Generation of Cancerous Neural Stem Cells Forming Glial Tumor by Oncogenic Stimulation

Stem Cell Reviews and Reports

Volumn 8, Issue 2, 2012, Pages 532-545

  Lee, Ji Seon ^a   Lee, Hong Jun ^b,c   Moon, Bo Hyun ^d   Song, Seung Hyun ^e   Lee, Mi Ok ^e   Shim, Sung Han ^e   Kim, Hyung Seok ^f   Lee, Min Cheol ^f   Kwon, Jeong Taik ^b   Fornace Jr , Albert J ^d   Kim, Seung U ^b,c   Cha, Hyuk Jin ^a  

^a Sogang University   (South Korea)

^b Chung Ang University College of Medicine   (South Korea)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e CHA University   (South Korea)

^f Chonnam National University Medical School   (South Korea)

Author keywords

Cancerous stem cells; Glial tumor; H Ras; Human neural stem cells; p53; v myc

Indexed keywords

BIOLOGICAL MARKER; PROTEIN P53;

ANIMAL; ARTICLE; BRAIN TUMOR; CANCER STEM CELL; CELL TRANSFORMATION; DISEASE PREDISPOSITION; FETAL STEM CELL; GENETICS; GLIOMA; HUMAN; METABOLISM; MOUSE; MOUSE MUTANT; NEURAL STEM CELL; ONCOGENE; ONCOGENE MYC; ONCOGENE RAS; PATHOLOGY;

ANIMALS; BIOLOGICAL MARKERS; BRAIN NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE SUSCEPTIBILITY; FETAL STEM CELLS; GENES, MYC; GENES, RAS; GLIOMA; HUMANS; MICE; MICE, SCID; NEOPLASTIC STEM CELLS; NEURAL STEM CELLS; ONCOGENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84861714815     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-011-9280-4     Document Type: Article

References (51)

