Clinical applications of omics technologies on Zheng differentiation research in traditional Chinese medicine

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Song, Ya Nan ^a   Zhang, Gui Biao ^a   Zhang, Yong Yu ^a   Su, Shi Bing ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; INTERLEUKIN 10;

ATHEROSCLEROSIS; CHINESE MEDICINE; CHRONIC KIDNEY DISEASE; CHRONIC LIVER DISEASE; CLINICAL PRACTICE; COMMON COLD; DIABETES MELLITUS; GENE LOCUS; GENOMICS; HEMODIALYSIS; HEMOSTASIS; HEPATITIS B; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; LIVER CIRRHOSIS; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH DISEASE; TRANSCRIPTOMICS;

EID: 84880174109     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/989618     Document Type: Review

References (94)

1. Lu A. P., Jiang M., Zhang C., Chan K., An integrative approach of linking traditional Chinese medicine pattern classification and biomedicine diagnosis. Journal of Ethnopharmacology 2012 141 2 549 556 10.1016/j.jep.2011.08.045
2. Jiang M., Yang J., Zhang C., Liu B., Chan K., Cao H., Lu A., Clinical studies with traditional Chinese medicine in the past decade and future research and development. Planta Medica 2010 76 17 2048 2064 2-s2.0-78649904312 10.1055/s-0030-1250456
3. Jiang M., Lu C., Zhang C., Syndrome differentiation in modern research of traditional Chinese medicine. Journal of Ethnopharmacology 2012 140 634 642 10.1016/j.jep.2012.01.033
4. Ryu H., Lee H., Kim H., Kim J., Reliability and validity of a cold-heat pattern questionnaire for traditional Chinese medicine. The Journal of Alternative and Complementary Medicine 2010 16 6 663 667 2-s2.0-77954203505 10.1089/acm.2009.0331
5. Hogeboom C. J., Sherman K. J., Cherkin D. C., Variation in diagnosis and treatment of chronic low back pain by traditional Chinese medicine acupuncturists. Complementary Therapies in Medicine 2001 9 3 154 166 2-s2.0-0035165554 10.1054/ctim.2001.0457
6. Jiang M., Zhang C., Zheng G., Traditional Chinese medicine Zheng in the era of evidence-based medicine: a literature analysis. Evidence-Based Complementary and Alternative Medicine 2012 2012 9 409568 10.1155/2012/409568
7. Keusch G. T., What do -omics mean for the science and policy of the nutritional sciences? The American Journal of Clinical Nurtrition 2006 83 2 520S 522S
8. Dai J. Y., Sun S. J., Cao H. J., Applications of new technologies and new methods in ZHENG differentiation. Evidence-Based Complementary and Alternative Medicine 2012 2012 8 298014 10.1155/2012/298014
9. Xue M., Yin H. J., Chen K. J., Some thoughts on studying essence of syndromes based on genomics. Chinese Journal of Integrated Traditional and Western Medicine 2006 26 1 88 90 2-s2.0-38049024108
10. Lu C. L., Qv X. Y., Jiang J. G., Proteomics and syndrome of Chinese medicine. Journal of Cellular and Molecular Medicine 2010 14 12 2721 2728 2-s2.0-78650053114 10.1111/j.1582-4934.2010.01178.x
11. Jia W., Liu P., Jiang J., Application of metabonomics in complicated theory system research of traditional Chinese medicine. China Journal of Chinese Materia Medica 2006 31 8 621 624
12. German J. B., Bauman D. E., Burrin D. G., Failla M. L., Freake H. C., King J. C., Klein S., Milner J. A., Pelto G. H., Rasmussen K. M., Zeisel S. H., Metabolomics in the opening decade of the 21st century: building the roads to individualized health. Journal of Nutrition 2004 134 10 2729 2732 2-s2.0-4744376167
13. Juan H. F., Huang H. C., System Biology: Applications in Cancer-Related Research 2012 World Scientific
14. Chuang H. Y., Hofree M., Ideker T., A decade of systems biology. Annual Review of Cell and Developmental Biology 2010 26 721 744 2-s2.0-78049413383 10.1146/annurev-cellbio-100109-104122
15. Lin L. L., Wang Y. H., Lai C. Y., Systems biology of meridians, acupoints, and Chinese herbs in disease. Evidence-Based Complementary and Alternative Medicine 2012 2012 13 372670 10.1155/2012/372670
