Co-delivery of Doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells

Small

Volumn 5, Issue 23, 2009, Pages 2673-2677

  Chen, Alex M ^a   Zhang, Min ^b   Wei, Dongguang ^c   Stueber, Dirk ^d   Taratula, Oleh ^a   Minko, Tamara ^b   He, Huixin ^a  

^a University Heights   (United States)

^b Department of Pharmaceutics Rutgers ^*  (United States)

^c Carl Zeiss Vision Inc USA   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Apoptosis; Co delivery; Gene expression; Nanotechnology; Simultaneous delivery of drug and siRNA

Indexed keywords

APOPTOSIS; CANCER CELLS; CO-DELIVERY; DOXORUBICIN; EFFLUX PUMPS; MESOPOROUS SILICA NANOPARTICLES; MULTIDRUG-RESISTANT CANCER CELLS;

BIOACTIVITY; CELL DEATH; CHEMOTHERAPY; GENE EXPRESSION; NANOPARTICLES; NANOTECHNOLOGY; SILICA;

RNA;

ANTINEOPLASTIC AGENT; DOXORUBICIN; NANOPARTICLE; SILICON DIOXIDE; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; FEMALE; FLUORESCENCE MICROSCOPY; GENETICS; HUMAN; NANOTECHNOLOGY; OVARY TUMOR; PATHOLOGY; PROTO ONCOGENE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; ULTRASTRUCTURE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FEMALE; GENES, BCL-2; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; NANOTECHNOLOGY; OVARIAN NEOPLASMS; RNA, SMALL INTERFERING; SILICON DIOXIDE;

EID: 73349141177     PISSN: 16136810     EISSN: 16136829     Source Type: Journal    
DOI: 10.1002/smll.200900621     Document Type: Article

References (47)

