The application of metabolomics in traditional chinese medicine opens up a dialogue between chinese and western medicine

Phytotherapy Research

Volumn 29, Issue 2, 2015, Pages 159-166

  Cao, Hongxin ^a,b   Zhang, Aihua ^a   Zhang, Huamin ^b   Sun, Hui ^a   Wang, Xijun ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Biomarkers; Drug discovery; Metabolomics; Systems biology; Traditional medicine; Western medicine

Indexed keywords

CHINESE MEDICINE; DRUG RESEARCH; HERB; HUMAN; INTEGRATIVE MEDICINE; MEDICAL PRACTICE; METABOLITE; METABOLOME; METABOLOMICS; MOLECULAR DYNAMICS; MORINDA OFFICINALIS; NONHUMAN; OXIDATIVE STRESS; PAEONIA; PAEONIAE ALBA; PAEONIAE RUBRA; PHENOTYPE; PLANT ROOT; PRESCRIPTION; REVIEW; SYSTEMS BIOLOGY; UPREGULATION; WESTERN MEDICINE; ANIMAL; DRUG DEVELOPMENT;

HERBACEOUS AGENT;

ANIMALS; DRUG DISCOVERY; DRUGS, CHINESE HERBAL; HUMANS; INTEGRATIVE MEDICINE; MEDICINE, CHINESE TRADITIONAL; METABOLOMICS;

EID: 84922721181     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5240     Document Type: Review

References (61)