16. Whichard Z. L., Sarkar C. A., Kimmel M., Corey S. J., Hematopoiesis and its disorders: a systems biology approach. Blood 2010 115 12 2339 2347 2-s2.0-77950626127 10.1182/blood-2009-08-215798
17. Rudy Y., Ackerman M. J., Bers D. M., Clancy C. E., Houser S. R., London B., McCulloch A. D., Przywara D. A., Rasmusson R. L., Solaro J. R., Trayanova N. A., Van Wagoner D. R., Varro A., Weiss J. N., Lathrop D. A., Systems approach to understanding electromechanical activity in the human heart a national heart, lung, and blood institute workshop summary. Circulation 2008 118 11 1202 1211 2-s2.0-54049152758 10.1161/CIRCULATIONAHA.108.772715
18. Xue M., Chen K. J., Yin H. J., Relationship between platelet activation related factors and polymorphism of related genes in patients with coronary heart disease of blood-stasis syndrome. Chinese Journal of Integrative Medicine 2008 14 4 267 273 2-s2.0-57749168386 10.1007/s11655-008-0267-1
19. Fang Z. Y., Jiang W. M., Zhu C. L., Distribution of Apo E gene sequencing in patients with coronary heart disease of phlegm-stasis syndrome. Chinese Journal of Integrated Traditional and Western Medicine 2011 31 9 1201 1204
20. Ouyang T., Song J. N., Miao Y., Lin Q., Niu X. H., Jin H., Chen B., Study on relationship between polymorphism of apolipoprotein E gene and syndromes of phlegm and blood stasis in patients with coronary heart disease. Journal of Chinese Integrative Medicine 2005 3 6 438 442 2-s2.0-33746663556
21. Mao Y. L., Yuan Z. K., Huang X. P., Lu F., Tan G., Hu Z., Study on relationship between the polymorphism of angiotensin converting enzyme gene and blood stasis syndrome in patients with coronary heart disease. Chinese Journal of Integrated Traditional and Western Medicine 2004 24 9 776 780 2-s2.0-16544382866
22. Ma X. J., Yin H. J., Chen K. J., Differential gene expression profiles in coronary heart disease patients of blood stasis syndrome in traditional Chinese medicine and clinical role of target gene. Chinese Journal of Integrative Medicine 2009 15 2 101 106 2-s2.0-65349092870 10.1007/s11655-009-0101-4
23. Yuan Z. K., Wang L. P., Huang X. P., The screening and the functional pathway analysis of differential genes correlated with coronary heart disease of blood stasis syndrome. Chinese Journal of Integrated Traditional and Western Medicine 2012 32 10 1313 1318
24. Zhao H. H., Hou N., Wang W., Study on proteomic specificity of unstable angina with qi deficiency and blood stasis syndrome. Chinese Journal of Integrated Traditional and Western Medicine 2009 29 6 489 492 2-s2.0-79952087497
25. Li X. F., Jiang Y. R., Gao Z. Y., Screening, identification and analysis of platelet differential functional proteins in patients with coronary heart disesse of blood-stasis pattern. Chinese Journal of Integrated Traditional and Western Medicine 2010 30 5 467 473
26. Zhao H. H., Chen J. X., Shi Q., Gel electrophoresis analysis on plasma differential protein in patients with unstable angina of blood-stasis pattern. Chinese Journal of Integrated Traditional and Western Medicine 2010 30 5 488 492
27. Jian W. X., Yuan Z. K., Huang X. P., Detection and analysis on plasma metabolomics in patient with coronary heart disease of Xin-blood stasis syndrome pattern. Chinese Journal of Integrated Traditional and Western Medicine 2010 30 6 579 584
28. Wang J., Li Z. F., Zhao H. H., Characteristics of urine metabonomics in patients with blood stasis syndrome of CHN unstable angina. Journal of Beijing University of Traditional Chinese Medicine 2012 35 4 284 288
29. Li Q. Y., Guo Z. Z., Liang J., Interleukin-10 genotype correlated to deficiency syndrome in hepatitis B cirrhosis. Evidence-Based Complementary and Alternative Medicine 2012 2012 6 298925 10.1155/2012/298925