1. E. A. Dubikovskaya, S. H. Thorne, T. H. Pillow, C. H. Contag, P. A. Wender, Proc. Natl. Acad. Sci, USA 2008, 105, 12128.
2. M. M. Gottesman, T. Fojo, S. E. Bates, Nature Rev. Cancer 2002, 2, 48.
3. R. I. Pakunlu, Y. Wang, W. Tsao, V. Pozharov, T. J. Cook, T. Minko, Cancer Res. 2004, 64, 6214.
4. A. K. Larsen, A. E. Escargueila, A. Skladanowski, Pharmacol. Therap. 2000, 85, 217.
5. G. D. Eytan, Biomed. Pharmacotherapy 2005, 59, 90.
6. G. SzakÁCs, K. Jakab, F. Antal, B. Sarkadi, Pathol. Oncol. Res. 2008, 4, 251.
7. R. I. Pakunlu, T. J. Cook, T. Minko, Pharm. Res. 2003, 20, 351.
8. T. Kanda, O. Yokosuka, F. Imazeki, M. Arai, H. Saisho, DNA Cell Biol. 2005, 24, 805.
9. R. T. Lima, L. M. Martins, J. E. Guimarães, C. Sambade, M. H. Vasconcelos, Cancer Gene Therapy 2004, 11, 309.
10. J. A. Menendez, L. Vellon, R. Colomer, R. Lupu, Int. J. Cancer. 2005, 115, 19.
11. G. J. Hannon, J. J. Rossi, Nature 2004, 431, 371.
12. K. A. Whitehead, R. Langer, D. G. Anderson, Nat. Rev. Drug Discovery 2009, 8, 129.
13. R. Juliano, M. R. Alam, V. Dixit, H. Kang, Nucl. Acids Res. 2008, 36, 4158.
14. J. A. Menendez, L. Vellon, R. Colomer, R. Lupu, Int. J. Cancer 2005, 115, 19.
15. Y. Wang, S. Gao, W. H. Ye, H. S. Yoon, Y. Y. Yang, Nat. Mater. 2006, 5, 791.
16. J. Yano, K. Hirabayashi, S.-i. Nakagawa, T. Yamaguchi, M. Nogawa, I. Kashimori, H. Naito, H. Kitagawa, K. Ishiyama, T. Ohgi, T. Irimura, Cancer Res. 2004, 10, 7721.
17. Y. Wang, S. Gao, W.-H. Ye, H. S. Yoon, Y.-Y. Yang, Nat. Mater. 2006, 5, 791.
18. M. Maszewska, J. Leclaire, M. Cieslak, B. Nawrot, A. Okruszek, A.-M. Caminade, J.- P. Majoral, Oligonucleotides 2003, 13, 193.
19. J. Lu, M. Liong, J. I. Zink, F. Tamanoi, Small 2007, 3, 1341.
20. Z. Liu, K. Chen, C. Davis, S. Sherlock, Q. Cao, X. Chen, H. J. Dai, Cancer Res. 2008, 68, 6652.
21. D. R. Radu, C.-Y. Lai, K. Jeftinija, E. W. Rowe, S. Jeftinija, C. S.-Y. Lin, J. Am. Chem. Soc. 2004, 126, 13216.
22. Z. Liu, M. Winters, M. Holodniy, H. J. Dai, Angew. Chem. Int. Ed. 2007, 46, 2023.
23. M. V. Yezhelyev, L. Qi, R. M. O'Regan, S. M. Nie, X. Gao, J. Am. Chem. Soc. 2008, 130, 9006.
24. D. J. Bharali, I. Keljbor, E. K. Stachowiak, P. Dutta, I. Roy, N. Kaur, E.J. Bergey, P. N. Prasad, M. K. Stachowiak, PNAS 2005, 102, 11539.
25. M. Thomas, A. M. Klibanov, PNAS 2003, 100, 918.
26. Z. Medarova, W. Pham, C. Farrar, V. Petkova, A. Moore, Nat. Med. 2007, 13, 372.
27. I.-K. Park, C.-P. Ng, J. Wang, B. Chu, C. Yuan, Z. S., Biomaterials 2008, 29, 724.
28. D. Luo, W. M. Saltzman, Nat. Biotech. 2000, 18, 893.
29. F. Torney, B. G. Trewyn, V. S. Y. Lin, K. Wang, Nat. Nanotech. 2007, 2, 295.
30. D. R. Radu, C.-Y. Lai, K. Jeftinija, E. W. Rowe, S. Jeftinija, V. S.-Y. Lin, J. Am. Chem. Soc. 2004, 126, 13216.
31. E. R. Gillies, M. J. Frechet, Bioconjugate Chem. 2005, 16, 361.
32. R. I. Pakunlu, Y. Wang, W. Tsao, V. Pozharov, T. J. Cook, T. Minko, Cancer Res. 2004, 64, 6214.
33. M. L. O'Brien, K. D. Tew, Eur. J. Cancer 1996, 32, 967.
34. C. Meijer, N. H. Mulder, H. Timmer-Bosscha, W. H. M. Petfrs, E. G. E. d. Vries, Int. J. Cancer 1991, 49, 582.
35. W. H. M. Peters, H. M. J. Roelofs, Cancer Res. 1992, 52, 1886.
36. Y.-L. Chiu, A. Ali, C. Y. Chu, H. Cao, T. M. Rana, Chem. Biol. 2004, 11, 1165.
37. H. M. Coley, W. B. Amoa, P. R. Twentyman, P. Workman, Br. J. Cancer 1993, 67, 1316.
38. D. Goren, A. T. Horowitz, D. Tzemach, M. Tarshish, S. Zalipsky, A. Gabizon, Clin. Cancer Res. 2000, 6, 1949.
39. H. L. Wong, R. Bendayan, A. M. Rauth, H. Y. Xue, K. Babakhanian, X. Y. Wu, J. Pharm. Exper. Ther. 2006, 317, 1372.
40. D. Goren, A. T. Horowitz, D. Tzemach, M. Tarshish, S. Zalipsky, G. A., Clin. Cancer Res. 2000, 6, 1949.
41. A. K. Larsen, A. E. Escargueil, A. Skladanowski, Pharmacol. Ther. 2000, 88, 217.
42. S. Bennis, C. Chapey, P. Couvreur, J. Robert, Eur. J. Cancer A 1994, 30, 89.
43. T. Minko, P. Kopeckova, J. Kopecek, Pharm. Res. 1999, 16, 986.
44. E. J. Gabbay, D. Grier, R. E. Fingerie, R. Reimer, R. Levy, S. W. Pearce, W. D. Wilson, Biochemistry 1976, 15, 2062.
45. M. Huigsloot, I. B. Tijdens, G. J. Mulder, B. van de Water, J. Biol. Chem. 2002, 277, 35869.
46. O. Hovorka, M. St'astny, T. Etrych, V. Subr, J. Strohalm, K. Ulbrich, B. Rihova, J. Controlled Release 2000, 80, 101.
47. T. Minko, P. Kopeckova, J. Kopecek, Int. J. Cancer. 2000, 86, 108.