Radix Paeoniae Rubra and Radix Paeoniae Alba attenuate CCl4-induced acute liver injury: An ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) based metabolomic approach for the pharmacodynamic study of traditional chinese medicines (TCMs)

International Journal of Molecular Sciences

Volumn 13, Issue 11, 2012, Pages 14634-14647

  Wang, Rui ^a   Xiong, Ai Zhen ^a   Teng, Zhong Qiu ^b   Yang, Qi Wei ^a   Shi, Yan Hong ^a   Yang, Li ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b BEIJING INSTITUTE OF TECHNOLOGY   (China)

Author keywords

Liver injury; Metabolomics; Radix Paeoniae Alba; Radix Paeoniae Rubra; UPLC MS

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLINE; CREATINE; DEOXYCHOLIC ACID; FOLIC ACID; GLYCOCHOLIC ACID; PAEONIA RADIX; PLANT MEDICINAL PRODUCT; BILE ACID; BIOLOGICAL MARKER; CARBON TETRACHLORIDE; HERBACEOUS AGENT; PLANT EXTRACT; PROTECTIVE AGENT;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID BLOOD LEVEL; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MASS SPECTROMETRY; NONHUMAN; PAEONIA; PAEONIAE ALBA; RAT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG-INDUCED LIVER INJURY; LIQUID CHROMATOGRAPHY; LIVER FUNCTION TEST; METABOLISM; METABOLOME; METABOLOMICS; PROCEDURES;

ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE; CHROMATOGRAPHY, LIQUID; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; LIVER FUNCTION TESTS; MALE; MASS SPECTROMETRY; MEDICINE, CHINESE TRADITIONAL; METABOLOME; METABOLOMICS; PAEONIA; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS;

EID: 84870711793     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131114634     Document Type: Article

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