30. Jiang Z. L., Zhang W., Zhang H., Liu Y. B., Li Q. Y., Su S. B., Relationship between gene polymorphisms of interleukin-10 and syndrome types of traditional Chinese medicine in posthepatitis B cirrhosis. Journal of Chinese Integrative Medicine 2009 7 11 1052 1056 2-s2.0-73949092731 10.3736/jcim20091106
31. Guan Y., Zhang H., Zhang W., Su S. B., Analysis of differential gene expression profile in peripheral blood of patients with chronic hepatitis B and syndromes of dual deficiency of liver and kidney yin and accumulation of dampness heat. Journal of Chinese Intergrative Medicine 2012 10 7 751 756
32. Wang R. B., Zhou G. Q., Jiang Y. Y., Exploration on relationship between TCM syndrome type and expression of human leucocyte antigen locus-DRB1 in patients with chronic hepatitis B. Chinese Journal of Integrated Traditional and Western Medicine 2007 27 10 898 900 2-s2.0-58149177457
33. Weng L., Du J., He W. T., Ling C.-Q., Characteristic genomics of peripheral blood monouclear cells of hepatocellular carcinoma patients with liver-kidney yin deficiency syndrome. Journal of Chinese Intergrative Medicine 2012 10 4 406 415 10.3736/jcim20120409
34. Guo Z. Z., Yu S. H., Guan Y., Molecular mechanisms of same TCM syndrome for different diseases and different TCM syndrome for same disease in chronic hepatitis B and liver cirrhosis. Evidence-Based Complementary and Alternative Medicine 2012 2012 9 120350 10.1155/2012/120350
35. Liu Y. P., Liu P., Dai R. Y., Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B. Journal of Pharmaceutical and Biomedical Analysis 2012 59 5 173 178 10.1016/j.jpba.2011.10.002
36. Song Y. N., Zhang H., Guan Y., Classification of traditional Chinese medicine syndromes in patients with chronic hepatitis B by SELDI-based proteinchip analysis. Evidence-Based Complementary and Alternative Medicine 2012 2012 10 626320 10.1155/2012/626320
37. Zhou Y. W., Xu P. C., Cheng Y., Basic pathogenesis of asthenia of healthy energy and blood stasis in liver cirrhosis studied by serum proteomics. Chinese Journal of Integrated Traditional and Western Medicine 2011 31 5 595 602
38. Chen Q. W., Huang X. Q., Yang G. J., Preliminary study of serum metabonomics on Yang deficiency syndrome of patients with primary liver cancer. Chinese Archives of Traditional Chinese Medicine 2012 30 3 526 529
39. Lu Q. S., Lei Y., Chen K. J., Relationship of the A1166C polymorphism of ATI R gene with TCM syndrome and efficacy of Chinese hypotensor in patients with essential hypertension. Chinese Journal of Integrated Traditional and Western Medicine 2005 25 8 682 686 2-s2.0-32944475921
40. Wan Y. X., Zhang T. Z., Research on relationship between angiotensinogen gene M235T and TCM syndrome type in essential hypertension patients. Chinese Journal of Integrated Traditional and Western Medicine 2008 28 1 36 38 2-s2.0-55949120726
41. Chu Y. G., Shi J., Hu Y. H., Seruum proteomic study on hypertension patients with Gan-Dan Damp-Heat syndrome. Chinese Journal of Integrated Traditional and Western Medicine 2010 30 1 37 41
42. Chu Y. G., Shi J., Hu Y. H., Serum proteomes of hypertension patients with abundant phlegm-dampness. Journal of Chinese Integrative Medicine 2009 7 7 29 35
43. Lu Y. H., Hao H. P., Wang G. J., Metabolomics approach to the biochemical differentiation of traditional Chinese medicine syndrome types of hypertension. Chinese Journal of Clinical Pharmacology Therapy 2007 12 10 1144 1150
44. Yang C. H., Lin J. M., Xie J., Study on the metabolic difference of hypertension patients of Gan-yang hyperactivity syndrome and Yin-Yang deficiency syndrome. Chinese Journal of Integrated Traditional and Western Medicine 2012 32 9 1204 1207
45. Jiang H. Q., Li Y. L., Xie J., Urine metabonomic study on hypertension patients of ascendant hyperactivity of Gan Yang syndrome by high performance liquid chromatography coupled with time of flight mass spectrometry. Journal of Integrated Traditional and Western Medicine 2012 32 3 333 337