1. D'AlessandroA, Zolla L. 2012. Metabolomics and cancer drug discovery: Let the cells do the talking. Drug Discov Today 17(1-2): 3-9.
2. Du WX, Zhu MD, Yuan HW. 2012. Dynamic study of correspondence of prescription and syndrome system: a system with combination of disease and syndrome, correspondence of prescription and syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi 32(6): 839-842.
3. Huang D, Yang J, Lu X, Deng Y, Xiong Z, Li F. 2013. An integrated plasma and urinary metabonomic study using UHPLC-MS: intervention effects of Epimedium koreanum on 'Kidney-Yang Deficiency syndrome' rats. J PharmBiomedAnal 76: 200-206.
4. Gong M, YeW, Xie Y,Wang S, Liang S, Zou Z. 2012. Metabonomic study of intervention effects of Morinda officinalis on'kidney-yang deficiency syndrome'. Zhongguo Zhong Yao Za Zhi 37(11): 1682-1685.
5. Kell DB. 2006. Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discov Today 11(23-24): 1085-1092.
6. Jiang M, Wang C, Zhang Y, Feng Y, Wang Y, Zhu Y. 2014. Sparse Partial-least-squares Discriminant Analysis for Different Geographical Origins of Salvia miltiorrhiza by 1 H-NMR-based Metabolomics. Phytochem Anal 25(1): 50-58.
7. Jian WX, Chen QH, Huang XP. 2012. Metabolomics study of the myocardial tissue of rats of cardiac blood stasis syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi 32(4): 515-520.
8. Jiang H, Nie L, Li Y, Xie J. 2012. Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription. J Sep Sci 35 (4): 483-489.
9. Jiang P, DaiW, Yan S, et al. 2011. Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method. J Ethnopharmacol 138(2): 530-536.
10. Li Y, Liu H, Wu X, Li D, Huang J. 2013a. An NMR metabolomics investigation of perturbations after treatment with Chinese herbal medicine formula in an experimental model of sepsis. OMICS 17(5):252-258.
11. Liu XJ, Zhou YZ, Li ZF, et al. 2012. Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy. J Pharm Pharmacol 64(4): 578-588.
12. Li Y, Liu H, Wu X, Li D, Huang J. 2013b. An NMR metabolomics investigation of perturbations after treatment with Chinese herbal medicine formula in an experimental model of sepsis. OMICS 17(5): 252-258.
13. Li Y,Wang Y, Su L, Li L, Zhang Y. 2013c. Exploring potential chemical markers by metabolomics method for studying the processing mechanism of traditional Chinese medicine using RPLC-Q-TOF/ MS: a case study of Radix Aconiti. Chem Cent J 7(1): 36.
14. Lv H, Sun H, Sun W, et al. 2008. Pharmacokinetic studies of a Chinese triple herbal drug formula. Phytomedicine 15(11): 993-1001.
15. Li X, Chen H, JiaW, Xie G. 2013d. A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study. Evid Based Complement Alternat Med 2013:836179.
16. Normile D. 2003. Asian medicine, the new face of traditional Chinese medicine. Science 299(5604):188-190.
17. Nicholson JK, Lindon JC. 2008. Systems biology: Metabonomics. Nature 455(7216):1054-1056.
18. Shi Q, Zhao H, Chen J, et al. 2014. Study on qi deficiency syndrome identification modes of coronary heart disease based on metabolomic biomarkers. Evid Based Complement Alternat Med 2014:281829.
19. Sun H, Zhang AH, Zou DX, Sun WJ, Wu XH, Wang XJ. 2014.Metabolomics coupled with pattern recognition and pathway analysis on potential biomarkers in liver injury and hepatoprotective effects of yinchenhao. Appl Biochem Biotechnol 173 (4):857-869.
20. Sun H, Zhang A, Wang X. 2012a. Potential Role of Metabolomic Approaches for Chinese Medicine Syndromes and Herbal Medicine. Phytother Res doi: 10.1002/ptr.4613.
21. Sun H, Zhang A, Yan G, et al. 2013. Metabolomic Analysis of Key Regulatory Metabolites in Hepatitis C Virus-infected Tree Shrews. Mol Cell Proteomics 12(3): 710-719.
22. Song YN, Zhang GB, Zhang YY, Su SB. 2013a. Clinical Applications of Omics Technologies on ZHENG Differentiation Research in Traditional Chinese Medicine. Evid Based Complement Alternat Med 2013: 989618.
23. Song X, Wang J, Wang P, Tian N, Yang M, Kong L. 2013b. 1H NMR-based metabolomics approach to evaluate the effect of Xue-Fu-Zhu-Yu decoction on hyperlipidemia rats induced by high-fat diet. J Pharm Biomed Anal 78-79: 202-210.
24. Suhre K, Shin SY, Petersen AK, et al. 2011. Human metabolic individuality in biomedical and pharmaceutical research. Nature 477(7362): 54-60.
25. Sun H, Ni B, Zhang A,Wang M, Dong H,Wang X. 2012b. Metabolomics study on Fuzi and its processed products using ultraperformance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition analysis. Analyst 137(1): 170-185.
26. Tan G, Liao W, Dong X, et al. 2012. Metabonomic profiles delineate the effect of traditional Chinese medicine sini decoction on myocardial infarction in rats. PLoS One 7(4): e34157.
27. Pelkonen O, Pasanen M, Lindon JC, et al. 2012. Omics and its potential impact on R&D and regulation of complex herbal products. J Ethnopharmacol 140(3): 587-593.
28. Wang X, Sun H, Zhang A, SunW,Wang P,Wang Z. 2011. Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: As pillars of the bridge between Chinese and Western medicine. J Pharm Biomed Anal 55(5): 859-868.
29. Wang X, Zhang A, Sun H. 2012a. Future perspectives of Chinese medical formulae: chinmedomics as an effector. OMICS 16 (7-8): 414-421.
30. Wang X, Yang B, Zhang A, Sun H, Yan G. 2012b. Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach. J Proteomics 75(4): 1411-1427.
31. Wilcoxen KM, Uehara T, Myint KT, Sato Y, Oda Y. 2010. Practical metabolomics in drug discovery. Expert Opin Drug Discov 5 (3): 249-263.
32. Wang X, Zhang A, Han Y, et al. 2012c. Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol Cell Proteomics 11(8): 370-380.
