Metabonomics for discovering biomarkers of hepatotoxicity and nephrotoxicity

Pharmazie

Volumn 67, Issue 2, 2012, Pages 99-105

  Zhang, Aihua ^a   Sun, Hui ^a   Wang, Ping ^a   Han, Ying ^a   Wang, Xijun ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 2 OXOISOVALERIC ACID; 8 HYDROXYDEOXYGUANOSINE; ANGIOGENESIS INHIBITOR; ARISTOLOCHIC ACID; ATORVASTATIN; BIOLOGICAL MARKER; CITRIC ACID; CREATINE; CYCLOSPORIN; DOXORUBICIN; FENOFIBRATE; GLUCOSE; GLUTATHIONE; HIPPURIC ACID; IPOMOEA NIL EXTRACT; LACTIC ACID; PLANT EXTRACT; POLYAMINE; PRAVASTATIN; PYROGLUTAMIC ACID; RAPAMYCIN; SUCCINIC ACID; TAURINE; TRICARBOXYLIC ACID; TRIMETHYLAMINE OXIDE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; DRUG; XENOBIOTIC AGENT;

AMINO ACID METABOLISM; ASCITES; CHEMOMETRICS; CHINESE MEDICINE; CITRIC ACID CYCLE; DRUG MANUFACTURE; DRUG METABOLISM; DRUG SAFETY; EDEMA; ENERGY METABOLISM; FOOD AND DRUG ADMINISTRATION; GAS CHROMATOGRAPHY; HISTOPATHOLOGY; HOMEOSTASIS; HUMAN; IPOMOEA NIL; LIPID METABOLISM; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; LOBAR PNEUMONIA; MASS SPECTROMETRY; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; SYSTEMS BIOLOGY; XENOBIOTIC METABOLISM; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG TOXICITY; KIDNEY DISEASE; METABOLISM; METABOLOMICS; METHODOLOGY; TOXIC HEPATITIS;

ANIMALS; BIOLOGICAL MARKERS; DRUG TOXICITY; DRUG-INDUCED LIVER INJURY; HUMANS; KIDNEY DISEASES; METABOLOMICS; PHARMACEUTICAL PREPARATIONS; XENOBIOTICS;

EID: 84860614132     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2012.1104     Document Type: Review

References (77)