46. Luo Y. Z., Wang C., Zeng L., Correlation between Chinese medicine syndromes and the NPHS1 gene and NPHS2 gene polymorphism as well as corticosteroid sensitivity in patients with minimal change disease. Journal of Integrated Traditional and Western Medicine 2012 32 7 914 917
47. Zhong Y. F., Chen Y. P., Deng Y. Y., Chen N., Wang Z. H., Correlation between traditional Chinese medicine syndromes in primary immunoglobulin A nephropathy and A267G in 5′-untranslated region within exonal of megsin gene. Journal of Chinese Integrative Medicine 2008 6 5 463 467 2-s2.0-44349151712 10.3736/jcim20080506
48. Hao Y. M., Hong M. C., Wang W. J., Study on proteins in urine of chronic renal failure patients of different TCM syndrome types. Journal of Integrated Traditional and Western Medicine 2012 32 9 1196 1199
49. Sun X. M., Tan W., Luo R., Two-dimensional gel electrophoresis analysis on plasma proteomics of chronic glomerulonephritis of Kidney-Yin deficiency syndrome. Journal of Tropical Medicine 2011 11 4 433 443
50. Jiang W. M., Tang S. H., Lai R. S., Study on the relationship between polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia. Chinese Journal of Integrated Traditional and Western Medicine 2006 26 1 38 41 2-s2.0-38049068182
51. Song J. N., Liu J. L., Fang X. Z., Hu Y. H., Lei Y., Niu X. H., Wu G., Chen B. S., Ma Y. L., Chen B., Jin H., Relationship between plasma protein expression profiles and states of Zang-Fu organs in patients with phlegm or blood stagnation syndromes due to hyperlipidemia and atherosclerosis. Journal of Chinese Integrative Medicine 2008 6 12 1233 1237 2-s2.0-65349131878 10.3736/jcim20081205
52. Liu J. L., Song J. N., Lei Y., Differential plasma protein profiles in patients with hyperlipidemia & atherosclerosis of different patterns of phlegm-stasis syndrome. Journal of Integrated Traditional and Western Medicine 2010 30 5 482 487
53. Yang Z. M., Chen W. W., Wang Y. F., Study on gene differential expressions of substance and energy metabolism in chronic superficial gastritis patients of Pi deficiency syndrome and of Pi-Wei hygroyrexia syndrome. Journal of Integrated Traditional and Western Medicine 2012 32 9 1180 1187
54. Wang Y. Q., Li F. F., Wang W. J., Zhao L. Y., Guo L., Wang H. F., Serum proteomics study of chronic gastritis with dampness syndrome in traditional Chinese medicine. Journal of Chinese Integrative Medicine 2007 5 5 514 516 2-s2.0-34648833618 10.3736/jcim20070507
55. Xie Y. Q., Wang H., Wu Y. P., Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy. Molecular Medicine Reports 2011 4 1219 1223
56. Wu T., Yang M., Wei H. F., Application of metabolomics in traditional Chinese medicine differentiation of Deficiency and Excess syndromes in patients with diabetes mellitus. Evidence-Based Complementary and Alternative Medicine 2012 2012 11 968083 10.1155/2012/968083
57. Xu W. J., Zhang L. X., Huang Y. H., Discrimination of type 2 diabetes mellitus corresponding to different traditional Chinese medicine syndromes based on plasma fatty acis profiles and chemometric methods. Journal of Ethnopharmacology 2012 143 463 468
58. Xu W., Huang Y., Wang L., Yang Q., Xiao H., Zhang D., Classification of diabetes deficiency syndromes based plasma fatty acid metabolic profilings using pre-column derivatization quantitative method. Chinese Journal of Chromatography 2010 28 6 547 550 2-s2.0-79959835038 10.3724/SP.J.1123.2010.00547
59. Wei H., Pasman W., Rubingh C., Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes. Molecular BioSystems 2012 8 1482 1491
60. Li X., Luo X., Lu X., Duan J., Xu G., Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine. Molecular BioSystems 2011 7 7 2228 2237 2-s2.0-79959237913 10.1039/c0mb00341g
61. Chen S., Lv F., Gao J., Lin J., Liu Z., Fu Y., Liu Y., Lin B., Xie Y., Ren X., Xu Y., Fan X., Xu A., HLA class II polymorphisms associated with the physiologic characteristics defined by traditional Chinese medicine: linking modern genetics with an ancient medicine. The Journal of Alternative and Complementary Medicine 2007 13 2 231 239 2-s2.0-34047181109 10.1089/acm.2006. 6126
