Doxorubicin treatment in vivo causes cytochrome c release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio

Cancer Research

Volumn 62, Issue 16, 2002, Pages 4592-4598

  Childs, April C ^a   Phaneuf, Sharon L ^a   Dirks, Amie J ^a   Phillips, Tracey ^a   Leeuwenburgh, Christiaan ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; CASPASE 3; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; DOXORUBICIN; PROTEIN BAX; PROTEIN BCL 2; TROPONIN T;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CARDIOTOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART WEIGHT; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BODY WEIGHT; CYTOCHROME C GROUP; DOXORUBICIN; HEART; INTRACELLULAR MEMBRANES; IRON; MALE; MITOCHONDRIA, HEART; MOLECULAR SEQUENCE DATA; MYOCARDIUM; ORGAN SIZE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 0037102148     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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