Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Cohen, Jonathan M ^a   Khandavilli, Suneeta ^a   Camberlein, Emilie ^a   Hyams, Catherine ^a   Baxendale, Helen E ^a   Brown, Jeremy S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BACTEREMIA; BACTERIAL COLONIZATION; CD4 LYMPHOCYTE COUNT; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNOGLOBULIN BLOOD LEVEL; INFECTION CONTROL; INFECTION PREVENTION; MOUSE; NONHUMAN; PATHOGEN CLEARANCE; PHAGOCYTOSIS; PROTEIN BLOOD LEVEL; RHINOPHARYNGITIS; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; T CELL DEPLETION; TH17 CELL; UPREGULATION; ANIMAL; BLOOD; IMMUNOLOGY; MUCOSA; NASOPHARYNX; PATHOGENICITY;

MUS; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTIBODIES, BACTERIAL; BACTEREMIA; MICE; MUCOUS MEMBRANE; NASOPHARYNX; PHAGOCYTOSIS; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE; TH17 CELLS;

EID: 80053917022     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025558     Document Type: Article

References (33)

1. Bogaert D, de Groot R, Hermans PW, (2004) Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect Dis 4: 144-154.
2. Granat SM, Ollgren J, Herva E, Mia Z, Auranen K, et al. (2009) Epidemiological evidence for serotype-independent acquired immunity to pneumococcal carriage. J Infect Dis 200: 99-106.
3. O'Brien KL, Wolfson LJ, Watt JP, Henkle E, oria-Knoll M, et al. (2009) Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 374: 893-902.
4. Fedson DS, Scott JA, (1999) The burden of pneumococcal disease among adults in developed and developing countries: what is and is not known. Vaccine 17 (Suppl 1:S11-8.): S11-S18.
5. Trotter CL, Waight P, Andrews NJ, Slack M, Efstratiou A, et al. (2010) Epidemiology of invasive pneumococcal disease in the pre-conjugate vaccine era: England and Wales, 1996-2006. Journal of Infection 60: 200-208.
6. Jackson LA, Janoff EN, (2008) Vaccines: pneumococcal vaccination of elderly adults: new paradigms for protection. Clin Infect Dis 47: 1328-1338.
7. van der PT, Opal SM, (2009) Pathogenesis, treatment, and prevention of pneumococcal pneumonia. Lancet 374: 1543-1556.
8. Lipsitch M, Whitney CG, Zell E, Kaijalainen T, Dagan R, et al. (2005) Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease? PLoS Med 2: e15.
9. Musher DM, Groover JE, Rowland JM, Watson DA, Struewing JB, et al. (1993) Antibody to capsular polysaccharides of Streptococcus pneumoniae: prevalence, persistence, and response to revaccination. Clin Infect Dis 17: 66-73.
10. McCool TL, Cate TR, Tuomanen EI, Adrian P, Mitchell TJ, et al. (2003) Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization. Infect Immun 71: 5724-5732.
11. Richards L, Ferreira DM, Miyaji EN, Andrew PW, Kadioglu A, (2010) The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease. Immunobiology 215: 251-263.
12. Roche AM, King SJ, Weiser JN, (2007) Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice. Infect Immun 75: 2469-2475.
13. Roche AM, Weiser JN, (2010) Identification of the Targets of Cross-Reactive Antibodies Induced by Streptococcus pneumoniae Colonization. Infect Immun 78: 2231-2239.
14. Zhang Q, Bagrade L, Bernatoniene J, Clarke E, Paton J, et al. (2007) Low CD4 T Cell Immunity to Pneumolysin Is Associated with Nasopharyngeal Carriage of Pneumococci in Children. J Infect Dis 195: 1194-1202.
15. Khader SA, Gaffen SL, Kolls JK, (2009) Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol 2: 403-411.
16. Higgins SC, Jarnicki AG, Lavelle EC, Mills KHG, (2006) TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis: Role of IL-17-Producing T Cells. J Immunol 177: 7980-7989.
17. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, et al. (2007) IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8: 369-377.
18. Lu YJ, Gross J, Bogaert D, Finn A, Bagrade L, et al. (2008) Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog 4: e1000159.
19. Zhang Z, Clarke TB, Weiser JN, (2009) Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. J Clin Invest 119: 1899-1909.
20. Morona J, Miller D, Morona R, Paton J, (2004) The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae. J Infect Dis 189: 1905-1913.
21. Basavanna S, Khandavilli S, Yuste J, Cohen JM, Hosie AHF, et al. (2009) Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis. Infect Immun 77: 3412-3423.
22. Wu HY, Virolainen A, Mathews B, King J, Russell MW, et al. (1997) Establishment of a Streptococcus pneumoniae nasopharyngeal colonization model in adult mice. Microb Pathog 23: 127-137.
23. Brown JS, Gilliland SM, Holden DW, (2001) A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence. Mol Microbiol 40: 572-585.
24. Yuste J, Botto M, Bottoms SE, Brown JS, (2007) Serum Amyloid P Aids Complement-Mediated Immunity to Streptococcus pneumoniae. PLoS Pathog 3: e120.
25. Hyams C, Camberlein E, Cohen JM, Bax K, Brown JS, (2010) The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms. Infect Immun 78: 704-715.
26. Arredouani MS, Yang Z, Imrich A, Ning Y, Qin G, et al. (2006) The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am J Respir Cell Mol Biol 35: 474-478.
27. Yuste J, Sen A, Truedsson L, Jonsson G, Tay LS, et al. (2008) Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway. Infect Immun 76: 3761-3770.
28. Holdsworth RJ, Neill GD, Irving AD, Cuschieri A, (1989) Blood clearance and tissue distribution of 99Tc-labelled pneumococci following splenectomy in rabbits. Br J Exp Pathol 70: 669-677.
29. Hussell T, Cavanagh MM, (2009) The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia. Biochem Soc Trans 37: 811-813.
30. Kirby AC, Newton DJ, Carding SR, Kaye PM, (2007) Evidence for the involvement of lung-specific gammadelta T cell subsets in local responses to Streptococcus pneumoniae infection. Eur J Immunol 37: 3404-3413.
31. Malley R, Trzcinski K, Srivastava A, Thompson CM, Anderson PW, et al. (2005) CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. PNAS 102: 4848-4853.
32. LeMessurier K, Hacker H, Tuomanen E, Redecke V, (2010) Inhibition of T Cells Provides Protection against Early Invasive Pneumococcal Disease. Infect Immun 78: 5287-5294.
33. Weber SE, Tian H, Pirofski LA, (2011) CD8+ Cells Enhance Resistance to Pulmonary Serotype 3 Streptococcus pneumoniae Infection in Mice. J Immunol 186: 432-442.