Metabolomics coupled with pattern recognition and pathway analysis on potential biomarkers in liver injury and hepatoprotective effects of Yinchenhao

Applied Biochemistry and Biotechnology

Volumn 173, Issue 4, 2014, Pages 857-869

  Sun, Hui ^a   Zhang, Ai Hua ^a   Zou, Di Xing ^a   Sun, Wen Jun ^a   Wu, Xiu Hong ^a   Wang, Xi Jun ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Liver injury; Metabolites; Metabolomics; Pattern recognition approach; Ultra performance liquid chromatography electrospray ionization quadruple time of flight mass spectrometry

Indexed keywords

BIOMOLECULES; CHROMATOGRAPHY; DISCRIMINANT ANALYSIS; DRUG PRODUCTS; INDEPENDENT COMPONENT ANALYSIS; IONIZATION OF LIQUIDS; LEAST SQUARES APPROXIMATIONS; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PATTERN RECOGNITION; PHYSIOLOGY;

HEPATOPROTECTIVE EFFECTS; INDEPENDENT COMPONENT ANALYSIS(ICA); LIVER INJURIES; METABOLOMICS; PARTIAL LEAST SQUARES-DISCRIMINANT ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY; TRADITIONAL CHINESE MEDICINE; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY;

BIOMARKERS;

1 NAPHTHYL ISOTHIOCYANATE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ARTEMISIA ANNUA EXTRACT; ASPARTATE AMINOTRANSFERASE; BETA GLUCURONIDASE; BILIRUBIN; BILIRUBIN GLUCURONIDE; BIOLOGICAL MARKER; GAMMA GLUTAMYLTRANSFERASE; MALONALDEHYDE; ALPHA-NAPHTHYL ISOCYANATE; HERBACEOUS AGENT; ISOCYANIC ACID DERIVATIVE; NAPHTHALENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; BIOCHEMISTRY; BLOOD SAMPLING; CHINESE MEDICINE; CHOLESTASIS; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; DRUG EFFECT; DRUG MECHANISM; ELECTROSPRAY MASS SPECTROMETRY; INDEPENDENT COMPONENT ANALYSIS; LIVER; LIVER INJURY; LIVER PROTECTION; MALE; METABOLISM; METABOLITE; METABOLOMICS; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PATTERN RECOGNITION; PYRIMIDINE METABOLISM; RAT; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; ARTEMISIA ANNUA; AUTOMATED PATTERN RECOGNITION; BLOOD; CHEMISTRY; DRUG EFFECTS; METABOLOME; PROCEDURES; TOXIC HEPATITIS; TOXICITY; WISTAR RAT;

ARTEMISIA ANNUA;

ANIMALS; ARTEMISIA ANNUA; BIOLOGICAL MARKERS; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; ISOCYANATES; MALE; MEDICINE, CHINESE TRADITIONAL; METABOLOME; METABOLOMICS; NAPHTHALENES; PATTERN RECOGNITION, AUTOMATED; RATS; RATS, WISTAR;

EID: 84902550670     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-014-0903-5     Document Type: Article

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