62. Ma X. J., Yin H. J., Chen K. J., Investigation of gene expression profiles in patients with blood stasis syndrome. Journal of Chinese Integrative Medicine 2008 6 4 355 360 2-s2.0-42549117173 10.3736/jcim20080406
63. Matsumoto C., Kojima T., Ogawa K., Kamegai S., Oyama T., Shibagaki Y., Kawasaki T., Fujinaga H., Takahashi K., Hikiami H., Goto H., Kiga C., Koizumi K., Sakurai H., Muramoto H., Shimada Y., Yamamoto M., Terasawa K., Takeda S., Saiki I., A proteomic approach for the diagnosis of "Oketsu" (blood stasis), a pathophysiologic concept of Japanese traditional (Kampo) medicine. Evidence-based Complementary and Alternative Medicine 2008 5 4 463 474 2-s2.0-56749105951 10.1093/ecam/nem049
64. Chen C. S., Lin L. W., Hsieh C. C., Differential gene expression in hemodialysis patients with "Cold" Zheng. The American Journal of Chinese Medicine 2006 34 3 377 385
65. Ma T., Tan C., Zhang H., Wang M., Ding W., Li S., Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network. Molecular BioSystems 2010 6 4 613 619 2-s2.0-77949682260 10.1039/b914024g
66. Yang L., Wang M., Wu W., Zhang L., Transcriptome analysis of cold syndrome using microarray. The American Journal of Chinese Medicine 2007 35 4 609 620 2-s2.0-34548162366 10.1142/S0192415X07005107
67. + among rheumatoid arthritis patients of cold or heat syndrome type with or without rheumatoid factor. Chinese Journal of Integrated Traditional and Western Medicine 2006 26 8 689 693 2-s2.0-38049084915
68. Van Wietmarschen H., Yuan K., Lu C., Gao P., Wang J., Xiao C., Yan X., Wang M., Schroën J., Lu A., Xu G., Van Der Greef J., Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients. Journal of Clinical Rheumatology 2009 15 7 330 337 2-s2.0-70350152573 10.1097/RHU.0b013e3181ba3926
69. Lu C., Liu Y. Y., Xiao C., Biological basis of Cold and Heat pattern of rheumatoid arthritis in traditional Chinese medicine. World Science and Technology 2010 12 5 814 817
70. Wang J. S., Zhao X. J., Yin P. Y., Metabonomics study on the subtypes of rheumatoid arthritis. World Science and Technology 2009 11 1 201 205
71. Mamtmin B., Upur H., Plasma metabonomics analysis of tumor patients of phlegm-stasis syndrome. Journal of Integrated Traditional and Western Medicine 2011 31 4 492 495
72. Chen Y. L., Chen W. W., Li R. L., Study on ribosomal protein gene expression in patients with ulcerative colitis of Pi-asthenic syndrome and Pi-sthenic syndrome. Journal of Integrated Traditional and Western Medicine 2011 31 5 603 607
73. Xiong X. G., Chen J., Liang Q. H., Proteomics study on the essence of Wind syndrome caused by Gan-Yand hyperactivity in Chinese medicine. Journal of Integrated Traditional and Western Medicine 2011 31 7 913 920
74. Wu Y., Cun Y., Dong J., Shao J., Luo S., Nie S., Yu H., Zheng B., Wang Q., Xiao C., Polymorphisms in PPARD, PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions. Journal of Genetics and Genomics 2010 37 6 371 379 2-s2.0-77954191014 10.1016/S1673-8527(09)60055-2
75. Van Der Greef J., Van Wietmarschen H., Schroën J., Wang M., Hankemeier T., Xu G., Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine. Planta Medica 2010 76 17 2036 2047 2-s2.0-78649907347 10.1055/s-0030-1250450
76. De Hoog C. L., Mann M., Proteomics. Annual Review of Genomics and Human Genetics 2004 5 267 293 2-s2.0-5444223979 10.1146/annurev.genom.4.070802.110305
77. Ding W. J., Zeng Y. Z., Li W. H., Zhang T. E., Liu W. W., Teng X. K., Ma Y. X., Yan S. L., Wan J. M. F., Wang M. Q., Identification of linkage disequilibrium SNPs from a Kidney-yang deficiency syndrome pedigree. The American Journal of Chinese Medicine 2009 37 3 427 438 2-s2.0-68149171589 10.1142/S0192415X09006953