1. Aoki M, Konya Y, Takagaki T, Umemura K, Sogame Y, Katsumata T, Komuro S (2011) Metabolomic investigation of cholestasis in a rat model using ultra-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 25: 1847-1852.
2. Arakaki AK, Skolnick J, McDonald JF (2008) Marker metabolites can be therapeutic targets as well. Nature 456: 443.
3. Astle J, Ferguson JT, German JB, Harrigan GG, Kelleher NL, Kodadek T, Parks BA, Roth MJ, Singletary KW, Wenger CD, Mahady GB (2007) Characterization of proteomic and metabolomic responses to dietary factors and supplements. J Nutr 137: 2787-2793.
4. Athersuch TJ; Castro-Perez J; Rodgers C; Nicholson JK;Wilson ID (2010) UPLC-MS; HPLC-radiometric; and NMR-spectroscopic studies on the metabolic fate of 3-fluoro-[U-14C]-aniline in the bile-cannulated rat. Xenobiotica 40: 510-523.
5. Bao Y, Zhao T, Wang X, Qiu Y, Su M, Jia W (2009) Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers. J Proteome Res 8: 1623-1630.
6. Barton RH;Waterman D; Bonner FW; Holmes E; Clarke R; Procardis Consortium; Nicholson JK; Lindon JC (2010) The influence of EDTA and citrate anticoagulant addition to human plasma on information recovery from NMR-based metabolic profiling studies. Mol Biosyst 6: 215-224.
7. Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IK, Brown IJ, de Iorio M, Daviglus ML, Holmes E, Stamler J, Nicholson JK, Elliott P (2010) Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology. J Clin Epidemiol 63: 970-979.
8. Bodor N, Buchwald P (2010) Recent advances in retrometabolic drug design (RMDD) and development. Pharmazie 65: 395-403.
9. Boudonck KJ, Mitchell MW, Német L, Keresztes L, Nyska A, Shinar D, Rosenstock M (2009) Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol Pathol 37: 280-292.
10. Chan W, Cai Z (2008) Aristolochic acid induced changes in the metabolic profile of rat urine. J Pharm Biomed Anal. 46: 757-762.
11. Chen M, Ni Y, Duan H, Qiu Y, Guo C, Jiao Y, Shi H, Su M, Jia W (2008) Mass spectrometry-based metabolic profiling of rat urine associated with general toxicity induced by the multiglycoside of Tripterygium wilfordii Hook. f. Chem Res Toxicol 21: 288-382.
12. Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ (2009) Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. Chem Res Toxicol 22:699-707.
13. Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, Nickson J, Tonge R, Wilson I, Nicholson J (2006) Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res 5: 1586-1601.
14. Denery JR, Nunes AA, Hixon MS, Dickerson TJ, Janda KD (2010) Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis. PLoS Negl Trop Dis 4: e834.
15. Ebbels TM, Keun HC, Beckonert OP, Bollard ME, Lindon JC, Holmes E, Nicholson JK (2007) Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J Proteome Res 6: 4407-4422.
16. Ellinger-Ziegelbauer H, Adler M, Amberg A, Brandenburg A, Callanan JJ, Connor S, Fountoulakis M, Gmuender H, Gruhler A, Hewitt P, Hodson M, Matheis KA, McCarthy D, Raschke M, Riefke B, Schmitt CS, Sieber M, Sposny A, Suter L, Sweatman B, Mally A (2011) The enhanced value of combining conventional and "omics" analyses in early assessment of drug-induced hepatobiliary injury. Toxicol Appl Pharmacol 252: 97-111.
17. Fonville JM, Maher AD, Coen M, Holmes E, Lindon JC, Nicholson JK (2010) Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification. Anal Chem 82: 1811-1821.
18. Heijne WH, Lamers RJ, van Bladeren PJ, Groten JP, van Nesselrooij JH, van Ommen B (2005) Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis. Toxicol Pathol 33: 425-433.
19. Heinzmann SS, Brown IJ, Chan Q, Bictash M, Dumas ME, Kochhar S, Stamler J, Holmes E, Elliott P, Nicholson JK (2010) Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption. Am J Clin Nutr 92: 436-443.
20. Holmes E, Nicholson JK, Tranter G (2001) Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks. Chem Res Toxicol 14: 182-191.
21. Ishihara K, Katsutani N, Asai N, Inomata A, Uemura Y, Suganuma A, Sawada K, Yokoi T, Aoki T (2009) Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis. Basic Clin Pharmacol Toxicol 105: 156-166.
22. Isoda K, Hasezaki T,Kondoh M, TsutsumiY,YagiK(2011) Effect of surface charge on nano-sized silica particles-induced liver injury. Pharmazie 66: 278-281.
23. Johansen KK, Wang L, Aasly JO, White LR, Matson WR, Henchcliffe C, Beal MF, Bogdanov M (2009) Metabolomic profiling in LRRK2-related Parkinson's disease. PLoS One 4: e7551.
24. Johnson CH, Karlsson E, Sarda S, Iddon L, Iqbal M, Meng X, Harding JR, Stachulski AV, Nicholson JK, Wilson ID, Lindon JC (2010) Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides. Xenobiotica 40: 9-23.
25. Klawitter J, Bendrick-Peart J, Rudolph B, Beckey V, Klawitter J, Haschke M, Rivard C, Chan L, Leibfritz D, Christians U, Schmitz V (2009) Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function. Chem Res Toxicol 22: 118-128.
