DNA damage and ER stress contribute to oblongifolin C-induced cell killing in Bax/Bak-deficient cells

Biochemical and Biophysical Research Communications

Volumn 457, Issue 3, 2015, Pages 300-306

  Xu, Wei ^a   Cheng, Min ^a   Lao, Yuanzhi ^b   Wang, Xiaoyu ^b   Wu, Jiangbin ^a   Zhou, Lingli ^c   Zhang, Yaou ^a   Xu, Hongxi ^b   Xu, Naihan ^a  

^a TSINGHUA UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Apoptosis; BAK; BAX; DNA damage; ER stress; Oblongifolin C

Indexed keywords

ANTINEOPLASTIC AGENT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; OBLONGIFOLIN C; PROTEIN BAK; PROTEIN BAX; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; BAK1 PROTEIN, MOUSE; BAX PROTEIN, MOUSE; CASPASE; TERPENE;

ANIMAL CELL; ARTICLE; CARCINOMA CELL LINE; CELL FRACTIONATION; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; EMBRYO; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ANIMAL; APOPTOSIS; CELL CULTURE; COLONIC NEOPLASMS; DEFICIENCY; DNA REPAIR; DRUG EFFECTS; GENETICS; HCT116 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

MURINAE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELLS, CULTURED; COLONIC NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; ENDOPLASMIC RETICULUM STRESS; HCT116 CELLS; HUMANS; MICE; MICE, KNOCKOUT; TERPENES;

EID: 84922695368     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.12.104     Document Type: Article

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