.W., Martineza G.V., Gillies R.J. Imaging pH and metastasis. NMR Biomed 2011, 24:582-591.
5. Vavere1 A.L., Biddlecombe G.B., Spees W.M., Garbow J.R., Wijesinghe D., Andreev O.A., et al. Anovel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res 2009, 69:4510-4516.
6. Lee E.S., Gao Z., Bae Y.H. Recent progress in tumor pH targeting nanotechnology. JControl Release 2008, 132:164-170.
7. Schmaljohann D. Thermo- and pH-responsive polymers in drug delivery. Adv Drug Deliv Rev 2006, 58:1655-1670.
8. Ulbrich K., Šubr V. Polymeric anticancer drugs with pH-controlled activation. Adv Drug Deliv Rev 2004, 56:1023-1050.
9. Bae Y., Fukushima S., Harada A., Kataoka K. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed 2003, 42:4640-4643.
10. Bae Y., Nishiyama N., Fukushima S., Koyama H., Yasuhiro M., Kataoka K. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced invivo antitumor efficacy. Bioconjug Chem 2005, 16:122-130.
11. Sudimack J., Lee R.J. Targeted drug delivery via the folate receptor. Adv Drug Deliv Rev 2000, 41:147-162.
12. Oyewumi M.O., Mumper R.J. Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice. JControl Release 2004, 24:613-626.
13. Goren D., Horowitz A.T., Tzemach D., Tarshish M., Zalipsky S., Gabizon A. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin Cancer Res 2000, 6:1949-1957.
14. Antony A.C. The biological chemistry of folate receptors. Blood 1992, 79:2807-2820.
15. Ross J.F., Chaudhuri P.K., Ratnam M. Differential regulation of folate receptor isoforms in normal and malignant tissues invivo and in established cell lines. Physiologic and clinical implications. Cancer 1994, 73:2432-2443.
16. Maeda H., Wu J., Sawa T., Matsumura Y., Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. JControl Release 2000, 65:271-284.
17. Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 2001, 41:189-207.
18. Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
19. Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 2005, 5:161-171.
20. Vicent M.J., Duncan R. Polymer conjugates: nanosized medicines for treating cancer. Trends Biotechnol 2006, 24:39-47.
21. Petros R.A., DeSimone J.M. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 2010, 9:615-627.
22. Vander Heiden M.G. Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 2011, 10:671-684.
23. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of sub-100nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 2011, 6:815-823.
24. Chen C.Y., Kim T.H., Wu W.C., Huang M.C., Wei H., Mount C.W., et al. pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. Biomaterials 2013, 34:4501-4509.
25. Yu X., Liu Z., Janzen J., Chafeeva I., Horte S., Chen W., et al. Polyvalent choline phosphate as a universal biomembrane adhesive. Nat Mater 2012, 11:468-476.
26. Yu X., Yang X., Horte S., Kizhakkedathu J.N., Brooks D.E. ATRP synthesis of poly(2-(methacryloyloxy)ethyl choline phosphate): a multivalent universal biomembrane adhesive. Chem Commun 2013, 49:6831-6833.
27. Yu X., Zou Y., Horte S., Janzen J., Kizhakkedathu J.N., Brooks D.E. Thermal reversal of polyvalent choline phosphate, a multivalent universal biomembrane adhesive. Biomacromolecules 2013, 14:2611-2621.
28. Han S., Hagiwara M., Ishizone T. Synthesis of thermally sensitive water-soluble polymethacrylates by living anionic polymerizations of oligo(ethylene glycol) methyl ether methacrylates. Macromolecules 2003, 36:8312-8319.
29. Aoshima S., Oda H., Kobayashi E. Synthesis of thermally-induced phase separating polymer with well-defined polymer structure by living cationic polymerization. I. Synthesis of poly(vinyl ether)s with oxyethylene units in the pendant and its phase separation behavior in aqueous solution. JPolym Sci Polym Chem 1992, 30:2407-2413.
30. Lutz J.F. Polymerization of oligo(ethylene glycol) (meth)acrylates: toward new generations of smart biocompatible materials. JPolym Sci Polym Chem 2008, 46:3459-3470.
31. Chiefari J., Chong Y.K., Ercole F., Krstina J., Jeffery J., Le T.P.T., et al. Living free-radical polymerization by reversible addition-fragmentation chain transfer: the RAFT process. Macromolecules 1998, 31:5559-5562.
32. Chen B., Jerger K., Fréchet J.M.J., Szoka F.C. The influence of polymer topology on pharmacokinetics: differences between cyclic and linear PEGylated poly(acrylic acid) comb polymers. JControl Release 2009, 140:203-209.
33. Shim Y.H., Bougard F., Coulembier O., Lazzaroni R., Dubois P. Synthesis and characterization of original 2-(dimethylamino)ethyl methacrylate/poly(ethyleneglycol) star-copolymers. Eur Polym J 2008, 44:3715-3723.
34. Bütün V., Armes S.P., Billingham N.C. Synthesis and aqueous solution properties of near-monodisperse tertiary amine methacrylate homopolymers and diblock copolymers. Polymer 2001, 42:5993-6008.
35. Chee C.K., Rimmer S., Soutar I., Swanson L. Fluorescence investigations of the thermally induced conformational transition of poly(N-isopropylacrylamide). Polymer 2001, 42:5079-5087.
36. Liu Z., Janzen J., Brooks D.E. Adsorption of amphiphilic hyperbranched polyglycerol derivatives onto human red blood cells. Biomaterials 2010, 31:3364-3373.
37. McManus M.L., Churchwell K.B., Strange K. Regulation of cell volume in health and disease. NEngl J Med 1995, 333:1260-1267.