26. Klawitter J, Haschke M, Kahle C, Dingmann C, Klawitter J, Leibfritz D, Christians U (2010) Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose. Br J Clin Pharmacol 70: 241-251.
27. Kumar BS, Lee YJ, Yi HJ, Chung BC, Jung BH (2010) Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach. Anal Chim Acta 661: 47-59.
28. Lawaetz AJ, Schmidt B, Staerk D, Jaroszewski JW, Bro R (2009) Application of rotated PCA models to facilitate interpretation of metabolite profiles: commercial preparations of St. John's Wort. Planta Med 75: 271-280. 271-279.
29. Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, Nair KS (2010) Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PLoS One 5: e10538.
30. Lee MS, Jung BH, Chung BC, Cho SH, Kim KY, Kwon OS, Nugraha B, Lee YJ (2009) Metabolomics study with gas chromatography-mass spectrometry for predicting valproic acid-induced hepatotoxicity and discovery of novel biomarkers in rat urine. Int J Toxicol 28: 392-404.
31. Lenz EM, Williams RE, Sidaway J, Smith BW, Plumb RS, Johnson KA, Rainville P, Shockcor J, Stumpf CL, Granger JH, Wilson ID (2007) The application of microbore UPLC/oa-TOF-MS and 1H NMR spectroscopy to the metabonomic analysis of rat urine following the intravenous administration of pravastatin. J Pharm Biomed Anal 44: 845-852.
32. Li F, Patterson AD, Höfer CC, Krausz KW, Gonzalez FJ, Idle JR (2010) Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol. 80: 1063-1074.
33. Li X, Kondoh M, Watari A, Hasezaki T, Isoda K, Tsutsumi Y, Yagi K (2011) Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice. Pharmazie 66: 282-286.
34. Liang Q, Ni C, Xie M, Zhang Q, Zhang YX, Yan XZ, Yang MJ, Peng SQ, Zhang YZ (2009) Nephrotoxicity study of Aristolochia fangchi in rats by metabonomics. Zhong Xi Yi Jie He Xue Bao 7: 746-752.
35. Liao Y, Peng SQ, Yan XZ, Zhang LS (2007) Metabonomics profile of urine from rats administrated with different treatment period of isoniazid. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 29: 730-737.
36. Liao Y, Peng SQ, Yan XZ, Chen HB, Zhang LS. (2008) Metabonomic profile of urine from rats administrated with different treatment period of rifampin. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 30: 696-702.
37. Lin Y, Si D, Zhang Z, Liu C (2009) An integrated metabonomic method for profiling of metabolic changes in carbon tetrachloride induced rat urine. Toxicology 256: 191-200.
38. Lin S, Yang Z, Zhang X, Bian Z, Cai Z (2011) Hippocampal metabolomics reveals 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity associated with ageing in Sprague-Dawley rats. Talanta 85: 1007-1012.
39. Liu Y, Huang R, Liu L, Peng J, Xiao B, Yang J, Miao Z, Huang H (2010) Metabonomics study of urine from Sprague-Dawley rats exposed to Huang-yao-zi using (1)H NMR spectroscopy. J Pharm Biomed Anal 52: 136-41.
40. Lu C, Wang Y, Sheng Z, Liu G, Fu Z, Zhao J, Zhao J, Yan X, Zhu B, Peng S (2010) NMR-based metabonomic analysis of the hepatotoxicity induced by combined exposure to PCBs and TCDD in rats. Toxicol Appl Pharmacol 248: 178-184.
41. Lv H, Liu L, Zhang Y, Song T, Lu J, Chen X (2010) Ingenuity pathways analysis of urine metabonomics phenotypes toxicity of gentamicin in multiple organs. Mol Biosyst 6: 2056-2067.
42. Ma C, Bi K, Zhang M, Su D, Fan X, JiW,Wang C, Chen X (2010a) Metabonomic study of biochemical changes in the urine of Morning Glory Seed treated rat. J Pharm Biomed Anal 53: 559-566.
43. Ma C, Bi K, Zhang M, Su D, Fan X, Ji W, Wang C, Chen X (2010b) Toxicology effects of Morning Glory Seed in rat: a metabonomic method for profiling of urine metabolic changes. J Ethnopharmacol 130: 134-142.
44. Ma C, Bi K, Su D, JiW, Zhang M, Fan X,Wang C, Chen X (2010c) Serum and kidney metabolic changes of rat nephrotoxicity induced by Morning Glory Seed. Food Chem Toxicol 48: 2988-2993.
45. Maddox JF, Luyendyk JP, Cosma GN, Breau AP, Bible RH Jr, Harrigan GG, Goodacre R, Ganey PE, Cantor GH, Cockerell GL, Roth RA (2006) Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide. Toxicol Appl Pharmacol 212: 35-44.
46. Mamas M, Dunn WB, Neyses L, Goodacre R (2011) The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Arch Toxicol 85:5-17.
47. Masson P, Alves AC, Ebbels TM, Nicholson JK, Want EJ (2010) Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS. Anal Chem 82: 7779-7786.
48. Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biologicalNMRspectroscopic data. Xenobiotica 29: 1181-1189.
49. Nicholson JK, Connelly J, Lindon JC, Holmes E (2002) Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 1: 153-161.
50. Niemann CU, Serkova NJ (2007) Biochemical mechanisms of nephrotoxicity: application for metabolomics. Expert Opin Drug Metab Toxicol 3: 527-544.
51. Ohta T, Masutomi N, Tsutsui N, Sakairi T, Mitchell M, Milburn MV, Ryals JA, Beebe KD, Guo L (2009) Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats. Toxicol Pathol 37: 521-535.