1. Sanai, N., Alvarez-Buylla, A., & Berger, M. S. (2005). Neural stem cells and the origin of gliomas. The New England Journal of Medicine, 353, 811-822.
2. Rich, J. N., Guo, C., McLendon, R. E., Bigner, D. D., Wang, X. F., & Counter, C. M. (2001). A genetically tractable model of human glioma formation. Cancer Research, 61, 3556-3560.
3. Zhu, Y., Guignard, F., Zhao, D., et al. (2005). Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell, 8, 119-130.
4. Kwon, C. H., Zhao, D., Chen, J., et al. (2008). Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Research, 68, 3286-3294.
5. Doetsch, F., Caille, I., Lim, D. A., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (1999). Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell, 97, 703-716.
6. Alvarez-Buylla, A., & Lim, D. A. (2004). For the long run: Maintaining germinal niches in the adult brain. Neuron, 41, 683-686.
7. Alcantara Llaguno, S. R., Chen, J., & Parada, L. F. (2009). Signaling in malignant astrocytomas: Role of neural stem cells and its therapeutic implications. Clinical Cancer Research, 15, 7124-7129.
8. Fan, X., & Eberhart, C. G. (2008). Medulloblastoma stem cells. Journal of Clinical Oncology, 26, 2821-2827.
9. Alcantara Llaguno, S., Chen, J., Kwon, C., et al. (2009). Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell, 15, 45-56.
10. Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999). Creation of human tumour cells with defined genetic elements. Nature, 400, 464-468.
11. Hahn, W. C. (2002). Immortalization and transformation of human cells. Molecules and Cells, 13, 351-361.
12. Rasheed, B. K., Wiltshire, R. N., Bigner, S. H., & Bigner, D. D. (1999). Molecular pathogenesis of malignant gliomas. Current Opinion in Oncology, 11, 162-167.
13. Chen, Z., Trotman, L. C., Shaffer, D., et al. (2005). Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature, 436, 725-730.
14. Ferbeyre, G., de Stanchina, E., Lin, A. W., et al. (2002). Oncogenic ras and p53 cooperate to induce cellular senescence. Molecular and Cellular Biology, 22, 3497-3508.
15. Reilly, K. M., Loisel, D. A., Bronson, R. T., McLaughlin, M. E., & Jacks, T. (2000). Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genetics, 26, 109-113.
16. Flax, J. D., Aurora, S., Yang, C., et al. (1998). Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nature Biotechnology, 16, 1033-1039.
17. Satoh, J. I., Obayashi, S., Tabunoki, H., Wakana, T., Kim, S. U. (2010). Stable expression of Neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1. F3. Cellular and Molecular Neurobiology, 30, 415-426.
18. Kim, S. U., Nagai, A., Nakagawa, E., et al. (2008). Production and characterization of immortal human neural stem cell line with multipotent differentiation property. Methods in Molecular Biology, 438, 103-121.
19. Arnold, R. S., Shi, J., Murad, E., et al. (2001). Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proceedings of the National Academy of Sciences of the United States of America, 98, 5550-5555.
20. Kim, S. U., Park, I. H., Kim, T. H., et al. (2006). Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease. Neuropathology, 26, 129-140.
21. Cai, J., Wu, Y., Mirua, T., et al. (2002). Properties of a fetal multipotent neural stem cell (NEP cell). Developmental Biology, 251, 221-240.
22. Singh, S. K., Hawkins, C., Clarke, I. D., et al. (2004). Identification of human brain tumour initiating cells. Nature, 432, 396-401.
23. Singh, S. K., Clarke, I. D., Terasaki, M., et al. (2003). Identification of a cancer stem cell in human brain tumors. Cancer Research, 63, 5821-5828.
24. Hemmati, H. D., Nakano, I., Lazareff, J. A., et al. (2003). Cancerous stem cells can arise from pediatric brain tumors. Proceedings of the National Academy of Sciences of the United States of America, 100, 15178-15183.
25. Bleau, A., Hambardzumyan, D., Ozawa, T., et al. (2009). PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell, 4, 226-235.
26. Patrawala, L., Calhoun, T., Schneider-Broussard, R., Zhou, J., Claypool, K., & Tang, D. (2005). Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Research, 65, 6207-6219.
27. Ginestier, C., Hur, M. H., Charafe-Jauffret, E., et al. (2007). ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell, 1, 555-567.
28. Jiang, T., Collins, B. J., Jin, N., et al. (2009). Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Research, 69, 845-854.
29. Huang, E. H., Hynes, M. J., Zhang, T., et al. (2009). Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Research, 69, 3382-3389.
30. Chen, Y. C., Chen, Y. W., Hsu, H. S., et al. (2009). Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochemical and Biophysical Research Communications, 385, 307-313.
31. Theodoropoulos, P. A., Polioudaki, H., Agelaki, S., et al. (2010). Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer. Cancer Letters, 288, 99-106.
32. Mani, S., Guo, W., Liao, M., et al. (2008). The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 133, 704-715.
33. Morel, A., Lievre, M., Thomas, C., Hinkal, G., Ansieau, S., & Puisieux, A. (2008). Generation of breast cancer stem cells through epithelial-mesenchymal transition. PloS One, 3, e2888.
34. Kabashima, A., Higuchi, H., Takaishi, H., et al. (2009). Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion. International Journal of Cancer, 124, 2771-2779.
35. DiMeo, T., Anderson, K., Phadke, P., et al. (2009). A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Research, 69, 5364-5373.
36. Mizumoto, Y., Kyo, S., Ohno, S., et al. (2006). Creation of tumorigenic human endometrial epithelial cells with intact chromosomes by introducing defined genetic elements. Oncogene, 25, 5673-5682.
37. Brockschmidt, C., Hirner, H., Huber, N., et al. (2008). Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut, 57, 799-806.
38. McGillicuddy, L. T., Fromm, J. A., Hollstein, P. E., et al. (2009). Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer Cell, 16, 44-54.
39. Li, Y., Bollag, G., Clark, R., et al. (1992). Somatic mutations in the neurofibromatosis 1 gene in human tumors. Cell, 69, 275-281.
40. Kastan, M., Zhan, Q., El-Deiry, W., et al. (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71, 587-597.
41. Hahn, W. C., & Weinberg, R. A. (2002). Rules for making human tumor cells. The New England Journal of Medicine, 347, 1593-1603.
42. Lundberg, A. S., Randell, S. H., Stewart, S. A., et al. (2002). Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene, 21, 4577-4586.
43. Eliyahu, D., Michalovitz, D., Eliyahu, S., Pinhasi-Kimhi, O., & Oren, M. (1989). Wild-type p53 can inhibit oncogene-mediated focus formation. Proceedings of the National Academy of Sciences of the United States of America, 86, 8763-8767.
44. Kim, H. S., Shin, J. Y., Yun, J. Y., Ahn, D. K., & Le, J. Y. (2001). Immortalization of human embryonic fibroblasts by overexpression of c-myc and simian virus 40 large T antigen. Experimental & Molecular Medicine, 33, 293-298.
45. Hermeking, H., & Eick, D. (1994). Mediation of c-Myc-induced apoptosis by p53. Science, 265, 2091-2093.
46. Yu, K., Ravera, C., Chen, Y., & McMahon, G. (1997). Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2. Cell Growth & Differentiation, 8, 731-742.
47. Ahn, S. M., Byun, K., Kim, D., et al. (2008). Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PloS One, 3, e3917.
48. Gupta, P. B., Onder, T. T., Jiang, G., et al. (2009). Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell, 138, 645-659.
49. Shieh, S. Y., Ikeda, M., Taya, Y., & Prives, C. (1997). DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell, 91, 325-334.
50. D'Orazi, G., Cecchinelli, B., Bruno, T., et al. (2002). Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nature Cell Biology, 4, 11-19.
51. Tang, Y., Zhao, W., Chen, Y., Zhao, Y., & Gu, W. (2008). Acetylation is indispensable for p53 activation. Cell, 133, 612-626.