33. Wang R, Xiong AZ, Teng ZQ, Yang QW, Shi YH, Yang L. 2012d. Radix Paeoniae Rubra and Radix Paeoniae Alba Attenuate CCl4-Induced Acute Liver Injury: An Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) Based Metabolomic Approach for the Pharmacodynamic Study of Traditional Chinese Medicines (TCMs). Int J Mol Sci 13(11): 14634-14647.
34. Wang PR, Wang JS, Yang MH, Kong LY. 2013a. Neuroprotective effects of Huang-Lian-Jie-Du-Decoction on ischemic stroke rats revealed by 1H NMR metabolomics approach. J Pharm Biomed Anal 88C: 106-116.
35. Wang X, Wang Q, Zhang A, et al. 2013b. Metabolomics study of intervention effects of Wen-Xin-Formula using ultra highperformance liquid chromatography/mass spectrometry coupled with pattern recognition approach. J Pharm Biomed Anal 74: 22-30.
36. Wang X, Wang H, Zhang A, et al. 2012e. Metabolomics study on the toxicity of aconite root and its processed products using ultraperformance liquid-chromatography/electrosprayionization synapt high-definition mass spectrometry coupled with pattern recognition approach and ingenuity pathways analysis. J Proteome Res 11(2): 1284-1301.
37. Wang X, Lv H, Sun H, et al. 2008a. Quality evaluation of Yin Chen Hao Tang extract based on fingerprint chromatogram and simultaneous determination of five bioactive constituents. J Sep Sci 31(1): 9-15.
38. Wang X, SunW, Sun H, et al. 2008b. Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS. J Pharm Biomed Anal 46(3): 477-490.
39. Wang L, Zhou GB, Liu P, et al. 2008c. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A 105: 4826-4831.
40. Wang X, Zhang A, Wang P, et al. 2013c. Metabolomics coupled with proteomics advancing drug discovery towards more agile development of targeted combination therapies. Mol Cell Proteomics 12(5): 1226-1238.
41. XuW, Zhang L, Huang Y, Yang Q, Xiao H, Zhang D. 2012a. Plasma fatty acid metabolic profiles for traditional Chinese medicine syndrome differentiation in diabetic patients using uncorrelated linear discriminant analysis. Se Pu 30(9): 864-869.
42. Xu W, Zhang L, Huang Y, Yang Q, Xiao H, Zhang D. 2012b. Discrimination of type 2 diabetes mellitus corresponding to different traditional Chinese medicine syndromes based on plasma fatty acid profiles and chemometric methods. J Ethnopharmacol 143(2): 463-468.
43. Xiang L, Jiang P, Zhan C, et al. 2012. The serum metabolomic study of intervention effects of the traditional Chinese medicine Shexiang Baoxin Pill and a multi-component medicine polypill in the treatment of myocardial infarction in rats. Mol Biosyst 8(9): 2434-2442.
44. Yang B, Zhang A, Sun H, et al. 2012. Metabolomic study of insomnia and intervention effects of Suanzaoren decoction using ultra-performance liquid-chromatography/electrosprayionization synapt high-definition mass spectrometry. J Pharm Biomed Anal 58: 113-124.
45. Yue R, Zhao L, Hu Y, et al. 2013a. Metabolomic study of collageninduced arthritis in rats and the interventional effects of huang-lian-jie-du-tang, a traditional chinese medicine. Evid Based Complement Alternat Med 2013: 439690.
46. Yue R, Zhao L, Hu Y, et al. 2013b. Rapid-resolution liquid chromatography TOF-MS for urine metabolomic analysis of collageninduced arthritis in rats and its applications. J Ethnopharmacol 145(2): 465-475.
47. Yan B, A JY, Hao HP, et al. 2011. Metabonomic phenotype of "formula corresponding to pattern types" based on "qi and yin deficiency pattern" of myocardial ischemia rat model. Yao Xue Xue Bao 46(8): 976-982.
48. Zhang A, Sun H, Wang P, Han Y, Wang X. 2012a. Future perspectives of personalized medicine in traditional Chinese medicine: a systems biology approach. Complement Ther Med 20(1-2): 93-99.
49. Zhu ZJ, Schultz AW, Wang J, et al. 2013. Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nat Protoc 8 (3): 451-460.
50. Zhang A, Sun H,Wang Z, SunW,Wang P,Wang X. 2010. Metabolomics: towards understanding traditional Chinese medicine. Planta Med 76(17): 2026-2035.
51. Zhang A, Sun H, Qiu S, Wang X. 2013a. Advancing Drug Discovery and Development from Active Constituents of Yinchenhao Tang, a Famous Traditional Chinese Medicine Formula. Evid Based Complement Alternat Med 2013: 257909.
52. Zhang A, Sun H, Han Y, et al . 2012b. Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach. Analyst 137: 4200-4208.
53. Zhang A, Sun H, Wang X. 2012c. Serum metabolomics as a novel diagnostic approach for disease: a systematic review. Anal Bioanal Chem doi: 10.1007/s00216-012-6117-1.
54. Zhang A, Sun H, Wang P, Han Y, Wang X. 2012d. Metabonomics for discovering biomarkers of hepatotoxicity and nephrotoxicity. Pharmazie 67(2): 99-105.
55. Zhang A, Sun H, Wang P, Han Y, Wang X. 2012e. Modern analytical techniques in metabolomics analysis. Analyst 137(2): 293-300.
56. Zhang A, Sun H, Wang P, Han Y, Wang X. 2012f. Recent and potential developments of biofluid analyses in metabolomics. J Proteomics 75(4): 1079-1088.
57. Zhang AH, Sun H, Qiu S, Wang XJ. 2013b. Recent Highlights of Metabolomics in Chinese Medicine Syndrome Research. Evid Based Complement Alternat Med 2013: 402159.
58. Zhang HM, Li SL, Zhang H, Wang Y, Zhao ZL, Chen SL, Xu HX.2012g. Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach. J Pharm Biomed Anal 62: 258-273.
59. Zhang A, Sun H, Yuan Y, SunW, Jiao G,Wang X. 2011. An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen-Hao-Tang based on its active constituents. Fitoterapia 82(8): 1160-1168.
60. Zhang F, Zhan Q, Dong X, et al. 2014. Shengxian decoction in chronic heart failure treatment and synergistic property of platycodonis radix: A metabolomic approach and its application. Mol Biosyst 2014;10(8):2055-63.
61. Zhao H, Li J, He X, et al. 2012. The protective effect of yi shen juan bi pill in arthritic rats with castration-induced kidney deficiency. Evid Based Complement Alternat Med 2012: 102641.