52. Pexa A, Boeger RH, Henle T, Schwedhelm E, Deussen A (2008) Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats. Br J Nutr 99: 993-999.
53. Park JC, Hong YS, Kim YJ, Yang JY, Kim EY, Kwack SJ, Ryu do H, Hwang GS, Lee BM (2009) A metabonomic study on the biochemical effects of doxorubicin in rats using (1)H-NMR spectroscopy. J Toxicol Environ Health A 72: 374-384.
54. Russmann S, Kullak-Ublick GA, Grattagliano I (2009) Current concepts of mechanisms in drug-induced hepatotoxicity. Curr Med Chem 16: 3041-3053.
55. Shi C, Wu CQ, Cao AM, Sheng HZ, Yan XZ, Liao MY (2007) NMR-spectroscopy-based metabonomic approach to the analysis of Bay41-4109, a novel anti-HBV compound, induced hepatotoxicity in rats. Toxicol Lett 173: 161-167.
56. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR,Wei JT, Varambally S, Beecher C, Chinnaiyan AM (2009) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457: 910-914.
57. Stewart D, McDougall GJ, Sungurtas J, Verrall S, Graham J, Martinussen I (2007) Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement. Mol Nutr Food Res 51: 645-651.
58. Stierum R, Heijne W, Kienhuis A, van Ommen B, Groten J (2005) Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals. Toxicol Appl Pharmacol 207: 179-188.
59. Sieber M, Wagner S, Rached E, Amberg A, Mally A, Dekant W (2009a) Metabonomic study of ochratoxin a toxicity in rats after repeated administration: phenotypic anchoring enhances the ability for biomarker discovery. Chem Res Toxicol 22: 1221-1231.
60. Sieber M, Hoffmann D, Adler M, Vaidya VS, Clement M, Bonventre JV, Zidek N, Rached E, Amberg A, Callanan JJ, DekantW, Mally A (2009b) Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity. Toxicol Sci 109: 336-349.
61. Urakami K, Zangiacomi V, Yamaguchi K, Kusuhara M (2010) Quantitative metabolome profiling of Illicium anisatum by capillary electrophoresis time-of-flight mass spectrometry. Biomed Res 31: 161-163.
62. Urayama S, Zou W, Brooks K, Tolstikov V (2010) Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer. Rapid Commun Mass Spectrom 24: 613-620.
63. Wang X, Sun H, Zhang A, SunW,Wang P,Wang Z (2011a) Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine. J Pharm Biomed Anal 55: 859-868.
64. Wang Y, Han T, Xue LM, Han P, Zhang QY, Huang BK, Zhang H, Ming QL, PengW, Qin LP (2011b) Hepatotoxicity of kaurene glycosides from Xanthium strumarium L. fruits in mice. Pharmazie 66: 445-449.
65. Wang Q, Jiang Y, Wu C, Zhao J, Yu S, Yuan B, Yan X, Liao M (2006) Study of a novel indolin-2-ketone compound Z24 induced hepatotoxicity by NMR-spectroscopy-based metabonomics of rat urine, blood plasma, and liver extracts. Toxicol Appl Pharmacol 215: 71-82.
66. Wang X, Lv H, Sun H, Liu L, Yang B, Sun W, Wang P, Zhou D, Zhao L, Dou S, Zhang G, Cao H (2008) Metabolic urinary profiling of alcohol hepatotoxicity and intervention effects of Yin Chen Hao Tang in rats using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. J Pharm Biomed Anal 48: 1161-1168.
67. Wang H, Ma C, Ma L, Du Z,Wang H, Ye H, Li G, Liu B, Xu G (2009a) Secondary metabolic profiling and artemisinin biosynthesis of two genotypes of Artemisia annua. Planta Med 75: 1625-1633.
68. Wang J, Reijmers T, Chen L, Van Der Heijden R, Wang M, Peng S, Hankemeier T, Xu G, Van Der Greef J (2009b) Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics. Metabolomics 5: 407-418.
69. Want EJ, Coen M, Masson P, Keun HC, Pearce JT, Reily MD, Robertson DG, Rohde CM, Holmes E, Lindon JC, Plumb RS, Nicholson JK (2010) Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies. Anal Chem 82: 5282-5289.
70. Watkins SM, German JB (2002) Metabolomics and biochemical profiling in drug discovery and development. Curr Opin Mol Ther 4: 224-228.
71. Waters NJ,Waterfield CJ, Farrant RD, Holmes E, Nicholson JK (2006) Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis. J Proteome Res 5: 1448-1459.
72. Wei R (2011) Metabolomics and its practical value in pharmaceutical industry. Curr Drug Metab. 12: 345-358.
73. Wei L, Liao P, Wu H, Li X, Pei F, Li W, Wu Y (2009) Metabolic profiling studies on the toxicological effects of realgar in rats by (1)H NMR spectroscopy. Toxicol Appl Pharmacol 234: 314-325.
74. Williams RE, Major H, Lock EA, Lenz EM, Wilson ID (2005) D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach. Toxicology 207: 179-190.
75. Workentine ML, Harrison JJ,Weljie AM, Tran VA, Stenroos PU, Tremaroli V,Vogel HJ, Ceri H, Turner RJ (2010) Phenotypic and metabolic profiling of colony morphology variants evolved from Pseudomonas fluorescens biofilms. Environ Microbiol 12: 1565-1577.
76. Xie G, Zheng X, Qi X, CaoY, ChiY, Su M, NiY, QiuY, LiuY, Li H, Zhao A, Jia W (2010) Metabonomic evaluation of melamine-induced acute renal toxicity in rats. J Proteome Res 9: 125-133.
77. Zhang A, Sun H, Wang Z, Sun W, Wang P, Wang X (2010) Metabolomics: towards understanding traditional Chinese medicine. Planta Med 76: 2026-2035.