78. Zhou L. P., Liu W. W., Zhang T. E., Resequencing DCDC5 in the flanking region of an LD-SNP derived from a Kidney-Yang deficiency syndrome family. Evidence-Based Complementary and Alternative Medicine 2011 2011 7 215653 10.1155/2011/215653
79. Li Z. G., Tong J. B., Peng B., Preliminary study on differential expressed genes in T lymphocyte of chronic obstructive pulmonary disease patients with Fei-qi deficiency syndrome. Chinese Journal of Integrated Traditional and Western Medicine 2006 26 12 1082 1085 2-s2.0-42949085781
80. Luo Y. J., Xiu Z. C., Huang S. P., Primary exploration on immune associated genome of patients with Pi-Qi deficiency syndrome. Chinese Journal of Integrated Traditional and Western Medicine 2005 25 4 311 314 2-s2.0-27744467497
81. Anderson N. G., Anderson N. L., Twenty years of two-dimensional electrophoresis: past, present and future. Electrophoresis 1996 17 3 443 453 2-s2.0-0029867292 10.1002/elps.1150170303
82. Liu P., Zhang Y. Y., Qiao J., Establishment and analysis of serum two-dimensional gel electrophoresis profiles of myasthenia gravis patients with spleen and kidney deficiency syndrome. Journal of Chinese Integrative Medicine 2007 5 2 150 154 2-s2.0-33947372138
83. Lai M. S., Fan R. Q., Study on application of SELDI protein chip technique in diagnosis of systemic lupus erythematosus of Yin deficiency caused intermal Heat syndrome. Journal of Integrated Traditional and Western Medicine 2010 30 1 26 29
84. Jia J., Yu Y., Deng J. H., A review of omics research in acupuncture: the relevance and future prospects for understanding the nature of meridians and acupoints. Journal of Ethnopharmacology 2012 140 594 603
85. Li X., Yang S., Qiu Y., Zhao T., Chen T., Su M., Chu L., Lv A., Liu P., Jia W., Urinary metabolomics as a potentially novel diagnostic and stratification tool for knee osteoarthritis. Metabolomics 2010 6 1 109 118 2-s2.0-77949319979 10.1007/s11306-009-0184-0
86. Lu A. P., Jia H. W., Xiao C., Lu Q. P., Theory of traditional chinese medicine and therapeutic method of diseases. World Journal of Gastroenterology 2004 10 13 1854 1856 2-s2.0-3543098689
87. Xue M., Chen K. J., Ma X. J., Liu J. G., Jiang Y. R., Miao Y., Yin H. J., Effects of Xuefu Zhuyu Oral Liquid on hemorheology in patients with blood-stasis syndrome due to coronary disease and their relationship with human platelet antigen-3 polymorphism. Journal of Chinese Integrative Medicine 2008 6 11 1129 1135 2-s2.0-56849107262 10.3736/jcim20081106
88. Yu S. H., Guo Z. Z., Guan Y., Combining ZHENG theory and high-throughput expression data to predict new effcts of Chinese herbal formulae. Evidence-Based Complementary and Alternative Medicine 2012 2012 8 986427 10.1155/2012/986427
89. Sun S. J., Dai J. Y., Wang W. Y., Metabonomic evaluation of ZHENG differentiation and treatment by Fuzhenghuayu Tablet in hepatitis-B-caused cirrhosis. Evidence-Based Complementary and Alternative Medicine 2012 2012 8 453503 10.1155/2012/453503
90. Sun P., Luo G. A., Qiao M. Q., Studies on the metabonomics of premenstrual syndrome Liver-Qi invasion patient interfered by Jingqianping Granules. World Science and Technology 2010 12 2 195 201
91. Hogeboom C. J., Sherman K. J., Cherkin D. C., Variation in diagnosis and treatment of chronic low back pain by traditional Chinese medicine acupuncturists. Complementary Therapies in Medicine 2001 9 3 154 166 2-s2.0-0035165554 10.1054/ctim.2001.0457
92. Zell B., Hirata J., Marcus A., Ettinger B., Pressman A., Ettinger K. M., Diagnosis of symptomatic postmenopausal women by traditional Chinese medicine practitioners. Menopause 2000 7 2 129 134 2-s2.0-0034064583
93. Wei H., Pasman W., Rubingh C., Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes. Molecular BioSystems 2012 8 1482 1491 10.1039/c2mb05445k
94. Yu J. W., Ma L. Z., Yang H. Y., Present research situation and prospect of intelligent diagnosis of traditional Chinese medicine. Liaoning Journal of Traditional Chinese Medicine 2010 37 1 50 53